The 12th Meeting of the Regional Certification Commission (RCC) for the Polio Endgame in the Region of the Americas was conducted virtually due to the pandemic of COVID-19. The meeting was composed of 5 steps: Step 1: An introductory meeting between RCC members and Secretariat Step 2: Assessment of the annual and containment reports by the reviewers Step 3: Observations and recommendations review Step 4: A meeting between RCC Chair and the Secretariat to review the draft report and general recommendations of the meeting Step 5: RCC meeting to review and approve the recommendations to each country and the final report and recommendations of the meeting