|
65679ffa212eaade2e0f07b4
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007020
|
GCRF_MRC_NS_MR/S001255/1
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.288144
|
0
|
0
|
0
|
0.288144
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
E-MHGAP INTERVENTION GUIDE IN ...LOW AND MIDDLE INCOME COUNTRIES: PROOF-OF-CONCEPT FOR IMPACT AND ACCEPTABILITY (EMILIA PROJECT)
more
|
E-MhGAP Intervention guide in ...Low and middle income countries: proof-of-concept for Impact and Acceptability (Emilia project)
more
|
Layperson summary The context... for the Emilia proposal is the 'mental health treatment gap'. This is the difference between the number of people with mental illness needing treatment and care, and the number who actually receive help. At present this gap is huge. Over 80% of people with severe mental disorders in low and middle income countries (LMICs) receive no treatment at all. The aim of the Emilia project is to assess if it is possible to produce a version of the World Health Organisation (WHO) Mental Health Global Action Programme Intervention Guide that is easily usable on smart phones and tablet devices, for use in this project by primary care staff in Nepal and Nigeria. We intend to assess if this electronic form of guidance is suitable for use in other LMICs, where over 85% of the world's population live. We will compare the training, support and supervision given to primary health care using the paper version and the electronic version of the WHO Mental Health Global Action Programme Intervention Guide (mhGAP IG). We will assess if the electronic version is more practical to use (ie more feasible) by answering the following questions. Is the electronic version more feasible to use in terms of: 1. greater staff acceptability 2. more often leading to an evidence-based intervention 3. a greater proportion of patients with depression are identified by primary care staff 4. being affordable and cost-effective 5. delivering better clinical support and supervision to primary care staff 6. leading to less stigma related to people with mental illness among primary care staff
more
|
0
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ffa212eaade2e0f07b5
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007015
|
GCRF_MRC_NS_MR/S004009/1
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.178879
|
0
|
0
|
0
|
0.178879
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
COGNITIVE STIMULATION THERAPY ...(CST) FOR DEMENTIA: INTERNATIONAL IMPLEMENTATION IN BRAZIL, INDIA AND TANZANIA (CST-INTERNATIONAL)
more
|
Cognitive Stimulation Therapy ...(CST) for dementia: International implementation in Brazil, India and Tanzania (CST-International)
more
|
Dementia presents huge financi...al costs and significantly reduces quality of life for people and their families. However, it remains largely unrecognised and untreated in low and middle income countries. There is an urgent need to introduce simple interventions which can address this treatment gap, something that has been done successfully in other places including the UK. Cognitive Stimulation Therapy (CST) is an evidence-based, group non-pharmacological intervention shown to significantly improve cognitive functioning and quality of life. It can be delivered to a wider population than can medication, as it has no known side-effects, can be delivered by non-medical personnel, does not require specialist equipment or training and is low cost. This key aim of this project is to create an ongoing and sustainable programme to implement CST in various regions within these three countries. A secondary objective is to increase awareness and skills in the detection and management of dementia, both for health workers and families. We have selected an upper middle income (Brazil), lower middle income (India) and low income (Tanzania) country, to provide a broad range of economic as well as geographical and cultural challenges. All three countries have already a) previously translated and adapted the CST manual, following the same (recommended) process, b) begun or completed initial testing, with positive results and c) engaged local stakeholders and gathered initial ideas on implementation. In each country, (i) we will investigate the things that are likely to help or hinder implementation of CST. We will interview a range of people including clinicians, policy makers and people with dementia and their families, enabling a rich perspective. (ii) We will develop an implementation strategy for each region included, but with shared themes across all sites. (iii) We will test this strategy through looking at how well it works. We will train CST trainers and attempt to recruit 50 people with dementia in each country (150 in total) into CST groups. We will see whether people attend the sessions, enjoy the sessions and whether facilitators are able to run sessions as intended. We will measure outcomes including cognition and quality of life in people with dementia and look at the costs of running groups in each setting. A three hour family educational session, developed as part of this study, will be offered by the researchers to all families of those who were screened and not included in the study, and to those who participate (after completion of follow-up measures, hence avoiding impact on outcomes). Wherever possible, this will be offered in a group format, both to encourage communication between family members and for the economy of time. People may be offered further support such as physical examinations, depending on the setting, needs and availability of resources (iv) Our testing phase will enable us to adapt and improve our implementation strategy, whi
more
|
0
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ffa212eaade2e0f07b6
|
2020
|
Switzerland
|
Swiss Agency for Development a...nd Co-operation
more
|
2020007029
|
177-Q37-2020-92646
|
3
|
Niger
|
South of Sahara
|
LDCs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0
|
0.372408
|
0
|
0
|
|
0.372408
|
|
|
|
|
COVID-19
|
COVID-19 General
|
100
|
COVID-19 NIGER
|
COVID-19 Niger
|
The SDC negotiates programme c...ontributions as part of institutional partnerships. For the assessment and negotiation of programme contributions, which is based on the NGO's overall programme, the organisation is required to have a long-standing track record and have successfully undergone the admission procedure. Programme contributions are an investment in the competences and capacities of the NGOs and in the relevance of their programmes.
more
|
|
12220
|
Basic health care
|
6,5,3,2,17,16,10
|
I.2.b. Basic Health
|
22000
|
Donor country-based NGO
|
Médecins Sans Frontières Sui...sse
more
|
|
COVID-19
|
|
65679ffa212eaade2e0f07b7
|
2020
|
Germany
|
Foreign Office
|
2020008412
|
6611211
|
8
|
Colombia
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.353248
|
0.353248
|
0
|
0
|
0.353248
|
0.353248
|
|
0.353248
|
|
0
|
Emergency projects (meeting ad...ditional funding needs)
more
|
|
100
|
BASIC HEALTH CARE
|
Basic health care
|
Basic health care, nutrition a...nd psychosocial care for internally displaced persons and Venezuelan refugees in Antioquia and Córdoba, Colombia
more
|
0
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
|
22000
|
Donor country-based NGO
|
Donor country-based NGO
|
|
|
|
65679ffa212eaade2e0f07b8
|
2020
|
Germany
|
Foreign Office
|
2020009734
|
6615302
|
1
|
Tunisia
|
North of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.023675
|
0.023322
|
0
|
0
|
0.023675
|
0.023322
|
|
0.023675
|
|
0
|
COVID-19
|
COVID-19 Personal Protective E...quipment
more
|
100
|
COVID-19 EQUIPPING A HOSPITAL ...IN TUNISIA WITH PROTECTION MATERIAL
more
|
Covid-19 Equipping a hospital ...in Tunisia with protection material
more
|
Purchasing protection material... against Covid-19 for the regional hospital of Feriana
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
23000
|
Developing country-based NGO
|
Developing country-based NGO
|
|
COVID-19
|
|
65679ffa212eaade2e0f07b9
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009737
|
RIGHT_1_200144
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
1.073277
|
0
|
0
|
0
|
1.073277
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR RIGHT1: PREVENTION OF EPI...LEPSY FROM BIRTH-RELATED BRAIN INJURY
more
|
NIHR RIGHT1: Prevention of epi...lepsy from birth-related brain injury
more
|
A UK and low- and middle-incom...e country (LMIC) partnership that aims to examine if a simple, pragmatic, and evidenced-based intrapartum care bundle for labour involving birth companions and empowering mothers will reduce perinatal brain injury and thus prevent epilepsy in India.
more
|
0
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ffb212eaade2e0f07ba
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009628
|
GACD_Membership
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0.179556
|
0.089778
|
0
|
0
|
0.179556
|
0.089778
|
0
|
0.179556
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
GLOBAL ALLIANCE FOR CHRONIC DI...SEASES ASSOCIATE MEMBERSHIP CONTRIBUTION
more
|
Global Alliance for Chronic Di...seases Associate Membership contribution
more
|
The Global Alliance for Chroni...c Diseases (GACD) funds implementation research to generate new knowledge on interventions and their implementation for the prevention or management of hypertension and/or diabetes. As an Associate Member of the alliance, the Department of Health and Social Care (DHSC) pays an annual fee to support the activities of the GACD.
more
|
|
99810
|
Sectors not specified
|
|
|
22000
|
Donor country-based NGO
|
Donor country-based NGO
|
|
|
|
65679ffb212eaade2e0f07bb
|
2020
|
Switzerland
|
Swiss Agency for Development a...nd Co-operation
more
|
2020007028
|
177-Q37-2020-92619
|
3
|
Kenya
|
South of Sahara
|
LMICs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0
|
0.760688
|
0
|
0
|
|
0.760688
|
|
|
|
|
COVID-19
|
COVID-19 General
|
100
|
COVID-19 KENYA
|
COVID-19 Kenya
|
The SDC negotiates programme c...ontributions as part of institutional partnerships. For the assessment and negotiation of programme contributions, which is based on the NGO's overall programme, the organisation is required to have a long-standing track record and have successfully undergone the admission procedure. Programme contributions are an investment in the competences and capacities of the NGOs and in the relevance of their programmes.
more
|
|
12220
|
Basic health care
|
6,5,3,2,17,16,10
|
I.2.b. Basic Health
|
22000
|
Donor country-based NGO
|
Médecins Sans Frontières Sui...sse
more
|
|
COVID-19
|
|
65679ffb212eaade2e0f07bc
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007016
|
GCRF_MRC_NS_MR/S021140/1
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.202106
|
0
|
0
|
0
|
0.202106
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
DEVELOPING HUMAN MODEL CELLULA...R SYSTEMS FOR STUDYING RED BLOOD CELL DISEASES AND AS SCREENING PLATFORMS
more
|
Developing human model cellula...r systems for studying Red Blood Cell diseases and as screening platforms
more
|
Red blood cell (RBC) diseases ...can result in chronic anaemia and are a major source of morbidity and mortality worldwide. Among these the thalassemia syndromes (alpha and beta thalassemia) and sickle cell disease (SCD) represent a significant global health problem and financial burden to health services with no drugs available for thalassemia and just 2 for SCD, but unsuitable for many patients. The mainstay therapy is RBC transfusion, with the only curative treatment bone marrow transplant. Thus, new cost-effective treatments are desperately required to deliver optimal therapies to the greatest number of people. However, studying these diseases is severely impeded by paucity of suitable and adequate quantities of material from patients, and lack of suitable cell lines that accurately mimic the disease state. Although erythroid cells can be generated in vitro from peripheral blood stem cells, the approach is severely limited by the restricted expansion potential of the cells and thus number of cells generated, with repeat collections required, a particularly unsuitable approach for anaemic patients. Mouse models of the diseases are therefore routinely used for both biological studies and drug evaluation, but fundamental differences exist between mouse and human erythropoiesis (the process of RBC production). New approaches and human systems for these disorders are therefore essential. We have recently developed methodology and generated 1) the first immortalised adult human erythroid cell line (BEL-A) that recapitulates normal adult erythropoiesis, with cells expressing normal levels of adult haemoglobin, undergoing normal development and expelling their nuclei to produce mature red cells, providing a sustainable supply of cells which we have extensively characterised, 2) a platform for introducing mutations into the BEL-A cells, creating sublines with single or multiple gene edits. We now have the unique opportunity to exploit these tools and technologies to create lines as human model cellular systems of RBC diseases, providing a sustainable and reproducible supply of cells for study. Disease mutations will be introduced into the genome of BEL-A cells. We plan to create eight beta thalassemia and five alpha thalassemia lines with mutations associated with different disease severity and with different mode of action, as well as a SCD line. The lines will provide the unique opportunity to study cell specific effects of human mutations and evaluate drugs and reagents in a human cellular context with a constant genetic background, removing the many experimental variables between patient samples. Furthermore, such a range of lines for a given disease will help determine variability in disease mechanisms, as well as evaluation of drugs etc across spectra of phenotypes. Lines will undergo extensive characterisation to validate disease phenotype and as a data resource to facilitate use of the lines by ourselves and others. Amongst the wide range of
more
|
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ffc212eaade2e0f07bd
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009643
|
RIGHT_2_200846
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
4.628225
|
0.374427
|
0
|
0
|
4.628225
|
0.374427
|
0
|
4.628225
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR RIGHT2: TRANSFORMING ACCE...SS TO CARE FOR SERIOUS MENTAL DISORDERS IN SLUMS
more
|
NIHR RIGHT2: Transforming Acce...ss to Care for Serious Mental Disorders in Slums
more
|
A UK and low- and middle-incom...e country (LMIC) research partnership to increase access to care and improve outcomes of serious mental disorders (SMDs) in slums in India and Nigeria, through development of an innovative collaborative care model involving traditional/faith healers, mental health professionals, primary care practitioners and community health workers (CHWs).
more
|
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ffc212eaade2e0f07be
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006894
|
GCRF_ESRC_AA_ES/S000976/1
|
3
|
Eastern Africa, regional
|
South of Sahara
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.547594
|
0
|
0
|
0
|
0.547594
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TREATING DEPRESSIVE SYMPTOMATO...LOGY IN CONGOLESE REFUGEES IN UGANDA AND RWANDA: ADAPTING AND EVALUATING COMMUNITY-BASED SOCIOTHERAPY
more
|
Treating depressive symptomato...logy in Congolese Refugees in Uganda and Rwanda: Adapting and Evaluating Community-based Sociotherapy
more
|
Refugees experience elevated r...ates of mental health difficulties including depression and post-traumatic stress disorder*1,2,3. Refugees face a wide-range of daily stressors (e.g. lack of access to basic resources, lack of safety and security, risk of family violence) that impact on mental health*4. Guidelines exist for delivering psychosocial support in emergency situations*5, but contention remains about which approaches are most effective, and whether these interventions can be delivered at sufficient scale*6. An absence of highly-skilled professionals means that the 'task-sharing' of roles to lay people is required*7. Community-based approaches offer promise for treating common mental disorders, are socially acceptable, and can decrease pressure on primary healthcare*8,9. Conflict in the Democratic Republic of Congo has led to large numbers of Congolese refugees in Rwanda and Uganda. Community-based Sociotherapy (CBS) has been delivered to over 20,000 people in Rwanda since 2005 to promote community connections and individual wellbeing after the genocide of 1994*10. CBS is delivered by lay-facilitators over fifteen weekly 3-hour group sessions. The WHO described CBS as an approach that uses 'the interactions between individuals and their social environment to facilitate the re-establishment of values, norms, and relationships...and at the same time provide the opportunity for debate, the sharing of experiences and coping mechanisms'*11, Compared with usual care, CBS resulted in significantly increased civic participation and significantly decreased distress in conflict-affected people in Rwanda at 8 months follow-up*12. The UNHCR has noted the potential of CBS for refugees*13, but it has not yet been evaluated in these populations. The project will use a mix of disciplines to: 1) adapt CBS and assessment measures for use with Congolese refugees in Rwanda and Uganda, 2) investigate the efficacy and cost-effectiveness of adapted CBS (aCBS) for reducing depressive symptoms in Congolese refugees, and determine whether changes in levels of social capital and daily stressors are integral to changes in depressive symptoms, 3) develop implementation guidance for adapting and disseminating aCBS for refugees across diverse settings in conjunction with the UNHCR. In the first phase, the Design, Implementation, Monitoring and Evaluation (DIME) approach*14 (which utilises key informant interviews and focus groups) will be used to adapt assessment measures and aCBS content. Then a 2-arm cluster randomised controlled trial (with pilot phase) will compare aCBS to an enhanced care as usual (i.e. training for NGO workers in mental health guidelines and reviewing referral pahways). Adult Congolese refugees (apart from those with complex mental health difficulties, active suicidal ideation and/or intellectual disabilities) will be eligible to participate. This will avoid the risk of participants being stigmatised by the use of mental health labels. Analyses w
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ffc212eaade2e0f07bf
|
2020
|
Germany
|
Foreign Office
|
2020008429
|
6611337
|
8
|
Pakistan
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
1.765826
|
1.765826
|
0
|
0
|
1.765826
|
1.765826
|
|
1.765826
|
|
0
|
Emergency projects (meeting ad...ditional funding needs)
more
|
|
100
|
BASIC HEALTH CARE IN PAKISTAN
|
Basic health care in Pakistan
|
Access to health care for the ...most vulnerable conflict affected population in Khyber Pakthunkwa (KP) und den Federally Administered Tribal Areas (FATA)
more
|
0
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
|
22000
|
Donor country-based NGO
|
Donor country-based NGO
|
|
|
|
65679ffc212eaade2e0f07c0
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009639
|
RIGHT_2_200842
|
1
|
Eastern Africa, regional
|
South of Sahara
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
5.624649
|
0.502831
|
0
|
0
|
5.624649
|
0.502831
|
0
|
5.624649
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR RIGHT2: IMPROVING MENTAL ...HEALTH IN AFRICA FOR CHILDREN WITH DEVELOPMENTAL DISORDERS
more
|
NIHR RIGHT2: Improving mental ...health in Africa for children with developmental disorders
more
|
A UK and low- and middle-incom...e country (LMIC) research partnership to improve the wellbeing and mental health of children with developmental disorders and their caregivers, by developing and evaluating a model of care with and for local Kenyan and Ethiopian communities.
more
|
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ffc212eaade2e0f07c1
|
2020
|
Germany
|
Foreign Office
|
2020008433
|
6611784
|
8
|
Colombia
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.5139585
|
0.5139585
|
0
|
0
|
1.027917
|
1.027917
|
|
1.027917
|
|
0
|
Emergency projects (meeting ad...ditional funding needs)
more
|
|
50
|
PRIMARY HEALTH CARE AND BASIC ...NEEDS COVERAGE FOR VULNERABLE REFUGEES
more
|
Primary health care and basic ...needs coverage for vulnerable refugees
more
|
Primary health care and basic ...needs coverage for vulnerable refugees, migrants and returnees from Venezuela through cash assistance and the distribution of property
more
|
0
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
|
22000
|
Donor country-based NGO
|
Donor country-based NGO
|
|
|
|
65679ffd212eaade2e0f07c2
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009626
|
HPSR_DA_129915
|
1
|
Far East Asia, regional
|
Far East Asia
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0.119902
|
0.071643
|
0
|
0
|
0.119902
|
0.071643
|
0
|
0.119902
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR HPSR-DA: CO-DEVELOPING AN... EVIDENCE-BASED PLAN TO STRENGTHEN THE HEALTH CARE SYSTEM AND INFORM POLICY TO REDUCE CANCER BURDEN IN MONGOLIA
more
|
NIHR HPSR-DA: Co-developing an... Evidence-based Plan to Strengthen the Health Care System and Inform Policy to Reduce Cancer Burden in Mongolia
more
|
Mongolia has the highest cance...r death rates in Asia-Pacific and cancer incidence is expected to double by 2040. The proposed study represents the first step of a health policy and systems research (HPSR) programme aiming to reduce cancer burden in Mongolia by strengthening its health care system and supporting evidence-based service planning and policy development. Collaborative preliminary work identified cancer prevention and early detection as the early focus of the HPSR Programme. In this developmental phase we will work with local stakeholders to describe current early detection and cancer prevention initiatives in Mongolia, and to identify and develop plans for future HPSR research and capacity building activities. We will conduct a scoping review, undertake a needs-and-gaps analysis, use consensus-elicitiation techniques to identify priorities, provide capacity-building training in Mongolia and the UK, and co-develop plans to advance our collaborative HPSR programme. The outputs from this activity can be applied/adapted for other DAC-list country/countries and therefore would benefit a wider geographical region.
more
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12182
|
Medical research
|
|
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51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ffd212eaade2e0f07c3
|
2020
|
Germany
|
Foreign Office
|
2020008441
|
6611877
|
8
|
Ukraine
|
Europe
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.973219
|
0.973219
|
0
|
0
|
0.973219
|
0.973219
|
|
0.973219
|
|
0
|
Emergency projects (meeting ad...ditional funding needs)
more
|
|
100
|
BASIC MEDICAL SERVICES UKRAINE
|
Basic medical services Ukraine
|
Improve access to comprehensiv...e primary health care (PHC) including sexual and reproductive health (SRH) and mental health (MHPS) for conflict-affected populations
more
|
0
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
|
22000
|
Donor country-based NGO
|
Donor country-based NGO
|
|
|
|
65679ffd212eaade2e0f07c4
|
2020
|
Switzerland
|
Swiss Agency for Development a...nd Co-operation
more
|
2020006909
|
177-Q37-2020-90515
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0
|
0.037274
|
0
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0
|
|
0.037274
|
|
|
|
|
COVID-19
|
COVID-19 General
|
100
|
RESISTÊNCIA E MOBILIZAÇÃO E...M TEMPOS DE CORONAVÍRUS.
more
|
Resistência e mobilização e...m tempos de coronavírus.
more
|
Fastenopfer (FO) is a Swiss Ca...tholic relief organization established in Luzern in 1961. It supports disadvantaged people and communities of all confessions aiming at overcoming hunger and poverty in partnership with organisations in 14 countries in Africa, Asia and Latin America as well as with partners in Switzerland. FO promotes socio- cultural and economic transformation towards sustainable development and is especially engaged in the areas of food security, sustainable economy and gender equality.
more
|
|
12264
|
COVID-19 control
|
16,10
|
I.2.b. Basic Health
|
22000
|
Donor country-based NGO
|
Fastenopfer
|
|
COVID-19
|
|
65679ffd212eaade2e0f07c5
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006911
|
GCRF_ESRC_IND_ES/S00145X/1
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.297676
|
0
|
0
|
0
|
0.297676
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
MENTAL HEALTH LITERACY IN URBA...N AND RURAL COMMUNITIES IN KERALA INDIA: AN INTERDISCIPLINARY APPROACH USING APPLIED THEATRE METHODOLOGY
more
|
Mental health literacy in urba...n and rural communities in Kerala India: An interdisciplinary approach using applied theatre methodology
more
|
This highly collaborative inte...rnational interdisciplinary partnership examines the applicability of the evidence based intervention of mental health literacy (MHL) for urban and rural communities through a multi-centre study in India using participatory theatre and media. We believe that our mutual sharing of research experiences, cultural identities and interdisciplinary exchanges will enable us to build our capacity for planning collaborative research of international significance. Our vision is to work towards the UN 2030 Agenda for Sustainable Development goals 3, 5, 8, and 10.The WHO estimates that mental and behavioural disorders account for about 12% of the global burden of diseases and this is likely to increase to 15% by 2020 . Our focus is in Kerala which has higher prevalence of mental ill-health (14.4%), suicidal risk (12.5%) and alcohol abuse than the rest of India. Thus there is a dire need to develop acceptable and affordable evidence based mental health interventions that are responsive to the local cultural and social contexts. Despite the high Human Development Index (HDI), stigma is widespread in Kerala and hence people with mental ill-health can internalise the public perceptions and become resistant to approach mental health facilities. Mental health literacy is proposed as an evidence based approach for enhancing tolerance, self-care, care for others and to reduce stigma. It is proposed that raising MHL can improve understanding about the risks to mental health, and methods of coping with these risks, thus promoting mental health for all. This project will extend partnerships and develop new collaborations between UK and Indian academics & researchers, service users, families, theatre practitioners and NGOs. Our plan is to conduct a multi-centre study using a 'theatre for development' (TFD) model, adopting a participatory approach to engage and empower urban and rural communities through co-production and co-creation of culturally appropriate knowledge and practice in promoting MHL. We will use participatory co-research methodology embracing the principles of co-production and use theatre and media for research engagement and data collection. Our mode of practice and co-production will draw heavily upon the methodologies employed under TFD but we will also incorporate and extend the community storytelling approaches in partnership with local communities and theatre workers to pilot an approach that allows communities, policymakers and professionals working with mental health to explore mental health as an issue of social justice and to promote MHL. It will do this by creating an interrogative performance space that brings together local practices and attitudes, professional orthodoxies, policy-related data and the latest understanding of mental illness in a way that allows multiple stakeholders to collectively imagine possible solutions. This project will also include widespread public engagement with people in creating m
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ffe212eaade2e0f07c6
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007063
|
GCRF_MRC_IN_MR/S004912/1
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.913598
|
0
|
0
|
0
|
0.913598
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
INTRODUCTION OF A CLINICAL GUI...DELINE TO MANAGE TYPE-2 DIABETES BY AYURVEDIC PRACTITIONERS IN INDIA: INTERVENTION DEVELOPMENT AND FEASIBILITY STUDY
more
|
Introduction of a clinical gui...deline to manage type-2 diabetes by ayurvedic practitioners in India: intervention development and feasibility study
more
|
Diabetes (type-2) is a complex... disorder with major health, social and economic consequences. India has the world's second largest diabetes population. Diabetes is one of the top diseases for which patients consult ayurvedic (traditional medical system) practitioners. A high proportion of diabetes patients use ayurvedic treatments, often from the beginning and exclusively and throughout their lives. These are particularly popular among rural, poor, older and tribal populations. The Indian government, therefore, deploys ayurvedic practitioners in Primary Health Centres (PHCs), often as the main clinical provider. Despite the effectiveness and safety of several ayurvedic medicines for managing diabetes found in study settings, strong concerns remain about the sub-optimal diabetes management of many patients in ayurvedic clinical practice. The actions to be taken at different stages of the diabetes care pathway are largely left to the judgement of the individual ayurvedic practitioner, resulting in unacceptable variations in ayurvedic clinical practice. Many non-evidence based ayurvedic medicines are prescribed by ayurvedic practitioners, which can have serious adverse effects on patients. A potential solution could be the introduction of a clinical guideline that will make recommendations based on the best available evidence. The main aim is to establish whether the introduction of a clinical guideline can improve the management of diabetes by ayurvedic practitioners as compared to usual ayurvedic management (i.e., without any clinical guideline). This will be tested in a future main study. Before this, we will develop the clinical guideline and will check with our participants if the main study can be conducted. The study will be conducted in Kerala, India - a vast population in Kerala is living with diabetes, and the utilisation of ayurveda is high. We will follow the standard clinical guideline development process. Recognising that the scientific evidence base is not large for many ayurvedic components (e.g., lifestyle), we will draw similar evidence from the standard western medicine clinical guidelines. A systematic review will be conducted on the effectiveness and safety of ayurvedic medicines in diabetes management, to generate evidence statements. These statements will be presented to an independent clinical guideline development committee (involving a range of stakeholders) for making the final decisions. Based on these decisions, the clinical guideline will be drafted and pre-tested among 20-30 ayurvedic practitioners. The clinical guideline will be shared with them, followed by qualitative interviews to improve it. Subsequently, a study will be conducted to check if the main study can be done. 12 rural PHCs with an ayurvedic practitioner will be randomly allocated either to the clinical guideline-based diabetes management group or the comparator group. At least 120 new diabetes patients, diagnosed by the participating ayurvedic pra
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ffe212eaade2e0f07c7
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007060
|
GCRF_MRC_IND_MR/P022030/1
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.265465
|
0
|
0
|
0
|
0.265465
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
DEVELOPMENT & VALIDATION OF A ...SCALABLE MOBILE PLATFORM FOR SCREENING OF DEVELOPMENTAL NEUROPSYCHIATRIC DISORDERS IN LOW-RESOURCE SETTINGS
more
|
Development & validation of a ...scalable mobile platform for screening of developmental neuropsychiatric disorders in low-resource settings
more
|
Worldwide, 1 in 161 children a...re diagnosed or diagnosable with Autism Spectrum Disorders (ASD). In India, our own study found a prevalence just over 1% in children aged 2 to 9 years. Although parents may notice ASD symptoms as early as 24 months, social and economic barriers to access to qualified health personnel mean that most of these children do not receive early diagnosis or intervention - or indeed any diagnosis or intervention at all. Moreover, many parents are unaware of age-appropriate developmental milestones and therefore clinical opinion is sought only when symptoms become obvious and impossible to ignore. This avoidable delay is an unfolding tragedy in light of evidence showing that front-line worker-delivered, parent-mediated interventions (e.g. PASS) lead to better behavioural and social outcomes. Scalable methods to flag up probable ASD would promote early referral to scarce specialist diagnostic facilities, connecting families with affordable, scalable, community-based interventions. We will realise this goal by developing a low-cost mobile screening platform ('Screening Tools for Autism Risk using Technology' (START)) usable in the home or in a routine health facility by the same non-specialist health workers who deliver PASS or other front-line interventions. START will collect data from multiple sources. First, parents will be asked simple questions about their child's everyday behaviour, based on established questionnaires that have been validated in the Indian cultural context. To help parents identify and report subtle abnormalities, these questions will be supplemented by videos illustrating typical versus ASD behaviours. This video-enabled questionnaire will be delivered on a tablet PC. Second, low-cost eye-tracking technology on the same tablet PC will be used to monitor the child's eye movements in simple tasks, such as those assessing preference for social versus non-social images, and measuring how quickly attention shifts to new objects appearing on the screen. Finally, a segment of parent and child interaction will be recorded using the inbuilt camera, and used to code for signs of atypical behaviour. This combination of multiple measures will provide independent channels of data collected on a single platform, potentially improving on current screening methods that rely on one technique solely. Combining these techniques becomes especially important in a setting where challenges such as poor awareness about ASD may impact on parent reporting of abnormal behaviour (for example, parents may not have noticed that their child avoids direct gaze). START's central innovation is its integration with existing front-line workers in LMICs, by adapting methods successfully employed in high income countries (HICs) to LMIC environments and resources. By virtue of its design to require minimal training, it will promote task-shifting - a concept the World Health Organization defines as 'a process of delegation whereby tasks are
more
|
0
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ffe212eaade2e0f07c8
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007051
|
GCRF_MRC_IND_MR/R024405/1
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.029642
|
0
|
0
|
0
|
0.029642
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PUBLIC HEALTH INITIATIVE ON LM...IC AIR POLLUTION (PHILAP)
more
|
Public Health Initiative on LM...IC Air Pollution (PHILAP)
more
|
The PHILAP proposal brings tog...ether a multidisciplinary team with a range of expertise to bear on the problem of health effects of air pollution in Delhi, India which is not only a critical case but also a microcosm of a wider global health concern in low and middle income countries, tied up with questions of social justice and equity. In particular, PHILAP seeks to characterise the burden of asthma in adolescents living in the slums of Delhi - a marginalised section of the population who have dropped out of the school system and are engaged in ad-hoc work in the informal sector. PHILAP will employ state-of-the-art miniature wearable sensors currently deployed in Delhi in the MRC-/NERC-funded (2016-21) DAPHNE (Delhi Air Pollution: Health and Effects) as part of the Air Pollution and Human Health (APHH) - Delhi programme, to measure actual personal exposure to particulate pollution and contemporaneously recording its physiological effects, such as changes in the respiratory rate/flow and physical activity levels, with the aim of correlating disease control of asthma with air pollution exposure. These measurements will be situated, and made sense of, in the social and cultural contexts of people's everyday lives through ethnographic fieldwork and interviews. By engaging the ethnographic data in dialogue with the scientific data of urban air pollution and exposure and its clinical effects, we hope to unpick the multiple strands in the entwined health dimensions of breathing and living with air pollution. PHILAP will harness these vast data-sets, produced and mobilised across the work-packages, into a series of public facing visual narratives that seek to foster dialogue at the interface of science, arts and humanities research.
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ffe212eaade2e0f07c9
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007054
|
GCRF_MRC_IND_MR/S014438/1
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.061923
|
0
|
0
|
0
|
0.061923
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
A PILOT STUDY TO DEVELOP AN EF...FICACIOUS ORAL CANCER SCREENING STRATEGY FOR INDIA
more
|
A pilot study to develop an ef...ficacious oral cancer screening strategy for India
more
|
Oral cancer imposes a huge bur...den globally, especially in low and middle income countries (LMICs) (8). This high burden of oral cancer is attributable to high prevalence of risk factors such as tobacco, areca nut (tamul) and alcohol. In most countries, cigarette smoking is the predominant form of tobacco use (9). However, in India, approximately 75% of tobacco consumption is in smokeless form (9). India has the highest burden of oral cancer globally (10). It is recognized that smokeless tobacco causes cancers of the mouth, gullet and pancreas (11). The proposed study will be conducted in Assam, where the prevalence of tobacco is 48% (12). In Assam, tamul is traditionally offered as a mark of respect and auspicious beginnings. We recently conducted a survey in Assam on tamul use. In all, 34% of subjects reported using tamul. Influencing factors were family (58%) and friends (34%). Majority of the subjects (60%) chewed tamul due to pressure at work, after food and during leisure with a mean age of initiation at 15 years. While knowledge about the ill-effects of tamul was low and willingness to quit high (77%), paradoxically, 81% of subjects had not attempted to quit the habit in the preceding 6 months. The 5-year survival rate for oral cancer is 80% in those diagnosed at early stage and only 20% in those diagnosed at advanced stage, underscoring the need for early detection (13). In India, most oral cancer patients present with advanced disease and have survival rates as low as 3-5%. There is, therefore, a pressing need to diagnose early and ideally at a pre-cancerous stage (2). In India and other LMICs, the current approach for oral cancer screening relies on visual inspection of the inner lining of the oral cavity (conventional oral examination [COE]) in tobacco/ alcohol users aged over 30 years (4). Yet, owing to issues with the method of screening (low sensitivity of COE) and size of the target population (ages 30+), this approach is not efficacious. For example, the eligible population for oral cancer screening in India based on COE is ~300 million, which reduces its operational feasibility and makes it cost prohibitive. Any screening system developed in LMICs should fulfill two features for optimal effectiveness: 1) The screening test should have high accuracy 2) The screening system (infrastructure, human resource and referral centres) has to be financially viable. Unfortunately, the current oral cancer screening strategy of visual inspection in India and several other LMICs fails at both these levels. Risk stratification tools for systematic identification of high-risk population could potentially drastically reduce the target population for screening. We propose a 3-step oral cancer screening strategy to enable effective implementation of the screening program. First, a risk prediction model will be used for identification of those at greatest risk of oral cancer, thus reducing the number of screened individuals and enhancing cost effec
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ffe212eaade2e0f07ca
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007062
|
GCRF_MRC_IND_MR/S036466/1
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.590488
|
0
|
0
|
0
|
0.590488
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PSYCHOLOGICAL, SOCIAL & BIOLOG...ICAL PREDICTORS OF CHILD MENTAL HEALTH AND DEVELOPMENT: SHARED AND DISTINCTIVE RISK AND PROTECTIVE FACTORS IN UK & INDIA
more
|
Psychological, social & biolog...ical predictors of child mental health and development: shared and distinctive risk and protective factors in UK & India
more
|
WHO figures estimate mental he...alth problems affect 12.8% of children in India, which equates to 60 million children. There is an urgent need for culturally sensitive longitudinal studies of community samples starting in pregnancy, designed to examine the earliest origins of child mental health problems to optimally inform the development of new and early interventions. Our study aims to do this in India and the UK. Research in western settings suggest that child mental health problems arise from a complicated mix of social, psychological and biological influences, in which key factors probably include, prenatal stress, early infant temperament, and harsh parenting as risks, and warm parenting as protective factors. There is now good evidence that individual variations and environmental exposures in early life contribute to risk for mental health problems in later childhood and beyond. However, previous research has been conducted almost exclusively in countries with Westernised standards of medical care and family arrangements, and where additional risks such as low birth weight and under-nutrition are rare. The aims of the proposed research are to compare early risk and protective factors for childhood mental health problems in UK and India to identify those that are common to Western and South Asian populations and those that are distinctive. We propose to follow up around 741 families of children in the Bangalore Child Health and Development study (BCHADS) who are living in the urban slums of Bangalore city, at age 4.5 years and age 7 years. We will compare the information we gather on these children's lives to that of the children taking part in our UK Wirral Child Health and Development Study (already collected). In both studies we have two rich data sets with parallel measures of risk and protective factors for child mental health outcomes from pregnancy onwards, including age 8-10 wks, 6 months, 14 months, 2 years, 4 years and 7 years of age. We have gathered detailed repeated measurement of key likely 'shared risks' and associated 'mechanisms' for conferring risk (e.g., gene activity, stress reactivity) and these include measures of early life stress, social support, poverty and economic adversity, early temperament, and caregiving (touch, interaction quality, parenting quality), cognitive and physical development. We will also assess risk and protective factors that may be 'distinctive' or particularly relevant to the South Asian setting: maternal nutrition in pregnancy, early immune function and gender discrimination associated with cultural favouring of the male child, and the practice of shared-caregiving as opposed to primary maternal rearing in Western societies. We also aim to advance cross-cultural measurement methods and develop new culturally sensitive measures of gender discrimination and the 'shared caregiving' parenting environment in India. This work will aid clinicians and researchers to refine their measurements in clin
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ffe212eaade2e0f07cb
|
2020
|
Germany
|
Foreign Office
|
2020008444
|
6611901
|
8
|
South Sudan
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.854701
|
0.854701
|
0
|
0
|
0.854701
|
0.854701
|
|
0.854701
|
|
0
|
Classified as not health-speci...fic activity
more
|
|
100
|
NUTRITION AND WASH (WATER, SAN...ITATION AND HYGIENE) PROJECT SOUTH SUDAN
more
|
Nutrition and WASH (water, san...itation and hygiene) project South Sudan
more
|
Integrated Nutrition and WASH ...project for internally displaced people and host communities
more
|
0
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
|
22000
|
Donor country-based NGO
|
Donor country-based NGO
|
|
|
|
65679fff212eaade2e0f07cc
|
2020
|
Germany
|
Foreign Office
|
2020008445
|
6611927
|
3
|
Bangladesh
|
South & Central Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.46666675
|
0.3213675
|
0
|
0
|
1.866667
|
1.28547
|
|
1.866667
|
|
0
|
Emergency projects (meeting ad...ditional funding needs)
more
|
|
25
|
IMPROVING THE HEALTH AND NUTRI...TIONAL SITUATION IN BANGLADESH
more
|
Improving the health and nutri...tional situation in Bangladesh
more
|
Improving the health and nutri...tional situation of refugees in Cox's Bazaar and contributing to the peaceful coexistence of refugee and host communities
more
|
0
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
|
22000
|
Donor country-based NGO
|
Donor country-based NGO
|
|
|
|
65679fff212eaade2e0f07cd
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008101
|
NF_NERC_IND_APHH India
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0
|
0.315716
|
0
|
0
|
0
|
0.631432
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
50
|
ATMOSPHERIC POLLUTION AND HUMA...N HEALTH IN AN INDIAN MEGACITY PHASE I (CALL)
more
|
Atmospheric Pollution and huma...n health in an Indian megacity phase I (call)
more
|
Pollution in Indian cities is ...a rapidly increasingly problem, with significant impacts on the economy and health of the population. The vision of this programme is to initiate efforts on air pollution hazards and impacts on health and the evidence to support measures for air quality improvements in Delhi
more
|
0
|
41082
|
Environmental research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679fff212eaade2e0f07ce
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007057
|
GCRF_MRC_GMB_MR/P023843/1
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.097041
|
0
|
0
|
0
|
0.097041
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
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100
|
MICA: BRAINTOOLS PHASE 1: OPTI...MISING NEURODEVELOPMENTAL OUTCOMES FOR GLOBAL HEALTH
more
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MICA: BRAINTOOLS Phase 1: Opti...mising neurodevelopmental outcomes for global health
more
|
The Centre for Brain & Cogniti...ve Development (CBCD) at Birkbeck has a world leading reputation for the multidisciplinary study of psychological development and mental health in early childhood, including development and application of new methodologies for large-scale longitudinal studies and trials. Our strategic vision is to bring this expertise in theory, study design, and technology development to bear on LMIC early mental health. Child psychiatry has traditionally focused on treating children and adolescents with a diagnosis. However, post-diagnostic treatments are typically expensive and inaccessible to most patients in LMICs (Belfer, 2008), who may also lack access to diagnostic services in general (Saxena et al., 2007). To meet the needs of LMICs, we need a radical shift in our approach. Rather than focus resources on children with a diagnosis, we need to shift towards direct measurement of the brain systems that are affected by early risk factors in infancy, and then use this information to develop low-cost, scalable and preventative treatments targeted towards those brain systems. To do this, we have planned an integrated long-term programme of research to identify the infant brain markers that predict neurodevelopmental outcomes in LMICs, to use these markers to test which common modifiable risk factors in LMICs affect key brain systems, and to identify protective factors that could represent targets for intervention to build resilience in LMIC settings. Directly assessing the effects of environmental risk factors in early childhood (rather than waiting for later neurodevelopmental outcome) enables rapid assessment of the efficacy of simple preventative interventions. Directly measuring brain development allows us to identify the most vulnerable children as early as possible, allowing limited resources to be focused on those most likely to benefit from preventative approaches. Taken together, focusing on brain development in early childhood is critical to revolutionising global mental health. We are optimally suited to leading this challenge because of our combined expertise in developing infant neural markers of long-term mental health and our experience in deploying novel technologies to measure early childhood brain development in low-resource settings. While our long-term vision entails widespread dissemination of expertise, a key first step is close engagement with selected LMIC sites for bi-directional knowledge exchange and feasibility assessments. Thus, we have carefully selected two LMIC partners who face contrasting challenges, MRC Gambia and Sangath India. Building on initial contacts, we will establish and consolidate a collaborative network with four short-term objectives (pump-priming projects), (1) collaboratively develop a feasible protocol for assessing human functional brain development in LMIC settings, (2) prepare a Masters course in Developmental Neuroscience for Global Health, (3) develop a plan for parent educa
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12182
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Medical research
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|
|
11000
|
Donor Government
|
Donor Government
|
|
|
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65679fff212eaade2e0f07cf
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007058
|
GCRF_MRC_IN_MR/T003537/1
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.108587
|
0
|
0
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0
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0.108587
|
0
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0
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0
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0
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Other health problems
|
Other health problems Research... and Development
more
|
100
|
INTRODUCTION OF A CLINICAL GUI...DELINE TO MANAGE TYPE-2 DIABETES BY AYURVEDIC PRACTITIONERS IN INDIA: INTERVENTION DEVELOPMENT AND FEASIBILITY STUDY
more
|
Introduction of a clinical gui...deline to manage type-2 diabetes by ayurvedic practitioners in India: intervention development and feasibility study
more
|
Diabetes (type-2) is a complex... disorder with major health, social and economic consequences. India has the world's second largest diabetes population. Diabetes is one of the top diseases for which patients consult ayurvedic (traditional medical system) practitioners. A high proportion of diabetes patients use ayurvedic treatments, often from the beginning and exclusively and throughout their lives. These are particularly popular among rural, poor, older and tribal populations. The Indian government, therefore, deploys ayurvedic practitioners in Primary Health Centres (PHCs), often as the main clinical provider. Despite the effectiveness and safety of several ayurvedic medicines for managing diabetes found in study settings, strong concerns remain about the sub-optimal diabetes management of many patients in ayurvedic clinical practice. The actions to be taken at different stages of the diabetes care pathway are largely left to the judgement of the individual ayurvedic practitioner, resulting in unacceptable variations in ayurvedic clinical practice. Many non-evidence based ayurvedic medicines are prescribed by ayurvedic practitioners, which can have serious adverse effects on patients. A potential solution could be the introduction of a clinical guideline that will make recommendations based on the best available evidence.The main aim is to establish whether the introduction of a clinical guideline can improve the management of diabetes by ayurvedic practitioners as compared to usual ayurvedic management (i.e., without any clinical guideline). This will be tested in a future main study. Before this, we will develop the clinical guideline and will check with our participants if the main study can be conducted. The study will be conducted in Kerala, India - a vast population in Kerala is living with diabetes, and the utilisation of ayurveda is high. We will follow the standard clinical guideline development process. Recognising that the scientific evidence base is not large for many ayurvedic components (e.g., lifestyle), we will draw similar evidence from the standard western medicine clinical guidelines. A systematic review will be conducted on the effectiveness and safety of ayurvedic medicines in diabetes management, to generate evidence statements. These statements will be presented to an independent clinical guideline development committee (involving a range of stakeholders) for making the final decisions. Based on these decisions, the clinical guideline will be drafted and pre-tested among 20-30 ayurvedic practitioners. The clinical guideline will be shared with them, followed by qualitative interviews to improve it. Subsequently, a study will be conducted to check if the main study can be done. 12 rural PHCs with an ayurvedic practitioner will be randomly allocated either to the clinical guideline-based diabetes management group or the comparator group. At least 120 new diabetes patients, diagnosed by the participating ayurvedic practitione
more
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12182
|
Medical research
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11000
|
Donor Government
|
Donor Government
|
|
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|
6567a000212eaade2e0f07d0
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007050
|
GCRF_MRC_IND_MR/R019541/1
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3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.002097
|
0
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0
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0
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0.002097
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0
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0
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0
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0
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Other health problems
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Other health problems Research... and Development
more
|
100
|
EARLY-LIFE ORIGINS OF BRAIN RE...SILIENCE TO MENTAL ILLNESS AND COGNITIVE IMPAIRMENT ACROSS THE LIFE-COURSE
more
|
Early-life origins of brain re...silience to mental illness and cognitive impairment across the life-course
more
|
Global Mental Health Instituti...onal pump priming award looking at Early-life origins of brain resilience to mental illness and cognitive impairment across the life-course in India
more
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12182
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Medical research
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11000
|
Donor Government
|
Donor Government
|
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6567a000212eaade2e0f07d1
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007065
|
GCRF_MRC_IDN_MR/P013996/1
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3
|
Indonesia
|
Far East Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.058678
|
0
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0
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0
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0.058678
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0
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0
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0
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0
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Other health problems
|
Other health problems Research... and Development
more
|
100
|
EXPLORING THE POTENTIAL OF CIV...IC ENGAGEMENT TO STRENGTHEN MENTAL HEALTH SYSTEMS IN INDONESIA.
more
|
Exploring the potential of civ...ic engagement to strengthen mental health systems in Indonesia.
more
|
MRC/HSRI award - Exploring the... potential of civic engagement to strengthen mental health systems in Indonesia.
more
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0
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12182
|
Medical research
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|
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11000
|
Donor Government
|
Donor Government
|
|
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6567a000212eaade2e0f07d2
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
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2020006775
|
GCRF_EPSRC_KEN_EP/R013837/1
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3
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Kenya
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South of Sahara
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LMICs
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ODA Grants
|
1
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10
|
110
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D02
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0
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0.10584
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0
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0
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0
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0.10584
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0
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0
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0
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0
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Other health problems
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Other health problems Research... and Development
more
|
100
|
SHAPE SENSING TEXTILE FOR ORTH...OTICS - SMARTSENSOTICS
more
|
Shape sensing textile for orth...otics - SmartSensOtics
more
|
Orthotic products are of great... importance to a number of people around the world. The process of fabricating orthoses is well established, but depends on a time and resource consuming plaster cast method developed over 100 years ago. This is associated to a number of reasons e.g. the fact that an Orthotist has to shape the patient's body to define the shape of an orthosis. In particular in the case of children or patients with joint contractures and anatomical deformities, such as those affected with neurological and neuromuscular medical conditions, such as Cerebral Palsy. This issue prevents the efficient application of MRI, CT or optical imaging techniques, because these require extensive post-processing to discriminate between the patient's body and the Orthotist's hands. Additionally, such imaging equipment is expensive and requires a highly technicians. Hence, providing orthoses is only possible if, hospitals, expensive medical scanners, consumables, and workshops are accessible. This is not the case in developing countries, consequently orthoses in LMICs are often fabricated form scrap such as old water canisters. Recently, the development of flexible, soft electronics, as well as the spread of wearable electronic devices has made significant progress. Here we want to develop a smart, portable and stretchable textile sleeve with integrated sensors connected to a smartphone to realize an entirely new, versatile, and wearable body shape imaging technique. The digital limb models by our system can then be used for the computer aided fabrication of customized orthotics, without the need for significant infrastructure. Our smart textile will contain an active array of stretchable strain sensors to measure the deformation of the textile itself. The knowledge of the strain distribution inside the tight fitting stretchable textile when worn over a limb or body part will be used to determine the exact three-dimensional shape of the limb. Any external influence such as the force applied by the Orthotist will also be quantified, but will not interfere with the shape measurement. The development and fabrication of biocompatible, polymer based strain gauges able to measure strain of >200% will be done in the semiconductor manufacturing cleanroom at the University of Sussex. This cleanroom is optimized for the fabrication of flexible electronic thin-film devices on plastic substrates. The sensors will then be unobtrusively integrated into an elastane fabric using embroidery, and interconnected using conductive yarns. We will evaluate the required sensor density to achieve a measurement resolution sufficient for the fabrication of orthotic products. In a next step, the acquired sensor data will be proceed on a smartphone to automatically generate a three-dimensional model of the imaged body part. Hence no professionals, additional infrastructure or consumables are needed to support the Orthotist in treating the patients. The generated digital model can
more
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0
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43082
|
Research/scientific institutio...ns
more
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11000
|
Donor Government
|
Donor Government
|
|
|
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6567a000212eaade2e0f07d3
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008474
|
MRC_AP_MR/S012877/1
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3
|
Lebanon
|
Middle East
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.08951
|
0
|
0
|
0
|
0.08951
|
0
|
0
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0
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0
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Other health problems
|
Other health problems Research... and Development
more
|
100
|
IDENTIFYING A PACKAGE OF COST-...EFFECTIVE INTERVENTIONS TO ADDRESS NON-COMMUNICABLE DISEASES IN GAZA
more
|
Identifying a package of cost-...effective interventions to address non-communicable diseases in Gaza
more
|
MRC/HSRI award Identifying a p...ackage of costeffective interventions to address noncommunicable diseases in Gaza
more
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0
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12182
|
Medical research
|
|
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11000
|
Donor Government
|
Donor Government
|
|
|
|
6567a000212eaade2e0f07d4
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006917
|
GCRF_ESRC_LBN_ES/T00424X/1
|
3
|
Lebanon
|
Middle East
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.531796
|
0
|
0
|
0
|
0.531796
|
0
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0
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0
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0
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Other health problems
|
Other health problems Research... and Development
more
|
100
|
GOAL: SUPPORTING GOVERNMENT AN...D PARTNERS IN STRENGTHENING HEALTH SYSTEMS FOR BETTER MENTAL HEALTH OF SYRIAN REFUGEES AND HOST COMMUNITIES IN LEBANON
more
|
GOAL: Supporting government an...d partners in strengthening health systems for better mental health of Syrian refugees and host communities in Lebanon
more
|
GOAL focuses on the challenge ...of supporting health systems providing for the mental health needs of people affected by protracted displacement, focusing on Lebanon. Poor mental health causes long-term suffering and disability, is a barrier to realising full potential of individuals and society, and impedes progress in achieving the SDGs. Poor mental health is often more common among protracted refugee populations than non-crisis affected populations. Effective mental health services exist, but there are major gaps in access to them, especially among refugee populations. The challenge is how to best deliver such services, including the design of health systems required to support this delivery. This is particularly challenging in protracted displacement settings which can place substantial additional pressure on already strained health systems and where an influx of international aid and actors can risk weakening national government-led responses. GOAL is a partnership between universities, the National Mental Health Programme at the Ministry of Public Health and civil society organisations in Lebanon. It addresses the following questions in the UKRI-GCRF Protracted Displacement call: (i) what should governments at every level do in order to anticipate and efficiently manage protracted stays, reduce refugees' dependence on humanitarian aid and implement systems that facilitate refugee /IDP integration, inclusion and social wellbeing? (ii) How can health care systems for the displaced be expanded to cover areas that are usually neglected in refugee/IDP settings such as (though not limited to) treatment of chronic illnesses, disability and mental health? (iii) How does gendered access to services, economic and cultural opportunities and levels of power influence differently the experiences, opportunities and limitations of men and women? The overall aim of GOAL to support government and partners in strengthening the ability of health systems to meet the mental health needs of refugee and host communities affected by protracted displacement, focusing on Lebanon as it is home to over one million Syrian refugees. It addresses two health system topics, governance and financing, identified as priority areas by key stakeholders in Lebanon and by external independent experts. GOAL's research is framed by the use of Transition Theory and gender is addressed as a cross-cutting issue informing all aspects of the project research. It follow a co-production approach, working closely with key stakeholders - particularly mental health service users. Quantitative and qualitative methods will be used and interdisciplinarity fostered. We also work with mental health service users to produce innovative materials (e.g. animations and augmented reality digital images) communicating the benefits of participation from people with lived experience of mental disorders in research and policy-making processes, and for advocacy and teaching. GOAL has capacity strengthening
more
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43082
|
Research/scientific institutio...ns
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
6567a001212eaade2e0f07d5
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007081
|
GCRF_MRC_MWI_MR/S035818/1
|
3
|
Malawi
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
1.074822
|
0
|
0
|
0
|
1.074822
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
GENERATION MALAWI: A STUDY OF ...FAMILY, MATERNAL AND CHILDHOOD MENTAL HEALTH
more
|
Generation Malawi: A study of ...family, maternal and childhood mental health
more
|
A lack of research training, r...esources, infrastructure and data in Low- and Middle-Income Countries (LMIC) greatly limits their ability to conduct studies of common mental health conditions. Nowhere is this more true than in Africa generally and in Malawi specifically, where sparse mental health care alone limits not only clinical research capacity, but also the ability to attract inward investment. In a partnership between UK and Malawian institutions, we propose to directly address this challenge by building clinical research capacity through the coordinated appointment of new researchers and research assistants, a programme of education and dissemination, and the development of a population mental health dataset focussed on an area of great unmet need - the mental heath of mothers and their children. After a period of piloting our research assessments and obtaining the necessary approvals, we will recruit 5000 mothers prior to delivery of their child from antenatal clinics in Lilongwe and Karonga districts, selected to represent urban and rural populations respectively. We will assess the mental health of mothers before and after birth, and the mental health of their spouses and other family members with a view to identifying the major risk factors for mental health disorders and mitigating variables that promote resilience. We will then examine the impact of maternal and, where possible, paternal mental health on the neurodevelopment of their offspring. In addition to creating new and highly valuable data, we will also create the bioresources needed for future genetics and 'omics based research. We believe this is essential to prevent the current imbalance in genetic research favouring rich countries of predominantly European ancestries leading to greater entrenchment of global health inequalities. As part of the proposed work, we will develop internationally competitive research capacity and datasets in Malawi, augment standard of care treatment, develop research training and the availability of affordable and effective interventions for depression and other common mental disorders, such as the 'Friendship Bench' intervention. Our research will be multidisciplinary, involving experts from psychiatry, clinical psychology, nursing, reproductive and child health, and social sciences in both UK and Malawi. Throughout the project, we will carefully monitor our progress and impact on the participants and their communities. The project, if funded, will lead to a step change in mental health research capacity in Malawi, paving the way for new inward investment and the development of evidence based interventions and policies.
more
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0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
6567a001212eaade2e0f07d6
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006780
|
GCRF_UKRI_NS_EP/T003723/1
|
3
|
Malawi
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.121111
|
0
|
0
|
0
|
0.121111
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
GCRF ANAEMIA NETWORK (ANET)
|
GCRF Anaemia Network (ANET)
|
Anaemia remains a major public... health problem to control in sub-Saharan Africa due to its complex causes which vary from not only direct health diseases (like iron deficiency, malaria etc) but to many predisposing causes in the the environment, culture, poverty and inequalities, and poor health and governance systems. Furthermore, anaemia control suffers from disjointed, fragmented approaches with individual programmes using different definitions of anaemia and tackling the problem from different perspectives. We aim to develop an interdisciplinary network that can lead in the control of this intractable challenge of anaemia in sub-Saharan Africa by leading cutting-edge research and facilitating the uptake and implementation of innovative solutions to prevent anaemia. We will bring together scientific experts in nutrition, food technology, global health, agriculture, social science, psychology, molecular biology and economics. We shall further include representatives of policy makers, international donor agencies, non-governmental organizations, commercial companies working in drug and food manufacturing and the public. They will firstly raise the awareness of the need for an inter-sectorial and harmonized approach to its control and secondly develop a strategic plan for research and programme implementation.
more
|
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11110
|
Education policy and administr...ative management
more
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
6567a001212eaade2e0f07d7
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007082
|
GCRF_MRC_MYS_MR/P024351/1
|
3
|
Malaysia
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.021247
|
0
|
0
|
0
|
0.021247
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
MICA: IMMUNOTHERAPY FOR ORAL C...ANCER PREVENTION AND TREATMENT
more
|
MICA: Immunotherapy for oral c...ancer prevention and treatment
more
|
Worldwide, oral cancer (OSCC) ...is the eighth most common cancer and a major global health concern, with an annual incidence of around 398,000 and more than 222,000 deaths worldwide. OSCC is often difficult to treat, surgery and radiotherapy remain the standard treatments but, despite improvements, are associated with significant morbidity and a relatively static 5-year survival rate of around 50-60%. Around 15-80% of OSCC develop from a precursor lesion (OPL), most commonly a white patch (leukoplakia). The current gold standard for determining leukoplakia management is pathological diagnosis of dysplasia, with transformation rates of 24.1% being reported in severe dysplasia. At present, the only effective treatment is surgical excision. However, studies indicate that this is not likely to reduce the risk of recurrence or malignant change. It is clear that more effective treatments are required for both premalignant lesions and established OSCC. Immunotherapy represents the most promising new cancer therapy for several decades. These treatments harness the power of the patient's immune system to fight the cancer, in the same way that the immune system might fight a virus. Cancers are recognised by the immune system as 'foreign' because they express proteins (antigens) not usually found in normal tissues. Some patients have a strong immune response against their cancer, this can be seen in the tumour tissue as immune cells (lymphocytes) attacking the cancer cells. However, most cancers are not well recognised by the immune system, and the immune system needs to be stimulated to respond. If we identify the abnormal proteins on the cancer cells, then we can design vaccines against these antigens to generate an immune response against the cancer cell (just like vaccinating against a virus), recent studies have shown that premalignant lesions in the cervix can be successfully cleared through vaccination. This type of cancer is caused by a virus (human papillomavirus) and vaccines are designed to target viral proteins. By contrast, in most cancers and premalignant lesions targetable antigens are unknown. This proposal aims to identify common tumour associated antigens (TAA, cancer testis antigens and others) expressed in OPL and OSCC as part of a therapeutic strategy to develop vaccines to treat and prevent this disease. Expression of cancer testis antigens have been described in OPL, and preliminary work by the Cancer Research Malaysia (CRM) team have identified two antigens, MADGED4B and FJX1 that are commonly expressed in both OPL and OSCC. We will extend this analysis, examining global gene expression in cases of dysplasia and with OSCC to identify common tumour antigens, focusing on those found early in the disease process, before cancer develops. We will use these antigens to make vaccines using a novel vaccine design developed by the University of Southampton team (UoS), and test these in a humanised mouse cancer models. The vaccine is based
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
6567a001212eaade2e0f07d8
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007966
|
NF_EPSRC_MYS_RCUKRG1
|
3
|
Malaysia
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.001663
|
0
|
0
|
0
|
0.008315
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
20
|
TO ESTABLISH SUSTAINABLE COLLA...BORATIONS BETWEEN UK RESEARCHERS AND RESEARCHERS IN SOUTH EAST ASIA
more
|
To establish sustainable colla...borations between UK researchers and researchers in South East Asia
more
|
Funding for flexible short-ter...m support for high-quality collaborative research between UK and SE Asia researchers which contribute to the economic development and welfare of the region. Topics include: Creative Economy, Energy-Food-Water Nexus, Mental Health, Capacity Building in Big Data & Technology Development through Astronomy, and Skills for Using Large Facilities.
more
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0
|
43082
|
Research/scientific institutio...ns
more
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
6567a001212eaade2e0f07d9
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006347
|
GCRF_AHRC_MEX_AH4008_AH/R00600...8/1
more
|
3
|
Mexico
|
Caribbean & Central America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0
|
0.008822
|
0
|
0
|
0
|
0.008822
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CHRONIC KIDNEY DISEASE OF UNKN...OWN ORIGIN: INTERDISCIPLINARY APPROACHES TO UNDERSTANDING A COMPLEX MEDICAL PHENOMENON
more
|
Chronic Kidney Disease of Unkn...own Origin: interdisciplinary approaches to understanding a complex medical phenomenon
more
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Over the past twenty years, ac...ross Low and Middle Income Countries (LMICs), there has been an unexplained increase and change in the causes of Chronic Kidney Disease (CKD). This new type of CKD is known as Chronic Kidney Disease of Unknown Origin (CKDu), today described as a new epidemic for countries in the global south, adding substantially to the burden of CKD globally. In Mexico, the focus of this application, the problem is critical given the high prevalence of CKD and inequalities in access to appropriate healthcare. CKDu is particularly problematic because it cannot be understood in conventional causal terms, meaning it is not an outcome of diabetes or hypertension, but is, instead, linked to social, cultural and environmental concerns. CKDu predominantly affects the young, is linked to informal work (e.g. the agri-industries and mining), as well as long term environmental harm and degradation. Despite increasing concern, it is difficult to establish the percentage of CKD deaths that can actually be classified as CKDu due to the complex conditions it emerges from. In the absence of single causes or established risk factors, explanations have been driven by community, labour and environmental activists in addition to small groups of epidemiologists, public health researchers and toxicologists engaged in exploratory research. Our partnership team has, in addition, two current independent pilot projects, conducted by University of Guadalajara (CI Lozano) and the University of Liverpool (PI Kierans). These projects are documenting a multidimensional picture of CKDu emergence, focusing on the links between the structural conditions of poverty, political economy, environment and the everyday lives of poor communities in the state of Jalisco, focusing on the community of Poncitlán on the shores of lake Chapala. Lozano is identifying the multiple risk factors and social determinants of renal damage, while Kierans takes an anthropological approach mapping the cultural production of clinical and scientific knowledge on CKDu and documenting the cultural and social practices associated with its emergence. CKDu is, therefore, a complex problem, an outcome of geographical, geological, historical, political, economic, social and biological processes. Establishing a collaborative, genuinely interdisciplinary partnership is critical for developing ways of understanding this condition and the responses needed for those living in poor and degraded environments. Existing research largely stems from clinical and scientific perspectives and priorities. Substantive contributions from the Arts and Humanities and Social Sciences are lacking, particularly those offering historically situated and culturally contextualised insights into the changing interrelationships between poverty work, health and environment. Taking a unique interdisciplinary approach, this partnership will make valuable contributions. It will integrate and expand our existing projects to incl
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0
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43082
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Research/scientific institutio...ns
more
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51000
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University, college or other t...eaching institution, research institute or think-tank
more
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University, college or other t...eaching institution, research institute or think?tank
more
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6567a002212eaade2e0f07da
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2020
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United Kingdom
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Department of Health and Soci...al Care
more
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2020009685
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16_137_49
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3
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Nepal
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South & Central Asia
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LDCs
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ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.70748
|
0
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0
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0
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0.70748
|
0
|
|
|
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Other health problems
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Other health problems Research... and Development
more
|
100
|
NIHR GLOBAL HEALTH RESEARCH GR...OUP ON NEPAL INJURY RESEARCH
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NIHR Global Health Research Gr...oup on Nepal Injury Research
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A UK and low- and middle-incom...e country (LMIC) partnership that aims to prevent injuries, make communities safer and improve injury outcomes in Nepal through collaborative research, surveillance, innovation, training, capacity building and policy development. The outputs from this activity can be applied/adapted for other DAC-list country/countries and therefore would benefit a wider geographical region.
more
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0
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12182
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Medical research
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51000
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University, college or other t...eaching institution, research institute or think-tank
more
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University, college or other t...eaching institution, research institute or think?tank
more
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|
|
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6567a002212eaade2e0f07db
|
2020
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United Kingdom
|
Department for Business, Innov...ation and Skills
more
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2020007089
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GCRF_MRC_AR_MR/T021845/1
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3
|
Nigeria
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South of Sahara
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LMICs
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ODA Grants
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1
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10
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110
|
D02
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0
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0.037132
|
0
|
0
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0
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0.037132
|
0
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0
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0
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0
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Other health problems
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Other health problems Research... and Development
more
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100
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IDENTIFYING THE HEALTH SYSTEMS... CHANGES NECESSARY TO SUSTAIN AND SCALE UP THE INTEGRATION OF MENTAL HEALTH SERVICES INTO PRIMARY CARE IN LAGOS, NIGERIA
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Identifying the health systems... changes necessary to sustain and scale up the integration of mental health services into primary care in Lagos, Nigeria
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STATEMENT OF THE PROBLEM: De...spite the huge burden of mental health problems, about 85% of people with severe mental illness in sub-Saharan Africa (SSA) do not receive any form of treatment. Integrating mental health services into primary health care (PHC) has been advocated as the most viable means of closing this treatment gap. The linear model of intervention development, efficacy testing and implementation led to problems with sustainability over time and in real world setting. As there are policy and ethical implications of developing effective heath programmes without sustainability and scale-up, an understanding of the factors and processes that influences sustainability and scale up of an evidence-based intervention is needed for proactive planning OVERALL AIM: This feasibility study aims to identify the strategies to facilitate the health system changes necessary to sustain and scale up mental health services in primary care in Lagos, Nigeria. SPECIFIC QUESTIONS TO BE ADRESSED BY THE PROJECT 1) what is the state of implementation of the MeHPriC Project and what are the factors that are currently underlying its implementation?, 2) What are the dynamic interactions between the different components of the programme as regards contexts (inner and outer), implementation processes, implementation actors and intervention outputs and outcomes?, 3) How do these components influence the sustainability of the programme, and 4) What strategies may be required to facilitate the changes necessary for sustainability and scale-up METHODOLOGY There are 5 phases of the study. 1. In Phase 1, We will review policy documents and conduct in-depth interviews with selected policy makers to develop hypotheses, assess whether the target indicators for the project are met, identify how they are met, identify the key contextual facilitators and constraints and the way they affect the outcome. 2. In Phase 2, we will conduct a quantitative survey amongst the stakeholders including policy makers and administrators, programme managers, PHC health workers and recipients of care. They will complete scales to assess organisational readiness to change, sustainability and perceived intervention acceptability and feasibility 3. In Phase 3, we will conduct a brief evaluation of the implementation and through in-depth interviews, we will examine the stakeholders' perception about the health systems constraints to delivering, scaling up and sustaining the intervention. We will also observe selected PHC facilities to enable us to understand the factors that act as facilitators or barriers to sustenance of the intervention delivery. 4. In Phase 4, we will conduct a Theory of Change (ToC) workshop that will draw mainly on the results from the analysis of the earlier phases in combination with scientific knowledge and programme experience to identify health system changes that will improve sustainability in the delivery of the intervention. 5. In Phase 5, we will anal
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12182
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Medical research
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51000
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University, college or other t...eaching institution, research institute or think-tank
more
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University, college or other t...eaching institution, research institute or think?tank
more
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|
|
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6567a002212eaade2e0f07dc
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2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
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2020007597
|
GCRF-RSRFFLAIR-FCGR120-FCG\R1\...201034
more
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3
|
Nigeria
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South of Sahara
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LMICs
|
ODA Grants
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1
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10
|
110
|
D02
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0
|
0.033026
|
0
|
0
|
0
|
0.033026
|
0
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0
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0
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0
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Other health problems
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Other health problems Research... and Development
more
|
100
|
EPIGENETICS OF COGNITIVE FUNCT...ION AND DECLINE AFTER STROKE (EPICOGFAST) - AN EXPLORATORY STUDY
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Epigenetics of Cognitive Funct...ion and Decline After STroke (EpiCogFAST) - An Exploratory Study
more
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Research Grant - Collaboration... between UK and a FLAIR Fellow based in Nigeria. Investigating how genetic modifications contribute to the development of memory problems related to stroke, particularly in people of African origin. SDG 3.
more
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12382
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Research for prevention and co...ntrol of NCDs
more
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51000
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University, college or other t...eaching institution, research institute or think-tank
more
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University, college or other t...eaching institution, research institute or think?tank
more
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|
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6567a002212eaade2e0f07dd
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2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
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2020007600
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GCRF-RSRFFLAIR-FR12019-FLR\R1\...191813
more
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3
|
Nigeria
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South of Sahara
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LMICs
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ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.105939
|
0
|
0
|
0
|
0.105939
|
0
|
0
|
0
|
0
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Other health problems
|
Other health problems Research... and Development
more
|
100
|
AFRICAN INNOVATIVE GENETICS OF... VASCULAR COGNITIVE IMPAIRMENT STUDY
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African Innovative Genetics of... Vascular Cognitive Impairment Study
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Fellowship award based in Nige...ria. Identifying genes that contribute to development of memory problems related to stroke, particularly in people of African origin who suffer worse outcomes following stroke. Identifying these genes and their function will aid development of new treatments for memory problems, and better prevention strategies. SDG 3.
more
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12382
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Research for prevention and co...ntrol of NCDs
more
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51000
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University, college or other t...eaching institution, research institute or think-tank
more
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University, college or other t...eaching institution, research institute or think?tank
more
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|
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6567a002212eaade2e0f07de
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
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2020007601
|
GCRF-RSRFFLAIR-FR12020-FLR\R1\...201000
more
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3
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Nigeria
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South of Sahara
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LMICs
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ODA Grants
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1
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10
|
110
|
D02
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0
|
0.113822
|
0
|
0
|
0
|
0.113822
|
0
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0
|
0
|
0
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Other health problems
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Other health problems Research... and Development
more
|
100
|
EFFECT OF CHARCOAL PRODUCTION ...ON AIR QUALITY, HUMAN RESPIRATORY AND CANCER RISK IN SOUTH-WEST, NIGERIA
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Effect of Charcoal Production ...on Air Quality, Human Respiratory and Cancer Risk in South-West, Nigeria
more
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Fellowship award based in Nige...ria. Investigating the effects of deforestation and charcoal production on air quality, human respiratory health and cancer risk in South-West Nigeria. SDG 3.
more
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41082
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Environmental research
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|
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51000
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University, college or other t...eaching institution, research institute or think-tank
more
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University, college or other t...eaching institution, research institute or think?tank
more
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|
|
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6567a002212eaade2e0f07df
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007092
|
GCRF_MRC_PAK_MR/N006062/1
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3
|
Pakistan
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South & Central Asia
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LMICs
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ODA Grants
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1
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10
|
110
|
D02
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0
|
0.012596
|
0
|
0
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0
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0.012596
|
0
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0
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0
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0
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Other health problems
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Other health problems Research... and Development
more
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100
|
MULTICENTER RCT TO EVALUATE TH...E CLINICAL AND COST-EFFECTIVENESS OF A CULTURALLY ADAPTED THERAPY (C-MAP) IN PATIENTS WITH A HISTORY OF SELF-HARM
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|
Multicenter RCT to evaluate th...e clinical and cost-effectiveness of a culturally adapted therapy (C-MAP) in patients with a history of self-harm
more
|
Suicide is a serious global pu...blic health issue ranked amongst the leading causes of death in many countries. The worldwide rates of suicide have increased by 60% in the last 45 years, and the 1.8% total global burden of disease attributed to suicide in 1998 is expected to increase to 2.4% by 2020. The WHO Mental Health Action Plan 2013-2020 and all the member states have committed to work towards the global target of a 10% reduction in the suicide rate by 2020. WHO's Mental Health Gap Action Programme includes suicide as one of the priority conditions and the recent WHO report 'Preventing suicide: a global imperative' calls for suicide prevention to be a high priority on the global public health agenda. More than 800 000 people across the world die due to suicide each year and for each suicide there are more than 20 people attempting suicide. Each suicide takes the life of the individual and has a tremendous effect on friends, family and the wider community. Up to 75% of all suicides occur in in low- and middle-income countries where resources and services are limited for treatment and support for people who need. There is a clear gap in the robust evaluation of culturally appropriate suicide prevention strategies in low and middle income countries. Individuals who have a history of self-harm are at much higher risk of dying by suicide than individuals who do not have such a history. The WHO recommends that offering them appropriate treatment should be a key component of all suicide prevention strategies. There are in excess of 100,000 acts of self-harm carried out in Pakistan annually. The aim of the proposed trial is to evaluate the clinical and cost-effectiveness of a culturally adapted psychological therapy (C-MAP) in patients with a history of self-harm. We carried out a study in Karachi to determine the effectiveness of a 6-8 session CBT-based intervention (C-MAP) in people who had recently self-harmed. The assessments were carried out at baseline, 3 & 6 months. There was a significant reduction from baseline in suicidal ideation, severity of depression and hopelessness in the intervention group compared to the Treatment as Usual (TAU) group at each follow up assessment. The findings from this work have highlighted the applicability of such an intervention to health services in Pakistan for patients who present after a self-harm episode. The proposed research will be conducted in Karachi, Lahore, Rawalpindi, Quetta and Peshawar. Participants will be randomized either to the Intervention (C-MAP) or TAU. The existing culturally adapted intervention (C-MAP) includes an evaluation of the self-harm episode, crisis skills, problem solving and basic cognitive techniques to manage emotions, negative thinking and relapse prevention strategies. The intervention will be delivered in six sessions over 12 weeks. Assessments will be conducted at baseline and at 3 months (end of intervention) 6 months and 12 months after randomisation. The outcome me
more
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0
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12182
|
Medical research
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|
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51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
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|
|
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6567a003212eaade2e0f07e0
|
2020
|
Germany
|
Foreign Office
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2020008482
|
6612206
|
8
|
Libya
|
North of Sahara
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UMICs
|
ODA Grants
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1
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10
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110
|
C01
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2.279202
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2.279202
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0
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0
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2.279202
|
2.279202
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2.279202
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0
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Emergency projects (meeting ad...ditional funding needs)
more
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100
|
EMERGENCY HEALTH MANAGEMENT IN... LIBYA
more
|
emergency health management in... Libya
more
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Support emergency health manag...ement at strategic and operational levels
more
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0
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
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41143
|
World Health Organisation - co...re voluntary contributions account
more
|
World Health Organisation (WHO...-CVCA)
more
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6567a003212eaade2e0f07e1
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007730
|
GCRF_NS_EP/V034502/1_CovidAgil...e
more
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3
|
Rwanda
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.100159
|
0
|
0
|
0
|
0.100159
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
GCRF_NF178 MOBILE ARTS FOR PEA...CE (MAP) AT HOME: ONLINE PSYCHOSOCIAL SUPPORT THROUGH THE ARTS IN RWANDA
more
|
GCRF_NF178 Mobile Arts for Pea...ce (MAP) at home: online psychosocial support through the arts in Rwanda
more
|
During COVID-19 lockdown the R...wandan government initiated strict measures to prevent movement outside the home. Restrictions due to the pandemic increased risks of gender-based violence, teenage pregnancy and school drop-out. Previous studies reported that 26.1% of the population were estimated to have symptoms related to posttraumatic stress disorder (Munyandamutsa et al. 2009), whereas recent studies have reported similar prevalence (RMHS, 2018) and genocide survivor organizations have reported an increase in mental distress during the lockdown. Deteriorating economic conditions pose a significant risk to young people's mental health, which could be further entrenched should further waves of the pandemic occur. Specifically, within Rwanda, there are no current initiatives to provide psychosocial support at home (including referral systems for those in need of more specialist intervention) or building two-way communication and synergies between formal and informal education structures (i.e. schools and community-based groups) to enable learning and social networking during social distancing. MAP at home examines the potential for providing mental health support and community engagement in Rwanda through interactive online platforms, participatory arts workshops, and communications between young people, educators, cultural artists and psychosocial workers across the five provinces of Rwanda: Rwamagana District (Eastern Province), Rubavu District (Western Province), Gicumbi District (Northern Province), Huye District (Southern Province), and Kicukiru District (Kigali Province). MAP at home will research the prevention of, response to and awareness of mental health and promotion of psychosocial well-being among youth, families, and community members through an innovative arts-based, culturally-informed approach, responsive to the needs of participants. MAP at home will generate knowledge on how to reach, engage and equip young people and caregivers with tools for psychosocial wellbeing through the development of a psychosocial module, online and participatory workshops (subject to COVID-19 guidance and social distancing measures), and integration of psychosocial workers. MAP will partner with community-based mental health provider Uyisenga Ni Imanzi, research organisation Institute of Research and Dialogue for Peace (IRDP), national cultural organisation Rwanda Arts Council, and government mental health providers Rwanda Biomedical Centre/Mental Health Division and National Rehabilitation Services to coproduce the design, implementation and dissemination of research from a local to national level. UNESCO serves as a project partner to align national to international policy implementation concerning youth policy and mental health. The project will respond to the following research questions in relation to COVID-19: *How can arts-based approaches be translated to online platforms to enhance psychosocial well-being? *What lessons can be learnt fro
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12264
|
COVID-19 control
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
COVID-19
|
|
6567a003212eaade2e0f07e2
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007105
|
GCRF_MRC_PAK_MR/T004959/1
|
3
|
South & Central Asia, regional
|
South & Central Asia
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.493871
|
0
|
0
|
0
|
0.493871
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CHILDREN LEARNING ABOUT SECOND...-HAND SMOKE: CLUSTER RANDOMISED-CONTROLLED TRIAL
more
|
Children Learning About Second...-hand Smoke: Cluster randomised-controlled trial
more
|
Breathing in other people's ex...haled smoke is called second-hand smoking. Second-hand smoke (SHS) contains harmful chemicals and is a serious health hazard to non-smokers. SHS is estimated to cost more than 800,000 lives per year, worldwide. Children are worst affected, almost a third of deaths from SHS exposure occur in children. A large proportion of the overall burden of diseases due to SHS in children is due to lung diseases such as asthma and chest infections and lung cancer. SHS exposure can also lead to meningitis in children. Children exposed to SHS are more likely to be hospitalised, fall short of their academic potential and take up smoking themselves as compared to those living in smoke-free environments. Recognising SHS as a public health threat, most countries have introduced bans on smoking in enclosed public spaces, which has significantly reduced adults' exposure to SHS. However, for many children, cars and homes remain the most likely places for them to breathe SHS. The only possible way to protect them from SHS is to make cars and homes completely smoke-free. For the last few years, we have been working with schools, parents and children to develop and test a school-based intervention called, 'Smoke-Free Intervention (SFI). It consists of six teaching lessons delivered by schoolteachers, four fun activities and one educational take home resource. Teaching lessons help to increase pupils' knowledge about the harms caused by breathing second-hand smoke. Fun activities include storytelling, role-playing, quizzes and games. These activities help to motivate children to act and feel confident in talking to adults to persuade them not to smoke inside homes. The take-home resource helps children to show what they have learned in school and to negotiate with their families to 'sign-up' to a voluntary contract to make their homes smoke-free. The results of this work show that it is possible to encourage children to discuss with their families ways of restricting smoking inside their homes. Our pilot study also showed that it is possible to recruit and retain schools and children and collect the necessary data for such studies. Inspired by our pilot work, we now propose a large study in Bangladesh and Pakistan where SHS is a major public health problem and a priority for policy makers. Through our work in these countries for several years, we have established collaborations with schools, local communities and policy makers. We wish to examine how effective SFI is, in reducing children's exposure to SHS in homes. We are also interested to see if SFI can improve children's lung health, academic performance and general quality of life, and if it can reduce their health service use. To provide accurate answers to these important questions, we will recruit a total of 66 schools and 2,636 children between 9-12 years of age. We will randomly allocate schools to two arms: arm 1 and arm 2. School teachers in arm 1 will receive training and resourc
more
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12182
|
Medical research
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|
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51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
6567a003212eaade2e0f07e3
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009636
|
HPSR_DA_129877
|
1
|
South & Central Asia, regional
|
South & Central Asia
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0.101946
|
0.045167
|
0
|
0
|
0.101946
|
0.045167
|
0
|
0.101946
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR HPSR-DA: IDENTIFICATION O...F RESEARCH PRIORITIES FOR A SAFE SYSTEMS APPROACH TO ROAD SAFETY IN NEPAL
more
|
NIHR HPSR-DA: Identification o...f research priorities for a safe systems approach to road safety in Nepal
more
|
The death rate for road traffi...c injuries in Nepal is now estimated at 22.7/100 000, ranking Nepal as 30th of 195 countries worldwide (Global Burden of Disease 2019). This study will identify the priorities for road safety research that would support the development of a multi-sectoral 'safe system' for road users in Nepal. The World Health Organisation has identified five 'pillars' of road safety, road safety management, safe roads, safe people, safe vehicles and having an effective post-crash response. Through existing networks we will engage up to 25 stakeholders for each of the five pillars. Interviews with each stakeholder will identify individual views on the evidence gaps. At a series of five workshops collated issues for each pillar will be discussed and ranked. The output will be consensus on the priorities for a programme of road safety research in Nepal. The outputs from this activity can be applied/adapted for other DAC-list country/countries and therefore would benefit a wider geographical region.
more
|
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12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
6567a004212eaade2e0f07e4
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009642
|
RIGHT_2_200806
|
1
|
South & Central Asia, regional
|
South & Central Asia
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
3.85474
|
0.298475
|
0
|
0
|
3.85474
|
0.298475
|
0
|
3.85474
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR RIGHT2: BEHAVIOURAL ACTIV...ATION INTERVENTION FOR DEPRESSION AND DIABETES IN SOUTH ASIA
more
|
NIHR RIGHT2: Behavioural activ...ation intervention for depression and diabetes in South Asia
more
|
A UK and low- and middle-incom...e country (LMIC) research partnership that aims to develop and evaluate a culturally adapted behavioural activation intervention for people with depression and diabetes in Bangladesh and Pakistan.
more
|
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
6567a004212eaade2e0f07e5
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009640
|
RIGHT_2_200817
|
1
|
South & Central Asia, regional
|
South & Central Asia
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
4.176578
|
0.506672
|
0
|
0
|
4.176578
|
0.506672
|
0
|
4.176578
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR RIGHT2: CARE FOR PERINATA...L DEPRESSION THROUGH ENHANCEMENTS TO THE 'THINKING HEALTHY PROGRAMME'
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|
NIHR RIGHT2: Care for perinata...l depression through enhancements to the 'Thinking Healthy Programme'
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A UK and low- and middle-incom...e country (LMIC) research partnership that aims to scale-up care for Perinatal Depression in Pakistan, Nepal, Bangladesh and Sri Lanka, through development of technology to support lay-therapists to deliver a World Health Organisation (WHO)-approved Cognitive Therapy based intervention.
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12182
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Medical research
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51000
|
University, college or other t...eaching institution, research institute or think-tank
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University, college or other t...eaching institution, research institute or think?tank
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