|
65679ff0212eaade2e0f0782
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008372
|
MRC_AA_MR/J012483/1
|
3
|
Africa, regional
|
Africa
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0
|
2.679509
|
0
|
0
|
0
|
2.679509
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TRANSFUSION AND TREATMENT OF S...EVERE ANAEMIA IN AFRICAN CHILDREN: A RANDOMISED CONTROLLED TRIAL (TRACT)
more
|
Transfusion and Treatment of s...evere Anaemia in African Children: a randomised controlled trial (TRACT)
more
|
MRC Global Health Trial award ...- Transfusion and Treatment of severe Anaemia in African Children: a randomised controlled trial (TRACT)
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff0212eaade2e0f0783
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008379
|
MRC_AA_MR/R011192/1
|
3
|
Africa, regional
|
Africa
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.532122
|
0
|
0
|
0
|
0.532122
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
BURDEN OF OBSTRUCTIVE LUNG DIS...EASE FOLLOW-UP IN LOW/MIDDLE INCOME COUNTRIES (BOLD II)
more
|
Burden of Obstructive Lung Dis...ease Follow-up in low/middle income countries (BOLD II)
more
|
MRC PSMB award - Burden of Obs...tructive Lung Disease Followup in low/middle income countries (BOLD II)
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff0212eaade2e0f0784
|
2020
|
Germany
|
Bundesministerium für Wirtsch...aftliche Zusammenarbeit und Entwicklung
more
|
2020006819
|
201706019-1631
|
3
|
Nepal
|
South & Central Asia
|
LDCs
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
0.246732
|
0
|
0
|
0
|
0.246732
|
|
0
|
|
0
|
Classified as not health-speci...fic activity
more
|
|
100
|
STRENGTHENING THE RESILIENCE O...F DISADVANTAGES POPULATIONS GROUPS IN MUGU UND BAJURA DISTRICTS, WESTERN NEPAL.
more
|
Strengthening the resilience o...f disadvantages populations groups in Mugu und Bajura districts, Western Nepal.
more
|
Strengthening the resilience o...f disadvantages populations groups in Mugu und Bajura districts, Western Nepal.
more
|
|
12240
|
Basic nutrition
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think-tank
more
|
|
|
|
65679ff0212eaade2e0f0785
|
2020
|
Germany
|
Bundesministerium für Wirtsch...aftliche Zusammenarbeit und Entwicklung
more
|
2020006410
|
202074243
|
1
|
Indonesia
|
Far East Asia
|
LMICs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0.22792
|
0.227704
|
0
|
0
|
0.22792
|
0.227704
|
|
0.22792
|
|
0
|
COVID-19
|
COVID-19 Therapeutics
|
100
|
HEALTHCARE FOR COVID-19 PATIEN...TS IN CHRISTIAN HOSPITALS, CONTINUATION
more
|
Healthcare for Covid-19 patien...ts in Christian Hospitals, continuation
more
|
Healthcare for Covid-19 patien...ts in Christian Hospitals, Central-java / Indonesia, continuation
more
|
|
12181
|
Medical education/training
|
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Donor country-based NGO
|
|
COVID-19
|
|
65679ff1212eaade2e0f0786
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006978
|
GCRF_MRC_AP_MR/S013865/1
|
3
|
Asia, regional
|
Asia
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.053736
|
0
|
0
|
0
|
0.053736
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CLASSIFICATION OF ORAL LESIONS... USING DEEP LEARNING FOR EARLY DETECTION OF ORAL CANCER
more
|
Classification of oral lesions... using deep learning for early detection of oral cancer
more
|
For the majority of cancers, e...arly detection results in better survival. Oral cancer is one of the few cancers that is visible and many of these cancers are preceded by a potentially malignant lesion where medical intervention can prevent the development of cancer. Taken together, oral cancer presents an opportunity for early detection. However, identifying which oral lesion has a propensity to become oral cancer is not straightforward without specialised training and this problem is confounded by the lack of specialists who are trained in this expertise particularly in low- and middle-income countries, where the majority of oral cancers are diagnosed. One innovative approach to overcome this is to develop an artificial intelligence algorithm to classify oral lesions into those that are benign and those that are potentially malignant or are occult cancer so that patients can be triaged accordingly to receive appropriate clinical management. In this project, we propose to work within a multi-disciplinary, international team to collate a library of images from existing and prospective collections that will facilitate the development of an artificial intelligence algorithm that will be tested and validated. The outcome of this project will pave the way for further rigorous testing, development of an App incorporating this automated tool and clinical validation for the early detection of oral cancer. The development of an automated tool for the classification of oral lesions will facilitate the identification of patients most at risk to develop oral cancer so that these individuals can be managed appropriately. This project is particularly impactful in the low- and middle-income countries as the majority of the global burden of oral cancer is found in these countries.
more
|
0
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff1212eaade2e0f0787
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008382
|
MRC_BGD_MR/M016501/1
|
3
|
Bangladesh
|
South & Central Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.1445
|
0
|
0
|
0
|
0.1445
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE BANGLADESH D-MAGIC TRIAL. ...DIABETES MELLITUS: ACTION THROUGH GROUPS OR INFORMATION FOR BETTER CONTROL?
more
|
The Bangladesh D-Magic Trial. ...Diabetes Mellitus: Action Through Groups or Information for Better Control?
more
|
MRC GACD award - The Banglades...h DMagic Trial. Diabetes Mellitus: Action Through Groups or Information for Better Control?
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff1212eaade2e0f0788
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008381
|
MRC_BGD_MR/P008941/1
|
3
|
Bangladesh
|
South & Central Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.139861
|
0
|
0
|
0
|
0.139861
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
MUSLIM COMMUNITIES LEARNING AB...OUT SECOND-HAND SMOKE IN BANGLADESH (MCLASS II): AN EFFECTIVENESS-IMPLEMENTATION HYBRID STUDY
more
|
Muslim Communities Learning Ab...out Second-hand Smoke in Bangladesh (MCLASS II): An effectiveness-implementation hybrid study
more
|
MRC GACD Resp Full April 2016 ...award - Muslim Communities Learning About Secondhand Smoke in Bangladesh (MCLASS II): An effectivenessimplementation hybrid study
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff2212eaade2e0f0789
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006986
|
GCRF_MRC_NS_MR/T02528X/1
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.155906
|
0
|
0
|
0
|
0.155906
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CHARMING - CONTROL OF HYPERTEN...SION AND DIABETES IN MINAS GERAIS
more
|
CHArMING - Control of Hyperten...sion and diAbetes in MINas Gerais
more
|
In Brazil, the frequency of ad...ults with high blood pressure is around 35%, while diabetes is self-reported in 6.2%. Getting treatment for hypertension and diabetes can avoid people having difficulty managing their illness and their problems getting worse. Limited access to health services and few health workers to support have led to deficiencies in treatment, outcomes and quality of life of hypertensive and diabetic patients. In Minas Gerais state, the university and hospital established a Telehealth Network, in 2005, to use digital health solutions to improve access and quality to health care. A specific intervention in hypertension and diabetes was developed with positive results in the HealthRise project (2016-2018), in the Northeast of Minas Gerais, a remote region with limited number of health resources. The present project will develop a framework to implement this intervention in a larger number of primary health care (PHC) units, using these locations to improve the management of patients with high blood pressure and diabetes. Training and clinical support developed by UFMG allow health workers in different roles to use the software and clinical workflows during a patient's visit to the PHC. The staff receives guidance and support from the software and additional specialist medical input to help managing hypertension and diabetes using the 'best practice'. Additionally the software contacts the patient via SMS to check in on the patient regularly, to help remind them about medication, activities and lifestyle changes such as diet that would help them manage and control their disease, empowering them in self-care when away from the care teams. The health care workers also participate in further online and face to face training to help continually develop understanding of the management of these patients. In the fist part of the project, over the first two years, the teams from the different organisations will work with clinical staff, researchers, software designers, and trainers, to look and improve the intervention and software tools as they are currently being used. In the second part of the project, in years three to five, the teams will undertake a study in the Mucury Valley to compare the use of the intervention and training across the 34 primary health centres: one half of the sites will be given the software and training to treat and manage their patients, and the other half the sites will continue to treat and manage patients in the standard way. This will be a significant step to evaluate this innovation that has been developed within Brazil and look at how best to support this approach at scale to the wider state or country, reaching many communities living in poor urban and rural settings and reducing the burden of these diseases in this continental country.
more
|
0
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff2212eaade2e0f078a
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006982
|
GCRF_MRC_BRA_MR/T03355X/1
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.034582
|
0
|
0
|
0
|
0.034582
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE RISK OF A CHRONIC CLINICAL... CONDITION FOLLOWING A PREVIOUS HOSPITALISATION BY A PSYCHIATRIC DISORDER: A LINKAGE NATIONWIDE STUDY IN BRAZIL
more
|
The risk of a chronic clinical... condition following a previous hospitalisation by a psychiatric disorder: a linkage nationwide study in Brazil
more
|
Multimorbidity is the occurren...ce of more than one chronic condition at a time. This can include conditions like cardiovascular disease, a mental health condition of long duration, such as a mood disorder or dementia or an infectious disease of long duration, such as Tuberculosis. Multimorbidity increases with age and also presents certain distinct patterns related to sex. On the other hand, mental disorders are commonly found together and usually have consequences on other chronic physical condition that the patient may have. Mental health disorders, in particular depression, represent an important risk factor for premature mortality. Multimorbidity can also increase the treatment costs, as subjects with depression will cost 50% more to health systems than those with one chronic condition alone. Cardiovascular diseases are also found to co-occur with depression, this might happen because these patients show difficulties in following their GP 's recommendations. It is of note that women seem to be at higher risk of morbidity from cardiovascular disease, while they are also at a higher risk of depression suggesting gender-specific mechanisms. Analysis of a recent health survey in adult Brazilians observed that the prevalence rate of multimorbidity are higher among women compared to men, among older people and those with lower educational level. We at the Center for Data Integration and Knowledge for Health (CIDACS) have access to very large datasets, which would commonly be known as Big Data. This data comprises information from Brazilian subjects that were listed or benefited by one of the several social programmes or were seen in any of the numerous public hospital of the country's universal health system. This project aims at increasing knowledge over the relationship of mental disorders and other chronic conditions to ameliorate the lives of those affected. More specifically we want to (A) estimate the the risk of hospitalisations or death by diabetes mellitus, cardiovascular diseases or stroke following a hospitalisation due to depressive disorders, alcohol and substance use-related disorders, and schizophrenia, (B) To estimate the risk of the occurrence or death by tuberculosis following a hospitalisation due to depressive disorders, alcohol and substance use-related disorders, and schizophrenia, (C) To investigate how these chronic conditions goes together in clusters and how these patterns evolve over time and ageing.
more
|
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff2212eaade2e0f078b
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006498
|
GCRF-BACImYF-Prg2019-YF190240
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.284665
|
0
|
0
|
0
|
0.284665
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
AMPLIFYING THE VOICES OF YOUNG... PEOPLE FOR SUSTAINABLE DEVELOPMENT IN MENTAL HEALTH
more
|
Amplifying the voices of young... people for sustainable development in mental health
more
|
Research grant - this project ...aims to advance our understanding of youth agency in mental health and ultimately contribute to the achievement of a sustainable and healthy future for Brazilian youth. Benefitting young people in Brazil. SDGs: 3, 10.
more
|
|
12340
|
Promotion of mental health and... well-being
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff2212eaade2e0f078c
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020007221
|
GCRF-RAECImFFF-1920-1-FF\1920\...1\61
more
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.230858
|
0
|
0
|
0
|
0.230858
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
FRONTIERS FOLLOW-ON FUNDING
|
Frontiers Follow-on Funding
|
This project led by researcher...s from the UK, Brazil, South Africa and the USA is titled 'Harnessing technology to improve prediction of future depression onset among Brazilian adolescents (the IDEA-TECH project)' The objective for this project is to test the predictive utility in Brazil of a risk calculator for future depression that we have developed in a middle-income country and determine whether prediction is improved by incorporating information on adolescents' experiences obtained in real-time via their smartphones.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff2212eaade2e0f078d
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006738
|
GCRF_EPSRC_KHM_EP/R014213/1
|
3
|
Cambodia
|
Far East Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.12935
|
0
|
0
|
0
|
0.12935
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
A STEP CHANGE IN LMIC PROSTHET...ICS PROVISION THROUGH COMPUTER AIDED DESIGN, ACTIMETRY AND DATABASE TECHNOLOGIES
more
|
A Step Change in LMIC Prosthet...ics Provision through Computer Aided Design, Actimetry and Database Technologies
more
|
Approximately 100M people worl...dwide need prosthetic and orthotic (P&O) devices [1]. Low-cost, robust devices are only half the story, an estimated 80-90% do not have access to P&O services 'due to a shortage of personnel, service units and health rehabilitation infrastructures' [2]. All three barriers could be addressed by data, so we propose research into novel tools to enhance P&O data. Access is particularly poor for people in Lower and Middle Income Countries (LMICs) such as Cambodia with its landmine legacy, who are typically young and live longer lives of more physical work than in the developed world, for whom most prosthetics technology has been developed. LMICs have higher levels traumatic amputation from accidents, conflict and landmine injuries, and humanitarian crises present particular access challenges [3]. Services are set up primarily for trauma injuries but by 2035 it is estimate diabetes may affect over 500M people, and is growing fastest in LMICs [4]. Through the International Society for Prosthetics and Orthotics (ISPO), substantial improvements have been made in P&O design and training for LMICs [2,5]. An overwhelming patient:clinician ratio remains and 'the development of the sector is too slow ... to meet existing needs or keep pace with the growing populations of people with disabilities' [2]. Even with ISPO accredited training, in South East Asian LMICs it is estimated that three times the current number of clinician is required for the current amputee population [6]. We will conduct two data-technology research studies, to develop tools to improve P&O service access, train clinicians and improve efficiency of service funding use. With a team of expert clinicians, academics and policy makers in Cambodia, we will investigate: 1) digital measurement tools to assess a user's residual limb anatomy, biomechanics of gait, typical daily prosthetic limb use, and health status, and 2) the architecture for a portable digital patient casenote system: a robust and secure IT network for travelling prosthetists to visit provincial areas to provide evidence-based treatment for those in remote communities who cannot afford to travel. Beside these scientific challenges, the context makes this work highly ambitious. Experience shows that care must be taken in applying P&O from Western countries directly in LMICs. As well as users' different needs, their relationship with clinicians and prosthetics are different for complex cultural, social and environmental reasons. We frame our scientific research using a first-of-kind ethnographic study of P&O service providers and users to ensure the developed technologies are practical. We will also conduct business modelling research, producing tools to ensure the technologies are cost effective and can be implemented sustainably. These technologies have the potential to transform the quality of life of prosthetic limb users worldwide and are required today. A more portable P&O service would enab
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff3212eaade2e0f078e
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006989
|
GCRF_MRC_CHN_MR/T008547/1
|
3
|
Cameroon
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0
|
0.016594
|
0
|
0
|
0
|
0.016594
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
RAPID DIAGNOSIS OF ONCHOCERCIA...SIS USING URINARY BIOMARKERS
more
|
Rapid diagnosis of onchocercia...sis using urinary biomarkers
more
|
Onchocerciasis or river blindn...ess is a parasitic disease affecting 17 million in sub-Saharan Africa. It causes visual impairment, sometimes leading to irreversible blindness, and intense itching of the skin. The symptoms of the disease can be controlled by annual treatment with the drug ivermectin, which kills the larval stages in the skin, but the adult worms are not eliminated and can survive for more than 10 years. Diagnosis of the disease has been dependent for many decades on microscopic examination of skin snips for the larval stage. This is a painful procedure that, not surprisingly, is being met with reduced compliance in communities that have been sampled repeatedly over many years. In this proposal, we aim to radically improve the diagnosis of onchocerciasis by testing for the presence of adult worms using a patient's urine sample. We have discovered that the worms release proteins and small RNA molecules into urine that can be detected by mass spectrometers and sequencing technology. The molecules are associated with small 'packets' called extracellular vesicles. We will isolate these vesicles from urine samples to identify the best markers for the disease. To facilitate the process, we will also test urine samples from African cattle, which are infected with a parasite very closely related to that which causes human onchocerciasis. By treating the cattle with drugs that kill the adult parasites, we will test whether the molecules released in urine are a good indicator of whether live worms remain in the host's body. This is a particularly important at the present time, as several drugs with potential activity against adult worms are being tested in clinical trials in humans, and currently the only way to know whether the worms have been killed is to perform surgery on the volunteers. In the final stages of the proposal, we will investigate methods to capture parasite molecules from urine in an efficient manner. This will be necessary to move away from a diagnostic test that is dependent on expensive laboratory equipment to a kit that ultimately could be used in rural Africa.
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff3212eaade2e0f078f
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006743
|
GCRF_EPSRC_CHN_EP/R013977/1
|
3
|
China (People's Republic of)
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.290496
|
0
|
0
|
0
|
0.290496
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
LOCOMOTE: LOW COST MORPHABLE T...ELEOPERATED ENDOSCOPE FOR GASTRIC INTESTINAL TRACT SCREENING
more
|
LoCoMoTE: Low Cost Morphable T...eleoperated Endoscope for Gastric Intestinal Tract Screening
more
|
Existing technologies are unab...le to meet China's endoscopic gastrointestinal (GI) screening needs, due to its large, aging population, insufficient infrastructure and high incidence of GI cancers. To address this challenge, we propose a novel and low cost soft endoscope, together with high-speed wireless communications to create a way to perform regular endoscopic screening programs in China. The soft endoscope will be able propel itself inside torturous, compliant environments, such as the human gastrointestinal tract, and dramatically reduce the pain associated with conventional endoscopes. Because of the self-propelling feature and the inherent safety of using soft material, the new endoscope can be operated by non-specialist staff with minimal training and be supervised or even controlled remotely by specialist clinicians with wireless communication. The endoscope will be operated by clinicians via a custom made haptic interface. The endoscope itself will be made to be low cost and disposable. Therefore, this will enable rural medical clinics to run regular endoscopic screening programs with the system, as it will require no additional sterilisation facilities and will be easy to learn to use. To facilitate adoption and to provide support for rural clinicians, the endoscope will be connected to a high-speed 5G wireless that will enable haptic tele-operation. Through this, expert clinicians in large hospitals all over the country will be able to monitor and directly control screening procedures from any location. Experts will therefore be able to train rural clinicians in techniques by physically demonstrating them, support rural clinics to ensure accurate diagnosis and allow experts to perform more complex procedures remotely. Aligning well with China's strategy of starting 5G commercial applications in 2020, this approach is timely and takes advantage of the wide-spread availability of wireless internet in China and deals directly with the challenges faced by efforts to create large-scale endoscopic screening programs in the country.
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff3212eaade2e0f0790
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006742
|
GCRF_EPSRC_CHN_EP/R014094/1
|
3
|
China (People's Republic of)
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.186146
|
0
|
0
|
0
|
0.186146
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
DEVELOPMENT OF NEW LOW COST PO...INT OF CARE DIAGNOSTIC TECHNOLOGIES FOR DIABETIC RETINOPATHY IN CHINA
more
|
Development of New Low Cost Po...int of Care Diagnostic Technologies for Diabetic Retinopathy in China
more
|
We will develop novel, low-cos...t, diagnostic technologies for the detection of a blinding condition called diabetic retinopathy (DR) in China. These technologies will enable cost-effective, large-scale detection of sight-threatening disease to be performed by non-expert health care workers at the time and place of patient care in China. Over 110 million people in China live with diabetes and this number is expected to increase to 150m by 2040. Diabetes causes visual loss through damage to blood vessels of the retina at the back of the eye. Treatments are effective (and increasingly affordable in China) but only if the disease is detected early enough. Improving early diagnosis and treatment of DR is one of the principal objectives of the Chinese Government's 5-Year National Plan of Eye Health (2016-2020). Current methods of detecting DR rely on costly imaging equipment and many skilled personnel to take and interpret retinal images. China has very few health workers with these skills. Case detection strategies which are cost-effective in Western Europe cannot possibly be replicated at the scale necessary for China. Building on an existing collaboration between the University of Liverpool, Peking University and the Chinese Medical Association (CMA), our joint research team from Liverpool and China of engineers, statisticians, education specialists, eye doctors and health economists are well placed to develop a new diagnostic imaging solution tailored to local needs. Our objectives for this project are: 1. To develop a novel, low-cost, robust imaging device for detection of DR 2. To develop new automated computer algorithms to rate images of the retina for sight-threatening disease 3. To develop a novel comparative judgement method to refine the DR severity grading from automated computer algorithms 4. To validate the new technologies in the UK and test them in China to ensure maximum cost-effectiveness We will develop a new low-cost, camera designed specifically for the needs of China. This device will produce both high-quality colour images and optical coherence tomography (OCT) images of the retina. OCT is widely available but current commercial systems are very expensive. Our new device will be based on our novel patent-pending technology and will be first tested on human donor tissue. We will develop and evaluate new, automated image analysis techniques allowing computers to learn to analyse both colour and OCT images of the retina. We aim to produce systems capable of differentiating between patients with and without DR and between those with mild/moderate and severe disease at the time and place of patient care. In order to achieve a high level of diagnostic accuracy (over and above automated image analysis), we will develop and evaluate a new human learning system. This system will harness the collective judgements of Chinese health workers to rank images in terms of DR severity. We will create a self-sustaining network of activi
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff3212eaade2e0f0791
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008547
|
NERC_CHN_APHH_China_NF_contrib...ution
more
|
3
|
China (People's Republic of)
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.327566
|
0
|
0
|
0
|
0.655132
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
50
|
ATMOSPHERIC POLLUTION AND HUMA...N HEALTH IN A CHINESE MEGACITY PROGRAMME. CONTRIBUTION TO NEWTON FUND PROGRAMME
more
|
Atmospheric Pollution and Huma...n Health in a Chinese Megacity Programme. Contribution to Newton Fund programme
more
|
Urban air pollution is a sever...e problem with significant impacts on economy and health of the population. Projects will address the sources and emissions of urban air pollution and the processes underlying and impacting on this, and the impacts on health.
more
|
0
|
41082
|
Environmental research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff3212eaade2e0f0792
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008094
|
NF_NERC_CHN_APHH China
|
3
|
China (People's Republic of)
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0
|
0.211895
|
0
|
0
|
0
|
0.42379
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
50
|
ATMOSPHERIC POLLUTION & HUMAN ...HEALTH IN A DEVELOPING MEGACITY - CALL1
more
|
Atmospheric Pollution & Human ...Health in a Developing Megacity - call1
more
|
Urban air pollution is a sever...e problem in China with significant impacts on the economy and the health of the population. This programme will support research on the sources and emissions of urban air pollution in China and the processes underlying and impacting on this, and the impacts on health
more
|
0
|
41082
|
Environmental research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff4212eaade2e0f0793
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006990
|
GCRF_MRC_CHN_MR/N015967/1
|
3
|
China (People's Republic of)
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.01994
|
0
|
0
|
0
|
0.01994
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PERFORMANCE OF EARLY RETINAL L...ASER (PEARL)
more
|
Performance of EArly Retinal L...aser (PEARL)
more
|
Diabetes, an illness in which ...the body cannot manage blood sugar safely, is often thought of as a disease of wealth. In fact, over 80% of diabetes occurs in poor or middle-income countries, where rates are growing very quickly. In China, there is ten times more diabetes now than there was 30 years ago, and rates (12%) exceed the US. Over years, diabetes damages blood vessels and vision cells in the eye, and can cause blindness. Most diabetic blindness can be prevented with laser if caught early, but only 10% of rural diabetic persons in China receive care. A major reason is that standard treatment of diabetic eye disease ('DR') calls for patients to return for examinations until their eyes reach a late stage called 'PDR', which may take many years, before any treatment is given. This can be very difficult for rural patients, who are often less educated and poorer, meaning they drop out before receiving care. We have completed a review of papers written about earlier treatment of DR, at a stage called 'No PDR' or 'NPDR.' This review showed studies are needed to prove that this approach is safe and beneficial, but evidence suggests that early treatment could be better to preserve vision, and easier for patients who might otherwise drop out of standard care. To fill the gap in evidence, we designed a study where patients with disease at an earlier stage ('NPDR,' the Early Group) get laser treatment right away in one eye chosen by chance and the other eye only get laser if 'PDR' develops later, which is the current standard. We will compare eyes treated at NPDR and PDR stages for several outcomes important to patients: vision, developing more serious 'PDR' disease, and damage to the eye from treatment. An important goal of this study is to find out if patients who get early treatment are less likely to drop out of follow-up. Since one eye of a patient can't 'drop out,' we will also have a second group of people who will get later treatment in both eyes only if PDR develops ('Standard Group'). We will compare the rate of dropout between the Early and Standard group. The cost of Early versus Standard treatment will also be examined. An equal number of urban and rural patients will be recruited, because our early work shows that rural patient are at special risk for dropping out, because of their lack of understanding of their disease, but we want to understand patients from both settings. Our study will have two main aims: 1. This kind of study, a 'trial,' is expensive and hard. We want to first do a small 'Pilot' (100 patients each in Early and Standard groups, versus 300 in each for the main trial) to show that we can find enough patients, convince them to join the study, give them the treatment as selected by chance, follow them for 1 year and collect necessary data. 2. Care of DR in rich settings often depends on expensive tests or advanced training to define the stages ('NPDR,' 'PDR') and complications of treatment that require further car
more
|
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff4212eaade2e0f0794
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008390
|
MRC_CHN_MR/T017112/1
|
3
|
China (People's Republic of)
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.098364
|
0
|
0
|
0
|
0.098364
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
REAL-WORLD TREATMENT EFFECTIVE...NESS IN PEOPLE WITH TYPE 2 DIABETES: MAXIMISING THE APPLICABILITY OF CLINICAL TRIALS
more
|
Real-world treatment effective...ness in people with type 2 diabetes: Maximising the applicability of clinical trials
more
|
MRC PSMB RM19/20 award to comp...are the efficacy, effectiveness and cost-effectiveness of three classes of novel antidiabetic drugs (DPP-4 inhibitors, SGLT2-inhibitors, and GLP-1 agonists), based on a network meta-Analysis of randomised clinical trials calibrated to routine data sources in order to make them more applicable to real-world settings
more
|
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff4212eaade2e0f0795
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008391
|
MRC_AY_MR/S023674/1
|
3
|
Colombia
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.094091
|
0
|
0
|
0
|
0.094091
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
BUILDING RESILIENCE IN ADOLESC...ENCE - IMPROVING QUALITY OF LIFE FOR ADOLESCENTS WITH MENTAL HEALTH PROBLEMS IN COLOMBIA (BRICS STUDY)
more
|
Building resilience in adolesc...ence - improving quality of life for adolescents with mental health problems in Colombia (BRiCs study)
more
|
MRC Adolescent Health Building... resilience in adolescence improving quality of life for adolescents with mental health problems in Colombia (BRiCs study)
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff4212eaade2e0f0796
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020008393
|
MRC_COL_MR/R011176/1
|
3
|
Colombia
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.309992
|
0
|
0
|
0
|
0.309992
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
USING GAME THEORY TO ASSESS TH...E EFFECTS OF SOCIAL NORMS AND SOCIAL NETWORKS ON ADOLESCENT SMOKING IN SCHOOLS: A PROOF OF CONCEPT STUDY
more
|
Using Game Theory to assess th...e effects of social norms and social networks on adolescent smoking in schools: a proof of concept study
more
|
MRC PSMB award - Using Game Th...eory to assess the effects of social norms and social networks on adolescent smoking in schools: a proof of concept study
more
|
0
|
12182
|
Medical research
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff4212eaade2e0f0797
|
2020
|
Germany
|
Foreign Office
|
2020009661
|
6615171
|
1
|
Belarus
|
Europe
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.005698
|
0.005696
|
0
|
0
|
0.005698
|
0.005696
|
|
0.005698
|
|
0
|
COVID-19
|
COVID-19 General
|
100
|
COVID-19 STOP-COVID IRDIZA
|
Covid-19 Stop-Covid Irdiza
|
Covid-Prevention in the Instit...ution Bychowskij/Irdiza for old and disabled persons.
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
12000
|
Recipient Government
|
Recipient Government
|
|
COVID-19
|
|
65679ff4212eaade2e0f0798
|
2020
|
Germany
|
Foreign Office
|
2020009662
|
6615172
|
1
|
Belarus
|
Europe
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.005698
|
0.005696
|
0
|
0
|
0.005698
|
0.005696
|
|
0.005698
|
|
0
|
COVID-19
|
COVID-19 General
|
100
|
COVID-19 STOP-COVID BOROWLJANY
|
Covid-19 Stop-Covid Borowljany
|
Covid-Prevention in the hospic...e for children Borowljany
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
12000
|
Recipient Government
|
Recipient Government
|
|
COVID-19
|
|
65679ff5212eaade2e0f0799
|
2020
|
Germany
|
Foreign Office
|
2020009670
|
6615173
|
1
|
Belarus
|
Europe
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.001709
|
0.00165
|
0
|
0
|
0.001709
|
0.00165
|
|
0.001709
|
|
0
|
Other health problems
|
Other health problems Other
|
100
|
MATERIAL FOR DISABLED PERSONS ...IN MINSK CIRCLE
more
|
Material for disabled persons ...in Minsk Circle
more
|
Provision of material for occu...pational therapy of disabled persons
more
|
|
12191
|
Medical services
|
|
I.2.a. Health, General
|
12004
|
Other public entities in recip...ient country
more
|
Other public entities in recip...ient country
more
|
|
|
|
65679ff5212eaade2e0f079a
|
2020
|
Germany
|
Foreign Office
|
2020009672
|
6615186
|
8
|
Myanmar
|
South & Central Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.05698
|
0.05698
|
0
|
0
|
0.11396
|
0.11396
|
|
0.11396
|
|
0
|
COVID-19
|
COVID-19 Personal Protective E...quipment
more
|
50
|
DISTRIBUTION OF CORONAVIRUS PR...EVENTION MATERIAL AND BASIC FOOD PARCELS FOR PEOPLE AFFECTED BY COVID-19 PANDEMIC
more
|
Distribution of Coronavirus pr...evention material and basic food parcels for people affected by Covid-19 pandemic
more
|
Supporting the people affected... by Covid-19 pandemic with basic food and hygieneproducts
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
23000
|
Developing country-based NGO
|
Developing country-based NGO
|
|
COVID-19
|
|
65679ff5212eaade2e0f079b
|
2020
|
Germany
|
Foreign Office
|
2020009674
|
6615188
|
8
|
Senegal
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.011293
|
0.011293
|
0
|
0
|
0.011293
|
0.011293
|
|
0.011293
|
|
0
|
COVID-19
|
COVID-19 Personal Protective E...quipment
more
|
100
|
SUPPLY OF MEDICAL PROTECTION E...QUIPMENT - COVID-19
more
|
Supply of medical protection e...quipment - Covid-19
more
|
Supply of medical protection e...quipment of Bilbassi hospital - masks, medical protection, thermometers etc.
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
12004
|
Other public entities in recip...ient country
more
|
Other public entities in recip...ient country
more
|
|
COVID-19
|
|
65679ff5212eaade2e0f079c
|
2020
|
Germany
|
Foreign Office
|
2020009675
|
6615189
|
8
|
Senegal
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.010665
|
0.010665
|
0
|
0
|
0.010665
|
0.010665
|
|
0.010665
|
|
0
|
COVID-19
|
COVID-19 Personal Protective E...quipment
more
|
100
|
KIRCHENGEMEINDE - SUPPLY OF FO...OD, MASKS AND STERILISATION LIQUIDS - COVID-19
more
|
Kirchengemeinde - Supply of fo...od, masks and sterilisation liquids - Covid-19
more
|
Support of a church community ...in regards to Corona hygine measures - production of masks, supply of sterilisation liquids, food - fast and active support of the rural communities
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
12000
|
Recipient Government
|
Recipient Government
|
|
COVID-19
|
|
65679ff5212eaade2e0f079d
|
2020
|
Germany
|
Foreign Office
|
2020009676
|
6615196
|
8
|
Namibia
|
South of Sahara
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.003373
|
0.003373
|
0
|
0
|
0.003373
|
0.003373
|
|
0.003373
|
|
0
|
Classified as not health-speci...fic activity
more
|
|
100
|
COVID-19 SUPPORT_ SOUP KITCHEN... FOR 5 VILLAGES IN THE //KARAS REGION, NAMIBIA
more
|
Covid-19 support_ Soup kitchen... for 5 villages in the //Karas Region, Namibia
more
|
The soup kitchen projects in 5... villages in the // Karas region are intended to offer immediate help to feed people in need, especially young learners that are in most cases malnourished.
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
23000
|
Developing country-based NGO
|
Developing country-based NGO
|
|
COVID-19
|
|
65679ff5212eaade2e0f079e
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009680
|
16_137_122
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.591252
|
0
|
0
|
0
|
0.591252
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR GLOBAL HEALTH RESEARCH GR...OUP ON ROAD SAFETY
more
|
NIHR Global Health Research Gr...oup on Road Safety
more
|
A UK and low- and middle-incom...e country (LMIC) partnership that aims to reduce the number and severity of road accidents in LMICs through the underpinning philosophy of local solutions for local problems.
more
|
0
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff6212eaade2e0f079f
|
2020
|
Germany
|
Foreign Office
|
2020009681
|
6615191
|
8
|
Gambia
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.008077
|
0.008077
|
0
|
0
|
0.008077
|
0.008077
|
|
0.008077
|
|
0
|
COVID-19
|
COVID-19 Therapeutics
|
100
|
SUPPLY OF EQUIPMENT FOR VENTIL...ATION MACHINES - COVID 19
more
|
Supply of equipment for ventil...ation machines - Covid 19
more
|
Supply of equipment for 36 ven...tilation machines for Covid-19 health centres
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
20000
|
Non-Governmental Organisation ...(NGO) and Civil Society
more
|
Non-governmental organisations... (NGOs) and civil society
more
|
|
COVID-19
|
|
65679ff6212eaade2e0f07a0
|
2020
|
Germany
|
Foreign Office
|
2020009682
|
6615203
|
8
|
Mauritania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.00151008
|
0.00151008
|
0
|
0
|
0.004576
|
0.004576
|
|
0.004576
|
|
0
|
COVID-19
|
COVID-19 Personal Protective E...quipment
more
|
33
|
SUPPORT OF A DISABLED CHILDREN...S' HOME
more
|
Support of a disabled children...s' home
more
|
Support of a disabled children...s' home through the procurement of special medication, sanitary items (also with regard to Covid-19)and food provisions
more
|
|
16010
|
Social Protection
|
|
I.6. Other Social Infrastructu...re & Services
more
|
11001
|
Central Government
|
Foreign Office
|
|
|
|
65679ff6212eaade2e0f07a1
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009684
|
16_137_45
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
1.014049
|
0
|
0
|
0
|
1.014049
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR GLOBAL HEALTH RESEARCH GR...OUP ON POST CONFLICT TRAUMA (PROTECT)
more
|
NIHR Global Health Research Gr...oup on Post Conflict Trauma (PrOTeCT)
more
|
A UK and low- and middle-incom...e country (LMIC) partnership that aims to improve the health and wellbeing of civilians afflicted by blast injuries, reduce the socio-economic burden of explosive remnants of war in the developing world, develop a research and innovation hub for orthopaedic, trauma and biomaterials researchers, engineers and clinicians and advance understanding of biomaterials and orthopaedic technology.
more
|
0
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff6212eaade2e0f07a2
|
2020
|
Germany
|
Foreign Office
|
2020009687
|
17580
|
8
|
Guinea-Bissau
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.018707
|
0.018707
|
0
|
0
|
0.018707
|
0.018707
|
|
0.018707
|
|
0
|
COVID-19
|
COVID-19 Other
|
100
|
SUPPLY OF SOLAR BASED HAND WAS...H STATIONS IN REGARDS TO COVID-19 MEASURES
more
|
Supply of solar based hand was...h stations in regards to Covid-19 measures
more
|
Supply of solar based hand was...h stations to the slum dwellers in order to support hygiene measures
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
20000
|
Non-Governmental Organisation ...(NGO) and Civil Society
more
|
Non-governmental organisations... (NGOs) and civil society
more
|
|
COVID-19
|
|
65679ff6212eaade2e0f07a3
|
2020
|
Germany
|
Foreign Office
|
2020009691
|
6615216
|
1
|
Serbia
|
Europe
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.005322
|
0.003954
|
0
|
0
|
0.005322
|
0.003954
|
|
0.005322
|
|
0
|
COVID-19
|
COVID-19 Other
|
100
|
SERBIA AT THE TIME OF CORONA
|
Serbia at the time of Corona
|
To inform wider public and rai...se awareness on different aspects of the COVID-19 pandemic and its consequences through involving qualified interlocutors from Serbia, Western Balkans and the EU.
more
|
|
15150
|
Democratic participation and c...ivil society
more
|
|
I.5.a. Government & Civil Soci...ety-general
more
|
23000
|
Developing country-based NGO
|
Developing country-based NGO
|
|
COVID-19
|
|
65679ff6212eaade2e0f07a4
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009692
|
16_137_97
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.88709
|
0
|
0
|
0
|
0.88709
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR GLOBAL HEALTH RESEARCH GR...OUP ON DEVELOPING PSYCHO-SOCIAL INTERVENTIONS FOR MENTAL HEALTH CARE
more
|
NIHR Global Health Research Gr...oup on Developing Psycho-Social Interventions for Mental Health Care
more
|
A UK and low- and middle-incom...e country (LMIC) partnership that aims to Develop psycho-social interventions for people with severe mental illnesses, utilising existing resources in communities.
more
|
0
|
12382
|
Research for prevention and co...ntrol of NCDs
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff7212eaade2e0f07a5
|
2020
|
Germany
|
Foreign Office
|
2020009698
|
6615229
|
8
|
Venezuela
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.050142
|
0.050142
|
0
|
0
|
0.050142
|
0.050142
|
|
0.050142
|
|
0
|
Classified as not health-speci...fic activity
more
|
|
100
|
COVID-19 DISTRIBUTION OF FOOD ...AND TECHNICAL SUPPLY FOR SCHOOLS
more
|
Covid-19 Distribution of Food ...and technical supply for schools
more
|
distribution of food and techn...ical (Food security and access to digital learning)
more
|
|
12240
|
Basic nutrition
|
|
I.2.b. Basic Health
|
20000
|
Non-Governmental Organisation ...(NGO) and Civil Society
more
|
Non-governmental organisations... (NGOs) and civil society
more
|
|
COVID-19
|
|
65679ff7212eaade2e0f07a6
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009699
|
17_63_131
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.783636
|
0
|
0
|
0
|
0.783636
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR GLOBAL HEALTH RESEARCH GR...OUP ON IMPROVING OUTCOMES IN SUB-SAHARAN AFRICAN DIABETES THROUGH BETTER DIAGNOSIS AND TREATMENT
more
|
NIHR Global Health Research Gr...oup on Improving Outcomes in Sub-Saharan African Diabetes Through Better Diagnosis and Treatment
more
|
A UK and low- and middle-incom...e country (LMIC) partnership that aims to build on existing relationships between Exeter and leading partners in Uganda and Cameroon to form a collaborative, multi-disciplinary research group to answer fundamental questions for diabetes detection and treatment needed for effective patient care, train the next generation of clinical researchers, and build crucial research capacity in sub-Saharan Africa.
more
|
0
|
12382
|
Research for prevention and co...ntrol of NCDs
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff7212eaade2e0f07a7
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009702
|
17_63_155
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
1.011073
|
0
|
0
|
0
|
1.011073
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR GLOBAL HEALTH RESEARCH GR...OUP ON CLEAN ENERGY ACCESS FOR THE PREVENTION OF NON-COMMUNICABLE DISEASE IN AFRICA THROUGH CLEAN AIR
more
|
NIHR Global Health Research Gr...oup on Clean Energy Access for the Prevention of Non-Communicable Disease in Africa Through Clean Air
more
|
A UK and low- and middle-incom...e country (LMIC) partnership that aims to conduct high quality translational research supporting sustained, evidenced-based equitable transition to clean household energy at scale in Cameroon, Kenya and Ghana, demonstrating the health (through reductions in non-communicable disease), health inequalities and climate impacts of this transition.
more
|
0
|
12382
|
Research for prevention and co...ntrol of NCDs
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff7212eaade2e0f07a8
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009703
|
17_63_20
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.631489
|
0
|
0
|
0
|
0.631489
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR GLOBAL HEALTH RESEARCH GR...OUP ON RESPIRATORY REHABILITATION (GLOBAL RECHARGE)
more
|
NIHR Global Health Research Gr...oup on Respiratory Rehabilitation (Global RECHARGE)
more
|
A UK and low- and middle-incom...e country (LMIC) partnership that aims to deliver an intervention to reduce disability through pulmonary rehabilitation in Kyrgyzstan, Uganda, India and Sri Lanka.
more
|
0
|
12182
|
Medical research
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff7212eaade2e0f07a9
|
2020
|
United Kingdom
|
Department of Health and Soci...al Care
more
|
2020009706
|
17_63_38
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.667686
|
0
|
0
|
0
|
0.667686
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NIHR GLOBAL HEALTH RESEARCH GR...OUP ON IMPROVING ASTHMA OUTCOMES IN AFRICAN CHILDREN
more
|
NIHR Global Health Research Gr...oup on Improving Asthma Outcomes in African Children
more
|
A UK and low- and middle-incom...e country (LMIC) partnership that aims to assess asthma control, current treatment, knowledge of and attitudes to asthma in African schools, and the barriers to achieving good control in 3000 asthmatic children aged 12 to 14 years in schools in six African countries, utilising data to design a school-based intervention.
more
|
0
|
12382
|
Research for prevention and co...ntrol of NCDs
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff7212eaade2e0f07aa
|
2020
|
Germany
|
Foreign Office
|
2020009708
|
6615259
|
1
|
Zimbabwe
|
South of Sahara
|
Other LICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.007322
|
0.0072815
|
0
|
0
|
0.014644
|
0.014563
|
|
0.014644
|
|
0
|
COVID-19
|
COVID-19 Personal Protective E...quipment
more
|
50
|
FOOD PARCELS AND OTHER SUPPORT... OF THE MOST LOCKDOWN-AFFECTED GROUPS
more
|
Food parcels and other support... of the most lockdown-affected groups
more
|
Relief for most lockdown-affec...ted groups by distribution of food parcels, seeds, fertilizer. Improving health safety precaution against Covid pandemic in schools
more
|
|
12240
|
Basic nutrition
|
|
I.2.b. Basic Health
|
23000
|
Developing country-based NGO
|
Developing country-based NGO
|
|
COVID-19
|
|
65679ff7212eaade2e0f07ab
|
2020
|
Germany
|
Foreign Office
|
2020009709
|
6615250
|
8
|
Nicaragua
|
Caribbean & Central America
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.019339
|
0.019339
|
0
|
0
|
0.019339
|
0.019339
|
|
0.019339
|
|
0
|
COVID-19
|
COVID-19 General
|
100
|
EDUCATING CANCER PATIENTS ABOU...T PROTECTION FROM COVID-19 AND REDUCING THE RISK OF INFECTION
more
|
Educating cancer patients abou...t protection from Covid-19 and reducing the risk of infection
more
|
Women suffering from cancer, w...ho are cared for in the state women's hospital Bertha Calderón and at the National Oncology Center, have stopped their treatments for fear of infection with the coronavirus. The purpose of this project is to explain to 2,500 women with cancer that are treated in these centers about the risks of infection, so that they can continue their treatment without fear of infection. For this reason, videos will be produced and shown on newly purchased television sets. The women also will receive hygiene kits and material.
more
|
|
12264
|
COVID-19 control
|
|
I.2.b. Basic Health
|
23000
|
Developing country-based NGO
|
Developing country-based NGO
|
|
COVID-19
|
|
65679ff8212eaade2e0f07ac
|
2020
|
Germany
|
Foreign Office
|
2020009711
|
6615241
|
8
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.017094
|
0.017094
|
0
|
0
|
0.017094
|
0.017094
|
|
0.017094
|
|
0
|
Classified as not health-speci...fic activity
more
|
|
100
|
DIRECT SUPPORT TO PEOPLE SUFFE...RING FROM COVID-19 IN TANZANIA
more
|
direct support to people suffe...ring from COVID-19 in Tanzania
more
|
Support of people/institutions... affected by the COVID-19 pandemic
more
|
|
12240
|
Basic nutrition
|
|
I.2.b. Basic Health
|
20000
|
Non-Governmental Organisation ...(NGO) and Civil Society
more
|
Non-governmental organisations... (NGOs) and civil society
more
|
|
COVID-19
|
|
65679ff9212eaade2e0f07ad
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006880
|
GCRF_ESRC_NS_ES/P010938/1
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
2.258422
|
0
|
0
|
0
|
2.258422
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
STRIDE: STRENGTHENING RESPONSE...S TO DEMENTIA IN DEVELOPING COUNTRIES (GCRF)
more
|
STRiDE: Strengthening response...s to dementia in developing countries (GCRF)
more
|
Dementia is not a 'developed w...orld' condition: there are already more people with dementia in LAMICs than in high-income economies, yet LAMICs are typically less equipped to respond to the high and increasing prevalence. By 2050, there will be 90 million people with dementia in LAMICs (Prince et al 2015). People with dementia, particularly at more severe stages, require intensive care and support, which is very costly. These costs are mostly borne by unpaid family carers, primarily women, who often have to leave paid work, risking personal impoverishment and societal productivity losses. LAMICs face rapid growth in numbers of people with dementia without well-developed or well-funded health and care systems. Family care availability is decreasing as a result of demographic, societal and economic changes. We will build research capability using economics, epidemiology and policy analyses to help LAMICs respond to the needs of the growing numbers of people with dementia in an ethical and sustainable way. The co-applicants, from the UK and South Africa, have strong track-records in dementia research in high-income countries (HICs) and LAMICs, research on health and long-term (social) care in LAMICs. We will partner Alzheimer's Disease International (ADI), a federation of 85 national Alzheimer/dementia associations. We will work with local researchers and NGOs in 7 LAMICs: Brazil, India, Indonesia, Kenya, Jamaica, Mexico, South Africa. To build capability we will offer formal training in research methods, application of those methods to generate new evidence and tools, and training and practice in use of evidence to inform policy. We will apply the best methodological approaches and publish our results in peer-reviewed journals, but more importantly we will ensure that our research generates practical tools for use directly by stakeholders to develop services and improve practice, or to influence policy. We will use systematic reviewing and meta-analysis to review evidence on what works in LAMICs and what can be delivered in particular contexts, but also make that research available online and in DVDs as evidence summaries written in plain (dementia-friendly) language and translated to relevant local languages. We will use Theory of Change (ToC) to co-develop with local partners (researchers/NGOs) and stakeholders (including people with dementia and carers) the research and training agenda for the project to ensure that our activities achieve maximum impact. ToC will also help us develop indicators to evaluate the project's impact. Our research programme will involve development and evaluation of an intervention to increase dementia awareness and reduce stigma, a qualitative study of costs and other impacts of providing family care to people with dementia in different contexts, generation of quantitative evidence on impacts and costs of dementia on individuals and families, and instruments to collect these data. We will use the evidence generated
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
|
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University, college or other t...eaching institution, research institute or think?tank
more
|
|
|
|
65679ff9212eaade2e0f07ae
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
more
|
2020006876
|
GCRF_ESRC_NS_ES/P010962/1
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
1.939625
|
0
|
0
|
0
|
1.939625
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
GCRF RESEARCH FOR HEALTH IN CO...NFLICT (R4HC-MENA): DEVELOPING CAPABILITY, PARTNERSHIPS AND RESEARCH IN THE MIDDLE AND NEAR EAST (MENA)
more
|
GCRF RESEARCH FOR HEALTH IN CO...NFLICT (R4HC-MENA): developing capability, partnerships and research in the Middle and Near East (MENA)
more
|
Two billion people currently l...ive in areas of conflict and fragility, reflecting a rapid increase in wars, ethnic strife and other man-made disasters since 2010. The world is also experiencing the greatest forced migration crisis since the Second World War with 65.3 million forcibly displaced persons, 40.8 million internally displaced persons (IDPs), 21.3 million refugees and a further 10 million stateless people. Across the Middle East and North Africa (MENA) region protracted conflicts in countries such as Syria and Libya, as well as Afghanistan, Iraq and Yemen, have led to dramatic increases of refugee populations in Turkey, Lebanon, the Occupied Palestinian Territories and Jordan. War affected populations from these countries have undergone the epidemiological transition and therefore present new health challenges. In particular, the diagnosis, management and treatment of non-communicable diseases (NCDs) present new challenges for domestic health systems, as well as for humanitarian and development aid providers. These challenges also threaten domestic health commitments to Universal Health Coverage (UHC) and the Sustainable Development Goals (SDGs). This new humanitarian-development-health nexus demands a unique research agenda radically different from traditional approaches that address health challenges in low-income countries with weak governments, institutions and a mainly communicable disease burden. Without proper research capacity to generate crucial evidence to inform health policy and care, it will be impossible for countries in the MENA region to plan for rational and affordable health systems, sound economic policy and more effective aid effectiveness. The vision for our R4HC (Research for Health in Conflict)-MENA partnership is to build sustainable research capacity in this region to address major health challenges arising from conflict, specifically cancer and mental health as key NCDs. R4HC-MENA will build research capacity in four distinct areas: (1) conflict and health, (2) the political economy of health in conflict, (3) cancer, and (4) mental health research in regions of conflict. This research capacity will focus on training staff in a variety of theoretical and practical methods for studying these areas, as well as conducting and publishing research projects to build further capability and disseminate findings. R4HC-MENA will enable lead countries in this region to grow and sustain research capacity that can critically inform aspects of health development that relate to armed conflict in the region. This will inform not only regional and international policy-makers, but also the development of affordable and equitable clinical models of care and pathways in complex NCDs such as cancer and mental health. R4HC-MENA will also link together regional ministries and academic centres, and key international partners, to widen the research to policy translation, and critically inform the health development agenda in other regio
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
|
|
11000
|
Donor Government
|
Donor Government
|
|
|
|
65679ff9212eaade2e0f07af
|
2020
|
Switzerland
|
Swiss Agency for Development a...nd Co-operation
more
|
2020006865
|
177-Q37-2020-90224
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0
|
0.061565
|
0
|
0
|
|
0.061565
|
|
|
|
|
COVID-19
|
COVID-19 General
|
100
|
AIDE HUMANITAIRE AUX PERSONNES... MENACÉES PAR LA PANDÉMIE DE CORONAVIRUS
more
|
Aide humanitaire aux personnes... menacées par la pandémie de coronavirus
more
|
Founded in 1901 as a catholic ...organisation, Caritas Switzerland (CACH) prevents, alleviates and combats poverty, while working across sectors and focusing on food security, access to clean and safe water, climate protection and disaster prevention, migration and education for children and adults. With its international programme that combines humanitarian work and development, CACH reaches out to 30 countries in Africa, Latin America and Asia as well as in Eastern Europe.
more
|
|
12264
|
COVID-19 control
|
3.3
|
I.2.b. Basic Health
|
22000
|
Donor country-based NGO
|
Caritas Suisse
|
|
COVID-19
|
|
65679ff9212eaade2e0f07b0
|
2020
|
United Kingdom
|
Department for Business, Innov...ation and Skills
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2020006840
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GCRF_ESRC_NS_ES/S00114X/1
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3
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Developing countries, unspecif...ied
more
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Regional and Unspecified
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Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.098833
|
0
|
0
|
0
|
0.098833
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
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100
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USING COLLABORATIVE VISUAL RES...EARCH METHODS TO UNDERSTAND EXPERIENCES OF MENTAL ILLNESS, COERCION AND RESTRAINT IN GHANA AND INDONESIA
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Using collaborative visual res...earch methods to understand experiences of mental illness, coercion and restraint in Ghana and Indonesia
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There have been many concerns ...over the human rights of people with mental illness in developing countries, particularly the use of chains, beating, confinement in cages, and other harmful practices by traditional and faith healers. The use of restraints, confinement and other mistreatment is harmful to physical and mental health, can increase stigma and make it difficult for people with mental illness to recover and be included as productive members of society. It has been suggested that partnerships between traditional and faith healers and health workers could help to prevent human rights abuses and enable people with mental illness to get treatment and care. However, it can be challenging to establish such partnerships and bring about change. Healers and health workers use different approaches to mental illness which can conflict, and healers can feel as if their knowledge and experience is not recognised. There can be complex reasons for using chains and other restraints, which are often not well understood. There are also many different types of healers in developing countries who carry out different practices. Health systems also differ between countries and mental health workers operate with very few resources. Therefore, the best ways in which to improve the treatment of people with mental illness and create partnerships between health workers and healers is likely to vary. This project will explore the experiences of people with mental illness and their families in Indonesia and Ghana, the reasons why people with mental illness are restrained and attempts by health workers to create partnerships with healers and stop human rights abuses. We have chosen these countries because there have been similar reports on the mistreatment of people with mental illness by healers and there are attempts by governments, charities and others to prevent human rights abuses and improve treatment. These include changes in the law and training of new mental health workers. In this study we will use documentary film as our research method. This is because film is easily accessible in different languages, and can use images as well as words to gain a deep insight into people's experiences from their own perspective. Film is also more accessible to people who do not have much education and cross-culturally. With the consent of the people involved, we will film the experiences of people with mental illness in Ghana and in Indonesia who have experienced restraint, their families, healers and health workers. We will also document attempts to create partnerships between healers and mental health workers in the two countries. We will conduct interviews with the participants, which will also be filmed if they agree. We will use the footage to create documentary films that will be used to learn more about the social and cultural context that might lead to the use of restraint such as understandings of mental illness, family relationships, distance from mental healt
more
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0
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43082
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Research/scientific institutio...ns
more
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11000
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Donor Government
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Donor Government
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|
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65679ff9212eaade2e0f07b1
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2020
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United Kingdom
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Department for Business, Innov...ation and Skills
more
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2020007006
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GCRF_MRC_AA_MR/S014527/1
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3
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Developing countries, unspecif...ied
more
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Regional and Unspecified
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Part I unallocated by income
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ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.059609
|
0
|
0
|
0
|
0.059609
|
0
|
0
|
0
|
0
|
Other health problems
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Other health problems Research... and Development
more
|
100
|
FEASIBILITY OF A CLUSTER RANDO...MISED TRIAL OF A NUTRITIONAL INTERVENTION TO IMPROVE OUTCOMES AFTER CANCER SURGERY IN LOW-INCOME COUNTRIES
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Feasibility of a cluster rando...mised trial of a nutritional intervention to improve outcomes after cancer surgery in low-income countries
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THE PROBLEM: For many types of... cancer, high quality surgery is the only cure. This is particularly true in low-income countries where treatments such as chemotherapy or radiotherapy may not be available. It is important that surgery goes well. When complications occur, longer term outcomes are worse, and some patients will die. It is increasingly recognised that boosting the health of patients before surgery can greatly improve the chances of success. Of course, a balance must be struck between the urgency to operate and remove the cancer and a desire to take time and improve a patient's health. Cancer often causes extreme weight loss and, in many countries, this occurs on top of pre-existing malnutrition. THE QUESTION: Would it be of benefit to intensively treat patients with nutritional supplements prior to surgery? Studies from high income countries suggest it could be, and the benefit may be even greater in low-income countries. THE TEAM: We are a well-established team working to improve surgical care worldwide. Surgeons from low- and middle-income countries are supported in Research Hubs and set their own research agenda. Nutrition in cancer surgery has been identified as an area of high priority. Our team has the broad set of skills required to make this work. OUR CURRENT WORK: We are gathering data on patients undergoing cancer surgery worldwide. It is the largest study of its kind and is taking place in 100 countries. This information will allow us to work out the relationship between malnutrition and the results of surgery in a way that hasn't been possible before. But what we really want to do is come up with a solution. This grant application is for funding to bridge the gap between our current observational study and a trial to treat patients prior to surgery. We have broad experience and are currently launching the FALCON trial, looking at steps to reduce wound infection after surgery in low-income countries. FUTURE PROPOSED TRIAL: We want to perform a large study in low- and middle-income countries giving a nutritional supplement (sometimes called ready-to-use therapeutic food) to patients undergoing cancer surgery. We will then measure whether it results in fewer complications and better outcomes after surgery. Before we can do that, we need to do three things. NEED FOR THIS PUMP PRIMING GRANT: First, we need to find a good way of screening patients for malnutrition in low-income countries. This is to identify those who may benefit most from a treatment. One would have thought that this would be easy and well-established, but it is not. Simple but accurate screening methods for malnutrition, which can be used by a nurse or a doctor for patients undergoing surgery, need to be developed or adapted. Second, we need to find an appropriate product. This needs to fulfil specific nutritional requirements but must be inexpensive, sustainable and ideally locally sourced. We will work with companies, experts, patients, and clinician
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0
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12182
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Medical research
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11000
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Donor Government
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Donor Government
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65679ff9212eaade2e0f07b2
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2020
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United Kingdom
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Department for Business, Innov...ation and Skills
more
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2020006998
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GCRF_MRC_IND_MR/T00858X/1
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3
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Developing countries, unspecif...ied
more
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Regional and Unspecified
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Part I unallocated by income
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ODA Grants
|
1
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10
|
110
|
D02
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0
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0.021905
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0
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0
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0
|
0.021905
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0
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0
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0
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0
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Other health problems
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Other health problems Research... and Development
more
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100
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MECHANISMS OF INTERGENERATIONA...L NUTRITIONAL PROGRAMMING OF NON-COMMUNICABLE DISEASES IN THREE COUNTRIES: A HEALTHY LIFE TRAJECTORIES INITIATIVE STUDY.
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Mechanisms of intergenerationa...l nutritional programming of non-communicable diseases in three countries: a Healthy Life Trajectories Initiative study.
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Non-communicable diseases (NCD...s) such as heart disease and diabetes are rapidly increasing in low- and middle-income countries (LMICs). These diseases are occurring at younger ages in LMICs compared to high-income countries, with accompanying economic and societal costs. There are now ~166 million people with diabetes in India and China alone (40% of the world's total). Current approaches to preventing diabetes or heart disease focus on weight reduction and increased physical activity in middle-aged adults with existing risk factors such as obesity or high blood pressure. While such approaches offer some benefit to the individual, they do little to address the risk in future generations. Research from many countries across the world has shown that low birth weight and poor growth of the fetus in the womb is related to an increased risk of developing diabetes and heart disease in later life. These effects are exacerbated by greater weight gain during childhood, adolescence or adulthood. It is suggested that undernutrition during critical periods of early development permanently alters the structure and function of the body's tissues and organs ('programming'), leading to an increased vulnerability to disease in later life. It is therefore possible that measures to optimise the health of young women before and during pregnancy, and measures to optimise the growth of infants and young children may have long-term beneficial effects on the health of the children. In this context, the Healthy Life Trajectories Initiative (HeLTI) programme was set up as a joint initiative funded by the Canadian Institutes of Health Research, Department of Biotechnology (India), Medical Research Council (South Africa) and the National Natural Science Foundation (China), in collaboration with the World Health Organisation. There are four separate but harmonised intervention studies in Mysore (India), Johannesburg (South Africa), Shanghai (China) and two provinces in Canada. The studies will test the concept that interventions addressing multiple domains of health spanning from before pregnancy, and continued through pregnancy and after birth will improve maternal and child health including the long-term well-being of the child. Our main outcome is a measure of adiposity (fat mass in relation to height) at five years of age in the child. While the exact intervention packages vary by country to ensure cultural and contextual appropriateness, they are all unified by both the overall aim of the intervention and approach. The studies are at slightly different points - two of the studies are in the preparatory phase while the other two have started the main study. As part of the main study, we will be collecting a range of biospecimens (blood, buccal and vaginal swabs, urine, stool, cord blood and placenta) from the women/mothers, fathers and children. Under this grant, we would like to undertake analyses of a selection of these biological samples, in order to understand
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0
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12182
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Medical research
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11000
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Donor Government
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Donor Government
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65679ff9212eaade2e0f07b3
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2020
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United Kingdom
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Department for Business, Innov...ation and Skills
more
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2020007001
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GCRF_MRC_MWI_MR/T008628/1
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3
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Developing countries, unspecif...ied
more
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Regional and Unspecified
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Part I unallocated by income
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ODA Grants
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1
|
10
|
110
|
D02
|
0
|
0.026011
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0
|
0
|
0
|
0.026011
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0
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0
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0
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0
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Other health problems
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Other health problems Research... and Development
more
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100
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CHILD MALNUTRITION& ADULT NCDS...-GENERATING EVIDENCE ON MECHANISTIC LINKS IN JAMAICA, MALAWI & ETHIOPIA TO INFORM FUTURE POLICY/PRACTICE (CHANGE STUDY)
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Child malnutrition& Adult NCDs...-Generating Evidence on mechanistic links in Jamaica, Malawi & Ethiopia to inform future policy/practice (CHANGE study)
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Severe malnutrition in early c...hildhood is a major public health concern globally. This has serious consequences: - Short term: for children to survive: malnutrition in all its forms underlies some 45% of all under 5 child deaths worldwide. - Long term: for children to thrive: there is increasing realisation that early life malnutrition contributes to the fast-growing global epidemic of non-communicable diseases (NCDs). As more children now survive episodes of malnutrition in childhood there is increasing need to understand what causes the long term problems. Evidence on this would lead to: improved early treatment of child malnutrition, improved longer term treatment aiming to reduce long term adverse effects. In this project we have a unique opportunity to explore three groups of children/adults in: - Jamaica: children suffering from severe malnutrition in the 1980s have been followed up on several occasions already, with scope for further analysis from already collected data. - Malawi: We recently followed up a group of children admitted for severe malnutrition in 2005/6. We plan to both analyse existing data in more depth: also to possible collect new data in future. - Ethiopia: Individuals who were young children at the time of the great Ethiopia famine of 1983-85 are about to be followed up in a pilot study. Learning from the above two projects will inform and improve plans for the Ethiopia work. We aim to understand what are the long term problems following early child malnutrition and why they occur (the 'mechanisms' by which the two problems are linked) The work proposed in this applicaiton is background towards the above future project. There are two main activities planned A) Review of exisiting evidence: we will search the scientific literature to better understand what other have found to date re links between early life malnutrition and adult NCDs. Through this we will identify key knowledge gaps to target in future work. B) Collaborator meeting - we will bring together the teams working on the above three groups of children to: learn from each other and share experiences. Through this better future work will be possible and there is great potential to enhance the overall learning compared to following each group as a stand-alone. This meeting will be organised in Ethiopia in Autumn 2019: we will invite a number of key experts to make detailed plans for future work. The Ethiopia/Malawi/UK teams will also visit Jamaica (the most advanced/experienced group) to learn from their experience and thus help plan better future projects in Malawi and Ethiopia.
more
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0
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12182
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Medical research
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11000
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Donor Government
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Donor Government
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