|
65679704212eaade2e0ee19e
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290006
|
2016-06289_1
|
3
|
Kenya
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.02684
|
0
|
0
|
0
|
0.02684
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
RECYCLING NETWORKS. GRASSROOTS... RESILIENCE TACKLING CLIMATE, ENVIRONMENTAL AND POVERTY CHALLENGES
more
|
Recycling networks. Grassroots... resilience tackling climate, environmental and poverty challenges
more
|
Millions of informal waste pic...kers collect household waste daily in cities around theglobe to earn a living. In doing so, they make a significant contribution to reducing thecarbon footprint of cities, recovering resources, improving environmental conditionsand health of low-income residents, creating jobs and income among the poor. Thisproject aims at examining the challenges that innovative grassroots initiatives andnetworks encounter and the livelihood practices they generate, to improve recyclingand household waste management in informal settlements of global South cities. Theproject's methodology is inspired by participatory action research through acombination of a) a multiple case study on waste picker initiatives in Managua(Nicaragua), Dar es Salaam (Tanzania), Buenos Aires (Argentina) and São Paulo(Brazil) and Kisumu (Kenya) based on interviews, observations, workshops anddocument analysis b) joint knowledge co- production with regional and global wastepicker networks erforming as knowledge hubs for the project c) an in-depth casestudy of the City of Kisumu, where the learnings from the multi-case studies will beintegrated and d) international joint research and waste picker seminars to co-produceknowledge to conceptualize solution to the challenges. Theoretically, the project willalso contribute to applying and expanding a combination of theories of socioenvironmentaland institutional entrepreneurship with resilience theories.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
65679704212eaade2e0ee19f
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290014
|
2016-06334
|
3
|
Kenya
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0559813
|
0
|
0
|
0
|
0.0559813
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
FLOOD RESILIENCE IN SLUMS: COM...MUNITY-RESPONSIVE ADAPTATION IN KIBERA, NAIROBI
more
|
Flood Resilience in Slums: Com...munity-Responsive Adaptation in Kibera, Nairobi
more
|
A large and growing number of ...the world's population live in slums, where the twin trajectories of rapid urbanisation andincreased flooding driven by climate change collide. Top-down policies designed to reduce flood risk in informalsettlements have to date been largely unsuccessful, yet many of the vulnerabilities faced by slum-dwellers cannot beaddressed by local action alone. Many observers posit that a fundamentally important part of the solution is to integrategovernment and community resilience initiatives, an approach we call Community-Responsive Adaptation. However,real-world examples of this type of integration are scarce, and have not been systematically evaluated, either in terms ofcost, or impact. In this study, we partner with an award-winning non-governmental organization, Kounkuey DesignInitiative, and with slum residents and local government, to co-design, build and evaluate three integrated adaptationprojects in Kibera, Nairobi. To evaluate the effects of the projects, we will carry out a 6-wave household survey across1500 households in high flood-risk zones, and compare flood damages and other measures of welfare in households withthe same baseline flood risk in treatment sites, and at comparable control sites. Finally, we will collect and analyzequalitative data to help understand the mechanisms behind success or failure of the package of interventions.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Stockholms universitet
|
|
|
|
65679706212eaade2e0ee1a0
|
2019
|
Sweden
|
The Swedish Research Council
|
20170290002
|
2016-05601_2
|
3
|
Rwanda
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.052877
|
0
|
0
|
0
|
0.052877
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
WHAT DOES NATIONAL OWNERSHIP D...O TO LOCAL PARTICIPATION? CAMBODIA AND RWANDA IN THE MIDST OF DEVELOPMENT TRENDS AND BUZZWORDS
more
|
What does national ownership d...o to local participation? Cambodia and Rwanda in the midst of development trends and buzzwords
more
|
This project challenges the wi...dely held assumption that national ownership in development aid is conducive to local participation. Examining previously underexplored links between two widely promoted approaches, it connects two major debates in development thinking that have been conspicuously separated. Designed as a qualitative comparative case study of two strategically selected low income countries and three major programmes in each, the project examines what happens to local participation as national ownership is strengthened. Cambodia and Rwanda are moving towards increased national ownership, though for partly different reasons and with Rwanda well ahead of Cambodia. The programmes studied all necessitate local engagement and have attracted donor attention and funding. The project will be conducted by two researchers with profound relevant expertise, in close collaboration with a reputable research institution in each country. Based on official documentation and 50 interviews in each country, manifestations will be traced of external influence and local engagement, which will illustrate qualities of national ownership and local participation in each programme. Comparative analyses within and between the countries, then, will illuminate the overall climate for local participation in a situation of strengthened national ownership, and shed light on what difference it makes locally that a country's development agenda is primarily nationally owned rather than donor driven.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
9.5
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
65679706212eaade2e0ee1a1
|
2018
|
Sweden
|
The Swedish Research Council
|
2014297144
|
2014-3364
|
3
|
South of Sahara, regional
|
South of Sahara
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.120823
|
0
|
0
|
0
|
0.120823
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
USING CHEMICAL ECOLOGY TO CONT...ROL THE WHITEFLY VECTOR OF CASSAVA VIRUS PANDEMICS IN AFRICA
more
|
Using chemical ecology to cont...rol the whitefly vector of cassava virus pandemics in Africa
more
|
Cassava is a major food securi...ty staples in sub-Saharan Africa. It is expected to be positively affected by anthropogenic global warming, and is hence projected to become increasingly important in the future. The greatest threats to Africa's cassava crop are two viral diseases, transmitted by the whitefly Bemisia tabaci, which are currently spreading throughout Africa. There is an urgent need for effective and sustainable strategies to control the vector. The project aims at developing novel control strategies for managing whiteflies on cassava based on insights into the chemical ecology of the species. The project is a collaboration between my group at Lund University and the International Institute for Tropical Agriculture (IITA), an Africa-based international not-for-profit research-for-development organization. The project combines my group's expertise in insect neuroscience, with IITA's extensive knowledge in plant biology and agricultural research for development. My skills are complimentary to those of the co-applicant Dr J.P. Legg (expert in plant virology), and the project itself multidisciplinary. The project will involve screenhouse and open field behavioral trials, analytical chemistry, electrophysiology, next-gen sequencing and genetics. We will deliver: Information about odor guided choice in whiteflies; Characterization of cassava volatiles; First mapping of the whitefly's olfactory system; The identification of whitefly volatile repellents.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Lunds universitet
|
|
|
|
65679707212eaade2e0ee1a2
|
2019
|
Sweden
|
The Swedish Research Council
|
20170290052
|
2016-05720_2
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0581647
|
0
|
0
|
0
|
0.0581647
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
INTERACTION BETWEEN KNOWLEDGE ...TRADITIONS IN NON-FORMAL ADULT EDUCATION: SCANDINAVIAN INFLUENCES, INDIGENOUS KNOWLEDGE SYSTEMS AND COLONIAL LEGACIES IN
more
|
Interaction between knowledge ...traditions in non-formal adult education: Scandinavian influences, Indigenous Knowledge Systems and colonial legacies in
more
|
Our aim is to investigate how ...interaction between different knowledge systems and learning traditions are of importance for the design of non-formal adult education activities in Eastern Africa. The project will specifically study the implementation, dissemination and interpretation of Nordic popular education ideas in Kenya and Tanzania, and focus on how these ideas interact with, on one hand, so-called Indigenous Knowledge Systems, and, on the other hand, educational traditions linked to the formal educational system established in the context of European colonization. Research questions are: How do interactions between different knowledge systems and learning traditions influence the design of non-formal and informal adult education for structurally vulnerable groups in contexts marked by a colonial history? Does this kind of interaction between different knowledge systems and learning traditions create new innovative educational ideas? What role do these interactions and innovations play in improving participants' life chances? Two ethnographic case studies will be carried out: one focusing on the folk high school inspired Folk Development Colleges in Tanzania, and the other on agricultural adult education activities linked to the cooperative movement in Kenya. The project involves researchers from Sweden, Tanzania and Kenya and the project is also intended to contribute to the strengthening of the Eastern African research community within the field of adult education
more
|
|
11182
|
Educational research
|
5;4.5;4.1
|
I.1.a. Education, Level Unspec...ified
more
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Linköpings universitet
|
|
|
|
65679707212eaade2e0ee1a3
|
2019
|
Sweden
|
The Swedish Research Council
|
20170290065
|
2016-05777
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.126905
|
0
|
0
|
0
|
0.126905
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
AIMING AT PROLONGING THE THERA...PEUTIC LIFESPAN OF ARTEMISININ-BASED COMBINATION THERAPIES IN AN ERA OF IMMINENT PLASMODIUM FALCIPARUM RESISTANCE IN EAS
more
|
Aiming at prolonging the thera...peutic lifespan of artemisinin-based combination therapies in an era of imminent Plasmodium falciparum resistance in Eas
more
|
Global malaria control is unde...r threat due to evolution and spread of P. falciparum resistance to artemisinin-based combination therapies (ACTs) in Southeast Asia. Artemisinin resistance is phenotypically characterized by delayed microscopy determined parasite clearance, which has been linked to mutations in the K13 propeller. However, K13 associated artemisinin resistance have not yet been documented in Africa. However, we have recently shown PCR determined delayed parasite clearance in parasite sub-populations in Bagamoyo District, Tanzania, using deep sequencing approaches, as well as temporal selection of genetic markers associated with lumefantrine tolerance/resistance. These findings may represent early warning signs of ACT resistance in East Africa. While awaiting development of alternative drugs optimal use of available tools are critically needed to protect/prolong the therapeutic lifespan of ACTs. We propose two new strategies with old tools. First, an extension of ACT therapy from 3 to 5 days. This will expose the parasites to 48 hours more of artemisinin. Second, to add a single low lose of the gametocytocidal drug primaquine (0.25 mg/kg) on the fifth treatment day to reduce transmission. This will be studied in a randomized controlled trial. The assessment will provide an opportunity to characterize the PCR determined day-3 and even day-5 positive parasite sub-population and improve the understanding of survival strategies among East-African P. falciparum.
more
|
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala universitet
|
|
|
|
65679707212eaade2e0ee1a4
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290007
|
2016-06289_2
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.02684
|
0
|
0
|
0
|
0.02684
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
RECYCLING NETWORKS. GRASSROOTS... RESILIENCE TACKLING CLIMATE, ENVIRONMENTAL AND POVERTY CHALLENGES
more
|
Recycling networks. Grassroots... resilience tackling climate, environmental and poverty challenges
more
|
Millions of informal waste pic...kers collect household waste daily in cities around theglobe to earn a living. In doing so, they make a significant contribution to reducing thecarbon footprint of cities, recovering resources, improving environmental conditionsand health of low-income residents, creating jobs and income among the poor. Thisproject aims at examining the challenges that innovative grassroots initiatives andnetworks encounter and the livelihood practices they generate, to improve recyclingand household waste management in informal settlements of global South cities. Theproject's methodology is inspired by participatory action research through acombination of a) a multiple case study on waste picker initiatives in Managua(Nicaragua), Dar es Salaam (Tanzania), Buenos Aires (Argentina) and São Paulo(Brazil) and Kisumu (Kenya) based on interviews, observations, workshops anddocument analysis b) joint knowledge co- production with regional and global wastepicker networks erforming as knowledge hubs for the project c) an in-depth casestudy of the City of Kisumu, where the learnings from the multi-case studies will beintegrated and d) international joint research and waste picker seminars to co-produceknowledge to conceptualize solution to the challenges. Theoretically, the project willalso contribute to applying and expanding a combination of theories of socioenvironmentaland institutional entrepreneurship with resilience theories.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
65679708212eaade2e0ee1a5
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290010
|
2017-05423
|
3
|
Bolivia
|
South America
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.042347
|
0
|
0
|
|
0.042347
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DOES HEAVY METAL POLLUTED WATE...R IN BOLIVIA DRIVE EVOLUTION TOWARDS ANTIBIOTIC RESISTANCE GENES IN WATER MICROBIOTA AND PATHOGENS?
more
|
Does heavy metal polluted wate...r in Bolivia drive evolution towards antibiotic resistance genes in water microbiota and pathogens?
more
|
Pollution of water is an incre...asing problem globally and absence of safe drinking water is a major problem for human health. Pollutants such as medical residues, metals, antibiotics, biocides and pathogenic bacteria are found in surface and ground water. The arid highlands of the Altiplano, at 3800 m, Bolivia face large problems with water pollution and inability to provide safe drinking water. Excessive mining occurs in the Andes mountain regions in Bolivia and rivers contaminated with e.g. Cd, Zn, As, Cu, Ni, Pb and Sn, runs from mining areas through cities such as El Alto and La Paz and may end up in lake Titicaca. The highly contaminated water environments shifts the microbial composition towards species with tolerance or resistance towards metals. Metal- and antibiotic resistance are linked: co-selection by heavy metals and antibiotics can occur if resistance determinants are present in the same cell (co-resistance) or if a common resistance mechanism confer resistance to both types of toxicants (cross-resistance). We will analyse several water sources, (along rivers, lakes and lagoons in La Paz, Milluni, Oruro and Titicaca) more or less affected by metal pollution. We will determine the microbial compositon and presence of pathogens by 16S, metagenomics and qPCR. Presence of antibiotic and metal resistance genes and levels of metal pollution will be determined. We will determine if metal ions drive antibiotic resistance transfer from microbiota to pathogenic bacteria.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
65679708212eaade2e0ee1a6
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290003
|
2017-05406_1
|
3
|
Cambodia
|
Far East Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.014477
|
0
|
0
|
|
0.014477
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
MAN'S BEST FRIEND: A CROSSBORD...ER TRANSDISCIPLINARY ONE HEALTH APPROACH TO RABIES CONTROL IN DOGS IN SOUTHEAST ASIA
more
|
Man's best friend: A crossbord...er transdisciplinary One Health approach to rabies control in dogs in Southeast Asia
more
|
Rabies is estimated to kill mo...re than 30,000 people every year in Asia. Most cases are caused by dog bites, and deaths most commonly occur among the poorest or the most remote population, unable to receive post-exposure prophylaxis. In Southeast Asia, dogs are not only used as farm dogs, or as pets, but also increasingly as a food source, with dogs moved between countries. Rabies is a serious threat, and people involved in the dog value chain may be at increased risk, and the cross-border movements are complicating control efforts. This network project has a One Health approach, and will bring together stakeholders and researchers from Lao PDR, Cambodia, Vietnam, Sweden and France. Workshops will be arranged around dog population dynamics, disease incidence, improvement of laboratory technologies and the best control strategies.An ongoing vaccine intervention in Cambodia will be used to study dog populations and changes in vaccination covers. The risk of rabies along the dog value chain will be assessed, and we will evaluate a novel method for easier diagnosis. Knowledge, attitudes and practices will be studied among dog owners, dog butchers and traders, and policy makers. In conclusion, this project will contribute to reducing the risk for people by improving diagnostic capacities, providing basic knowledge of dog population dynamic needed for efficient vaccination strategies, and establishing a strong inter-sectoral network for rabies control in this region.
more
|
NTDs
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala universitet
|
|
|
|
65679709212eaade2e0ee1a7
|
2019
|
Sweden
|
The Swedish Research Council
|
20170290092
|
2016-05898
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.126905
|
0
|
0
|
0
|
0.126905
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
LYTIC ENZYMES AS TOOLS FOR TRE...ATING MYCOBACTERIAL INFECTIONS
more
|
Lytic enzymes as tools for tre...ating mycobacterial infections
more
|
Mycobacterial infections remai...n among the globally most deadly and disabling diseases, the most common being tuberculosis (TB), a respiratory contiguous disease caused by a direct contact with the acid-fast bacterium, Mycobacterium tuberculosis. The disease is most prevalent among the poor in low and middle income countries and the emergence of multi-drug resistant mycobacterial strains has made TB a serious public concern. A major hurdle in the treatment of TB is the complex multi-layered structure of the mycobacterial cell wall, of which the outermost hydrophobic mycolic acid layer limits the entry of the antibiotics into the cells. Mycobacteriophages gain entry into the microorganism with the help of different lytic enzymes active against the different layers of the cell wall. In this project, we intend to explore the possibility of using LysB, the enzyme hydrolysing the bonds in the mycolic acid layer, in inhibiting the bacterial growth and hence allowing the treatment with a lower antibiotic concentration during a shorter time. A number of LysB enzymes will be chosen by bioinformatics analysis in databases, their recombinant production, rational protein engineering based on molecular modelling studies, and evaluation in the absence and presence of an antibiotic, on growth inhibition and killing of the non-pathogenic M. smegmatis. The activity and stability of the most effective enzyme variant will be further studied in a liposome formulation used for drug delivery.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
9.5
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Lunds universitet
|
|
|
|
65679709212eaade2e0ee1a8
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290029
|
2017-05479
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.108581
|
0
|
0
|
|
0.108581
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
A ONE HEALTH APPROACH TO STREN...GTHENING CAPACITIES FOR DETECTION OF EMERGING ZOONOSES IN ASIAN WILDLIFE AND PEOPLE
more
|
A One Health approach to stren...gthening capacities for detection of emerging zoonoses in Asian wildlife and people
more
|
Emerging infectious diseases t...hreaten global biodiversity and public health. Our project goal is to enhance the capability for detection of zoonotic and emerging pathogens in Asian wildlife and people. Samples will be collected from wild animals and people working in the animal-human-ecosystem interface for analysis of selected viral and bacterial pathogens and antimicrobial resistance. The 4-year project will include surveillance and screening of elephants and wildlife workers for tuberculosis, along with sampling primates and rodents for other zoonotic pathogens. Safe and efficient immobilization techniques will be developed to enable optimal sample collection and to ensure human safety and animal welfare during handling of wildlife. Cutting edge technologies will be used for evaluation of physiological functions to prevent complications during immobilization, and for identification of novel pathogens. A strong emphasis will be put on strengthening individual and institutional capacities in conjunction with the research activities. With an emphasis on the One Health approach, contributing collaborators are from complementary fields of veterinary and human health, microbiology, metagenomics, bioinformatics, and wildlife conservation at scientific and governmental institutions. Our research on emerging pathogens and wildlife immobilization is of direct relevance for local livelihoods (health and poverty alleviation), wildlife resource management and biodiversity conservation.
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
9.5
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges lantbruksuniversitet
|
|
|
|
65679709212eaade2e0ee1a9
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290049
|
2017-05570_1
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.047052
|
0
|
0
|
|
0.047052
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
END MALARIA ON ISLANDS IN VANU...ATU: THE ROLLOUT OF INNOVATIVE ANTI-PLASMODIUM VIVAX STRATEGIES
more
|
End malaria on islands in Vanu...atu: the rollout of innovative anti-Plasmodium vivax strategies
more
|
In the Asia-Pacific region, ma...laria elimination faces the challenges presented by the high proportion of Plasmodium vivax infections. The existence of latent and persistent P. vivax hypnozoites in the liver makes this species less amenable to elimination efforts than P. falciparum. Vanuatu is an archipelago of 68 inhabited islands in the southwest Pacific. Our overall purpose is to achieve sustainable malaria elimination in the entire archipelago, based on the achievement on Aneityum Island over the last 25 years. Furthermore innovative strategies for P. vivax elimination are desired. With the establishment of the Center for Malaria Elimination in Port Vila, we specifically aim to 1) establish a robust malaria surveillance system to detect asymptomatic and sub-microscopic infections by PCR and identify remaining hotspots, 2) examine the containment strategy of short-term mass drug administration in concert with long-term vector control to eliminate infections in detected hotspots, 3) support the wider use of primaquine against P. vivax hypnozoites by investigating human CYP2D6 polymorphisms and G6PD deficiency related to primaquine metabolism and safety, respectively, 4) create a local economic mechanism such as malaria free award to encourage changes in human behaviors towards self-protection against malaria infections, and 5) characterize the changes in genetic diversity of the last parasites and human anti-parasite immunity after malaria elimination.
more
|
0
|
12262
|
Malaria control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
65679709212eaade2e0ee1aa
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290063
|
2017-05607_2
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.070578
|
0
|
0
|
|
0.070578
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
RESOLVING THE MYSTERY BEHIND T...HE MOSQUITO-BORNE O'NYONG'NYONG VIRUS – DIAGNOSTIC CHALLENGE, RESERVOIR, PREVALENCE AND TRANSMISSION.
more
|
Resolving the mystery behind t...he mosquito-borne O'nyong'nyong virus – diagnostic challenge, reservoir, prevalence and transmission.
more
|
The world have recently been a...lerted by sudden outbreaks of mosquito-borne viruses such as Zika virus and chikungunya virus in new continents, although both of these were already causing disease in Africa and Southeast Asia. One such mosquito-borne virus with potential for global spread is O'nyong-nyong virus (ONNV), which has caused large outbreaks in Africa. The outbreaks have so far occurred in resource-limited developing countries and often been misdiagnosed as chikungunya, a closely related virus with similar symptoms. The purpose of the proposed project is to characterize ONNV regarding mosquito vectors, tropism, potential animal reservoirs, prevalence, incidence, and distribution. For this we will develop specific diagnostic assays for ONNV IgG and IgM antibody detection and to apply those for determining the prevalence and distribution of infection in humans and animals in a region of Kenya where ONNV is suspected to occur. Concomitantly we will study the incidence of O'nyong-nyong fever in patients with clinical acute symptoms, which indicates an ONNV infection, using detection of viral RNA by RT-PCR and IgM antibodies. We will study ONNV's mosquito vector by sampling mosquitoes to characterize which vectors harbor ONNV. Further, we will experimentally investigate ONNV tropism and competence in different mosquito species, to better understand if ONNV have the potential to use other mosquito vectors and gain the potential to spread beyond known endemic regions.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
65679709212eaade2e0ee1ab
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290065
|
2017-05617_2
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.065149
|
0
|
0
|
|
0.065149
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
ENHANCED ACTIVATION OF MACROP...HAGES DURING TB-COINFECTION
more
|
Enhanced activation of macrop...hages during TB-coinfection
more
|
This project focuses on immune... control of human tuberculosis (TB), the effect of helminthic worm coinfection and how current treatment strategies could be optimized to shorten duration of anti-TB chemotherapy, and protect those at risk for developing active disease. Coinfection with intestinal helminthic parasites can prevent an efficient TB-protection by suppressing bactericidal functions in macrophages (MQ), triggering progression from latent to active TB disease. Our previous results indicate that nutritional deficiencies in the nitric oxide (NO) and glutathione axis may contribute to poor control of mycobacteria by human MQ. Using a translational approach combining clinical TB studies (Ethiopia) with ex vivo infection experiments we will determine if N-acetyl cysteine and L-citrulline administration can revert the effect of chronic helminth infection in MQ by switching them from their immunosuppressed regulatory M2 phenotype to a proinflammatory M1 phenotype and simultaneously trigger enhanced NO production, to achieve better host control of mycobacteria. Modalities affecting macrophage activation will be studied in TB patients with/without concurrent helminth infection, before and after deworming. Our research will answer if adjunctive immune boosting therapies that strengthens and activates macrophages can expedite current anti-TB treatment, and whether interventions like deworming could be beneficial on large scale for individuals living in low resource areas.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Linköpings universitet
|
|
|
|
65679709212eaade2e0ee1ac
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290070
|
2017-05631
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.141156
|
0
|
0
|
|
0.141156
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
EXPLORING HOST TARGET INTERACT...IONS AS POTENTIAL NEW TREATMENT OPTIONS FOR HIGHLY PATHOGENIC RNA VIRUSES LIKE EBOLA, CRIMEAN CONGO HEMORRHAGIC FEVER AN
more
|
Exploring host target interact...ions as potential new treatment options for highly pathogenic RNA viruses like Ebola, Crimean Congo Hemorrhagic Fever an
more
|
Incidences of emerging infecti...ons caused by RNA viruses are increasing and outbreaks threaten human health all around the world. This project focus on the important RNA viruses Ebola, Crimean Congo Hemorrhagic Fever and Zika, to understand the basic biology of proteins involved in virus-host interactions and to validate these as novel targets for antiviral therapy. To target host proteins involved in virus replication processes is one way to avoid resistance development that often is a problem for treatments directed to viral proteins. During 4 years we plan to work in a multidisciplinary project team involving virologists, molecular biologists, medicinal chemists, pharmacokinetic experts, pharmacologists and toxicologists from several universities and research institutions to generate new knowledge about pathogenic RNA viruses and develop novel antiviral compounds targeting these pathogens. We also plan to collaborate with experts in the countries affected by the studied viruses to evaluate the effect of our compounds on clinical patient isolates. By combining existing expertise, with unique access to biosafety level 4 laboratories and in vivo animal models as well as state of the art drug discovery facilities we can form the critical mass needed to translate basic science into novel general antiviral treatment options for these serious infections.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
6567970a212eaade2e0ee1ad
|
2018
|
Sweden
|
The Swedish Research Council
|
2018290083
|
2018-04246
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0.598361
|
0.14959
|
0
|
0
|
0.598361
|
0.14959
|
0
|
0
|
0
|
0.598361
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
EPIGENETIC ALTERATIONS IN THE ...IMMUNE DEFENSE IN TUBERCULOSIS-EXPOSED INDIVIDUALS
more
|
Epigenetic alterations in the ...immune defense in tuberculosis-exposed individuals
more
|
Tuberculosis (TB) remains one ...of the major health challenges of our time. Control of this epidemic is hampered by the lack of an effective vaccine and emergence of multi-drug resistance. This project addresses the question of how the immune system is altered epigenetically due to TB exposure in both peripheral blood and in the lungs. The project builds on our previous studies, in which we demonstrate that mycobacterial exposure triggers epigenetic changes in immune cells. In the present study we will 1) use an existing collection of cryo-preserved immune cells isolated from TB-exposed individuals area in order to identify an epigenetic biosignature that reflects TB exposure, 2) investigate the epigenomes in immune cells of health care workers before and after a year of medical residency in high-endemic areas to validate the finding and 3) map the epigenome of immune cells isolated from TB-patients and their household contacts and investigate whether the biosignature is useful as a biomarker to discriminate these exposed individuals from unexposed controls. The results will enhance the understanding of how natural exposure to TB affects lung immunity and the generated knowledge will have importance for guiding the development of novel strategies for prevention, diagnosis and prediction of treatment outcome.
more
|
|
12263
|
Tuberculosis control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Linköpings universitet
|
|
|
|
6567970a212eaade2e0ee1ae
|
2019
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2017067859A
|
SE-0-SE-6-11035A0102-GGG-99810
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D01
|
0
|
0
|
0.164706
|
0
|
0
|
0
|
0.164706
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
SECONDMENTS TO FAO - AMR - SEC...ONDMENT TO FAO - AMR GE, NEW STRATEGY
more
|
Secondments to FAO - AMR - Sec...ondment to FAO - AMR GE, New Strategy
more
|
Secondment to FAO/AMR. AMR is ...a cross-boarder health threat which is increasing in may coutries and threathens the healt of both people and animals. It is also extreamly costly in it allows to spread.
more
|
|
99810
|
Sectors not specified
|
3.9
|
IX. Unallocated / Unspecified
|
41301
|
Food and Agricultural Organisa...tion
more
|
FAO/Food and Agriculture Organ...ization
more
|
|
|
|
6567970a212eaade2e0ee1af
|
2019
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2015061634A
|
SE-0-SE-6-6105013703-GGG-12250
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
0
|
0.366777
|
0
|
0
|
0
|
0.366777
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
REACT 2015-2018 - REACT 2015-2...018 (NEW STRATEGY 2018-2022)
more
|
ReAct 2015-2018 - ReAct 2015-2...018 (New strategy 2018-2022)
more
|
Continued core support to the ...network ReAct working to advocate for improved antiobiotic resistance preparedness globally with particular focus on Africa, Asia and Latinamerica.
more
|
|
12250
|
Infectious disease control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala Universitet
|
|
|
|
6567970a212eaade2e0ee1b0
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290064
|
2017-05617_1
|
3
|
Ethiopia
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.065149
|
0
|
0
|
|
0.065149
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
ENHANCED ACTIVATION OF MACROP...HAGES DURING TB-COINFECTION
more
|
Enhanced activation of macrop...hages during TB-coinfection
more
|
This project focuses on immune... control of human tuberculosis (TB), the effect of helminthic worm coinfection and how current treatment strategies could be optimized to shorten duration of anti-TB chemotherapy, and protect those at risk for developing active disease. Coinfection with intestinal helminthic parasites can prevent an efficient TB-protection by suppressing bactericidal functions in macrophages (MQ), triggering progression from latent to active TB disease. Our previous results indicate that nutritional deficiencies in the nitric oxide (NO) and glutathione axis may contribute to poor control of mycobacteria by human MQ. Using a translational approach combining clinical TB studies (Ethiopia) with ex vivo infection experiments we will determine if N-acetyl cysteine and L-citrulline administration can revert the effect of chronic helminth infection in MQ by switching them from their immunosuppressed regulatory M2 phenotype to a proinflammatory M1 phenotype and simultaneously trigger enhanced NO production, to achieve better host control of mycobacteria. Modalities affecting macrophage activation will be studied in TB patients with/without concurrent helminth infection, before and after deworming. Our research will answer if adjunctive immune boosting therapies that strengthens and activates macrophages can expedite current anti-TB treatment, and whether interventions like deworming could be beneficial on large scale for individuals living in low resource areas.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Linköpings universitet
|
|
|
|
6567970b212eaade2e0ee1b1
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290055
|
2017-05581_1
|
3
|
Guinea
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.047052
|
0
|
0
|
|
0.047052
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
HOW WAS EBOLA STOPPED? DETERMI...NING THE ROLE OF RISK COMMUNICATION AND SOCIAL MOBILIZATION DURING THE OUTBREAK IN SIERRA LEONE
more
|
How was Ebola stopped? Determi...ning the role of risk communication and social mobilization during the outbreak in Sierra Leone
more
|
Striking in one of the world's... poorest countries, Ebola caused enormous human and economic losses in Sierra Leone, during and after the outbreak in 2014-2016. Risk communication and social mobilisation are powerful, but often overlooked tools in combating a disease outbreak. This research project aims to understand how these interventions work and how they influenced the epidemic curve, as they could be the key to dramatically alter the course of an infectious disease outbreak.Using a mix of quantitative, qualitative and quasi-experimental methods, the proposed studies will in four years assess the influence communication channels such as radio, governmental campaigns and community sources had on Ebola-specific knowledge, behaviour, risk perception and stigma. Furthermore, it will look at how risk communication affected the epidemic curve and interview journalists and stakeholders to determine what can be learned from this outbreak. An experiment in which radio journalists and an audience are asked to create and listen to stories of a hypothetical new disease outbreak, will give further insights into what kind of messages are effective.Collaborating with local and international actors in Sierra Leone and the USA, this project has the potential to gather evidence in a new combination of research fields and can produce practical recommendations for future health emergencies. This is of paramount importance so that a devastating outbreak of this magnitude will never be repeated.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
6567970c212eaade2e0ee1b2
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290062
|
2017-05607_1
|
3
|
Kenya
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.070578
|
0
|
0
|
|
0.070578
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
RESOLVING THE MYSTERY BEHIND T...HE MOSQUITO-BORNE O'NYONG'NYONG VIRUS – DIAGNOSTIC CHALLENGE, RESERVOIR, PREVALENCE AND TRANSMISSION.
more
|
Resolving the mystery behind t...he mosquito-borne O'nyong'nyong virus – diagnostic challenge, reservoir, prevalence and transmission.
more
|
The world have recently been a...lerted by sudden outbreaks of mosquito-borne viruses such as Zika virus and chikungunya virus in new continents, although both of these were already causing disease in Africa and Southeast Asia. One such mosquito-borne virus with potential for global spread is O'nyong-nyong virus (ONNV), which has caused large outbreaks in Africa. The outbreaks have so far occurred in resource-limited developing countries and often been misdiagnosed as chikungunya, a closely related virus with similar symptoms. The purpose of the proposed project is to characterize ONNV regarding mosquito vectors, tropism, potential animal reservoirs, prevalence, incidence, and distribution. For this we will develop specific diagnostic assays for ONNV IgG and IgM antibody detection and to apply those for determining the prevalence and distribution of infection in humans and animals in a region of Kenya where ONNV is suspected to occur. Concomitantly we will study the incidence of O'nyong-nyong fever in patients with clinical acute symptoms, which indicates an ONNV infection, using detection of viral RNA by RT-PCR and IgM antibodies. We will study ONNV's mosquito vector by sampling mosquitoes to characterize which vectors harbor ONNV. Further, we will experimentally investigate ONNV tropism and competence in different mosquito species, to better understand if ONNV have the potential to use other mosquito vectors and gain the potential to spread beyond known endemic regions.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
6567970c212eaade2e0ee1b3
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290004
|
2017-05406_2
|
3
|
Lao People's Democratic Republ...ic
more
|
Far East Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.014477
|
0
|
0
|
|
0.014477
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
MAN'S BEST FRIEND: A CROSSBORD...ER TRANSDISCIPLINARY ONE HEALTH APPROACH TO RABIES CONTROL IN DOGS IN SOUTHEAST ASIA
more
|
Man's best friend: A crossbord...er transdisciplinary One Health approach to rabies control in dogs in Southeast Asia
more
|
Rabies is estimated to kill mo...re than 30,000 people every year in Asia. Most cases are caused by dog bites, and deaths most commonly occur among the poorest or the most remote population, unable to receive post-exposure prophylaxis. In Southeast Asia, dogs are not only used as farm dogs, or as pets, but also increasingly as a food source, with dogs moved between countries. Rabies is a serious threat, and people involved in the dog value chain may be at increased risk, and the cross-border movements are complicating control efforts. This network project has a One Health approach, and will bring together stakeholders and researchers from Lao PDR, Cambodia, Viet Nam, Sweden and France. Workshops will be arranged around dog population dynamics, disease incidence, improvement of laboratory technologies and the best control strategies.An ongoing vaccine intervention in Cambodia will be used to study dog populations and changes in vaccination covers. The risk of rabies along the dog value chain will be assessed, and we will evaluate a novel method for easier diagnosis. Knowledge, attitudes and practices will be studied among dog owners, dog butchers and traders, and policy makers. In conclusion, this project will contribute to reducing the risk for people by improving diagnostic capacities, providing basic knowledge of dog population dynamic needed for efficient vaccination strategies, and establishing a strong inter-sectoral network for rabies control in this region.
more
|
NTDs
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala universitet
|
|
|
|
6567970c212eaade2e0ee1b4
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290056
|
2017-05581_2
|
3
|
Liberia
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.047052
|
0
|
0
|
|
0.047052
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
HOW WAS EBOLA STOPPED? DETERMI...NING THE ROLE OF RISK COMMUNICATION AND SOCIAL MOBILIZATION DURING THE OUTBREAK IN SIERRA LEONE
more
|
How was Ebola stopped? Determi...ning the role of risk communication and social mobilization during the outbreak in Sierra Leone
more
|
Striking in one of the world's... poorest countries, Ebola caused enormous human and economic losses in Sierra Leone, during and after the outbreak in 2014-2016. Risk communication and social mobilisation are powerful, but often overlooked tools in combating a disease outbreak. This research project aims to understand how these interventions work and how they influenced the epidemic curve, as they could be the key to dramatically alter the course of an infectious disease outbreak.Using a mix of quantitative, qualitative and quasi-experimental methods, the proposed studies will in four years assess the influence communication channels such as radio, governmental campaigns and community sources had on Ebola-specific knowledge, behaviour, risk perception and stigma. Furthermore, it will look at how risk communication affected the epidemic curve and interview journalists and stakeholders to determine what can be learned from this outbreak. An experiment in which radio journalists and an audience are asked to create and listen to stories of a hypothetical new disease outbreak, will give further insights into what kind of messages are effective.Collaborating with local and international actors in Sierra Leone and the USA, this project has the potential to gather evidence in a new combination of research fields and can produce practical recommendations for future health emergencies. This is of paramount importance so that a devastating outbreak of this magnitude will never be repeated.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
6567970d212eaade2e0ee1b5
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290031
|
2017-05497
|
3
|
Mozambique
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.162872
|
0
|
0
|
|
0.162872
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
CHEST: COORDINATION OF HEALTH ...AND SOCIAL CARE FOR TB PATIENTS IN MOZAMBIQUE: A PRAGMATIC CLUSTER RANDOMIZED CONTROLLED TRIAL
more
|
CHEST: Coordination of HEalth ...and Social care for TB patients in Mozambique: A pragmatic cluster randomized controlled trial
more
|
Mozambique has a high burden o...f tuberculosis (TB), a disease that mostly affects the poor and can worsen poverty. The economic burden of TB (direct and indirect costs) can worsen adherence, treatment outcomes, and even result in death. Cash transfers can help this situation, but many TB patients eligible are not included in general cash transfer schemes. The main purpose of this study is to develop and evaluate a bi-directional referral system between health and social services to increase TB patients' access to grants, improve their health and wellbeing, and increase TB notification rates . A pragmatic cluster randomized trial assess this system's impact on TB notification rates, TB treatment success rates and rates of occurrence of catastrophic costs. This will be combined with analysis of the proportion of TB patients accessing the clinic, patient quality of life, proportion of TB suspects referred to health centres , and a process and cost evaluation alongside the trial. Data will be collected from registers, patient questionnaires, interviews and focus group discussions. Multivariate analysis will be conducted to assess intervention effectiveness, along with framework analysis for qualitative outcomes. Knowledge generated from this study will help develop models to connect health and social services, deliver cash transfers to TB patients and improve case detection of TB in Mozambique and ways to improve TB patients' health and wellbeing in low-income settings.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
6567970d212eaade2e0ee1b6
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290057
|
2017-05581_3
|
3
|
Sierra Leone
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.047052
|
0
|
0
|
|
0.047052
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
HOW WAS EBOLA STOPPED? DETERMI...NING THE ROLE OF RISK COMMUNICATION AND SOCIAL MOBILIZATION DURING THE OUTBREAK IN SIERRA LEONE
more
|
How was Ebola stopped? Determi...ning the role of risk communication and social mobilization during the outbreak in Sierra Leone
more
|
Striking in one of the world's... poorest countries, Ebola caused enormous human and economic losses in Sierra Leone, during and after the outbreak in 2014-2016. Risk communication and social mobilisation are powerful, but often overlooked tools in combating a disease outbreak. This research project aims to understand how these interventions work and how they influenced the epidemic curve, as they could be the key to dramatically alter the course of an infectious disease outbreak.Using a mix of quantitative, qualitative and quasi-experimental methods, the proposed studies will in four years assess the influence communication channels such as radio, governmental campaigns and community sources had on Ebola-specific knowledge, behaviour, risk perception and stigma. Furthermore, it will look at how risk communication affected the epidemic curve and interview journalists and stakeholders to determine what can be learned from this outbreak. An experiment in which radio journalists and an audience are asked to create and listen to stories of a hypothetical new disease outbreak, will give further insights into what kind of messages are effective.Collaborating with local and international actors in Sierra Leone and the USA, this project has the potential to gather evidence in a new combination of research fields and can produce practical recommendations for future health emergencies. This is of paramount importance so that a devastating outbreak of this magnitude will never be repeated.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
6567970d212eaade2e0ee1b7
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290050
|
2017-05570_2
|
3
|
Solomon Islands
|
Oceania
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.047052
|
0
|
0
|
|
0.047052
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
END MALARIA ON ISLANDS IN VANU...ATU: THE ROLLOUT OF INNOVATIVE ANTI-PLASMODIUM VIVAX STRATEGIES
more
|
End malaria on islands in Vanu...atu: the rollout of innovative anti-Plasmodium vivax strategies
more
|
In the Asia-Pacific region, ma...laria elimination faces the challenges presented by the high proportion of Plasmodium vivax infections. The existence of latent and persistent P. vivax hypnozoites in the liver makes this species less amenable to elimination efforts than P. falciparum. Vanuatu is an archipelago of 68 inhabited islands in the southwest Pacific. Our overall purpose is to achieve sustainable malaria elimination in the entire archipelago, based on the achievement on Aneityum Island over the last 25 years. Furthermore innovative strategies for P. vivax elimination are desired. With the establishment of the Center for Malaria Elimination in Port Vila, we specifically aim to 1) establish a robust malaria surveillance system to detect asymptomatic and sub-microscopic infections by PCR and identify remaining hotspots, 2) examine the containment strategy of short-term mass drug administration in concert with long-term vector control to eliminate infections in detected hotspots, 3) support the wider use of primaquine against P. vivax hypnozoites by investigating human CYP2D6 polymorphisms and G6PD deficiency related to primaquine metabolism and safety, respectively, 4) create a local economic mechanism such as malaria free award to encourage changes in human behaviors towards self-protection against malaria infections, and 5) characterize the changes in genetic diversity of the last parasites and human anti-parasite immunity after malaria elimination.
more
|
0
|
12262
|
Malaria control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
6567970e212eaade2e0ee1b8
|
2019
|
Sweden
|
The Swedish Research Council
|
20170290068
|
2016-05780_3
|
3
|
South Sudan
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0352514
|
0
|
0
|
0
|
0.0352514
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF ORAL EFLORNITHI...NE FOR LATE-STAGE AFRICAN SLEEPING SICKNESS
more
|
Development of oral eflornithi...ne for late-stage African sleeping sickness
more
|
Eflornithine is one of only th...ree main-stay drugs registered for the treatment of late-stage human African trypanosomiasis, a uniformly fatal disease if left untreated. Eflornithine is currently recommended as a first line treatment, but due to its complicated intravenous administration, numerous patients are left untreated. A simplified mode of administration would enable more patients having access to treatment. Eflornithine is available as a racemate, a 50:50 mixture of its complementary stereoisomers. L-eflornithine is about 10-20-fold more potent but its absorption after oral dose is less favoured compared with D-eflornithine. The project will explore by non-clinical in vitro, in vivo and pharmacometric methods, a simplified, oral treatment alternative for eflornithine chemotherapy in late-stage T.b. gambiense sleeping sickness by seeking ways to improve the oral absorption of L-eflornithine.
more
|
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
6567970e212eaade2e0ee1b9
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290043
|
2017-05536
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.152014
|
0
|
0
|
|
0.152014
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
ASSESSING THE RISK OF MALARIA ...MOSQUITOES BY IDENTIFYING THE GENETIC BASIS OF THEIR HOST PREFERENCE.
more
|
Assessing the risk of malaria ...mosquitoes by identifying the genetic basis of their host preference.
more
|
The vectors of malaria in sub-...Saharan Africa are changing, reducing the efficacy of our control efforts with our current monitoring tools, in an ever-increasing number of difficult to predict regions . The once prominent human preferring and indoor biting species, Anopheles gambiae sensu stricto, is being superseded as the main vector of malaria in many regions by Anopheles arabiensis, a species in which various populations demonstrate surprisingly plastic biting and host preferences. Populations of An. arabiensis also differ in their degree of human preference, from highly anthropophilic to highly zoophilic. Therefore, our human host- and indoor biting-centered vector control measures are not nearly as effective against this rising threat. The development of a screening tool to quickly and accurately assess the host preference of An. arabiensis populations is required to enable the rational targeting of vector control resources to communities known to be at risk for significant malaria transmission. The purpose of the proposed research is to identify genetic markers of host preference in the malaria vector mosquito An. arabiensis, to be integrated into current monitoring protocols to assess the current, and predict future, human biting risk of An. arabiensis populations associated with human habitation. The aim of the project is to increase the portfolio of existing vector control tools that can be integrated for the sustainable control of malaria in sub-Saharan Africa.
more
|
0
|
12262
|
Malaria control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges lantbruksuniversitet
|
|
|
|
6567970e212eaade2e0ee1ba
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290044
|
2017-05543
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.146585
|
0
|
0
|
|
0.146585
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
TARGETING HOST SEEKING MALARIA... MOSQUITOES USING A TRICK EVOLVED BY THEIR PARASITES
more
|
Targeting host seeking malaria... mosquitoes using a trick evolved by their parasites
more
|
HMBPP, a metabolite of the mal...aria parasite, Plasmodium falciparum, significantly impacts host seeking and blood feeding of African malaria mosquitoes. HMBPP indirectly induces the release of a volatile organic compound blend from human blood that acts as a potent attractant. The discovery of HMBPP, and its effects, provides the qualities needed for the development of a targeted novel mosquito control agent. The overall purpose and aim of this research proposal is the development of a novel lure to be used for mass trapping of mosquitoes in regions affected by malaria. A specific aim is to confirm that the HMBPP-induced blend attracts wild African malaria mosquitoes. This will be done both in semi-field enclosures and under field conditions. Another aim is to investigate why malaria mosquitoes are attracted to gametocyte carrying patients, by analysing volatiles, exhaled and emitted, by patients in malaria endemic areas. Finally, I will investigate whether mosquitoes probe micro-vessel beds, where the male and female mature gametocytes are present, and thereby clarify if HMBPP production of gametocytes is the reason for the observed increased transmission rate in most endemic settings. The findings of the proposed research will increase our understanding of malaria parasite transmission by the development of a novel control tool to reduce parasite transmission success in affected communities.
more
|
0
|
12262
|
Malaria control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Stockholms universitet
|
|
|
|
6567970f212eaade2e0ee1bb
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290074
|
2017-05644
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.130297
|
0
|
0
|
|
0.130297
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
MALARIA ELIMINATION IN ZANZIBA...R. NEW TOOLS AND STRATEGIES
more
|
Malaria elimination in Zanziba...r. New tools and strategies
more
|
Nowhere in sub-Saharan Africa ...has malaria control provided as great impact as in Zanzibar thus now also providing first hand evidence of obstacles towards potential elimination. Residual asymptomatic infections and shift in mosquito behaviour as well as insecticidal resistance represent such important threats. We want to better understand these control escaping mechanisms and prevent/overcome these constraints by new targeted interventions. Besides in depth surveillance of malaria control coverage and impact, we want to study parasite population dynamics, molecular characteristics and gene flows whilst under heavy intervention exposure. We also propose proof of concept studies on two new potential interventions: mass drug administration against residual parasite reservoir and toxic attractive sugar bait traps against especially outdoor transmission. Methodologies include trend analyses of uniquely comprehensive epidemiological, clinical parasitological, entomological and demographic parameters, also including molecular surveillance expanded to include methods such as whole parasite genome sequencing, phylogenetic analyses etc.Major collaborators are Zanzibar Malaria Elimination Programme, a molecular research unit in USA and entomological expertise from Sweden and UK. We expect to provide responses to new emerging obstacles for future malaria elimination in sub-Saharan Africa and possibly proof of concept answer to: Is malaria elimination possible in high endemic Africa?
more
|
0
|
12262
|
Malaria control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
6567970f212eaade2e0ee1bc
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290051
|
2017-05570_3
|
3
|
Vanuatu
|
Oceania
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.047052
|
0
|
0
|
|
0.047052
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
END MALARIA ON ISLANDS IN VANU...ATU: THE ROLLOUT OF INNOVATIVE ANTI-PLASMODIUM VIVAX STRATEGIES
more
|
End malaria on islands in Vanu...atu: the rollout of innovative anti-Plasmodium vivax strategies
more
|
In the Asia-Pacific region, ma...laria elimination faces the challenges presented by the high proportion of Plasmodium vivax infections. The existence of latent and persistent P. vivax hypnozoites in the liver makes this species less amenable to elimination efforts than P. falciparum. Vanuatu is an archipelago of 68 inhabited islands in the southwest Pacific. Our overall purpose is to achieve sustainable malaria elimination in the entire archipelago, based on the achievement on Aneityum Island over the last 25 years. Furthermore innovative strategies for P. vivax elimination are desired. With the establishment of the Center for Malaria Elimination in Port Vila, we specifically aim to 1) establish a robust malaria surveillance system to detect asymptomatic and sub-microscopic infections by PCR and identify remaining hotspots, 2) examine the containment strategy of short-term mass drug administration in concert with long-term vector control to eliminate infections in detected hotspots, 3) support the wider use of primaquine against P. vivax hypnozoites by investigating human CYP2D6 polymorphisms and G6PD deficiency related to primaquine metabolism and safety, respectively, 4) create a local economic mechanism such as malaria free award to encourage changes in human behaviors towards self-protection against malaria infections, and 5) characterize the changes in genetic diversity of the last parasites and human anti-parasite immunity after malaria elimination.
more
|
0
|
12262
|
Malaria control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
6567970f212eaade2e0ee1bd
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290005
|
2017-05406_3
|
3
|
Viet Nam
|
Far East Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.014477
|
0
|
0
|
|
0.014477
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
MAN'S BEST FRIEND: A CROSSBORD...ER TRANSDISCIPLINARY ONE HEALTH APPROACH TO RABIES CONTROL IN DOGS IN SOUTHEAST ASIA
more
|
Man's best friend: A crossbord...er transdisciplinary One Health approach to rabies control in dogs in Southeast Asia
more
|
Rabies is estimated to kill mo...re than 30,000 people every year in Asia. Most cases are caused by dog bites, and deaths most commonly occur among the poorest or the most remote population, unable to receive post-exposure prophylaxis. In Southeast Asia, dogs are not only used as farm dogs, or as pets, but also increasingly as a food source, with dogs moved between countries. Rabies is a serious threat, and people involved in the dog value chain may be at increased risk, and the cross-border movements are complicating control efforts. This network project has a One Health approach, and will bring together stakeholders and researchers from Lao PDR, Cambodia, Viet Nam, Sweden and France. Workshops will be arranged around dog population dynamics, disease incidence, improvement of laboratory technologies and the best control strategies.An ongoing vaccine intervention in Cambodia will be used to study dog populations and changes in vaccination covers. The risk of rabies along the dog value chain will be assessed, and we will evaluate a novel method for easier diagnosis. Knowledge, attitudes and practices will be studied among dog owners, dog butchers and traders, and policy makers. In conclusion, this project will contribute to reducing the risk for people by improving diagnostic capacities, providing basic knowledge of dog population dynamic needed for efficient vaccination strategies, and establishing a strong inter-sectoral network for rabies control in this region.
more
|
NTDs
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala universitet
|
|
|
|
6567970f212eaade2e0ee1be
|
2019
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2019060854A
|
SE-0-SE-6-12876A0101-AFR-12250
|
1
|
Africa, regional
|
Africa
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
3.40528
|
0.892933
|
0
|
0
|
3.40528
|
0.892933
|
0
|
3.40528
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
JOINT PROGRAMMING INITATIVE ON... ANTIMICROBIAL RESISTANCE (JPIAMR) 2019-2023 - JPIAMR CALL DIAGNOSTICS AND SURVEILLANCE 2019
more
|
Joint Programming Initative on... Antimicrobial Resistance (JPIAMR) 2019-2023 - JPIAMR Call Diagnostics and Surveillance 2019
more
|
The African Academy of Science...s (AAS) has applied to Sida for funding of 32.2 million SEK to provide grant management services plus additional capacity building and networking activties for African grantees funded by research calls of the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) during the period 2019-11-01 until 2023-12-31. Of the 32.2 million SEK, 18.8 million SEK will be forwarded to seven African researchers participating in five transnational research consortia that have applied for Sida funding and were selected in the JPIAMR 2019 call Diagnostics and Surveillance of Antimicobial Resistance: Development of tools, technologies and methods for global use .The objectives of the proposed Sida partnership with the JPIAMR and AAS is to combine resources, infrastructures, and strengths of multiple countries in order to facilitate innovative research projects to curb AMR with an One Health approach integrating human, animal and evironmental health; to support and increase the participation of researchers in low-income countries in sub-Saharan Africa and other sub-Saharan countries where Sweden has bilateral development cooperation in the global fight against AMR; and to build capacity and support the formation of a network of AMR researchers on the African continent.JPIAMR is a global collaborative organization and platform, engaging 27 nations to curb AMR with a One Health approach. In the JPIAMR 2019 call, 19 funding organizations from 15 countries went together to fund transnational research projects. Funding was allocated to 12 projects with a total sum of 12.1 million Euro (approx. 129.7 million SEK) with Sida's contribution of 1.71 millio Euro (approx. 18.1 million SEK) representing ca. 14% of the total funding.
more
|
|
12250
|
Infectious disease control
|
6.3;3.d;3.b;3.9;3.3
|
I.2.b. Basic Health
|
21000
|
International NGO
|
AAS/African Academy of Science...s
more
|
|
|
|
65679710212eaade2e0ee1bf
|
2019
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2019061021A
|
SE-0-SE-6-12206A0101-COD-74010
|
1
|
Democratic Republic of the Con...go
more
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.10138596
|
0.03595636
|
0
|
0
|
0.596388
|
0.211508
|
0
|
0.596388
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
17
|
SWEDISH RED CROSS DISASTER RIS...K REDUCTION IN KINSHASA
more
|
Swedish Red Cross Disaster Ris...k Reduction in Kinshasa
more
|
The Swedish Red Cross has appl...ied for support for the project Disaster Risk Reduction in Kinshasa of SEK 5,639,385 for the period 2019-2021. The project will be carried out in three areas in the municipality of Limeté, which are some of Kinshasa's poorest areas, and where the population is exposed to recurrent floods that cause major health problems, destruction of homes and property, and which annually injure many and harvests lives. The overall aim of the project is to contribute to reducing the vulnerability of girls and boys, women and men in urban communities to disasters in Kinshasa province. The project has three principle outputs: (I) Risk awareness among the target population and local authorities is enhanced; (II) Targeted girls, boys, women and men have reduced their vulnerability to disaster and epidemic by 2020 and have undertaken mitigation interventions at community level; (III) Lessons learnt are promoted and shared amongst practitioners and decision-makers at provincial, national and regional levels. The project has a strong rights perspective and intends to strengthen the target group's knowledge of their human rights to protection and health. The project intends to disseminate information on many different levels and has, among other things, planned for a radio and TV campaign, and activities in schools in the project area. The project plans to install an early warning system, and carry out several simulation exercises to train the target group in disaster preparedness. The project also has a large lessons learnt component, which aims to share experiences and lessons learnt with relevant actors in order to create a sustainable project that others can learn from and build on. The Swedish Embassy contributes with SEK 5,639,385 and the partner's input is up to SEK 4,309,635 primarily covering administrative costs such as salaries and rents. To a large extent the Project will be implemented by the DR Congo Red Cross, hence project funds will be transferred to them, via the Swedish Red Cross.
more
|
|
43060
|
Disaster Risk Reduction
|
3.d
|
IV.2. Other Multisector
|
21000
|
International NGO
|
Svenska Röda Korset
|
|
|
|
65679711212eaade2e0ee1c0
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290919
|
2018-03918
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.135726
|
0
|
0
|
|
0.135726
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
UNDERSTANDING THE EPIDEMIOLOGY... OF RESPIRATORY SYNCYTIAL VIRUS INFECTION AS A GROUNDWORK FOR ANTIVIRAL TREATMENT
more
|
Understanding the epidemiology... of respiratory syncytial virus infection as a groundwork for antiviral treatment
more
|
Respiratory Syncytial Virus (R...SV) is globally the most common cause of pneumonia in children under two years of age. The morbidity/mortality is considerable, not least in Sub-Saharan Africa. No effective treatment or vaccine exist. We will develop anti-RSV therapy from drug discovery onwards through epidemiological investigation by collaboration with Mozambique.Purpose and aims: i/ to understand the epidemiology of RSV respiratory infection in children in Mozambique and in Sweden, as groundwork for future antiviral treatment, ii/ to identify viral and host factors including antibody respone of importance for pathogenesis of RSV infection, and iii/to elucidate the efficacy, safety and molecular mechanism of action of our lead anti-RSV compound.Work plan: We have formed a research network within infectious disease epidemiology and drug discovery with collaborators from Maputo, Stockholm and Gothenburg. We will analyze retrospective data from our studies om respiratory infections dominated by RSV, and perform prospective studies in both countries, with focus on genetic diversity in both pathogen and host, and on antibody responses that might lead to more severe symptoms. The methodology includes molecular epidemiology and diagnostics in humans, as well as cell biology and chemistry to define drug mechanisms. Novel seroassays will be developed. The time plan is linked to mutual PhD programs and encompasses 4 years. Importance: Treatment of RSV will improve child health globally.
more
|
0
|
12250
|
Infectious disease control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
65679712212eaade2e0ee1c1
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290933
|
2018-04246
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.130297
|
0
|
0
|
|
0.130297
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
EPIGENETIC ALTERATIONS IN THE ...IMMUNE DEFENSE IN TUBERCULOSIS-EXPOSED INDIVIDUALS
more
|
Epigenetic alterations in the ...immune defense in tuberculosis-exposed individuals
more
|
Tuberculosis (TB) remains one ...of the major health challenges of our time. Control of this epidemic is hampered by the lack of an effective vaccine and emergence of multi-drug resistance. This project addresses the question of how the immune system is altered epigenetically due to TB exposure in both peripheral blood and in the lungs. The project builds on our previous studies, in which we demonstrate that mycobacterial exposure triggers epigenetic changes in immune cells. In the present study we will 1) use an existing collection of cryo-preserved immune cells isolated from TB-exposed individuals area in order to identify an epigenetic biosignature that reflects TB exposure, 2) investigate the epigenomes in immune cells of health care workers before and after a year of medical residency in high-endemic areas to validate the finding and 3) map the epigenome of immune cells isolated from TB-patients and their household contacts and investigate whether the biosignature is useful as a biomarker to discriminate these exposed individuals from unexposed controls. The results will enhance the understanding of how natural exposure to TB affects lung immunity and the generated knowledge will have importance for guiding the development of novel strategies for prevention, diagnosis and prediction of treatment outcome.
more
|
0
|
12263
|
Tuberculosis control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Linköpings universitet
|
|
|
|
65679712212eaade2e0ee1c2
|
2020
|
Sweden
|
The Swedish Research Council
|
2019290007
|
2019-03732
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.189402
|
0
|
0
|
|
0.189402
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
HARNESSING FLOWERING PLANTS FO...R THE CONTROL OF MALARIA
more
|
Harnessing flowering plants fo...r the control of malaria
more
|
Malaria mortality has signific...antly decreased since 2000 due to successful control. However, this fragile gain is threatened by emerging resistance to insecticides among malaria mosquitoes and by drug resistance by the malaria parasites. Knowledge of the natural vector ecology is now recognised as a prerequisite for malaria elimination and eradication, and can be harnessed in the development of new strategies for vector control. Plant feeding plays a pivotal role in vector biology and offers novel ways to manipulate the connection between plant and vector to weaken or eliminate pathogen transmission, either by itself or as a component of integrated vector control. However, we have limited understanding of how malaria mosquitoes select plants for feeding, and how the natural diversity of plants affects mosquito competence for malaria parasites. The purpose of this study is to identify the mechanism by which malaria mosquitoes select host plants to obtain sugars needed for survival and reproduction, and how this behaviour is affected by the interaction of secondary metabolites in plant nectar and malaria parasites. The aim of the project is to harness the properties of attractive host plants for the development of odour-bait technology, and to identify plant secondary compounds that have detrimental effects on the development and survival of malaria parasites. Results of this project may further be used in health and policy decisions for the reduction of malaria prevalence.
more
|
0
|
12262
|
Malaria control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges lantbruksuniversitet
|
|
|
|
65679712212eaade2e0ee1c3
|
2020
|
Sweden
|
The Swedish Research Council
|
2019290030
|
2019-04150_2
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.094733
|
0
|
0
|
|
0.094733
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
IDENTIFICATION OF BACTERIAL IN...FECTIONS AND ANTIBIOTIC RESISTANCE IN LOW INCOME COUNTRIES BY RAPID OPTICAL DNA MAPPING
more
|
Identification of bacterial in...fections and antibiotic resistance in low income countries by rapid optical DNA mapping
more
|
Antibiotic resistance is one o...f the main threats to global health. The situation is particularly alarming in Low- and Middle-Income Countries (LMICs) since surveillance systems and easy-to-use tools for monitoring are lacking. The goal of this project is to use Optical DNA Mapping (ODM) as a genetic tool in LMICs. ODM is a method for coarse genetic analysis of bacteria that identifies the bacteria and reveals the resistance genes they are carrying. The method will be implemented at the neonatal ward at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania. We have selected this setting for several reasons. First of all, Tanzania is one of many LMICs where simple microscopes are used in the clinical setting to diagnose tuberculosis. We will in this project repurpose these microscopes for ODM, which means that there is no extra cost for infrastructure. Second, we selected neonates because these patients are the most sensitive to resistant infections and have a high mortality. We therefore believe that any intervention that will result from this project will have immediate impact regarding decreased mortality. The project includes development of the ODM assay in Sweden, including adaptation to simple microscopy, a screen for resistant bacteria at the neonatal ward at MNH, teaching of staff at MNH in handling the ODM technique and finally implementation of ODM in routine testing in the neonatal ward at MNH.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Chalmers tekniska högskola
|
|
|
|
65679712212eaade2e0ee1c4
|
2020
|
Sweden
|
The Swedish Research Council
|
2019290031
|
2019-04202
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.183951
|
0
|
0
|
|
0.183951
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
EPIGENETIC MODULATION OF ANTIB...IOTIC RESISTANCE GENE TRANSFER IN BACTERIA
more
|
Epigenetic modulation of antib...iotic resistance gene transfer in bacteria
more
|
Antibiotic resistance is incre...asing in bacteria. The problem has escalated by recent overuse of antibiotics in humans and animals and by contaminated environments. Today we face a real risk that emergence of multi-resistance in bacterial pathogens might render some infections untreatable and throw humanity back to the pre-antibiotic era. We have performed transconjugation experiments using bacteria derived direclty from natural contaminated water sources in Bolivia to study tranfer of antibiotic resistance genes. Recipient bacteria with obtained resistance were whole genome sequenced and the tranferred genetic material was analyzed. We found that genes encoding epigenetic methyltransferases and restriction endonucleases were part of the mobile DNA. We will now address the impact of epigenetic modifications in donor and recipient bacteria by taking advantage of Long-Read sequencing techniques (PacBio) that allows assemly of entire chromosomes and plasmids and also detect methylation profiles. Our preliminary data indicate that strain specific methylation profiles are present in E coli. We have found isolats that seemingly are unable to take up mobile genetic material while other isolates seems hypereffective in acquisition of foreign DNA. We hypotheze that this is due to epigenetic modifications of donor and recipient strains. The results will improve our understanding on how superbugs with antibiotic multiresistance can emerge and spread globally.
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
9.5
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
65679712212eaade2e0ee1c5
|
2020
|
Sweden
|
The Swedish Research Council
|
2019290057
|
2019-04720
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.189466
|
0
|
0
|
|
0.189466
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
EXPLORING EPIGENETIC ALTERATIO...NS OF CELLULAR IMMUNITY IN MULTIDRUG-RESISTANT TUBERCULOSIS WITH RELEVANCE FOR NEW THERAPY USING EPIGENETIC
more
|
Exploring epigenetic alteratio...ns of cellular immunity in multidrug-resistant tuberculosis with relevance for new therapy using epigenetic
more
|
Multidrug-resistant tuberculos...is (MDR-TB) with low treatment success rates is a growing global problem, and a priority is to find new effective therapies. This project aims to explore the effects of epigenetic- and immune-modulating drugs on MDR-TB in Ethiopia. Our data from TB patients suggests that impaired cellular immunity in infected tissue is associated with high expression of suppressive immune checkpoint molecules. However, effector mechanisms in TB-infected cells can be enhanced by histone deacetylase inhibitors (HDACi). In a clinical trial in Ethiopia, we recently demonstrated that vitamin D3 and the HDACi, phenylbutyrate, could improve recovery from pulmonary TB. Using mass cytometry and chromatin profiling, we will now study immune checkpoint molecules and epigenetic alterations in immune cells obtained from treatment-responders with drug-susceptible or MDR-TB (year 1). In parallel, we will enroll an MDR-TB cohort to test selected HDACi on alveolar macrophage function and if blockade with immune checkpoint modulators can enhance cytotoxic T cell responses in blood cells in vitro (year 1-3). Next, patients' MDR-TB isolates will be used in an in vitro infection model to test if epigenetic priming in combination with immune checkpoint modulation will enhance effector cell function and reduce bacterial growth (year 3). This collaborative project will promote clinical discoveries and the development of next-generation therapies for difficult-to-treat MDR-TB patients.
more
|
0
|
12263
|
Tuberculosis control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
65679712212eaade2e0ee1c6
|
2020
|
Sweden
|
The Swedish Research Council
|
2019290058
|
2019-04725
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.102662
|
0
|
0
|
|
0.102662
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
MAPPING OF HUMAN IMMUNE PROTEC...TIVE RESPONSES IN THE LUNG OF INDIVIDUALS WITH LATENT OR ACTIVE TUBERCULOSIS INFECTION
more
|
Mapping of human immune protec...tive responses in the lung of individuals with latent or active Tuberculosis infection
more
|
Close to 2 million individuals... die every year from Tuberculosis (TB). The existing vaccine does not provide a full protection, and drug resistance is rising. The lack of correlates of protection hampers the generation of new vaccines. Immune responses in TB lung lesions are central for such understanding, since these account for containment or systemic spreading and transmission. Using, in situ sequencing, a powerful spatially resolved transcriptomic method, the immune topography of the Tuberculosis lesions in lung biopsies from patients (with latent or active TB, co-infected or not with HIV) and non-human primates (vaccinated and protected and with latent or active TB or with SIV coinfection) will be defined.Specifically, ? 250 transcripts coding for innate and adaptive immune response as well as Mycobacterium tuberculosis (Mtb) molecules regulated in response to immune stress will be aligned with the tissue morphology at cellular resolution. Maps of immune transcripts in different granulomas in the same lung, in diverse areas of the granuloma and in proximity to the Mycobacterium tuberculosis (Mtb) bacilli will be outlined. Networks of co-expressed transcripts will be identified. The heterogeneity between lesions and also the common networks in various lesions will be defined in annotated areas and in a non-supervised manner.Thus, immune topography involved in protection against progression to active TB will be defined, providing a guide in development of new vaccines.
more
|
0
|
12263
|
Tuberculosis control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
65679713212eaade2e0ee1c7
|
2020
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2019060038A
|
SE-0-SE-6-6105015601-GGG-12250
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
2.171623
|
0
|
0
|
|
2.171623
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
REACT STRATEGIC PLAN 2019-2023... - REACT STRATEGIC PLAN 2019-2023 (NEW STRATEGY 2018-2022)
more
|
ReAct Strategic Plan 2019-2023... - ReAct Strategic Plan 2019-2023 (New strategy 2018-2022)
more
|
The contribution is a support ...to the implementation of ReAct's Strategic Plan 2019-2023 with a total budget of 113 MSEK. Sida's support will be 72 MSEK in total for 2019-2022 (four years). ReAct has been a cooperation partner to Sida since 2005. AMR - antimicrobial resistance.
more
|
0
|
12250
|
Infectious disease control
|
3.8
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala universitet
|
|
|
|
65679713212eaade2e0ee1c8
|
2020
|
Sweden
|
The Swedish Research Council
|
2019290005
|
2019-03715_2
|
3
|
Ethiopia
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.062499
|
0
|
0
|
|
0.062499
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
EXPLORATION OF EAST AFRICAN ME...DICINAL HERBS IN THE SEARCH FOR NOVEL ANTIBACTERIAL AGENTS
more
|
Exploration of East African Me...dicinal Herbs in the Search for Novel Antibacterial Agents
more
|
Antimicrobial resistance has b...ecome a major threat to human health and development. As our currently used antibiotics lose efficiency, we risk rapidly increasing number of untreatable infections leading to an increased number of lethal cases, longer hospital stays, and related suffering and economic burden. Antibiotic resistance is expected to hit developing countries especially hard, with 90% of the lethal infections predicted to happen in Africa and Asia.This study aims to make use of East African indigenous knowledge to use natural resources in finding new ways to control bacterial infections. Following an ethnomedical survey, medicinal plants will be collected in Kenya and Tanzania. Their constituents will be isolated, and identified by NMR and MS analyses. The bioactivity and toxicity of the isolated constituents will be determined using bacterial and cell-based assays. The biochemical pathways targeted by the most promising bioactive substances will be identified by chemical genomics. Advanced NMR techniques will subsequently be used to identify the binding mode of the substances to their protein targets to support their development into drugs.Besides achieving high scientific goals, the project aims the multidisciplinary training of East African PhD students. It will support the economic development of East Africa by strategic knowledge transfer and by promoting patient safety on the use of plants as a result of the scientific investigation of ethnomedical practices.
more
|
0
|
43082
|
Research/scientific institutio...ns
more
|
9.5
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala universitet
|
|
|
|
65679713212eaade2e0ee1c9
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290918
|
2018-03914
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.043034
|
0
|
0
|
|
0.043034
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
TARGETING ALPHAVIRUS HOST PROT...EIN INTERACTIONS TO DEVELOP ANTIVIRAL THERAPIES
more
|
Targeting alphavirus host prot...ein interactions to develop antiviral therapies
more
|
The alphaviruses are a group o...f viruses that have caused a number of severe diseases including chikungunya fever in millions of people in recent decades. The viruses are transmitted by mosquitoes in tropical regions, including many low-income countries. Most infected individuals recover, but in some cases joint pain may persist for several months or even years, and effects of outbreaks on working communities are devastating.Currently no antiviral therapies or vaccines have been approved for any alphavirus infection. In recent research, we showed that viral RNA replication is entirely dependent on interaction with the cellular protein G3BP. We propose to form a collaborative network to use structure-based methods to design compounds which would block viral interaction with G3BP, thus blocking replication of chikungunya virus and the others in the alphavirus group. We will test a number of compounds for antiviral activity, with the best performing compounds being used as templates to design improvements in a second generation of compounds. We will organise a number of meetings at each location and we will apply for further funds to expand our network in future years.Anti-alphaviral compounds would be of enormous benefit for global health, especially in regions of low or low-to-middle income. We hope that this collaboration network proposal will act as a seed for a very strong international network with the delivery of such a drug as our priority.
more
|
0
|
12250
|
Infectious disease control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
65679714212eaade2e0ee1ca
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290978
|
2018-05194_2
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.021173
|
0
|
0
|
|
0.021173
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DESIGNING IMPLEMENTATION RESEA...RCH FOR INTEGRATION OF TUBERCULOSIS, DIABETES, AND TOBACCO CONTROL PROGRAMME
more
|
Designing implementation resea...rch for integration of tuberculosis, diabetes, and tobacco control programme
more
|
Many low- and middle-income co...untries (LMICs) are facing both a persistent burden of infectious diseases and an emerging burden of chronic non-communicable diseases (NCDs). Tuberculosis (TB) co-exists with other NCDs, including diabetes mellitus (DM). Smoking increases the risk of both TB and DM. Health systems in many LMICs are ill-prepared and currently facing the triple burden of smoking, TB, and DM, which drives these countries into the vicious cycle of poverty. We will create the stakeholder network and link researchers and policymakers to discuss enablers and barriers and develop models for the integration of TB, DM, and tobacco control programs at primary health care centres, district, provincial, and national levels. We will conduct formative research using realist evaluation, concept mapping, and social network analysis to guide the model developments. The collaboration envisaged in the project between Sweden, India and Indonesia will help to identify priority areas and strategies for integration of TB, DM, and tobacco control in LMICs, which can be modified and applied in the context of a developed country (Sweden). Project activities include workshops, discussions with stakeholders, data analysis, paper and proposal writing during 2019-2020. This research link project will enhance research capacity and competence of researchers in four universities in India and Indonesia for designing and conduct implementation research to strengthen the health systems.
more
|
0
|
12263
|
Tuberculosis control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
65679714212eaade2e0ee1cb
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290977
|
2018-05194_1
|
3
|
Indonesia
|
Far East Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.021173
|
0
|
0
|
|
0.021173
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DESIGNING IMPLEMENTATION RESEA...RCH FOR INTEGRATION OF TUBERCULOSIS, DIABETES, AND TOBACCO CONTROL PROGRAMME
more
|
Designing implementation resea...rch for integration of tuberculosis, diabetes, and tobacco control programme
more
|
Many low- and middle-income co...untries (LMICs) are facing both a persistent burden of infectious diseases and an emerging burden of chronic non-communicable diseases (NCDs). Tuberculosis (TB) co-exists with other NCDs, including diabetes mellitus (DM). Smoking increases the risk of both TB and DM. Health systems in many LMICs are ill-prepared and currently facing the triple burden of smoking, TB, and DM, which drives these countries into the vicious cycle of poverty. We will create the stakeholder network and link researchers and policymakers to discuss enablers and barriers and develop models for the integration of TB, DM, and tobacco control programs at primary health care centres, district, provincial, and national levels. We will conduct formative research using realist evaluation, concept mapping, and social network analysis to guide the model developments. The collaboration envisaged in the project between Sweden, India and Indonesia will help to identify priority areas and strategies for integration of TB, DM, and tobacco control in LMICs, which can be modified and applied in the context of a developed country (Sweden). Project activities include workshops, discussions with stakeholders, data analysis, paper and proposal writing during 2019-2020. This research link project will enhance research capacity and competence of researchers in four universities in India and Indonesia for designing and conduct implementation research to strengthen the health systems.
more
|
0
|
12263
|
Tuberculosis control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
65679714212eaade2e0ee1cc
|
2020
|
Sweden
|
The Swedish Research Council
|
2019290041
|
2019-04366
|
3
|
Kenya
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.043432
|
0
|
0
|
|
0.043432
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
CRIMEAN CONGO HEMORRHAGIC FEVE...R VIRUS IN HUMANS, ANIMALS AND TICKS IN KENYA
more
|
Crimean Congo Hemorrhagic Feve...r Virus in Humans, Animals and Ticks in Kenya
more
|
The world has faced severe ou...tbreaks of vector-borne diseases, some from viruses whose surveillance and activity was ignored. Crimean Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonotic disease, endemic in Africa with high-case fatality rate. The disease has no treatment and vaccine. An epidemic would be catastrophic. Relative to other hemorrhagic diseases, Crimean Congo hemorrhagic fever (CCHF) has received less attention, although previous studies in Kenya include fatal human cases, detection of CCHFV antibodies in humans and virus isolations from Hyalomma ticks. These studies show evidence of CCHFV activity in Kenya, however basic information about its epidemiology is lacking. The goal of this project is to leverage strengths and opportunities from Swedish and Kenyan researchers to determine the prevalence and distribution of CCHFV in humans, ticks, livestock and small wild mammals in Kenya. Further, we aim to characterize the strains of CCHFV that circulate in mammals and ticks in Kenya. The study locations present a distinct ecology and human-animal interactions: The Maasai Mara ecosystem and Ol Pejeta Conservancy. The trans-disciplinary team from Kenya and Sweden using the 'One Health' concept will generate new information that will be channeled to the Zoonotic Disease Unit-Kenya for inter-sectoral deliberations on policies, guidelines, and actions from project outcomes.
more
|
0
|
12250
|
Infectious disease control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
65679715212eaade2e0ee1cd
|
2020
|
Sweden
|
The Swedish Research Council
|
2019290055
|
2019-04663
|
3
|
Mozambique
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.043432
|
0
|
0
|
|
0.043432
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
ZOONOTIC TUBERCULOSIS IN MOZAM...BIQUE: A ONE HEALTH APPROACH
more
|
Zoonotic tuberculosis in Mozam...bique: a One Health Approach
more
|
Very little is known in Africa... about the spread and transmission of tuberculosis (TB) between individuals and from animals to humans. In Mozambique there is a high prevalence of bovine TB in certain regions, and in particular in the district of Govuro where the prevalence of TB is 40% in cattle. The overall aim of this project is to:consolidate a transdisciplinary research group with focus on TB (human and bovine) in Mozambique,make use of the high prevalence of bovine TB in cattle to investigate novel immunological markers of protection against TB that may support the development of new TB vaccine strategies,create a demographic site in Govuro district for in depth studies of the impact of TB and other zoonotic diseases on animal and human health.In this collaboration we will meet for seminars and workshops with focus on One Health, and jointly search for future funding for the research project.
more
|
0
|
12263
|
Tuberculosis control
|
3.3
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
65679715212eaade2e0ee1ce
|
2020
|
Sweden
|
The Swedish Research Council
|
2018290984
|
2018-05419
|
3
|
Nepal
|
South & Central Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.043432
|
0
|
0
|
|
0.043432
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF POINT-OF-CARE D...IAGNOSTICS FOR MULTIDRUG RESISTANT ESCHERICHIA COLI IN CLINICAL ISOLATES FROM NEPAL
more
|
Development of Point-of-Care D...iagnostics for Multidrug Resistant Escherichia coli in clinical isolates from Nepal
more
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The research question: Antibio...tic resistance in bacteria is a global problem. Poverty and related socio-economic factors in Nepal have caused a huge increase in the multidrug resistant Escherichia coli (MDREC). Combating 'antibiotic resistance' needs 'rational treatment' - that requires early detection of the pathogen.What will be done: We aim to develop a point-of-care diagnostics for the MDREC strains in clinical isolates from two hospitals (Manmohan Memorial and Kathmandu Model Hospital) in Nepal. The Nepalese team led by Dr. Basista P. Rijal and Dr. Basudha Shrestha will isolate DNA from the clinical isolates and ship to Sweden. The Swedish team led by Prof. Suparna Sanyal, will employ shotgun sequencing (at Sci-life Lab) and bioinformatics to identify species- and strain-specific biomarkers. DNA microchips will be developed for PCR or RPA based solid detection of MDREC.Mode of Collaboration: We will conduct two joint meetings each year, consisting of workshops and seminars. Experts from the antibiotic field will be invited. The researchers from Nepal will visit Uppsala 2-3 months / year. The Swedish researchers will spend 2 - 3 weeks in Nepal every year. The project will end with an international conference in Nepal.Impact: This project will aid in eradication of the antibiotic resistance problem. Junior researchers and students will receive technical and pedagogic training. If successful, this project will have a positive impact on the socio-economic status of Nepal.
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0
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12250
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Infectious disease control
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3.3
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I.2.b. Basic Health
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51000
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University, college or other t...eaching institution, research institute or think-tank
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Uppsala universitet
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65679715212eaade2e0ee1cf
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2020
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Sweden
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The Swedish Research Council
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2018290951
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2018-04662
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3
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Pakistan
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South & Central Asia
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LMICs
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ODA Grants
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1
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10
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110
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D02
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0
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0.041739
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0
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0
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0.041739
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0
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0
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0
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0
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Communicable diseases
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Communicable diseases Research... and Development
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100
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CLINICAL AND EXPERIMENTAL STUD...IES IN THE CO-MORBIDITY OF DIABETES AND TUBERCULOSIS
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Clinical and Experimental Stud...ies in the co-morbidity of Diabetes and Tuberculosis
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The underlying biological mech...anisms in the interaction between Diabetes (DM) and Tuberculosis (TB) are poorly understood despite their implications in clinical management. A synergic Swedish-Pakistani clinical and experimental research network will address DM/TB interaction.The immunobiology of granulomas in DM-TB and TB patients will be compared. In situ sequencing of multiple transcripts in granuloma sections will define the localization and activation of different immune cell populations in relation to the clinical status of the patient.The gene expression in blood from TB or latent TB with DM will be compared in genome-wide microarrays. T cell responses of TB/DM will be defined in multiplex assays. Novel mechanisms, markers and predictors of comorbidity will be defined.STAT3 protection against tb infection in mice will be studied. Whether STAT3 inhibition improves TB /DM will be tested in experimental animal models of the comorbidity and in cells from patients.The inflammatory environment of the granuloma might activate HIF-1a protective immune responses. HIF-1a function is hampered in DM. Whether HIF-1a stabilization by experimental or clinically approved drugs might affect the outcome of infection of diabetic mice with tuberculosis will be studied.The network includes complementary expertise in a global health problem, careful coordination for further research and funding, common workshops, training and personnel transfer at both sites.
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0
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12263
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Tuberculosis control
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3.3
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I.2.b. Basic Health
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51000
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University, college or other t...eaching institution, research institute or think-tank
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Karolinska Institutet
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