|
656796ef212eaade2e0ee16c
|
2017
|
Sweden
|
The Swedish Research Council
|
2014297550
|
2014-2819
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0945361
|
0
|
0
|
0
|
0.0945361
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
WORMS AND DE-WORMING: IMPLICAT...IONS ON DEVELOPMENT AND TREATMENT OF VISCERAL LEISHMANIASIS
more
|
WORMS AND DE-WORMING: IMPLICAT...IONS ON DEVELOPMENT AND TREATMENT OF VISCERAL LEISHMANIASIS
more
|
Visceral leishmaniasis (VL) is... a parasitic disease of poor people, which typically also are heavily exposed to worm infections. Our project aim to understand the impact of worms and worm proteins on development and control of visceral leishmaniasis (VL) and determine if de-worming can enhance immune responses and facilitate clearance of Leishmania donovani and thereby improve the efficacy of already existing drugs anti-leishmanials. We want to test this experimentally and in a clinical trial. Worms, being potent inducers of Th2 and regulatory responses, can be envisaged to affect the ability of the host to respond to Th1 controlled infections (e.g. Leishmania). The drugs (e.g. pentavalent antimonials, SbV) commonly used against leishmaniasis depend on host residual immunity to clear parasite infection. Thus, boosting Th1 immunity may enhance therapeutic efficacy, as suggested by combined therapy with the Th1 cytokine IFNg and SbV, which promoted parasite clearance over SbV monotherapy. Human VL is suitable as a model for a human disease where deworming can be envisaged to have impact. VL patients are hospitalized and the treatment time is manageable 15-30 days. Analysis of proteins from human worms may allow identification of immune modulatory proteins specific for human worms, which may be a contributing or underlying factor to immune failure in patients developing VL disease. Targeting such molecules may be used to treatments worms and to enhance control of co-infection.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796ef212eaade2e0ee16d
|
2018
|
Sweden
|
The Swedish Research Council
|
2014292041
|
2014-3071
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.126576
|
0
|
0
|
0
|
0.126576
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF A MUCOSAL VACCI...NE AGAINST HELICOBACTER PYLORI INFECTION INCLUDING PHASE I CLINICAL TESTING IN INDIA
more
|
Development of a mucosal vacci...ne against Helicobacter pylori infection including Phase I clinical testing in India
more
|
Gastric Helicobacter pylori in...fection is the main cause of peptic ulcers and gastric cancer. Remarkably, an estimated 80-90% of the adults in low and middle income countries are infected with H. pylori. An estimated 10-15% of the infected individuals will develop peptic ulcer disease and 1-2% gastric cancer. Antibiotic treatment can cure peptic ulcer disease but reinfection is common. From a public health perspective, a vaccine against H. pylori will reduce the consumption of antibiotics, the incidence of associated symptoms and rate of reinfections. The main target group for such a vaccine would be adults in low and middle income countries where H. pylori infection is endemic. Our group at the University of Gothenburg (UG) has been working for the last 20 years on the development of a mucosally delivered vaccine against H. pylori infection. Based on the results from our pre-clinical studies, a vaccine candidate will be chosen to advance to Phase I clinical trials in H. pylori infected adults and later in children in close collaboration with an industrial partner. The vaccine will be scaled up for production under GMP conditions. Pre-vaccine specific immune responses in H. pylori infected individuals in India will be studied and a Phase I trial will be carried out in India. Considering the previous experience at UG in developing mucosal vaccines, we are optimistic that we could develop an effective and low-cost H. pylori vaccine under the framework of this application.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
656796f0212eaade2e0ee16e
|
2017
|
Sweden
|
The Swedish Research Council
|
2014296808
|
2014-3360
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0592021
|
0
|
0
|
0
|
0.0592021
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
SYNTHESIS OF ANTI-MALARIA, ANT...I-TUBERCULOSIS AND ANTI-HIV DRUGS BY CABON-HYDROGEN BOND ACTIVATION
more
|
Synthesis of anti-Malaria, ant...i-Tuberculosis and anti-HIV Drugs by Cabon-Hydrogen Bond Activation
more
|
Malaria, tuberculosis and HIV ...are huge problems for the Indian Society (Appendix C1). Unfortunately, the world leading pharmaceutical companies mainly develop new drugs to satisfy the demand of the industrialized countries, and therefore drug development against these diseases receives relatively small attention. Our research proposal is directed to development of new catalytic procedures for new drugs and drug intermediates against malaria, tuberculosis and HIV. The basic strategy is the so called *carbon-hydrogen (C-H) bond activation*. This is a modern synthetic methodology, which is environmentally benign, cost-efficient and operationally simple. However, development of catalytic C-H activation methods require explicit knowledge to control the complicated chemical processes. The specific goals of the research are development of new C-H activation based methods for synthesis of quinoline (anti malarial), benzofurane (anti-tubercular and anti HIV), cyclic sulfonamide (anti-HIV) based drugs. The successful achievement of the research proposal will contribute to establishment of this important new research area in India (in IIT Bombay), Ph.D. education of research fellows and dissemination of this important synthetic technology in the Indian research society. The technology transfer to the domestic Indian pharmaceutical research companies, will help to find new drugs for treatment of malaria, tuberculosis and HIV improving the services of the Indian health-care sector.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Stockholms universitet
|
|
|
|
656796f0212eaade2e0ee16f
|
2016
|
Sweden
|
The Swedish Research Council
|
2014006290
|
2013-6310_1
|
3
|
Kenya
|
South of Sahara
|
Other LICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0204523
|
0
|
0
|
0
|
0.0204523
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
THE PREECLAMPSIA-MALARIA CONNE...CTION: PREDICTION, DIAGNOSIS, AND HOPE FOR TREATMENT
more
|
The preeclampsia-malaria conne...ction: prediction, diagnosis, and hope for treatment
more
|
Women are particularly vulnera...ble to malaria during pregnancy because malaria parasites accumulate in the placenta and the condition is estimated to be responsible for 200 000 infant deaths annually. The disease mechanisms are poorly understood, largely due to the lack of adequate animal models. We propose to use a placental perfusion model to study the interaction between malaria parasites accumulated in the human placenta in relation to the development of preeclampsia with ot without intrauterine growth restriction. The studies will also provide immediate guidance for ongoing efforts to develop a vaccine, protecting women from pregnancy malaria, and basic insight about the disease processes, which can lead to new treatment and prevention strategies for these complicated pregnancies affecting women in the sub-Saharan region. The specific aims of this project are to uncover common disease mechanisms behind PE with or without IUGR and pregnancy-associated malaria (PAM); to enable predictive diagnosis of high risk cases in the field; to prove feasibility of a cure using A1M in perfusion experiments. This work involves personnel and high risk pregnancy patients from Kenya, Egypt, Tanzania, and Ghana.
more
|
|
12262
|
Malaria control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Lunds universitet
|
|
|
|
656796f0212eaade2e0ee170
|
2017
|
Sweden
|
The Swedish Research Council
|
2014297489
|
2014-2636
|
3
|
Kenya
|
South of Sahara
|
Other LICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0939511
|
0
|
0
|
0
|
0.0939511
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
VECTOR CONTROL BY MULTIPLE CLA...SSES OF SMALL ORGANIC COMPOUNDS TO COMBAT MOSQUITO-BORNE INFECTIOUS DISEASES AND SUPPRESS INSECTICIDE RESISTANCE
more
|
Vector Control by Multiple Cla...sses of Small Organic Compounds to Combat Mosquito-Borne Infectious Diseases and Suppress Insecticide Resistance
more
|
Insect vectors transmit numero...us viral- and parasite infections between humans or from animals to humans. Worst affected are poor people living in vulnerable communities in tropical and sub-tropical regions. Vector control by insecticides is the dominant way to combat and prevent transmission of mosquito-borne diseases. Due to globalization, environmental changes and increased insecticide resistance, there is an urgent need for new approaches and strategies for efficient vector control. This proposal aims to design, synthesize and develop multiple novel chemical classes of insecticides for control of Aedes aegypti (transmits e.g. dengue and chikungunya) and Anopheles gambiae (transmits malaria). We will target a form of acetylcholinesterase (AChE1) not present in vertebrates, and identify diverse selective chemical starting points by high throughput screening (HTS). Evaluation of a performed HTS targeting mosquito AChE1 has shown promising results. We have identified several classes of substances that are selective for the mosquito-form over human AChE. These multiple chemical starting points will be synthetically explored and optimized into insecticides. Early on in the discovery process we will include, in addition to the target-specific endpoints, response estimates that address human safety, environmental fate and effect, resistance sensitivity, and cost of goods. Mosquito testing, including laboratory testing and field studies, will be performed in Kenya.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
656796f0212eaade2e0ee171
|
2018
|
Sweden
|
The Swedish Research Council
|
2014294227
|
2014-3331
|
3
|
Kenya
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.13233
|
0
|
0
|
0
|
0.13233
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
NOVEL INTERVENTION STRATEGY AG...AINST MALARIA MOSQUITOES - DEVELOPMENT OF AN ODOUR-BASED TRAPPING SYSTEM FOR GRAVID MOSQUITOES
more
|
Novel intervention strategy ag...ainst malaria mosquitoes - development of an odour-based trapping system for gravid mosquitoes
more
|
Gravid malaria mosquitoes, ess...ential for both population increase and malaria transmission, are largely unexploited as a target for integrated vector management (IVM) strategies. In a novel breakthrough toward the creation of a mass trapping system for malaria vectors, we identified several synthetic odour blends that attract gravid mosquitoes. Our current objectives are to use this knowledge to develop a ?super-blend? to attract gravid malaria mosquitoes under field conditions, and to optimise the positioning of gravid traps within the landscape. The overall aim is to demonstrate that gravid traps can reduce malaria prevalence under epidemiologically relevant conditions. The ?super blend? will be created in large-tent assays, then optimised binary choice assays inside a large semi-field enclosure at icipe?s field station in Kenya. Field evaluation of the ?super blend? will then be conducted as a multi choice assay at two sites in Kenya and at one site in Ethiopia, in collaboration with icipe and Addis Ababa University, respectively. To establish the importance of landscape features in the selection of oviposition sites, we will conduct a longitudinal survey of mosquito breeding sites and the surrounding environment. Finally, we aim to reduce malaria prevalence in a western Ethiopian village by augmenting existing IVM interventions with our odour-baited gravid traps. Entomological and parasitological data will be monitored before and during interventions to assess the effect.
more
|
|
12262
|
Malaria control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges Lantbruksuniversitet
|
|
|
|
656796f0212eaade2e0ee172
|
2017
|
Sweden
|
The Swedish Research Council
|
2014297490
|
2014-4218
|
3
|
Kenya
|
South of Sahara
|
Other LICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.028782
|
0
|
0
|
0
|
0.028782
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
VECTOR CONTROL BY MULTIPLE CLA...SSES OF SMALL ORGANIC COMPOUNDS TO COMBAT MOSQUITO-BORNE INFECTIOUS DISEASES AND SUPPRESS INSECTICIDE RESISTANCE
more
|
Vector Control by Multiple Cla...sses of Small Organic Compounds to Combat Mosquito-Borne Infectious Diseases and Suppress Insecticide Resistance
more
|
Insect vectors transmit numero...us viral- and parasite infections between humans or from animals to humans. Worst affected are poor people living in vulnerable communities in tropical and sub-tropical regions. Vector control by insecticides is the dominant way to combat and prevent transmission of mosquito-borne diseases. Due to globalization, environmental changes and increased insecticide resistance, there is an urgent need for new approaches and strategies for efficient vector control. This proposal aims to design, synthesize and develop multiple novel chemical classes of insecticides for control of Aedes aegypti (transmits e.g. dengue and chikungunya) and Anopheles gambiae (transmits malaria). We will target a form of acetylcholinesterase (AChE1) not present in vertebrates, and identify diverse selective chemical starting points by high throughput screening (HTS). Evaluation of a performed HTS targeting mosquito AChE1 has shown promising results. We have identified several classes of substances that are selective for the mosquito-form over human AChE. These multiple chemical starting points will be synthetically explored and optimized into insecticides. Early on in the discovery process we will include, in addition to the target-specific endpoints, response estimates that address human safety, environmental fate and effect, resistance sensitivity, and cost of goods. Mosquito testing, including laboratory testing and field studies, will be performed in Kenya.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
656796f1212eaade2e0ee173
|
2017
|
Sweden
|
The Swedish Research Council
|
2014293189
|
2014-4220
|
3
|
Lebanon
|
Middle East
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.019539
|
0
|
0
|
0
|
0.019539
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
GUT BACTERIA IN VECTOR MOSQUIT...OES: TRANSMISSION, HOST DEPENDENCY AND EFFECTS ON THE IMMUNE SYSTEM
more
|
Gut bacteria in vector mosquit...oes: transmission, host dependency and effects on the immune system
more
|
More and more evidence support... the hypothesis that microbial interactions play a vital role in shaping the fate of their host organisms. While the host-organism exposure to microbes set the prerequisite for interactions, also inherent properties of the host organism are expected to affect the relationship. Two vector mosquitoes of great importance are the malaria vector Anopheles gambiae and Aedes albopictus, vector of Dengue and Chikungunya viruses. The possibility to negatively impact vector competence by interfering with the host-microbial relationship is the long-term purpose of this project. However, to achieve interference, we need to better understand the bacterial relationship with the mosquito hosts. What is affecting the gut flora composition in mosquitoes, the ecological niche or host-specific physiological factors or both? The rationale is to compare the microbial flora composition of two vector mosquito species that have completely distinct ecologies, and investigate what effect on fitness the gut flora play. The aims presented here will give responses to fundamental questions in microbial ecology that only could be investigated in controlled lab settings. How will the microbial composition change in both species when bred in the same environment? Which is the mode of bacterial transfer between mosquitoes? What impact does the gut microbial-flora have on basal systemic immune activity and fecundity?
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges Lantbruksuniversitet
|
|
|
|
656796f1212eaade2e0ee174
|
2017
|
Sweden
|
The Swedish Research Council
|
2014292979
|
2014-4040
|
3
|
Malaysia
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.028782
|
0
|
0
|
0
|
0.028782
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
FOSTERING SWEDEN-MALAYSIA RESE...ARCH PARTNERSHIP: ENHANCING RESEARCH CAPACITY AND COMPETENCE FOR THE DEVELOPMENT OF AN EARLY WARNING OF DENGUE, A CLIMAT
more
|
Fostering Sweden-Malaysia rese...arch partnership: Enhancing research capacity and competence for the development of an early warning of dengue, a climat
more
|
Dengue fever, a viral infected... disease transmitted by mosquitoes (vector), is a major public health challenge in Malaysia despite the fact that concerted surveillance and control efforts are in place. An early warning with precise forecast of outbreak allows timely decision-making and mitigation. Such epidemic prediction capability is not demonstrated in current surveillance system. In early 2014, researchers from Umea University have initiated a multidisciplinary and multinational collaboration for the development of a dengue early warning system for Singapore and Malaysia. Umeå researchers possess substantial experience in disease forecasting modeling using various statistical and mathematical techniques. This project promotes research capacity and expertise required for disease forecast. Activities such as workshops, seminars and visits to Disease Control Division are planned to facilitate exchange or transfer of knowledge or ideas and develop strategies for studies including forecast of dengue, development of early warning system, economic evaluation and information distribution. Subsequently, knowledge and experience gained will be translated as course modules for graduate students in the University of Malaya. Anticipated outcomes include long-term research partnership and advance knowledge of disease early warning that may contribute to reducing burden of dengue and promote healthy living and wellbeing in the community.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
656796f1212eaade2e0ee175
|
2017
|
Sweden
|
The Swedish Research Council
|
2014291003
|
2014-4254
|
3
|
Malaysia
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.025857
|
0
|
0
|
0
|
0.025857
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
*DENGUE-SCREENING* - ELECTROME...CHANICAL MICRO-TOTAL ANALYSIS SYSTEM (µTAS) FOR SENSITIVE AND RAPID DETECTION OF DENGUE FEVER
more
|
*Dengue-Screening* - Electrome...chanical micro-total analysis system (µTAS) for sensitive and rapid detection of dengue fever
more
|
The research project will be d...riven by merging the expertise on biosensors fabrication based on high throughput printing technology (Linköping University, Sweden), and quartz micro-balance (QCM) and microfluidics technology (International Islamic University, Malaysia) for the development of Micro Total Analysis System (µTAS) for point-of-care detection of dengue fever. The QCM-µTAS offers an ultrasensitive, cost-effective and mobile platform for the development of distributed biosensors for decentralization health care management and control of dengue in low and middle-income countries, where the access to resources and infrastructure is limited. The latest figures from Malaysia health authority shows a dramatic four times increase in dengue cases reported and with a triple increase in the number of deaths caused by dengue in the first quarter of 2014. This is a global threat not only limited to the citizens living in dengue hot spot countries, also to billions of international travelers travelling to the tropical countries. The Dengue-Screen test is expected to improve the health care management of dengue by providing rapid, mobile and cost effective diagnostics tools. Together with the scientific goal, the Dengue-Screen project also strengthens the collaboration between the involved Universities in the vision of exchange of researcher, knowledge and support future joint applications to larger national and international funding for long term collaboration.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Linköpings universitet
|
|
|
|
656796f1212eaade2e0ee176
|
2017
|
Sweden
|
The Swedish Research Council
|
2014294597
|
2014-3134
|
3
|
Mali
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.103311
|
0
|
0
|
0
|
0.103311
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
PERSONALISING ANTI MALARIA THE...RAPY THROUGH HAND-HELD POINT OF CARE NANOTECHNOLOGY DEVICES.
more
|
Personalising anti malaria the...rapy through hand-held point of care nanotechnology devices.
more
|
Aim: to test the first point o...f care application of drug resistance molecular markers for optimal antimalarial treatment, through a novel nanotechnology-based device with the potential of allowing optimal, personalized, malaria chemotherapy. Three studies: 1- lab fine tuning of the hand-held device for point of care parasite analysis in terms of specificity and sensitivity for genetic polymorphism call, vs established methods; information feedback to the technology developers for machine optimization. The device will fastly genotype the parasite prior to treatment, giving information for optimal ACT choices. 2- The field (Mali): an artemether-lumefantrine (AL) vs artesunate-amodiaquine (ASAQ) efficacy trial will be conducted in high transmission regions of Mali. The pfmdr1 N86Y mutation will be used as the reference (86N allele: resistance to AL; 86Y allele: resistance to ASAQ). In one arm the infection is genotyped. If 86Y, it is treated with AL, if 86N, with ASAQ. In another arm AL and ASAQ are used randomly without support information, in accordance to the national guidelines for the treatment of uncomplicated malaria. An increased in efficacy, as well as decreased selection of resistance associated alleles is expected at arm1. 3- Finally, the output of the trial will be re-analysed with reference methods (PCR-RFLP, direct PCR amplicon sequencing) for the post-hoc evaluation of the specificity and sensitivity of the device in the field conditions
more
|
|
12262
|
Malaria control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796f1212eaade2e0ee177
|
2014
|
UNFPA
|
UNFPA
|
2014003411
|
|
1
|
Pakistan
|
South & Central Asia
|
LMICs
|
ODA Grants
|
4
|
10
|
110
|
C01
|
0.025778
|
0.025778
|
0
|
0
|
0.025778
|
0.025778
|
|
|
|
|
Classified as not health-speci...fic activity
more
|
|
100
|
DATA ON POPULATION AND DEVELOP...MENT
more
|
Output 12: Data on Population ...and Development
more
|
Pakistan - Islamabad - Outcome... 4: Strengthened national policies and international development agendas through integration of evidence-based analysis on population dynamics
more
|
Data on Population and Develop...ment
more
|
13010
|
Population policy and administ...rative management
more
|
|
I.3. Population Policies/Progr...ammes & Reproductive Health
more
|
12000
|
Recipient government
|
|
|
|
|
656796f2212eaade2e0ee178
|
2014
|
Sweden
|
|
2014006122
|
2013-167
|
3
|
South of Sahara, regional
|
South of Sahara
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.11662
|
0
|
0
|
0
|
0.11662
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
SWE-2012-098:REDUCING RISKS OF... EMERGING ZOONOSES TO SMALLHOLDERS IN SUB-SAHARAN AFRICA: RIFT VALLEY FEVER AND LASSA FEVER AT THE HUMAN/LIVESTOCK/WILD
more
|
SWE-2012-098:Reducing risks of... emerging zoonoses to smallholders in sub-Saharan Africa: Rift Valley fever and Lassa fever at the human/livestock/wildlife interface
more
|
The proposed post doctoral pro...ject will be part of an international, interdisciplinary consortium, Dynamic drivers of disease in Africa (DDDAC), with the aim to reduce risks of disease emergence and negative consequences for human wellbeing by studying the interactions between ecosystems, wildlife, domestic animals and human health. The objectives of this project is to focus on Rift Valley fever (RVF) in Kenya and Lassa fever in Sierra Leone, two emerging zoonotic diseases caused by two different viruses, vectored by arthropods and rodents respectively in two different ecosystems. By studying the epidemiology of RVF, important knowledge will be gained that may contribute to establishing an early warning system. The experiences of RVF epidemiology will further be a basis in the work on developing tools to assess the health, economic, social and environmental impact of Lassa fever virus.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges Lantbruksuniversitet
|
|
|
|
656796f2212eaade2e0ee179
|
2014
|
Germany
|
BMZ
|
2014006464
|
201418342
|
1
|
Sierra Leone
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
1.79116
|
0.729733
|
0
|
0
|
1.79116
|
0.729733
|
0
|
1.3792
|
|
0.411968
|
Communicable diseases
|
Ebola
|
100
|
REHABILITATION OF HEALTH STRUC...TURES DURING AND AFTER THE EBOLA-EPEDEMIE, PSYCHOSOCIAL SUPPORT AND RECONSTRUCTION FACILITIES TO AFFECTED PERSONS IN SLE
more
|
Rehabilitation of health struc...tures during and after the Ebola-Epedemie, psychosocial support and reconstruction facilities to affected persons in SLE
more
|
Security of the company and la...sting rehabilitation of health structures during and after the Ebola-Epedemie, psychosocial support and reconstruction facilities to affected persons in Sierra Leone
more
|
|
73010
|
Reconstruction relief and reha...bilitation
more
|
|
VIII.2. Reconstruction Relief ...& Rehabilitation
more
|
22000
|
National NGOs
|
Donor country-based NGO
|
|
|
|
656796f2212eaade2e0ee17a
|
2014
|
UNICEF
|
UNICEF
|
2014006291
|
2580/A0/02/802/002
|
8
|
Libya
|
North of Sahara
|
UMICs
|
ODA Grants
|
4
|
10
|
110
|
C01
|
0.234282
|
0.234282
|
0
|
0
|
0.234282
|
0.234282
|
0
|
0
|
1
|
2
|
Classified as not health-speci...fic activity
more
|
|
100
|
BASIC EDUCATION SYSTEMS AND PO...LICIES
more
|
BASIC EDUCATION SYSTEMS AND PO...LICIES
more
|
BASIC EDUCATION SYSTEMS AND PO...LICIES
more
|
|
11110
|
Education policy and administr...ative management
more
|
|
I.1.a. Education, Level Unspec...ified
more
|
|
|
|
|
|
|
656796f3212eaade2e0ee17b
|
2017
|
Sweden
|
The Swedish Research Council
|
2014291739
|
2014-4224
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.028782
|
0
|
0
|
0
|
0.028782
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
COLONIZATION WITH AND POSSIBLE... SPREAD OF MULTI RESISTANT ESCHERICHIA COLI BACTERIA DURING HOSPITAL STAY IN TANZANIA
more
|
Colonization with and possible... spread of multi resistant Escherichia coli bacteria during hospital stay in Tanzania
more
|
Multiresistant bacteria are a ...fastly growing world-wide threat to human health. These resistant bacteria may easily spread between patients in the hospital setting in the absence of proper hygiene. Escherichia coli, present in the normal human gut, may produce enzymes called Extended Spectrum â-Lactamases (ESBL) or carbapenemases, which degrade penicillins, cephalosporins and carbapenems, respectively. There is no study in Africa, including Tanzania, investigating the risk to acquire ESBL- or carbapenemas-producing E. coli during hospital stay. We will investigate this risk for patients in the pediatric and gynecological units at a hospital in the Moshi area, Tanzania. The prevalence of colonization in faeces will be related to antibiotic use and possible contamination of the hospital environment with these bacteria. For comparison colonization of patients in the outpatient setting will be investigated as well. The prevalence of the globally present O25b-ST131 clone said to be largely responsible for the spread of ESBL will be determined as will the genotypes of ESBL- and carbapenemas-producing strains to elucidate possible transmission routes. The results will be used to increase the local knowledge of basic hygiene routines and their implementation in daily hospital care in order to decrease the spread of multiresistant bacteria between patients. The study will also increase the competence at the local microbiological laboratory in diagnosing resistant bacteria.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
656796f3212eaade2e0ee17c
|
2017
|
Sweden
|
The Swedish Research Council
|
2014296901
|
2014-6070
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.028665
|
0
|
0
|
0
|
0.028665
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
TOWARDS DISCOVERY OF ANTI-TUBE...RCULOSIS NATURAL PRODUCTS FROM GEOTHERMAL HOTSPRINGS IN TANZANIA
more
|
Towards Discovery of anti-Tube...rculosis Natural Products from Geothermal Hotsprings in Tanzania
more
|
The main objective of this pro...ject is to create the reciprocal scientific research collaboration between the Tanzanian and Swedish research groups by improving research and training in the area of natural products chemistry and related fields to international standards. Hence, this mutual collaborative research will focus on searching and developing anti-TB agents from plants surrounding the hot springs in Tanzania.
more
|
|
12263
|
Tuberculosis control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Stockholms universitet
|
|
|
|
656796f3212eaade2e0ee17d
|
2014
|
Sweden
|
|
2014005243
|
2011-7381
|
3
|
Uganda
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0364437
|
0
|
0
|
0
|
0.0364437
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
RATIONAL DOSAGE SCHEDULES OF A...RTEMISININ BASED COMBINATION TREATMENT FOR MALARIA DEVELOPED IN COLLABORATION BETWEEN SWEDEN AND UGANDA
more
|
Rational dosage schedules of a...rtemisinin based combination treatment for malaria developed in collaboration between Sweden and Uganda
more
|
Plasmodium falciparum malaria ...is a public health problem killing 0.9 million people yearly-most of them children in Africa South of Sahara. Artemisinin combination therapy (ACT) of short-acting artermisinin derivatives and long acting compounds are WHO recommended first line therapy. Alarming reports from Asia suggest that the sensitivity of artemisinin compounds in treating malaria may be decreasing. Consequently, correct dosages of ACT:s are critical to preserve the efficacy of these essential antimalarials in Africa. This project reevaluates recommended dosage regimens of ACT:s in treating uncomplicated falciparum malaria in Africa. We focus on improving the pediatric dosages of ACT:s and to investigate if locally available cooking oil may provide predictable absorption of lumefantrine, one of the most used ACT partner drugs. This collaborative project between Uganda and Sweden will strengthen competence in rational drug dosage principles in the two countries. A clinical pharmacology centre on rational drug therapy of infectious diseases including malaria and HIV/AIDS will be established in Uganda. Our collaboration builds on 10 years of joint research and training. We use state of the art methods in clinical drug design, in clinical research, in drug analysis and in concentration-effect modelling. The grant contributes to train junior and senior staff in Uganda and Sweden by frequent short visits to learn from each other and strengthen collaboration.
more
|
|
12262
|
Malaria control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796f3212eaade2e0ee17e
|
2018
|
Sweden
|
The Swedish Research Council
|
2014293071
|
2014-2823
|
3
|
Uganda
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.126576
|
0
|
0
|
0
|
0.126576
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
FUNDAMENTAL DETAILS OF SEVERE ...MALARIA
more
|
Fundamental Details of Severe ...Malaria
more
|
Rosetting is a virulent parasi...te phenotype associated with the occurrence of severe malaria, but what is its biological function to the parasite, why does it exist? We here suggest that rosetting enhances the invasion of the parasite into attached- rosetting- erythrocytes since we have found associations between the multiplication rate of the parasites, rosetting and peripheral parasitemia of Ugandan malaria patients. We were however not able to prove this at the molecular level with in vitro propagated strains using antibodies to the identified ligands. As a consequence we suggest to explore freshly isolated parasites (including merozoites) in detail, identify the red blood receptors used, ligands as well as serum proteins employed by the parasite at the level of the merozoite as well as the iRBC. Aims Aim 1. Isolate parasites of patients with different invasion characteristics Aim 2. Determine involved parasite ligands and receptors Aim 3. Understand merozoite invasion as a function of rosetting The purpose of the suggested work is to explore in what way Plasmodium falciparum erythrocyte rosetting enhances parasite invasion to initiate severe malaria. In an extended purpose we also aim to further the capacity for research in Uganda through the eduction of PhD students and post-docs, writing and presenting publications as well as the running of courses. Further, this will generate knowledge essential for the populations exposed to malaria.
more
|
|
12262
|
Malaria control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796f3212eaade2e0ee17f
|
2017
|
Sweden
|
The Swedish Research Council
|
2014292831
|
2014-4286
|
3
|
Uganda
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.028782
|
0
|
0
|
0
|
0.028782
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
FINDING NEW WAYS FOR THE P. FA...LCIPARUM MALARIA PARASITE TO INVADE RED BLOOD CELLS
more
|
Finding new ways for the P. fa...lciparum malaria parasite to invade red blood cells
more
|
Malaria kills almost one milli...on people every year. The symptoms include fever, anemia and sometimes death. P. falciparum is the parasite that is responsible for most of the deaths. It is a major contribution to children?s high morbidity and mortality in countries like Uganda. There is no vaccine and resistance against medications is an increasing problem. The parasites live inside erythrocytes where they multiply, and every 48 hours new mini-parasites, so called merozoites, exit the bursting old erythrocytes and enter new erythrocytes. We want to study the process of invasion into new erythrocytes. If we know exactly which proteins the merozoites bind to, we can use this in creating a vaccine or in forming new drugs. We will use combinations of parasites with defined invasion pathways or merozoite antigen knock-out parasites together with erythrocytes that lack specific antigens on their surface, or antibodies against these antigens. We will combine our own expertise of malaria with our collaborator?s expertise in erythrocyte variants, and we believe that this can create totally new opportunities to find new ways of invasion for the P. falciparum parasites. This knowledge is urgently needed to be able to make a vaccine against malaria.
more
|
|
12262
|
Malaria control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Lunds universitet
|
|
|
|
656796f3212eaade2e0ee180
|
2016
|
Sweden
|
The Swedish Research Council
|
2014006053
|
2013-6311
|
3
|
Vanuatu
|
Oceania
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0867177
|
0
|
0
|
0
|
0.0867177
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
SUSTAINABLE MALARIA FREEDOM ON... ISLANDS: THE STRATEGY FOR PLASMODIUM VIVAX ELIMINATION IN VANUATU
more
|
Sustainable malaria freedom on... islands: the strategy for Plasmodium vivax elimination in Vanuatu
more
|
For Asia Pacific sites with lo...w and unstable malaria transmission, elimination should be feasible. The challenges have to do with Plasmodium vivax. Islands provide natural ecological experiments and a great potential for intervention studies. On Aneityum island, Vanuatu both P. falciparum and P. vivax malaria were eliminated with short-term mass drug administration (MDA) in 1991 and sustained case surveillance and vector control with a high degree of community participation. I intend to i) assess whether malaria freedom can be sustained and ii) examine the applicability of the proposed elimination strategy at the natural endemic margin to larger areas. For its evaluation annual malariometric surveys of the entire population on Aneityum will be continued in comparison with six Vanuatu islands with variable malaria transmission. I specifically aim to: 1) investigate resurgence and relate them to anti-malaria immune responses and parasite antigen diversities, 2) examine the strategy of radical MDA in concert with vector control to eliminate P. vivax infections in selected islands, 3) assess feasibility of sustainable community commitment after malaria elimination and impacts of malaria elimination on people?s gains, tourism and community development. The outcomes can serve as a model for the proposal of community-directed strategies towards sustainable malaria freedom to follow the short-term push by external donors, particularly for the areas where P. vivax can be a concern.
more
|
|
12262
|
Malaria control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796f5212eaade2e0ee181
|
2017
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2015061123
|
SE-0-SE-6-6105013701-GGG-12250
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
1.755
|
0
|
0
|
0
|
1.755
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
REACT 2015-2018
|
ReAct 2015-2018
|
Continued core support to the ...network ReAct working to advocate for improved antiobiotic resistance preparedness globally with particular focus on Africa, Asia and Latinamerica.
more
|
|
12250
|
Infectious disease control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
UPPSALA UNIVERSITET
|
|
|
|
656796f9212eaade2e0ee182
|
2019
|
Sweden
|
The Swedish Research Council
|
20160290037
|
2015-03640_3
|
3
|
Angola
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0406096
|
0
|
0
|
0
|
0.0406096
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DIAGNOSING INFECTIOUS DISEASES... IN LOW-INCOME COUNTRIES AND REGIONS, HAVING UNDER-DEVELOPED INFRASTRUCTURES IN COLLABORATION WITH THE UN ORGAN FAO/IAEA
more
|
Diagnosing infectious diseases... in low-income countries and regions, having under-developed infrastructures in collaboration with the UN organ FAO/IAEA
more
|
Defined by the WHO, zoonotic d...iseases are those diseases and infections that are naturally transmitted between vertebrate animals and man with or without an arthropod intermediate. Such diseases represent one of the leading causes of illness and death from infectious disease. In most developing countries, zoonotic diseases are among those diseases that contribute significantly to an already overly burdened public health system. Infectious and parasitic diseases rank second among the top killers of the world and in low-income countries, especially in Africa, these diseases are even the dominant causes of death. The countrywide economic loss due to zoonotic disease is immense, cementing poverty and underdevelopment in many regions of the world.The two populations whose biological and social realities put them at greater risk for the negative impacts of zoonotic diseases are women and children.The present project will, in a multidisciplinary collaboration between a PhD student to be employed in the project and senior researchers at Uppsala University, the UN organ FAO/IAEA labs in Africa, Stockholm University, the Technical University of Denmark (DTU) and the Swedish University of Agricultural Sciences, develop a novel, sensitive, low-cost, diagnostics unit, providing an efficient analytical platform for detection of pathogens causing zoonotic infections in under-developed countries. The unit is based on state-of-the-art nano- and biotechnology and combines analysis of changes in rotation dynamics of probe-tagged magnetic nanobeads with a single-molecule detection approach which applies padlock ligation technique and rolling circle amplification (RCA) of the probed pathogen biomolecules (RNA and DNA). Specifically the project contains a number of well-defined, subtasks including:•Optimization and development of DNA-base detection of organisms having constant target sequence (first 18 months) and RNA-base detection of organisms having variable target sequence (year 1.5-3.5). This work includes extraction and purification of DNA/RNA target from samples received from the above mentioned labs in Africa as well as design of padlock probes and capture probes.•Optimization of the conjugation protocol used for attaching biomolecules on the surface of the magnetic nanobeads (first 24 months).•Measurements of the RCA products formed from the new padlock probes using the bead-based magnetic bioassay in a commercial AC suceptometer (year 2-3.5). This includes: Determining the limit of detection for the different pathogens, detection of antimicrobial resistance and resistant clones (salmonella and campylobacter), detection of a wide range of different strains of E. coli, investigation of mixed viral populations, subpopulations and individual copies of Avian influenza virus, West Nile virus and Rift Valley Fever virus in clinical samples, introducing new variants of the three viruses in the diagnostic assay.•Detection of pathogen targets in a working prototype
more
|
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala universitet
|
|
|
|
656796f9212eaade2e0ee183
|
2017
|
Sweden
|
The Swedish Research Council
|
20160290027
|
2015-03449_1
|
3
|
Bangladesh
|
South & Central Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0317363
|
0
|
0
|
0
|
0.0317363
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF AN IMPROVED, SI...NGLE-STRAIN, LOCALLY PRODUCED ORAL CHOLERA VACCINE
more
|
Development of an improved, si...ngle-strain, locally produced oral cholera vaccine
more
|
We have previously been deeply... involved in the development of the internationally available, closely related oral cholera vaccines (OCVs) Dukoral® and Shanchol®. These vaccines are effective, but the use of several strains and two inactivation methods makes their manufacture complex and relatively expensive, and OCVs are therefore still severely underused globally. In developing a new generation of OCVs, a central aim is to make it affordable for the populations in greatest need. This can be achieved by simplifying manufacture whilst maintaining the levels of protection afforded by currently available OCVs. Using a single vaccine strain and one inactivation method would considerably simplify and reduce the cost of manufacture. We have recently developed a novel concept and also engineered a new type of vaccine strains for such a new generation of OCVs, whereby the several V. cholerae O1 components in Dukoral and Shanchol can be replaced by a single-strain/single-formulation component with full retention of protective immunogenicity. We now propose, in collaboration with partners in India and Bangladesh, (1) to develop this novel single-strain OCV prototype combined with recombinantly produced cholera toxin B subunit into a truly low-cost, and also thermo- and pH-stable vaccine formulation for worldwide use including stockpiling purposes. A first-generation of the new OCV is planned to go into clinical testing in Bangladesh in early 2017 with product approval hoped for already in 2018/19. In parallel, (2) we will also develop a second-generation OCV formulation, which by including a novel cholera-toxin-derived mucosal adjuvant may provide adequate protection after single-dose administration, a feature which would be especially valuable for use in cholera outbreaks. The projected novel, low-cost, thermo- and pH-stable vaccine can be produced at a fraction of the cost of current vaccines, and should be attractive for worldwide use including stockpiling purposes. Relevant countries: Most countries in South and South-East Asia, the same for Sub-Saharan Africa, and selected low-income countries in the Western hemisphere, e.g. Haiti, Dominican rep.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
656796fa212eaade2e0ee184
|
2017
|
Sweden
|
The Swedish Research Council
|
20160290030
|
2015-03449_4
|
3
|
Democratic Republic of the Con...go
more
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0317363
|
0
|
0
|
0
|
0.0317363
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF AN IMPROVED, SI...NGLE-STRAIN, LOCALLY PRODUCED ORAL CHOLERA VACCINE
more
|
Development of an improved, si...ngle-strain, locally produced oral cholera vaccine
more
|
We have previously been deeply... involved in the development of the internationally available, closely related oral cholera vaccines (OCVs) Dukoral® and Shanchol®. These vaccines are effective, but the use of several strains and two inactivation methods makes their manufacture complex and relatively expensive, and OCVs are therefore still severely underused globally. In developing a new generation of OCVs, a central aim is to make it affordable for the populations in greatest need. This can be achieved by simplifying manufacture whilst maintaining the levels of protection afforded by currently available OCVs. Using a single vaccine strain and one inactivation method would considerably simplify and reduce the cost of manufacture. We have recently developed a novel concept and also engineered a new type of vaccine strains for such a new generation of OCVs, whereby the several V. cholerae O1 components in Dukoral and Shanchol can be replaced by a single-strain/single-formulation component with full retention of protective immunogenicity. We now propose, in collaboration with partners in India and Bangladesh, (1) to develop this novel single-strain OCV prototype combined with recombinantly produced cholera toxin B subunit into a truly low-cost, and also thermo- and pH-stable vaccine formulation for worldwide use including stockpiling purposes. A first-generation of the new OCV is planned to go into clinical testing in Bangladesh in early 2017 with product approval hoped for already in 2018/19. In parallel, (2) we will also develop a second-generation OCV formulation, which by including a novel cholera-toxin-derived mucosal adjuvant may provide adequate protection after single-dose administration, a feature which would be especially valuable for use in cholera outbreaks. The projected novel, low-cost, thermo- and pH-stable vaccine can be produced at a fraction of the cost of current vaccines, and should be attractive for worldwide use including stockpiling purposes. Relevant countries: Most countries in South and South-East Asia, the same for Sub-Saharan Africa, and selected low-income countries in the Western hemisphere, e.g. Haiti, Dominican rep.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
656796fa212eaade2e0ee185
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290086
|
2015-03442
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.11507
|
0
|
0
|
0
|
0.11507
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
COMBINING METABOLOMICS AND GEN...OMICS TO DEVELOP NEW APPROACHES FOR DIAGNOSING AND UNDERSTANDING BLOODSTREAM INFECTIONS CAUSED BY ANTIMICROBIAL RESISTAN
more
|
Combining metabolomics and gen...omics to develop new approaches for diagnosing and understanding bloodstream infections caused by antimicrobial resistan
more
|
Bloodstream infections (BSIs) ...caused by bacterial pathogens are a leading healthcare problem worldwide and a common cause of morbidity and mortality even in the countries with advanced healthcare systems. Treating the BSIs often demands intensive care measures including artificial ventilation and blood dialysis during such complications as multiple organ failure. The negative impact of BSI is especially pronounced in the low-income countries where the quality of the healthcare may be not capable of handling critically ill patients and/or the number of hospitals and their location is disproportional to demographic needs. Additionally, BSIs combined with antimicrobial resistance (AMR) constitute a particularly difficult problem to tackle. The infection develops quickly, the choice of effective therapies is limited and the process of selecting an appropriate treatment is slow as it involves the isolation of the etiologic agent. In case of multi-AMR of the pathogen, and lack of effective antimicrobials, medical professionals may have to fight the severe infection virtually unarmed with only empiric therapies. The grave scenario of returning to the pre-antimicrobial era is looming, and there are limited data regarding the epidemiology of AMR and BSI in low-income countries. Further, diagnostic methods for BSI are currently slow, ineffective and push healthcare personnel to administrate empirical treatment that may be not beneficial for the patient and may drive the AMR globally even further. Considering the urgent global challenges associated with AMR and BSIs, the aims of our study are:1.To investigate the burden and clinical epidemiology of BSI in a tertiary hospital in Vietnam, a lower-middle income country with a population of 90.6 million. The identification and characterization of the bacteria causing BSI will be performed in the context of AMR (using whole genome sequencing). The influence of AMR and the type of infecting pathogen on the disease outcome will be analyzed.2.To determine species specific and AMR metabolite signatures of bacteria causing BSIs. This will be performed in both blood samples from subjects with BSI and in bacterial cultures of AMR pathogens with distinct genetic backgrounds. Metabolomics data from clinical samples will be integrated with the corresponding data from genomic sequencing to produce reliable markers of AMR/BSI.3.To develop a rapid diagnostic approach for the analysis of metabolite signatures of AMR/BSI in dry blood samples. Such samples can be quickly shipped from remote areas to the bigger health centers/laboratories and we aim to analyze the efficiency and the impact of such diagnostic strategy in low-income settings in Vietnam. To achieve the identified aims we will combine cutting-edge methods as next generation bacterial genome sequencing and highly sensitive metabolite analysis with clinical data and advanced bioinformatics. Statistical significance will be secured through recruiting of 7,000 participa
more
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12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
656796fa212eaade2e0ee186
|
2016
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2012006011
|
SE-0-SE-6-5404004301-GGG-12250
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
0
|
0.00451715
|
0
|
0
|
0
|
0.00451715
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
NETWORK REACT
|
Network ReACt
|
ReAct is a non-profit internat...ional network to improve the management of antibiotic resistance. ReAct's vision is that current and future generations will have access to effective prevention and treatment of bacterial infections as part of their right to health. ReAct aims to increase the global awareness of the negative effects of ABR, to increase the evidence generation, to promote innovation etc.
more
|
|
12250
|
Infectious disease control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
UniversityCollegeResearchOther
|
|
|
|
656796fa212eaade2e0ee187
|
2017
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2012006132
|
SE-0-SE-6-5404004302-GGG-12250
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
0
|
0.0239709
|
0
|
0
|
0
|
0.0239709
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
NETWORK REACT - EXPANSION CSO ...CHILD
more
|
Network ReACt - Expansion CSO ...child
more
|
ReAct is a non-profit internat...ional network to improve the management of antibiotic resistance. ReAct's vision is that current and future generations will have access to effective prevention and treatment of bacterial infections as part of their right to health. ReAct aims to increase the global awareness of the negative effects of ABR, to increase the evidence generation, to promote innovation etc.
more
|
|
12250
|
Infectious disease control
|
|
I.2.b. Basic Health
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
UniversityCollegeResearchOther
|
|
|
|
656796fa212eaade2e0ee188
|
2020
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2016060395
|
SE-0-SE-6-5410005501-GGG-31182
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
0.71663559
|
0
|
0
|
|
2.171623
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
33
|
ICIPE 2016-2022
|
ICIPE 2016-2022
|
The primary mandate of icipe i...s research in integrated control methodologies for crop and livestock insect pests and other related arthropods, and insect vectors of tropical diseases and the strengthening of scientific and technological capacities
more
|
0
|
31182
|
Agricultural research
|
5.b,15.1,13.1,12.a
|
III.1.a. Agriculture
|
47054
|
International Centre of Insect... Physiology and Ecology
more
|
ICIPE/International Centre of ...Insect Physiology and Ecology
more
|
|
|
|
656796fb212eaade2e0ee189
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290025
|
2015-05954_2
|
3
|
Ghana
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0230139
|
0
|
0
|
0
|
0.0230139
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
PLASMODIUM FALCIPARUM MALARIA:... UNDERSTANDING THE ROLE OF CONSERVED VERSUS POLYMORPHIC ANTIGENS IN ACQUIRED IMMUNITY
more
|
Plasmodium falciparum malaria:... understanding the role of conserved versus polymorphic antigens in acquired immunity
more
|
A vaccine against malaria is u...rgently needed. The aim of this collaborative research project is to examine the role of antigen diversity on the antibody response and acquired immunity against clinical episodes of malaria; with the overall purpose of identifying candidate antigens to be included in a multi-component malaria vaccine. The project will describe parasite diversity in relation to antibody responses and protective immunity in individuals with different degree of exposure within defined geographical regions in Ghana and Kenya, as well as in travellers experiencing first time infections. We will focus on a subset of antigens (n=10) that have been shown to be potential targets of protective immunity and include both conserved and polymorphic proteins. We will sequence the parasites collected from the community to define precisely the diversity at the selected loci, express these antigens and then analyse the antibody responses to conserved and diverse antigens. We will specifically investigate combinations of antigens and variants of antigens to which antibodies confer protection. The project will use samples that are and have been collected within longitudinal well-established cohorts in Ghana and Kenya, as well as Swedish travelers. The proposed collaboration includes workshops and involves several PhD students including a joint PhD supervision between Ghana, Kenya and Sweden, and will be mutually beneficially for the research development of all partners.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796fd212eaade2e0ee18a
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290024
|
2015-05954_1
|
3
|
Kenya
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0230139
|
0
|
0
|
0
|
0.0230139
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
PLASMODIUM FALCIPARUM MALARIA:... UNDERSTANDING THE ROLE OF CONSERVED VERSUS POLYMORPHIC ANTIGENS IN ACQUIRED IMMUNITY
more
|
Plasmodium falciparum malaria:... understanding the role of conserved versus polymorphic antigens in acquired immunity
more
|
A vaccine against malaria is u...rgently needed. The aim of this collaborative research project is to examine the role of antigen diversity on the antibody response and acquired immunity against clinical episodes of malaria; with the overall purpose of identifying candidate antigens to be included in a multi-component malaria vaccine. The project will describe parasite diversity in relation to antibody responses and protective immunity in individuals with different degree of exposure within defined geographical regions in Ghana and Kenya, as well as in travellers experiencing first time infections. We will focus on a subset of antigens (n=10) that have been shown to be potential targets of protective immunity and include both conserved and polymorphic proteins. We will sequence the parasites collected from the community to define precisely the diversity at the selected loci, express these antigens and then analyse the antibody responses to conserved and diverse antigens. We will specifically investigate combinations of antigens and variants of antigens to which antibodies confer protection. The project will use samples that are and have been collected within longitudinal well-established cohorts in Ghana and Kenya, as well as Swedish travelers. The proposed collaboration includes workshops and involves several PhD students including a joint PhD supervision between Ghana, Kenya and Sweden, and will be mutually beneficially for the research development of all partners.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796fd212eaade2e0ee18b
|
2017
|
Sweden
|
The Swedish Research Council
|
20160290029
|
2015-03449_3
|
3
|
Mozambique
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0317363
|
0
|
0
|
0
|
0.0317363
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF AN IMPROVED, SI...NGLE-STRAIN, LOCALLY PRODUCED ORAL CHOLERA VACCINE
more
|
Development of an improved, si...ngle-strain, locally produced oral cholera vaccine
more
|
We have previously been deeply... involved in the development of the internationally available, closely related oral cholera vaccines (OCVs) Dukoral® and Shanchol®. These vaccines are effective, but the use of several strains and two inactivation methods makes their manufacture complex and relatively expensive, and OCVs are therefore still severely underused globally. In developing a new generation of OCVs, a central aim is to make it affordable for the populations in greatest need. This can be achieved by simplifying manufacture whilst maintaining the levels of protection afforded by currently available OCVs. Using a single vaccine strain and one inactivation method would considerably simplify and reduce the cost of manufacture. We have recently developed a novel concept and also engineered a new type of vaccine strains for such a new generation of OCVs, whereby the several V. cholerae O1 components in Dukoral and Shanchol can be replaced by a single-strain/single-formulation component with full retention of protective immunogenicity. We now propose, in collaboration with partners in India and Bangladesh, (1) to develop this novel single-strain OCV prototype combined with recombinantly produced cholera toxin B subunit into a truly low-cost, and also thermo- and pH-stable vaccine formulation for worldwide use including stockpiling purposes. A first-generation of the new OCV is planned to go into clinical testing in Bangladesh in early 2017 with product approval hoped for already in 2018/19. In parallel, (2) we will also develop a second-generation OCV formulation, which by including a novel cholera-toxin-derived mucosal adjuvant may provide adequate protection after single-dose administration, a feature which would be especially valuable for use in cholera outbreaks. The projected novel, low-cost, thermo- and pH-stable vaccine can be produced at a fraction of the cost of current vaccines, and should be attractive for worldwide use including stockpiling purposes. Relevant countries: Most countries in South and South-East Asia, the same for Sub-Saharan Africa, and selected low-income countries in the Western hemisphere, e.g. Haiti, Dominican rep.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
656796fd212eaade2e0ee18c
|
2019
|
Sweden
|
The Swedish Research Council
|
20160290036
|
2015-03640_2
|
3
|
Mozambique
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0406096
|
0
|
0
|
0
|
0.0406096
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DIAGNOSING INFECTIOUS DISEASES... IN LOW-INCOME COUNTRIES AND REGIONS, HAVING UNDER-DEVELOPED INFRASTRUCTURES IN COLLABORATION WITH THE UN ORGAN FAO/IAEA
more
|
Diagnosing infectious diseases... in low-income countries and regions, having under-developed infrastructures in collaboration with the UN organ FAO/IAEA
more
|
Defined by the WHO, zoonotic d...iseases are those diseases and infections that are naturally transmitted between vertebrate animals and man with or without an arthropod intermediate. Such diseases represent one of the leading causes of illness and death from infectious disease. In most developing countries, zoonotic diseases are among those diseases that contribute significantly to an already overly burdened public health system. Infectious and parasitic diseases rank second among the top killers of the world and in low-income countries, especially in Africa, these diseases are even the dominant causes of death. The countrywide economic loss due to zoonotic disease is immense, cementing poverty and underdevelopment in many regions of the world.The two populations whose biological and social realities put them at greater risk for the negative impacts of zoonotic diseases are women and children.The present project will, in a multidisciplinary collaboration between a PhD student to be employed in the project and senior researchers at Uppsala University, the UN organ FAO/IAEA labs in Africa, Stockholm University, the Technical University of Denmark (DTU) and the Swedish University of Agricultural Sciences, develop a novel, sensitive, low-cost, diagnostics unit, providing an efficient analytical platform for detection of pathogens causing zoonotic infections in under-developed countries. The unit is based on state-of-the-art nano- and biotechnology and combines analysis of changes in rotation dynamics of probe-tagged magnetic nanobeads with a single-molecule detection approach which applies padlock ligation technique and rolling circle amplification (RCA) of the probed pathogen biomolecules (RNA and DNA). Specifically the project contains a number of well-defined, subtasks including:•Optimization and development of DNA-base detection of organisms having constant target sequence (first 18 months) and RNA-base detection of organisms having variable target sequence (year 1.5-3.5). This work includes extraction and purification of DNA/RNA target from samples received from the above mentioned labs in Africa as well as design of padlock probes and capture probes.•Optimization of the conjugation protocol used for attaching biomolecules on the surface of the magnetic nanobeads (first 24 months).•Measurements of the RCA products formed from the new padlock probes using the bead-based magnetic bioassay in a commercial AC suceptometer (year 2-3.5). This includes: Determining the limit of detection for the different pathogens, detection of antimicrobial resistance and resistant clones (salmonella and campylobacter), detection of a wide range of different strains of E. coli, investigation of mixed viral populations, subpopulations and individual copies of Avian influenza virus, West Nile virus and Rift Valley Fever virus in clinical samples, introducing new variants of the three viruses in the diagnostic assay.•Detection of pathogen targets in a working prototype
more
|
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala universitet
|
|
|
|
656796fe212eaade2e0ee18d
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290062
|
2015-05874
|
3
|
Pakistan
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0460278
|
0
|
0
|
0
|
0.0460278
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF ANTIBIOFILM AND... ANTIMICROBIAL STRATEGIES IN PATHOGENS RELEVANT FOR DEVELOPING COUNTRIES
more
|
Development of antibiofilm and... antimicrobial strategies in pathogens relevant for developing countries
more
|
In developing countries, infec...tious diseases are still a major cause of morbidity or mortality. and in industrialized countries, they contribute to life quality. Biofilm formation is a significant virulence factor in 60-80% of the human microbial infections. Biofilm formation also is a cause of treatment failure, as biofilm forming cells are tolerant to antibiotics and the actions of the immune system. As established antibiotics score mostly insufficient, treatment strategies for biofilm forming bacteria are urgently required. In this project, biofilm formation of relevant pathogens will be analyzed by molecular and system biology methods, a screen for anti-microbial compounds will be performed and the mode of action of anti-microbial compounds will be analyzed on biofilm forming and multdrug resistant bacteria. The study will be extended to clinical isolates to demonstrate generality of the findings.Pakistani and Swedish scientists' experts will perform mutually beneficial collaborative research projects, visit to establish novel collaborations on both sides and to exchange ideas and knowledge to educate young researchers to work on basic scientific discoveries of infectious diseases that eventually translated into new therapies. With the support of Swedish research links, reciprocal educational workshops and seminars and hands-on trainings on techniques in infectious diseases will also be organized to establish a long-term research-oriented collaborative network.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796fe212eaade2e0ee18e
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290090
|
2015-03159
|
3
|
South of Sahara, regional
|
South of Sahara
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.12485
|
0
|
0
|
0
|
0.12485
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
IDENTIFICATION OF NOVEL OVIPOS...ITION ATTRACTANTS FOR MALARIA MOSQUITOES
more
|
Identification of novel ovipos...ition attractants for malaria mosquitoes
more
|
One child dies in malaria ever...y minute. The most effective way to prevent malaria transmission is vector control. The long-term sustainability of the currently used vector control tools, long lasting insecticide treated nets and indoor residual spraying is threatened by the development of insecticide resistance, as well as behavioural avoidance of adult mosquitoes. Furthermore they completely omit malaria vectors that do not (exclusively) feed on humans, indoors, at night. Therefore we need novel vector control tools. One attractive alternative is odour bated gravid traps. This intervention could target all malaria vectors irrespective of their host-seeking behaviour and insecticide resistance status. The purpose of this application is to identify novel oviposition attractants that can be used as odour bates in gravid traps. Recently we identified cedrol, a sesquiterpene alcohol as the first oviposition attractant for African malaria vectors. It is likely that gravid Anopheles females use a range of volatiles to find suitable oviposition sites and blends of attractant semiochemicals are expected to improve the efficiency of the gravid trap. Finding the source(s) of cedrol, might help to identify novel putative oviposition attractants released from the same or similar sources. The available data suggest that cedrol may be a result of fungal metabolism and we will therefore examine the fungal community in the oviposition substrates cedrol was identified from. We will utilize fungal cultures as substrates in ovipositon bioassays and collect and identify the volatiles released from the cultures. Based on the data novel putative oviposition attractants will be selected for evaluation in oviposition bioassays with An. gambiae females. Furthermore, recent evidence suggest that it may be possible to develop odour baits that attract a range of malaria vectors and thereby target all of them with an odour bated gravid trap. Here we will test the effect of cedrol and any other confirmed An. gambiae oviposition attractants on the oviposition behaviour of other primary and secondary malaria vectors like An. funestus An. coustani and An. rivulorum.. Identification of an odour blend that attract several primary and secondary malaria vectors would be a large step forward in the development of novel malaria control interventions.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Kungliga Tekniska högskolan
|
|
|
|
656796ff212eaade2e0ee18f
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290092
|
2015-03287
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.12485
|
0
|
0
|
0
|
0.12485
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
CLINICAL FIELD STUDIES FOR POI...NT-OF-CARE DIAGNOSTICS USING MINIATURE MICROSCOPY SCANNERS
more
|
Clinical field studies for poi...nt-of-care diagnostics using miniature microscopy scanners
more
|
We have developed a low-cost m...iniaturized microscopy scanner that digitizes patient samples at high magnification and transfers the generated virtual slides over mobile networks. Our central server receives the virtual slides and allows the biological samples to be remotely analyzed by automated computer vision or visually assessed by a human observer. A proof-of-concept study supported by the Swedish Research Council has been conducted in 2014-2015 and shown the method to be feasible. We now plan to implement the novel multipurpose diagnostic platform in two settings in Tanzania: 1) As a diagnostic method for detection of malaria in blood samples obtained from patients presenting with fever at the primary health care level and 2) as a diagnostic and monitoring method for detection of soil-transmitted helminthes and schistosomiasis in stool and urine obtained from schoolchildren within a transmission surveillance survey. Captured digital images of the specimens are transferred to the central server to detect malaria parasites in blood smears, and helminth eggs in stool and urine, and to return the results to the technician in the field.The point-of-care study will be carried out in the Bagamoyo District and the transmission surveillance study in the Masasi/Muheza District in Tanzania in collaboration with Muhimbili University of Health and Allied Sciences (MUHAS). The study will include a comparison with conventional microscopy with regard to diagnostic accuracy (sensitivity, specificity, positive and negative predictive value), an evaluation of usability, interpretability and assessment of time to achieve diagnosis. The project advances the field by bringing a powerful, multiplexed diagnostic tool from the laboratory to the point-of-care. The instruments are constructed out of components of mobile phones, make use of the expanding mobile networks and allow remote image processing in a highly scalable cloud computing environment. Previous mobile microscopy projects have been limited with regard to the sample area that can be captured, whereas the technology to be tested in the current project can digitally scan an entire microscopy slide. The method will aid in the combat of infectious diseases at the point-of-care level of health care and has the potential to improve access to diagnostics, enable task-shifting and shorten the time to diagnosis.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796ff212eaade2e0ee190
|
2017
|
Sweden
|
The Swedish Research Council
|
20160290028
|
2015-03449_2
|
3
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0317363
|
0
|
0
|
0
|
0.0317363
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF AN IMPROVED, SI...NGLE-STRAIN, LOCALLY PRODUCED ORAL CHOLERA VACCINE
more
|
Development of an improved, si...ngle-strain, locally produced oral cholera vaccine
more
|
We have previously been deeply... involved in the development of the internationally available, closely related oral cholera vaccines (OCVs) Dukoral® and Shanchol®. These vaccines are effective, but the use of several strains and two inactivation methods makes their manufacture complex and relatively expensive, and OCVs are therefore still severely underused globally. In developing a new generation of OCVs, a central aim is to make it affordable for the populations in greatest need. This can be achieved by simplifying manufacture whilst maintaining the levels of protection afforded by currently available OCVs. Using a single vaccine strain and one inactivation method would considerably simplify and reduce the cost of manufacture. We have recently developed a novel concept and also engineered a new type of vaccine strains for such a new generation of OCVs, whereby the several V. cholerae O1 components in Dukoral and Shanchol can be replaced by a single-strain/single-formulation component with full retention of protective immunogenicity. We now propose, in collaboration with partners in India and Bangladesh, (1) to develop this novel single-strain OCV prototype combined with recombinantly produced cholera toxin B subunit into a truly low-cost, and also thermo- and pH-stable vaccine formulation for worldwide use including stockpiling purposes. A first-generation of the new OCV is planned to go into clinical testing in Bangladesh in early 2017 with product approval hoped for already in 2018/19. In parallel, (2) we will also develop a second-generation OCV formulation, which by including a novel cholera-toxin-derived mucosal adjuvant may provide adequate protection after single-dose administration, a feature which would be especially valuable for use in cholera outbreaks. The projected novel, low-cost, thermo- and pH-stable vaccine can be produced at a fraction of the cost of current vaccines, and should be attractive for worldwide use including stockpiling purposes. Relevant countries: Most countries in South and South-East Asia, the same for Sub-Saharan Africa, and selected low-income countries in the Western hemisphere, e.g. Haiti, Dominican rep.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
656796ff212eaade2e0ee191
|
2018
|
Sweden
|
The Swedish Research Council
|
20160290091
|
2015-03217
|
3
|
Uganda
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.12485
|
0
|
0
|
0
|
0.12485
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
PAPER MICROARRAYS AS COMPREHEN...SIVE LOW-COST POINT OF CARE DIAGNOSTICS OF PAEDIATRIC INFECTIOUS DISEASES IN UGANDA (PI-POC)
more
|
Paper microarrays as comprehen...sive low-cost point of care diagnostics of paediatric infectious diseases in Uganda (PI-POC)
more
|
Paper microarrays as comprehen...sive low-cost point of care diagnostics of paediatric infectious diseases in Uganda (PI-POC)
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Karolinska Institutet
|
|
|
|
656796ff212eaade2e0ee192
|
2019
|
Sweden
|
The Swedish Research Council
|
20160290035
|
2015-03640_1
|
3
|
Uganda
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0406096
|
0
|
0
|
0
|
0.0406096
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DIAGNOSING INFECTIOUS DISEASES... IN LOW-INCOME COUNTRIES AND REGIONS, HAVING UNDER-DEVELOPED INFRASTRUCTURES IN COLLABORATION WITH THE UN ORGAN FAO/IAEA
more
|
Diagnosing infectious diseases... in low-income countries and regions, having under-developed infrastructures in collaboration with the UN organ FAO/IAEA
more
|
Defined by the WHO, zoonotic d...iseases are those diseases and infections that are naturally transmitted between vertebrate animals and man with or without an arthropod intermediate. Such diseases represent one of the leading causes of illness and death from infectious disease. In most developing countries, zoonotic diseases are among those diseases that contribute significantly to an already overly burdened public health system. Infectious and parasitic diseases rank second among the top killers of the world and in low-income countries, especially in Africa, these diseases are even the dominant causes of death. The countrywide economic loss due to zoonotic disease is immense, cementing poverty and underdevelopment in many regions of the world.The two populations whose biological and social realities put them at greater risk for the negative impacts of zoonotic diseases are women and children.The present project will, in a multidisciplinary collaboration between a PhD student to be employed in the project and senior researchers at Uppsala University, the UN organ FAO/IAEA labs in Africa, Stockholm University, the Technical University of Denmark (DTU) and the Swedish University of Agricultural Sciences, develop a novel, sensitive, low-cost, diagnostics unit, providing an efficient analytical platform for detection of pathogens causing zoonotic infections in under-developed countries. The unit is based on state-of-the-art nano- and biotechnology and combines analysis of changes in rotation dynamics of probe-tagged magnetic nanobeads with a single-molecule detection approach which applies padlock ligation technique and rolling circle amplification (RCA) of the probed pathogen biomolecules (RNA and DNA). Specifically the project contains a number of well-defined, subtasks including:•Optimization and development of DNA-base detection of organisms having constant target sequence (first 18 months) and RNA-base detection of organisms having variable target sequence (year 1.5-3.5). This work includes extraction and purification of DNA/RNA target from samples received from the above mentioned labs in Africa as well as design of padlock probes and capture probes.•Optimization of the conjugation protocol used for attaching biomolecules on the surface of the magnetic nanobeads (first 24 months).•Measurements of the RCA products formed from the new padlock probes using the bead-based magnetic bioassay in a commercial AC suceptometer (year 2-3.5). This includes: Determining the limit of detection for the different pathogens, detection of antimicrobial resistance and resistant clones (salmonella and campylobacter), detection of a wide range of different strains of E. coli, investigation of mixed viral populations, subpopulations and individual copies of Avian influenza virus, West Nile virus and Rift Valley Fever virus in clinical samples, introducing new variants of the three viruses in the diagnostic assay.•Detection of pathogen targets in a working prototype
more
|
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Uppsala universitet
|
|
|
|
65679700212eaade2e0ee193
|
2019
|
Sweden
|
The Swedish Research Council
|
20170290053
|
2016-05721
|
3
|
Bolivia
|
South America
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0380715
|
0
|
0
|
0
|
0.0380715
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
SUSTAINABLE DEVELOPMENT, FISCA...L POLICY AND NATURAL RESOURCES MANAGEMENT. BOLIVIA, CHILE AND PERÚ IN THE NORDIC COUNTRIES' MIRROR
more
|
Sustainable development, Fisca...l Policy and Natural Resources Management. Bolivia, Chile and Perú in the Nordic countries' mirror
more
|
The project Sustainable develo...pment, Fiscal Policy and Natural Resources Management. Bolivia, Chile and Peru in the Nordic countries'mirror is a collaborative network of scholars in Europe and Latin America. These researchers will develop a three year project with the aim of consolidate a high quality network in Natural Resources studies in the Sustainable development framework. They will do three workshops, two in Sweden and one in Bolivia. In the planning, there are six articles and one book, written in collaboration between the researchers of this project and with other scholars whom will enhance our proposal. Also, and in the aim to extract lessons from successful countries to the underdeveloped and developing regions, the group will share the results to a broader public and authorities through a web page and periodical policy briefs. The ambition is that the joint work envisaged in this proposal will generate a flexible but consistent research network, which will continue to cooperate in further directions. Specific focus may change, but it will be kept in the general idea of extracting lessons for development from successful experiences of countries that today are both rich and equitable in comparative international terms.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
9.5.1
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Umeå universitet
|
|
|
|
65679701212eaade2e0ee194
|
2020
|
Sweden
|
The Swedish Research Council
|
20170290014
|
2016-05627
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.130297
|
0
|
0
|
|
0.130297
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
COMBATTING ANTIMICROBIAL RESIS...TANCE BY NOVEL ANTIMALARIAL MOLECULES AGAINST PLASMODIUM VIVAX AND P. FALCIPARUM FROM SOUTH AMERICA AND SOUTH-EAST ASIA
more
|
Combatting antimicrobial resis...tance by novel antimalarial molecules against Plasmodium vivax and P. falciparum from South America and South-East Asia
more
|
Malaria, caused by parasites o...f the genus Plasmodium, is a global health concern, killing half a million humans yearly, mostly in the least developed countries. Malaria puts a heavy burden on the economic progress of the afflicted countries, especially in the low-income strata of those societies. Despite the severity of the problem, global efforts to combat malaria remain insufficient. No efficient malaria vaccine has been developed, and resistance to existing antimalarial drugs is emerging. This project aims at identifying novel promising lead compounds to combat resistant Plasmodium strains. Frontline techniques in yeast genomics will be used to identify the targets of molecules with antiplasmodial activity, and to improve the selectivity for the parasite ortholog of the target over the human counterpart. We have a special view to use the yeast system to access protein targets expressed in parasite life cycle stages that are difficult to access by other methods. The Brazilian partners contribute knowledge about disease models and genetic engineering of the malaria parasite, as well as dedicated genetic drug screening systems. The Cambodian partner is a world-leading expert in Plasmodium drug resistance genomics. The Swedish partners contribute bioinformatics, high-throughput yeast screening methodology, and medicinal chemistry for redesign and development of leads. We want to further develop a long-lasting international collaboration in this field of great global importance.
more
|
0
|
12182
|
Medical research
|
3.b
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
65679701212eaade2e0ee195
|
2018
|
Sweden
|
The Swedish Research Council
|
20170290025
|
2016-05660_1
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0460278
|
0
|
0
|
0
|
0.0460278
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF ODOR-BASED TOOL...S FOR PUSH-PULL MANAGEMENT OF FRUIT FLIES.
more
|
Development of odor-based tool...s for push-pull management of fruit flies.
more
|
In Africa, a guild of native a...nd invasive fruit fly species batters horticultural production, and threatens food production, food security and revenue, particularly of smallholder farmers. Here we propose to develop a set of odor-based tools that can be employed in push-pull strategies for sustainable control of fruit flies. These include: Development of a general fruit-odor based bait that target females across the fruit fly guild, Development a food-odor based bait that attracts multiple fruit fly species, Research and development of the use of native Cleoma gynandra as a 'catch crop' of Bactrocera spp, Field trials of baits and trap crop in suppressing fly populations, Unravel the parapheromone detection circuitry in fruit flies to rationally enhance baits. Cognizant of the fact that no silver bullet can lead to sustainable control of fruit flies, particularly not in low-income countries, we thus aim for development of a set of tools, that together with e.g. biological control, cultural practices, repellents, provide management options adapted to local agroecological settings.
more
|
|
31182
|
Agricultural research
|
|
III.1.a. Agriculture
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges lantbruksuniversitet
|
|
|
|
65679701212eaade2e0ee196
|
2019
|
Sweden
|
The Swedish Research Council
|
20170290054
|
2016-05726
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.126905
|
0
|
0
|
0
|
0.126905
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
ISLANDS OF SUCCESS. HOW TO MAK...E DEVELOPMENT PROJECTS WORK IN CHALLENGING CONTEXTS.
more
|
Islands of success. How to mak...e development projects work in challenging contexts.
more
|
The purpose of this project is... twofold: First, we will study how contexts characterized by poor institutions (in which corruption and clientelism are prevalent) pose challenges for development projects. Second, we will identify viable strategies for institution-building within development projects implemented in such contexts. There is urgent need to address the current knowledge gap in how to build good institutions in difficult contexts, in order to achieve development goals. We pay particular attention to the role of local participation as development strategy. It is commonly argued that projects should adopt an approach of local influence and ownership in order to be successful and produce lasting outcomes. However, scattered evidence suggests that in contexts of corruption and clientelism, participation tends to benefit primarily local elites and capture is common. This project suggests that in order to harness the promise of local participation, democratic participation should play a role in the input, decision-making side of the project. When it comes to implementation, the focus should be on impartiality in implementing and enforcing the rules of the organisation. In this four-year project, we will study four strategically selected cases of community electrification in Tanzania. In addition to a substantial number of interviews, we analyse project documentation, make observations in the field and organise group discussions for validating findings.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
9.5
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
65679701212eaade2e0ee197
|
2017
|
Sweden
|
Swedish International Developm...ent Authority
more
|
2017061151A
|
SE-0-SE-6-11035A0101-GGG-99810
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D01
|
0.748801
|
0.23571
|
0.00344955
|
0
|
0.748801
|
0.23571
|
0.00344955
|
0
|
0
|
0.748801
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
SECONDMENTS TO FAO - AMR
|
Secondments to FAO - AMR
|
Secondment to FAO/AMR. AMR is ...a cross-boarder health threat which is increasing in may coutries and threathens the healt of both people and animals. It is also extreamly costly in it allows to spread.
more
|
|
99810
|
Sectors not specified
|
|
IX. Unallocated / Unspecified
|
41301
|
Food and Agricultural Organisa...tion
more
|
FAO/FOOD AND AGRICULTURE ORGAN...IZATION
more
|
|
|
|
65679702212eaade2e0ee198
|
2017
|
Sweden
|
Ministry of Foreign Affairs
|
2017020112
|
UD2017-09841-FN
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.351
|
0.351
|
0
|
0
|
0.351
|
0.351
|
0
|
0.351
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
AMR INTERAGENCY COORDINATING G...ROUP WITHIN WHO
more
|
AMR Interagency Coordinating G...roup within WHO
more
|
AMR Interagency Coordinating G...roup within WHO
more
|
|
12250
|
Infectious disease control
|
|
I.2.b. Basic Health
|
41143
|
World Health Organisation - co...re voluntary contributions account
more
|
World Health Organisation - vo...luntary contributions account
more
|
|
|
|
65679702212eaade2e0ee199
|
2018
|
Sweden
|
The Swedish Research Council
|
20170290026
|
2016-05660_2
|
3
|
Ethiopia
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0460278
|
0
|
0
|
0
|
0.0460278
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF ODOR-BASED TOOL...S FOR PUSH-PULL MANAGEMENT OF FRUIT FLIES.
more
|
Development of odor-based tool...s for push-pull management of fruit flies.
more
|
In Africa, a guild of native a...nd invasive fruit fly species batters horticultural production, and threatens food production, food security and revenue, particularly of smallholder farmers. Here we propose to develop a set of odor-based tools that can be employed in push-pull strategies for sustainable control of fruit flies. These include: Development of a general fruit-odor based bait that target females across the fruit fly guild, Development a food-odor based bait that attracts multiple fruit fly species, Research and development of the use of native Cleoma gynandra as a 'catch crop' of Bactrocera spp, Field trials of baits and trap crop in suppressing fly populations, Unravel the parapheromone detection circuitry in fruit flies to rationally enhance baits. Cognizant of the fact that no silver bullet can lead to sustainable control of fruit flies, particularly not in low-income countries, we thus aim for development of a set of tools, that together with e.g. biological control, cultural practices, repellents, provide management options adapted to local agroecological settings.
more
|
|
31182
|
Agricultural research
|
|
III.1.a. Agriculture
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges lantbruksuniversitet
|
|
|
|
65679703212eaade2e0ee19a
|
2018
|
Sweden
|
The Swedish Research Council
|
20170290024
|
2016-05655_2
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0224386
|
0
|
0
|
0
|
0.0224386
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
TESTING THE POTENTIAL OF MICRO...ALGA-BACTERIA CONSORTIUM TO MANAGE PATHOGENS IN CULTURED SHRIMPS
more
|
Testing the potential of micro...alga-bacteria consortium to manage pathogens in cultured shrimps
more
|
Shrimp aquaculture is playing ...a pivotal role in ensuring food and nutritional security of the growing population, in most of the south Asian countries. However, disease outbreaks among cultured animals put significant constraint and affect the economic development. Vibrios belonging to the Harveyi clade are pathogenic marine bacteria affecting both vertebrates and invertebrates causing devastating luminescent Vibriosis. The virulence of vibrios is controlled by different regulatory systems, including quorum sensing (QS-bacterial cell to cell communication through signal molecules). We have in a previous study seen that in the presence of microalgae there is a down regulation of virulence genes expression in Harveyi clade vibrios with known QS regulation. In the present study, by a series of experiments, we will investigate the QS response of pathogenic Harveyi clade Vibrios when grown together with microalgae in the presence of the gnotobiotic Artemia as a crustacean model organism, and simultaneously determine the effect on survival of Artemia infected with pathogenic Harveyi clade vibrios. Our intention is to work and develop a small-scale gnotobiotic model system that is easy to control. At the latter part of the project period we will test the system on Asian tiger shrimp, which is a marine crustacean widely reared for food, and the most important cultured marine product in Sri Lanka and in India.
more
|
|
31382
|
Fishery research
|
|
III.1.c. Fishing
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Göteborgs universitet
|
|
|
|
65679704212eaade2e0ee19b
|
2018
|
Sweden
|
The Swedish Research Council
|
20170290027
|
2016-05660_3
|
3
|
Kenya
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0460278
|
0
|
0
|
0
|
0.0460278
|
0
|
0
|
0
|
0
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
DEVELOPMENT OF ODOR-BASED TOOL...S FOR PUSH-PULL MANAGEMENT OF FRUIT FLIES.
more
|
Development of odor-based tool...s for push-pull management of fruit flies.
more
|
In Africa, a guild of native a...nd invasive fruit fly species batters horticultural production, and threatens food production, food security and revenue, particularly of smallholder farmers. Here we propose to develop a set of odor-based tools that can be employed in push-pull strategies for sustainable control of fruit flies. These include: Development of a general fruit-odor based bait that target females across the fruit fly guild, Development a food-odor based bait that attracts multiple fruit fly species, Research and development of the use of native Cleoma gynandra as a 'catch crop' of Bactrocera spp, Field trials of baits and trap crop in suppressing fly populations, Unravel the parapheromone detection circuitry in fruit flies to rationally enhance baits. Cognizant of the fact that no silver bullet can lead to sustainable control of fruit flies, particularly not in low-income countries, we thus aim for development of a set of tools, that together with e.g. biological control, cultural practices, repellents, provide management options adapted to local agroecological settings.
more
|
|
31182
|
Agricultural research
|
|
III.1.a. Agriculture
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges lantbruksuniversitet
|
|
|
|
65679704212eaade2e0ee19c
|
2017
|
Sweden
|
The Swedish Research Council
|
20170290044
|
2016-05703_2
|
1
|
Kenya
|
South of Sahara
|
Other LICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0.2808
|
0.0702001
|
0
|
0
|
0.2808
|
0.0702001
|
0
|
0
|
0
|
0.2808
|
Communicable diseases
|
Communicable diseases Research... and Development
more
|
100
|
PORTABLE DIAGNOSTICS FOR DISEA...SE AND DRUG RESISTANCE WITH FOCUS ON MALARIA AND BACTERIAL INFECTIONS
more
|
Portable diagnostics for disea...se and drug resistance with focus on malaria and bacterial infections
more
|
Cassava is one of the most imp...ortant crops in the tropics with a remarkable tolerance to drought and ability to grow on poor soils. However, it has relatively low nutritional quality having dire implications for millions of people dependent on this staple crop. Particularly problematic is the low ß-carotene level, which can lead to provitamin A deficiency with severe health and economic consequences, including early mortality, impaired physical ability and blindness. Efforts to breed for varieties with increased b-carotene have therefore been undertaken, but is difficult to combine with high starch content, which is a vital trait for farmers's acceptance and the market value. Here we propose a new exploratory approach by cross-species comparative genomics and molecular network analysis in combination with functional testing by genetic transformation and the emerging technique of genome editing. We do this by generating transcript, smallRNA and metabolite data of specific varieties with different genetic background and ß-carotene content to identify new candidate genes and key enzymes leading to increased ß-carotene levels and sustained starch content. We will also identify molecular signatures associated to these traits to screen existing germplasms for more lines to be incorporated in breeding programs. The findings will serve either for marker assisted breeding or as engineering approach by gene-editing to overcome possible constrains in traditional breeding.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Sveriges lantbruksuniversitet
|
|
|
|
65679704212eaade2e0ee19d
|
2019
|
Sweden
|
The Swedish Research Council
|
20170290051
|
2016-05720_1
|
3
|
Kenya
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0581647
|
0
|
0
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0
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0.0581647
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0
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0
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0
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0
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Communicable diseases
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Communicable diseases Research... and Development
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100
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INTERACTION BETWEEN KNOWLEDGE ...TRADITIONS IN NON-FORMAL ADULT EDUCATION: SCANDINAVIAN INFLUENCES, INDIGENOUS KNOWLEDGE SYSTEMS AND COLONIAL LEGACIES IN
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Interaction between knowledge ...traditions in non-formal adult education: Scandinavian influences, Indigenous Knowledge Systems and colonial legacies in
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Our aim is to investigate how ...interaction between different knowledge systems and learning traditions are of importance for the design of non-formal adult education activities in Eastern Africa. The project will specifically study the implementation, dissemination and interpretation of Nordic popular education ideas in Kenya and Tanzania, and focus on how these ideas interact with, on one hand, so-called Indigenous Knowledge Systems, and, on the other hand, educational traditions linked to the formal educational system established in the context of European colonization. Research questions are: How do interactions between different knowledge systems and learning traditions influence the design of non-formal and informal adult education for structurally vulnerable groups in contexts marked by a colonial history? Does this kind of interaction between different knowledge systems and learning traditions create new innovative educational ideas? What role do these interactions and innovations play in improving participants' life chances? Two ethnographic case studies will be carried out: one focusing on the folk high school inspired Folk Development Colleges in Tanzania, and the other on agricultural adult education activities linked to the cooperative movement in Kenya. The project involves researchers from Sweden, Tanzania and Kenya and the project is also intended to contribute to the strengthening of the Eastern African research community within the field of adult education
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11182
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Educational research
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5;4.5;4.1
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I.1.a. Education, Level Unspec...ified
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51000
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University, college or other t...eaching institution, research institute or think-tank
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Linköpings universitet
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