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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Botswana: Guidelines on Good Manufacturing Practices

Ministry of Health, Gabarone, Botswana (2009) C2

Drug Advisory Board

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Assessment of Learning Disabilities: Cooperation between Teachers, Psychologists and Parents

Tuija Aro and Timo Ahonen Niilo Mäki Institute (2011) C2

African edition

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Community Health Extension Workers Strategy in Uganda (2015/16- 2019/20)

Ministry of Health, Republic of Uganda (2016) C1

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Guidelines for the Development of Pharmaceutical Services in Primary Health Care

Pan American Health Organization (PAHO) (2011) C_WHO

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The State of Access to Education by Women and Girls with Disabilities. The case of Uganda

Guzu Beatrice (Executive Secretary of NCD) (2014) C1

A Paper submitted to the 56th session of the UN Committee to CEDOW, July 2014, Geneva

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Ethical considerations for use of unregistered interventions for Ebola viral disease

World Health Organization (2014)

West Africa is experiencing the largest, most severe, most complex outbreak of Ebola virus disease in history. On 11 August 2014, WHO convened a consultation where the participants concluded that in the particular context of the current Ebola outbreak in West Africa, it is ethically acceptable to of... more

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WHO implementation tool for pre-exposure prophylaxis of HIV infection - Module 9

World Health Organization (WHO) World Health Organization (WHO) (2017) C_WHO

Module 9 Strategic planning July 2017 Module 9: Strategic planning. As WHO recommends offering PrEP to people at substantial HIV risk, this module offers public health guidance for policy-makers on how to prioritize services, in order to reach those who could benefit most from PrEP, and in wh... more

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Guidelines for essential trauma care
recommended

Mock, C et al World Health Organization (WHO) (2004) C_WHO

The Guidelines for essential trauma care seek to set achievable standards for trauma treatment services which could realistically be made available to almost every injured person in the world. They then seek to define the resources that would be necessary to assure such care. These include human res... more

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European Resuscitation Council Guidelines 2021: Paediatric Life Support

Van de Voorde, P.; et al. European Resuscitation Council (2021) CC

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SAM2020: An agenda for scaling-up the management of Severe Acute Malnutrition by 2020

Action Against Hunger (2015) C1

The agenda focuses on six critical changes necessary for more children suffering from SAM to access effective treatment. Building on lessons from the last decade, and the experiences of other successful health initiatives, the agenda addresses issues ranging from the creation of a more enabling envi... more

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Namibia: Community - Based Health Care Policy

Ministry of Health and Social Services (MOHSS) (2007) C1

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Pastoral care as a resource for development in the global healthcare context: Implications for Africa’s healthcare delivery system

Agbiji E., Agbiji O.M. AOSIS (2016) C1

HTS Teologiese Studies/Theological Studies ISSN: (Online) 2072-8050, (Print) 0259-9422

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Prevention of drug use in schools

Ranaweera, S.; and D. Samarashinghe World Health Organization (WHO), Regional Office for South-East Asia (2022) C_WHO

Schools are generally the most popular setting for drug-use- prevention programmes, and are used both by governmental and non-governmental agencies. This may be for many reasons: ease of obtaining funding for school drug-use-prevention programmes, the captive audience, and the popular perception... more

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National HIV and AIDS Priority Action Plan 2015/2016 - 2017/2018

Uganda AIDS Commission; Ministry of Health, Uganda (2015) C1

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Diagnostic errors. Technical Series on Safer Primary Care

World Health Organization WHO (2016) C_WHO

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Inclusive humanitarian action: a study into humanitarian partnership agreement (HPA) agency practice in the Nepal earthquake response

Searle, L. CBM; Humanitarian Advisory Group; Care, et al. (2016) C2

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Risk Communication and Community Engagement Considerations: Ebola Response in Democratic Republic of the Congo

World Health Organization WHO (2018) C_WHO

Overview: Risk communication and community engagement are essential for any disease outbreak response. This is particularly critical during outbreaks of Ebola which may create fear in the public and frontline responders alike due to severe presentation of symptoms, misunderstanding of the causes of ... more

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Group Interpersonal Therapy (IPT) For Depression

World Health Organization WHO (2016) C_WHO

WHO recommends interpersonal therapy (IPT) as a possible first line treatment for depression. With this new manual, the World Health Organization (WHO) gives guidance on the use of interpersonal therapy (IPT) using a 8 session group protocol. The manual - which is part of WHO’s mhGAP programme - d... more

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Manual for Health Counselors. The MANAS Program

S. Chatterjee and N. Chowdhary Sangath (2018) CC

This manual is a resource for Health Counselors working in Family Physician Clinics (FPC) as part of the MANAS program. This program is for common mental disorders like depression and anxiety seen in primary health care facilitieslike the FPC; since depression is the common... more

Guidelines for essential trauma care recommended

Guidelines for essential trauma care
recommended