Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Since December 2016, the El Niño Southern Oscillation (ENSO) has affected Peru, causing heavy rainfall, floods, landslides, hail and electric storms. Although the impact has been particularly serious in the northern coastal regions, levels of affectation are reported in all 24 of the country’s de...partments.
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Substance use disorders
Chapter G.3
The COVID-19 pandemic has affected job satisfaction among healthcare workers; yet this has not been empirically examined in sub-Saharan Africa (SSA). We addressed this gap by examining job satisfaction and associated factors among healthcare workers in Ghana and Kenya during the COVID-19 pandemic. W...e conducted a cross-sectional study with healthcare workers (N = 1012). The two phased data collection included: (1) survey data collected in Ghana from April 17 to May 31, 2020, and (2) survey data collected in Ghana and Kenya from November 9, 2020, to March 8, 2021. We utilized a quantitative measure of job satisfaction, as well as validated psychosocial measures of perceived preparedness, stress, and burnout; and conducted descriptive, bivariable, and multivariable analysis using ordered logistic regression. We found high levels of job dissatisfaction (38.1%), low perceived preparedness (62.2%), stress (70.5%), and burnout (69.4%) among providers. High perceived preparedness was positively associated with higher job satisfaction (adjusted proportional odds ratio (APOR) = 2.83, CI [1.66,4.84]); while high stress and burnout were associated with lower job satisfaction (APOR = 0.18, CI [0.09,0.37] and APOR = 0.38, CI [0.252,0.583] for high stress and burnout respectively). Other factors positively associated with job satisfaction included prior job satisfaction, perceived appreciation from management, and perceived communication from management. Fear of infection was negatively associated with job satisfaction. The COVID-19 pandemic has negatively impacted job satisfaction among healthcare workers. Inadequate preparedness, stress, and burnout are significant contributing factors. Given the already strained healthcare system and low morale among healthcare workers in SSA, efforts are needed to increase preparedness, better manage stress and burnout, and improve job satisfaction, especially during the pandemic.
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This guide supports the low-dose, high-frequency practice of scenerios needed to maintain competency in prevention and management of postpartum hemorrhage. The document is learner centered and is directly linked to service delivery standards. It is part of the Helping Mothers Survive Bleeding After ...Birth training package.
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CBDRR Practice. Case Studies 2
No publication year indicated.
More than 100 countries across the world now have reported cases of COVID-19. People traveling to these countries or people who have travelled abroad might possibly have come in contact with people affected with COVID-19 during their stay or even while in transit at the airports. Within these countr...ies, few countries have reported very large number of cases and deaths putting passengers from these countries particularly at higher risk of infection.
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t aims to enable participants to:
know more about children’s reactions to distress
know what psychological first aid for children is and what it is not
understand the three action principles of ‘Look, Listen and Link’ in relation to children
have practised providing PFA t...o a child and caregiver in distress
have considered complex reactions and situations
be aware of the importance of self-care when helping others.
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An Economist Intelligence Unit briefing paper | The Economist Intelligence Unit (EIU) undertook a study aimed at assessing the degree of commitment of 15 countries within the AsiaPacific region to integrating those with mental illness into their communities. The research was commissioned and funded... by Janssen Asia Pacific, a division of Johnson & Johnson Pte. Ltd. This report focuses on the results of this benchmarking study, called the Asia-Pacific Mental Health Integration Index. Drawing on lessons from the EIU’s 2014 European Mental Health Integration Index, this edition index compares the level of effort in each of the countries on indicators associated with integrating individuals suffering from mental illness into society. Data for the Index was collected between March and May 2016. The set of 18 indicators were grouped into four categories.
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Einen zweiseitigen Fragebogen in deutscher und arabischer Sprache zur Verwendung für das Kundengespräch in der Apotheke
PFA for Red Cross and Red Crescent Societies has several parts that can be used separately or together. It comprises this guide, a small booklet on PFA, and four training modules on PFA. This guide has general information about psychological first aid. It can be used on its own for psycho-education ...and as a reference for the training modules that accompany it. The training modules include instructions, notes, and training resources for the facilitators.
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Last update: 2 April 2020
Die Infoblätter können kostenlos auf der Webseite http://www.lgl.bayern.de/gesundheit/infektionsschutz/asylbewerber_gesundheit/index.htm unter dem Punkt "Asylbewerber und Gesundheit" heruntergeladen werden. Weitere Versionen in folgenden Sprachen dort erhältlich: Arabisch, Bulgarisch, Englisch, ...Französisch, Griechisch, Italienisch, Kroatisch, Polnisch, Rumänisch, Russisch, Serbisch (kyrillische oder lateinische Schrift), Spanisch, Türkisch, Ungarisch.
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The Sendai Framework for Disaster Risk Reduction highlights children as among the most vulnerable groups who must be empowered to get ready for natural hazards and play a vital role in preventing and reducing risk.
This child-friendly booklet is for kids who are 6-12 years old to generate earthqu...ake awareness among children through animated characters and simple but strong messages.
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