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Buruli ulcer (BU), the second most common mycobacterial disease in West Africa, is a necrotizing skin disease that can lead to high morbidity in affected patients. The disease is caused by Mycobacterium ulcerans (MU), whose major virulence factor is mycolactone. Although early infection can be treat
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ed with antibiotics, an effective preventative strategy is challenging due to unknown reservoir(s) and unresolved mode(s) of transmission.
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Indoor residual spraying (IRS) involves applying residual insecticide to potential vector resting sites on the interior surfaces of human dwellings or other buildings. The main aim of IRS is to kill vectors before they are able to transmit pathogens to humans. When carried out correctly, IRS has his
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torically been shown to be a powerful intervention to reduce adult vector density and longevity for mosquitoes, sand flies and triatomine bugs and can reduce the transmission of vector-borne diseases.
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All malaria-endemic countries in the Region of the Americas have taken on the challenge to eliminate the disease and to put in place measures to orient their health programs and strategies in that direction. This manual explains how to implement measures to achieve malaria elimination and prevent it
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s reestablishment by increasing the intensity and quality of interventions, reorienting initiatives, reducing delays that favor transmission, and ensuring adequate monitoring to adjust interventions.
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Paludisme | Guides médicaux MSF
recommended
La page intitulée « Paludisme » sur le site des Guides médicaux de Médecins Sans Frontières (MSF) fournit des directives cliniques détaillées pour le diagnostic, le traitement et la prévention du paludisme, en particulier dans les contextes humanitaires et les zones à ressources limitées.
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Elle décrit les différentes espèces de Plasmodium responsables de la maladie, les symptômes cliniques associés aux formes simples et sévères, les méthodes de diagnostic telles que les tests rapides et la microscopie, ainsi que les protocoles thérapeutiques adaptés à chaque situation, y compris pour les populations vulnérables comme les enfants et les femmes enceintes. La page aborde également les stratégies de prévention, notamment l'utilisation de moustiquaires imprégnées d'insecticide et la chimioprévention saisonnière dans les zones à transmission élevée. Ces recommandations sont basées sur les lignes directrices de l'Organisation mondiale de la santé (OMS) et l'expérience de MSF sur le terrain.
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This UNHCR guidance note provides comprehensive recommendations for the prevention and control of malaria in refugee settings worldwide. Aligned with the WHO Global Technical Strategy for Malaria, it outlines strategies to ensure access to effective prevention, diagnosis and treatment, implement sus
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tainable transmission reduction measures and strengthen surveillance systems. The document is intended as a practical resource for humanitarian actors, public health officials and partners involved in planning and implementing malaria programmes in refugee operations, with the aim of reducing malaria-related morbidity and mortality among vulnerable populations.
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WHO has updated it recommendations for 3 key malaria prevention strategies: seasonal malaria chemoprevention (SMC), perennial malaria chemoprevention (PMC – previously known as intermittent preventive treatment in infants, or IPTi) and intermittent preventive treatment of malaria in pregnancy (IPT
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p). When given to the young children and pregnant women who are most vulnerable to malaria, preventive chemotherapy has been shown to be a safe, effective and cost-effective strategy for reducing the disease burden and saving lives.
The updated recommendations on SMC, PMC and IPTp, published today in the WHO Guidelines for malaria, will support the broader use of chemoprevention among young children at high risk of severe malaria in areas with both seasonal and year-round transmission and promote expanded access to preventive chemotherapy in pregnancy.
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Relapsing malaria caused by Plasmodium vivax parasites poses a significant challenge to global malaria elimination efforts. About one third of the population remains at risk of contracting P. vivax malaria, and 85% of P. vivax infections stem from reactivated latent parasites, leading to chronic ana
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emia and increased morbidity and mortality. In addition to diagnostic tools that can detect the acute, blood-stage of P. vivax, new tools are needed to detect the dormant infections before they reactivate and contribute to morbidity and onwards transmission
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Implementation reference guide. This Malaria Surveillance Assessment Toolkit implementation reference guide is a comprehensive reference document, as well as a step by-step guide. It aligns and adapts available tools into a single set of standardized tools, which can be used to conduct malaria surve
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illance assessments across all transmission settings. Use of these standardized tools allows comparison of results between countries and within the same country over time, enabling countries to track their progress towards surveillance system strengthening.
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This selection of online courses provides a comprehensive education in malaria and related infectious diseases, set within the broader frameworks of global health and epidemiology. Courses such as the Global Disease Masterclass and Immunology: The Immune System and Infectious Diseases (both offered
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by Imperial College London on Coursera), explore malaria alongside diseases such as HIV, tuberculosis and emerging infections. Spanning several weeks, they provide insights into disease dynamics, immune responses, and public health interventions, and are suitable for learners from beginner to intermediate levels.
Specialised courses such as 'Medical Entomology' from the Institut Pasteur focus on mosquito vectors and parasite transmission, which are critical to malaria control. Additionally, French-language courses such as 'Le paludisme' from Aix-Marseille Université offer in-depth knowledge of malaria biology, prevention and treatment strategies.
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The Malaria Partners International Webinar Series highlights the vital importance of education in the fight against malaria. The series provides a variety of educational resources, which have been created and curated by Malaria Partners International and its global partners. Key webinars address cri
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tical topics such as the intersection of malaria and climate change, the impact of the pandemic on malaria control efforts, and the challenges of protecting vulnerable groups such as children and pregnant women. The series also highlights advances in malaria diagnostics, using case studies such as the Ghana Microscopy Project, and provides foundational knowledge on malaria transmission and prevention. By fostering awareness and knowledge sharing, these webinars support global efforts towards malaria eradication.
Accessed on 01/07/2025.
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Le paludisme reste un enjeu majeur de santé publique dans de nombreux pays à faible et moyen revenu. En 2018, l’OMS estimait à environ 228 millions le nombre de cas de paludisme, responsable de 405 000 décès principalement en Afrique subsaharienne. L’utilisation intensive des outils antipal
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udiques disponibles a permis de réduire significativement la transmission dans de nombreuses régions endémiques au cours de la dernière décennie. Cependant, l’éradication du paludisme dans les zones à forte transmission reste une perspective lointaine.
Ce MOOC offre aux participants un aperçu complet des diverses disciplines et questions clés de la recherche sur le paludisme. Il aborde notamment la biologie cellulaire et moléculaire des parasites, la recherche clinique sur le terrain et en milieu hospitalier, les technologies génomiques avancées, la recherche translationnelle sur les nouveaux outils de lutte contre les parasites et vecteurs (médicaments, vaccins), l’épidémiologie du paludisme et la recherche clinique en santé publique. Le cours est accessible à toute personne intéressée par le paludisme, à condition de posséder une formation initiale en sciences de la vie.
Ce MOOC fait partie des MOOCs du Diplôme des Maladies Infectieuses de l’Institut Pasteur (DNM2IP).
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This document outlines the best practices for mosquito control and surveillance in United Nations duty stations affected by mosquito-borne diseases. It sets out an integrated vector management (IVM) approach combining environmental, biological, mechanical, chemical and personal protection strategies
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to reduce mosquito populations and the transmission of diseases. Key elements include targeted control of larval and adult mosquitoes, the proper use of insecticides, community engagement, and ongoing surveillance.
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Vector control, alongside case management, remains the most effective approach to controlling and eliminating malaria. Key interventions, such as indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs), have significantly reduced malaria
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transmission in many African countries. This has enabled some countries to transition from the control phase to the elimination phase.
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Malaria Mini: The Basics is an accredited video course led by Dr John F. Fisher. It provides clinicians with the essential knowledge needed to recognise, prevent and treat malaria. In under an hour, it covers the parasite’s life cycle, transmission
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, diagnostic methods and the treatment of both uncomplicated and severe cases. It emphasises practical skills such as taking travel histories and identifying critical symptoms. Designed for flexibility, the course includes quizzes and offers Continuing Medical Education (CME) credits. It is accessible online for free.
Accessed on 17/07/2025.
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The National Strategic Plan on Malaria Prevention and Elimination Period 2021 – 2025 seeks to build on the previous national successes of the National Institute of Malariology, Parasitology, and Entomology (NIMPE) while addressing current challenges to reduce the overall burden of malaria in the S
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outhern and Central provinces and to initiate elimination activities in remaining focal areas of transmission throughout the country. The overall targets proposed to be reached by 2025 are:
Reduce malaria morbidity rate to below 0.015/1,000 population
Reduce malaria mortality rate to below 0.002/100,000 population
Eliminate malaria in 55 provinces
Ensure no malaria outbreaks
To address the urgent threat of drug resistance, Viet Nam has committed to accelerate efforts to eliminate locally-acquired P. falciparum by 2023.
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The WHO Mekong Malaria Elimination programme hosted a two-day workshop in Nha Trang City, Viet Nam, from 31 October to 1 November 2024, gathering representatives from the Greater Mekong Subregion (GMS) countries of Cambodia, China, the Lao People’s Democratic Republic, Thailand and Viet Nam, as we
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ll as technical experts. The workshop focused on reviewing malaria surveillance, progress towards elimination and prevention of re-establishment of malaria transmission.
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The overall objective of this approach is to accelerate efforts toward malaria elimination by increasing
access to early diagnosis and treatment. The specific objectives are to: Minimize the barriers that the population faces in accessing timely, quality diagnosis and treatment. Reduce the time bet
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ween diagnosis and the start of treatment. Reduce the parasite reservoir in symptomatic infected persons through early treatment. Maximize the transmission-blocking strategy by taking early action on gametocytes. Decrease the incidence of P. vivax relapses.Ultimately, disrupt malaria transmission and prevent mortalit.
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This ECDC overview summarises the number of travel-associated malaria cases reported in the EU/EEA in 2023. The cases are based on confirmed reports through the EpiPulse platform and only include infections acquired outside mainland Europe. The data show the number of cases and the infection rate pe
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r 100,000 travellers by country of infection. The aim is to inform public health authorities and travellers about malaria risk. Analyses are limited to locations with repeated cases or sufficient case numbers. Infection rates were calculated using IATA air travel data. The findings reflect reported cases only and do not imply ongoing transmission.
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Antimalarial chemotherapy is crucial for reducing morbidity, mortality, and drug resistance, and is the cornerstone of malaria control. Existing antimalarial drugs act at different stages of the parasite’s life cycle. These drugs range from classic agents such as chloroquine and quinine to newer a
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rtemisinin derivatives. They include tissue schizonticides, blood schizonticides, gametocytocides, and sporontocides. Artemisinin and its derivatives are the most effective and fastest-acting treatment against drug-resistant Plasmodium falciparum, achieving rapid parasite clearance and reducing transmission potential. Other key drugs include mefloquine, halofantrine, proguanil, sulfadoxine–pyrimethamine, atovaquone–proguanil, tetracyclines, clindamycin and azithromycin. Each of these drugs has a specific mechanism of action, pharmacokinetics, efficacy, safety profile and contraindications. Rational drug combinations and adherence to national treatment guidelines are essential for managing resistance, ensuring safety in vulnerable populations such as children and pregnant women, and optimising therapeutic outcomes in cases of both uncomplicated and severe malaria.
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Malaria remains a significant public health concern in the SADC region, accounting for 20% of childhood deaths, as well as prompting numerous outpatient visits and hospitalisations. Around three-quarters of the population, including 35 million children under the age of five and 8.5 million pregnant
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women, are at risk. Transmission patterns vary from high and stable in the north to malaria-free in the south, with low, unstable and seasonal zones in between. Although interventions such as indoor residual spraying (IRS), insecticide-treated nets (ITNs/LLINs), intermittent preventive treatment in pregnancy (IPTp), rapid diagnostic tests (RDTs), and artemisinin-based combination therapies (ACTs) have reduced the malaria burden, challenges persist in terms of funding, human resources, surveillance, and cross-border coordination. Achieving malaria elimination in the SADC region requires harmonised regional standards, strengthened surveillance, and improved access to quality treatment and policy prioritisation.
Accessed on 27/08/2025.
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