Quick reference guide on clinical management of patients with Dengue Fever
Protocol for the management of specialized centres for the treatment of people with alcohol and other drug abuse problems (CETAD) in the framework of the COVID-19 pandemic. Version 1.
Misceláneo
Capítulo J.3
Edición: Matías Irarrázaval & Andres Martin
Traductores: Fernanda Prieto-Tagle & Ana Pérez
Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Active Community Policy Strategy - Containment, mitigation and recovery plan on post-confinement in response to COVID-19
WHO regional publications. Western Pacific series ; no.3
The book has three main parts. The first part describes research in Viet Nam conducted on medicinal plants in line with the national policy of developing a system of medicine and pharmacy that integrates the modern and traditional systems. Th...e second part, which constitutes the core of the book, describes and illustrates the 200 most valuable species of wild and cultivated medicinal plants in Viet Nam. Each plant species is first documented by a full colour drawing illustrating the plant's distinctive features and natural colours. Explanatory notes for each species provide a concise description of the plant and give local names, flowering period, geographical distribution, parts used, chemical composition, and therapeutic uses. Information on indications and dosage is also provided.
To facilitate retrieval of information, the third part indexes plant species according to botanical name, Vietnamese name, and English name.
Large File to download: 75 MB!
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21.12.2020
Available in English, Spanish, Italian and Portuguese
Environmental Research Letters
Microplastic debris floating at the ocean surface can harm marine life. Understanding the severity of this harm requires knowledge of plastic abundance and distributions. Dozens of expeditions measuring microplastics have been carried out since the 1970s, but they ha...ve primarily focused on the North Atlantic and North Pacific accumulation zones, with much sparser coverage elsewhere. Here, we use the largest dataset of microplastic measurements assembled to date to assess the confidence we can have in global estimates of microplastic abundance and mass. We use a rigorous statistical framework to standardize a global dataset of plastic marine debris measured using surface-trawling plankton nets and coupled this with three different ocean circulation models to spatially interpolate the observations. Our estimates show that the accumulated number of microplastic particles in 2014 ranges from 15 to 51 trillion particles, weighing between 93 and 236 thousand metric tons, which is only approximately 1% of global plastic waste estimated to enter the ocean in the year 2010. These estimates are larger than previous global estimates, but vary widely because the scarcity of data in most of the world ocean, differences in model formulations, and fundamental knowledge gaps in the sources, transformations and fates of microplastics in the ocean.
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The Lancet Regional Health - Americas 2024;30: 100681
Published Online 3 February 2024 https://doi.org/10.1016/j.lana.2024.100681
El desarrollo de los pueblos y muy especialmente el de aquellos que se esfuerzan por escapardel hambre, de la miseria, de las enfermedades endémicas, de la ignorancia; que buscan unamás amplia participación en los frutos de la civilización, una valoración más activa de suscualidades humanas; q...ue se orientan con decisión hacia el pleno desarrollo, es observado por laIglesia con atención. Apenas terminado el segundo Concilio Vaticano II, una renovada toma deconciencia de las exigencias del mensaje evangélico obliga a la Iglesia a ponerse al servicio delos hombres para ayudarles a captar todas las dimensiones de este grave problema yconvencerles de la urgencia de una acción solidaria en este cambio decisivo de la historia de lahumanidad.
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21.12.2020
Available in English, Spanish, Italian and Portuguese
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