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Integrating Clinical Research into Epidemic Response: The Ebola Experience

Gerald Keusch, Keith McAdam, Patricia Cuff, Michelle Mancher, and Emily R. Busta National Academies of Sciences, Engineering, and Medicine (2017) C1

The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Repub... more

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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Leaving no one behind in the Covid-19 Pandemic: a call for urgent global action to include migrants & refugees in the Covid-19 response

Lancet Migration (2020) C2

Accessed: 27.04.2020 Leaving no one behind in the Covid-19 Pandemic: a call for urgent global action to include migrants & refugees in the Covid-19 response People on the move, whether they are economic migrants or forcibly displaced persons such asylum seekers, refugees, and internally displa... more

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Integrated Outbreak Analytics Toolkit

Global Outbreak Alerts Response Network GOARN (2025) CC

Integrated Outbreak Analytics (IOA) applies a multidisciplinary approach to understanding outbreak dynamics and to inform outbreak response. It aims to drive comprehensive, accountable, and effective public health and clinical strategies by enabling communities, and national and subnational health a... more

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Guidance on administration of COVID-19 vaccine boosters in Africa
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2022) CC

17 Febr. 2022. As part of the “Strategy to Achieve Global COVID-19 Vaccination by mid-2022”, global targets of 40% population coverage by end of 2021 and 70% coverage by June 2022 have been set by the World Health Organization (WHO), to successfully prevent severe illness and deaths, minimize so... more

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Responding to COVID-19: Guidance for humanitarian agencies

ALNAP; CERAH; LSHTM (2020) C2

How should humanitarian organisations prepare and respond to COVID-19 in humanitarian settings in low- and middle-income countries? This Rapid Learning Review outlines 14 actions, insights and ideas for humanitarian actors to consider in their COVID-19 responses. It summarises and synthesises the... more

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Haiti & Dominican Republic Cholera Operation Summary of the Plan of Action

International Federation of Red Cross And Red Crescent Societies (2015) C1

The Haiti & Dominican Republic Cholera Operation Plan of Action outlines the Red Cross's strategy to combat cholera on the island of Hispaniola following the 2010 outbreak in Haiti. As part of a 10-year national strategy, the plan includes an initial two-year emergency response (2014-2016) with a bu... more

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State of the world's nursing 2020: Investing in education, jobs and leaderships

Organisation mondiale de la Santé (2020) C_WHO

Nurses are critical to deliver on the promise of “leaving no one behind” and the global effort to achieve the Sustainable Development Goals (SDGs). They make a central contribution to national and global targets related to a range of health priorities, including universal health coverage, mental... more

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Safe Pregnancy and Birth. App

Hesperian (2015)

Available in English and Spanish, Hesperian’s comprehensive app on pregnancy and birth contains a wealth of information on: how to stay healthy during pregnancy how to recognize danger signs during pregnancy, birth, and after birth what to do when a danger sign arises whe... more

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UNICEF Cholera Toolkit - Arabic version

UNICEF (2016) CC

The document is a UNICEF cholera toolkit designed to support prevention, preparedness, and response to cholera outbreaks. It provides guidance on water sanitation, hygiene, and health education, along with practical tools and resources for managing outbreaks. It is intended for use by UNICEF teams, ... more

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Resilience Building: A guide to flood, cyclone, earthquake, drought and safe schools programming

Action Aid (2016) CC

This guidance document is meant to support practitioners working in disaster prone contexts to develop and implement more effective integrated resilience programming. It promotes programming that cuts across different fields of work like rights awareness, food security, emergency preparedness, livel... more

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Course: Antibiotic Resistance – The Silent Tsunami
recommended

ReAct (2019) C2

This course is designed for anyone with an interest in antibiotic resistance, no matter if you are a member of the public, a student, a health professional or any other expert. Our focus is to provide an overview of antibiotic resistance from several different angles. An important aim is to give an... more

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Melarsoprol Resistance in African Trypanosomiasis

Fairlamb, A.H.; Horn, D. Elsevier Ltd. (2018) CC

Arsenical monotherapies were previously very successful for treating human African trypanosomiasis (HAT). Melarsoprol resistance emerged as early as the 1970s and was widespread by the late 1990s. Melarsoprol resistance represents the only example of widespread drug resistance in HAT patients wher... more

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Antibiotic Resistance in Food Animals in Africa: A Systematic Review and Meta-Analysis

Founou, L.L.; D. Gyamfi Amoako, R. Carrel Founou, et al. (2015) C2

MICROBIAL DRUG RESISTANCEVolume 24, Number 5, 2018ªMary Ann Liebert, Inc.DOI: 10.1089/mdr.2017.0383 Antibiotic resistance (ABR) is a worldwide publichealth concern, with serious health, economic, and so-cietal repercussions. Its emergence is attributed to the se-lective pressure exerted by antib... more

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What Kind of Statetegic Policy for a Better Taking Care of Tuberculosis in Senegal

Abdoulaye F., M. Bop, A. Kane Journal of Tropical Diseases (2013) CC

HIV infection, due to the immunosuppressant that leads, nowadays constitutes an aggravating factor of endemic tuberculosis. Tuberculosis remains a huge burden to human health, even in the early 21st century. The situation is deteriorating in many countries, particularly because of the synergy with t... more

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Pandemic Preparedness and Response – Lessons from the H1N1 Influenza of 2009

Harvey V. Fineberg (2014)

New England Journal of Medicine 2014; 370:1335-1342. Please download the pdf-file from the nejm Website! A number of viruses have pandemic potential. The most recent global pandemic was caused by the influenza A (H1N1) strain, which was first detected in North America in 2009. The 2009 H1N1 pande... more

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Still at risk: Restrictions endanger Rohingya women and girls in Bangladesh

Vigaud-Walsh, Francisca Refugees International (RI) (2018) C1

In April 2018, Refugees International (RI) conducted a mission to Bangladesh, to research the GBV (gender-based violence) response for Rohingya women and girls. RI found that the entire humanitarian system is struggling under tremendous constraints in Bangladesh, and protection and health actors do ... more

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Colombia: Situational Report - June 2019

Respuesta a Venezolanos RAV (2019) CC

According to official figures from Migración Colombia by the end of June 2019, there were more than 1.4 million Venezuelan refugees and migrants living in Colombia. The majority of people have settled in the border departments of La Guajira and Norte de Santander, continuing to cities along the Car... more

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Vamos proteger-nos da cólera

UNICEF (2019) C_UNICEF

The PDF "Vamos proteger-nos da Cólera" provides comprehensive guidance on cholera prevention and response strategies, particularly for use in community health settings. It emphasizes the importance of safe water use by treating water with bleach, boiling it for at least 5 minutes, or using purifica... more

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World Heart Federation Cholesterol Roadmap 2022

Ray, K.K.; Ference, B.A.; Séverin, T. et al. World Heart Federation (2022) CC

Background: Atherosclerotic cardiovascular diseases (ASCVD) including myocardial infarction, stroke and peripheral arterial disease continue to be major causes of premature death, disability and healthcare expenditure globally. Preventing the accumulation of cholesterol-containing atherogenic lipopr... more

Guidance on administration of COVID-19 vaccine boosters in Africa recommended

Course: Antibiotic Resistance – The Silent Tsunami recommended

Guidance on administration of COVID-19 vaccine boosters in Africa
recommended

Course: Antibiotic Resistance – The Silent Tsunami
recommended