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Toolboxes
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2
Amélioration de la santé des populations en Afrique
n October 2019, WHO convened the first meeting of the Buruli ulcer laboratory network (BU-LABNET) in Yaoundé, Cameroon, bringing together 11 laboratories from nine countries at the Pasteur Centre of Cameroon (CPC), the network’s Coordinating Centre. The network was formally established at th
...
is meeting (1) and its members were those present. The objective of BU LABNET is to improve diagnosis of Buruli ulcer based on polymerase chain reaction (PCR) using standardized testing protocols, involving external quality assurance programmes and sharing knowledge among member laboratories.
more
The aim of the meeting was to broaden the network’s initiatives. Preliminary work involved integrating laboratory testing for skin NTDs other than Buruli ulcer, such as cutaneous leishmaniasis, mycetoma, leprosy and yaws, while extending the network’s reach to encompass additional laboratories.
Guidelines for the treatment of human African trypanosomiasis. Web Annex A. Commissioned by WHO Cochrane Response
WHO Guidelines for the Treatment of Human African Trypanosomiasis. Web Annex B
HAT diagnosis relies on laboratory techniques because clinical signs and symptoms are unspecific. Serodiagnostic tests exist only for Tbg and are based on the detection of specific antibodies, thus they are not confirmatory of infection. With the current low disease prevalence, the positive predicti
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ve value of serological tests is particularly low. Field-applicable tools include the card agglutination test for trypanosomiasis (CATT) used mainly in active screening by specialized mobile teams, and the rapid diagnostic tests that are more suitable for individual testing at point-of-care. Confirmation of Tbg infection requires microscopic examination of body fluids necessitating specific training. The best performing methods are laborious and reach 85–95% diagnostic sensitivity when performed by skilled personnel.
more
Having established the goal of eliminating transmission of gambiense human African trypanosomiasis (g-HAT) to humans, the HAT-e-TAG considered which elements should be developed to assess this goal.
HAT diagnosis relies on laboratory techniques because clinical signs and symptoms are unspecific. Serodiagnostic tests exist only for Tbg and are based on the detection of specific antibodies, thus they are not confirmatory of infection. With the current low disease prevalence, the positive predicti
...
ve value of serological tests is particularly low. Field-applicable tools include the card agglutination test for trypanosomiasis (CATT) used mainly in active screening by specialized mobile teams, and the rapid diagnostic tests that are more suitable for individual testing at point-of-care.
more
Trichiasis surgery for trachoma
recommended
3rd edition
Trachoma is the leading infectious cause of blindness worldwide. In April 2023, it was a public health problem
in approximately 40 countries, with an estimated 116 million people at risk and 1.5 million people affected
by the late blinding stage o
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f the disease (1). About 84% of those at risk of trachoma are in the World Health
Organization (WHO)’s African Region; about 52% of those at risk of trachoma live in Ethiopia
more
En tant que département technique de l'OMS chargé du paludisme, le Programme mondial de lutte contre le paludisme a un rôle important à jouer dans la conduite de la riposte mondiale contre cette maladie. Grâce à ses actions directes et à son réseau, il peut façonner l'écosystème du paludi
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sme et avoir un impact au niveau des pays. Dans cette optique, le Programme mondial de lutte contre le paludisme a élaboré une stratégie opérationnelle décrivant ses priorités pour la période 2024-2030 et les 4 leviers stratégiques pour contrôler et éliminer le paludisme qui relèvent de manière décisive du mandat du Programme : normes et critères, nouveaux outils et innovation, informations stratégiques axées sur les résultats et leadership. La stratégie décrit la façon dont le Programme mondial de lutte contre le paludisme se transformera également en la mise en place d’une collaboration plus efficace avec d’autres programmes, les bureaux régionaux et pays ainsi que les partenaires, en s’appuyant sur les enseignements tirés du treizième programme général de travail de l'OMS (GPW13) et des priorités du GPW14.
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Malaria in pregnancy is a significant health problem in malaria-endemic areas. It not only causes substantial childhood morbidity and mortality but also increases the risks of adverse events for pregnant women and their developing fetuses. Most of t
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he burden in these areas is due to infection with Plasmodium falciparum. Artemisinin-based combination therapy (ACT) has been recommended as first-line treatment for uncomplicated P. falciparum malaria in all populations, including pregnant women in their second and third trimesters, since 2006. However, for women in their first trimester of pregnancy, WHO recommended as first-line treatment a combination of quinine and clindamycin.
Based on a review of the evidence conducted in 2022, WHO now recommends artemether–lumefantrine, the ACT with the most human safety data available, as the preferred treatment for uncomplicated P. falciparum malaria in the first trimester of pregnancy. This document presents all relevant evidence on the effects and safety in early pregnancy of artemisinins and partner medicines used in ACTs from both studies in experimental animals and observational studies in humans.
more
Report of a virtual meeting 21–23 June 2022
WHO recommends artemisinin-based combination therapies for treating uncomplicated malaria, alongside studies to monitor treatment effectiveness. Given the threat of antimalarial resistance, including partial resistance in several African countries, molecular tools are vital for tracking resistance.
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In 2015, WHO launched the External Quality Assessment scheme for nucleic acid amplification testing to ensure reliable lab results. Coordinated by WHO and operated by the United Kingdom National External Quality Assessment Service for Parasitology, the scheme provides quality-controlled specimens and reports to help improve testing accuracy. Experts recently discussed expanding the scheme to include antimalarial resistance markers.
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2nd edition. The purpose of this document is to present updated standardized protocols that P. falciparum-endemic countries can use to determine the prevalence of parasites with pfhrp2/3 gene deletions causing negative HRP2 RDT results among symptomatic falciparum patients. The findings should be us
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ed to guide RDT selection; more specifically when to shift away from exclusive use of HRP2 to detect P. falciparum infections.
more
The aim of this protocol is to support the conduct of entomological comparative efficacy assessments for vector control products and the associated non-inferiority analysis. This evidence is used to inform discussions within the guidelines development context as to whether a new vector control prod
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uct should be considered as covered by one or more existing WHO recommendations or not. Alternatively, the evidence may inform the extension of an existing WHO recommendation or the development of a new one, provided that non-inferiority is demonstrated
more
This document outlines the best practices for mosquito control and surveillance in United Nations duty stations affected by mosquito-borne diseases. It sets out an integrated vector management (IVM) approach combining environmental, biological, mechanical, chemical and personal protection strategies
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to reduce mosquito populations and the transmission of diseases. Key elements include targeted control of larval and adult mosquitoes, the proper use of insecticides, community engagement, and ongoing surveillance.
more
The purpose of the guideline is to provide information to stakeholders on the necessary requirements for a complete prequalification dossier for insecticide-treated nets (ITNs). Its aim is to establish the baseline for dossier requirements which are necessary to assess ITN products for the purposes
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of prequalification, describe the data requirements for fulfilling each dossier module, and to provide standardized information for applicants and testing facilities generating data for ITN prequalification dossiers. The document is supported by implementation guidance documents which provide specific information and considerations for how applicants may approach the generation of supporting information and compilation of a complete product dossier.
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WHO guidelines for clinical management of arboviral diseases: dengue, chikungunya, Zika and yellow fever
recommended
The new WHO guidelines provide clinical management recommendations for four of the most widespread arboviruses affecting humans: dengue, chikungunya, Zika, and yellow fever.
An integrated approach is vital, as these four diseases often present with similar symptoms, especially in the early stages
...
of infection, and multiple arboviruses may circulate simultaneously in certain regions. This makes clinical differentiation challenging, particularly where diagnostic testing is not readily available.
This guideline is available in online format on the MAGICapp platform
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Le Plan d'action régional pour la vaccination dans les Amériques (RIAP) constitue une étape fondamentale pour consolider les progrès accomplis et offre une vision concrète pour relever les défis actuels et futurs en vue d'atteindre les objectifs fixés pour l'année 2030. Ce plan est essentiel
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pour renforcer les systèmes de santé, améliorer l'accès à la vaccination et optimiser la coordination entre les parties prenantes, en veillant à ce que tous les secteurs de la population aient la possibilité de bénéficier de programmes de vaccination résilients, efficaces et équitables tout au long du parcours de vie. Conçu dans le cadre stratégique de la politique pour la Revitalisation de la vaccination en tant que bien de santé publique pour une santé universelle et aligné sur le Programme pour la vaccination à l’horizon 2030, le plan d’action synthétise les priorités déterminées par les pays et les territoires, en utilisant des indicateurs qui ciblent six axes stratégiques d’intervention : la gouvernance, la surveillance, l'intégration, la communication, les ressources humaines et la prise de décision fondée sur des données probantes. Cette approche globale et inclusive réaffirme la volonté de parvenir à la couverture sanitaire universelle et d'atteindre les objectifs de développement durable. À l'avenir, il sera essentiel de maintenir un engagement fort à tous les niveaux en adaptant les stratégies aux changements que connaîtront les pays et les territoires, afin de faire progresser efficacement leurs efforts de vaccination par la mise en œuvre de meilleures pratiques et d’approches novatrices. Toutes les parties prenantes sont encouragées à participer à cet effort collectif pour que la vaccination soit considérée comme un bien public et que la population soit protégée contre les maladies évitables par la vaccination.
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