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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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A Textbook of Gynecology for Less-Resourced Locations

Heleen van Beekhuizen and Regine Unkels The Global Library of Women’s Medicine by Sapiens Publishing (2012)

This textbook seeks to support various levels of health personnel in less-resourced locations by providing evidence-based information about low-tech diagnostic and treatment options for common gynecological conditions such as cervical, ovarian and breast cancer, problems in early pregnancy, contrace... more

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Infection Rates and Risk Factors for Infection Among Health Workers During Ebola and Marburg Virus Outbreaks: A Systematic Review

Saranya A, Selvaraj E Lee, Mason Harrell, et al. (2018) CC

The Journal of Infectious Diseases, jiy435, https://doi.org/10.1093/infdis/jiy435. Many outbreaks reported high proportions of infected HWs. Similar HW infection rates and exposure risk factors in both past and recent EVD and MVD outbreaks emphasize the need to improve the implementation of approp... more

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Experience of living with type 1 diabetes in a low-income country: a qualitative study from Liberia

Adler, A.J.; Trujillo, C.; Schwartz, L.; et al. BMJ Journals (2021) CC

While epidemiological data for type 1 diabetes (T1D) in low/middle-income countries, and particularly low-income countries (LICs) including Liberia is lacking, prevalence in LICs is thought to be increasing. T1D care in LICs is often impacted by challenges in diagnosis and management. These challeng... more

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Climate Change and Pollen Allergies

Damialis, A.; Traidl-Hoffmann, C.; Treudler, R. (2019) CC

Biodiversity and Health in the Face of Climate Change pp 47–66 This chapter reviews the emerging importance of pollen allergies in relation to ongoing climate change. Allergic diseases have been increasing in prevalence over the last decades, partly as the result of the impact of climate change. ... more

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Human Resources for Health in Ethiopia

The Collaborative Africa Budget Reform Initiative (CABRI) (2016) C1

Ethiopia has seen high economic growth over the last decade, but remains a poor country with a high burden of disease. It has made considerable health gains in recent years, mainly by having health policies that focus on extending primary healthcare, using health extension workers. It... more

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Hidden Burdens of Conflict

International Alert, Global Initiative on Psychiatry; London School of Hygiene & Tropical Medicine, et al. (2017) C1

Some 32% of internally displaced persons (IDPs) in Ukraine suffer from post-traumatic stress disorder (PTSD) as a result of the conflict in the east. Among the 2,203 respondents surveyed across Ukraine, the study also found a high prevalence of mental disorders such as depression (22%) and anxiety ... more

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Сборник научных статей по материалам Конгресса ≪Психическое здоровье человека XXI века≫
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Союз охраны психического здоровья, Issa, world council for psychotheraphy et al. Союз охраны психического здоровья, Issa, world council for psychotheraphy et al. (2016) C2

В сборнике представлены статьи специалистов в сфере охраны психического здоровья по различным академическим дисциплинам, включая общую медицину, психиатрию, пси�... more

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COTS (Cholera Outbreak Training and Shigellosis) Program Health Promotion Worker Pocket Card
recommended

COTS Program Cholera Outbreak Training and Shigellosis (2011) CC

The COTS Cholera Outbreak Training and Shigellosis Program Pocket Card provides essential guidelines for health promotion workers to prevent and manage cholera and shigellosis outbreaks. It emphasizes proper sanitation, hygiene practices, safe water handling, and food safety as the primary methods f... more

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Generic protocol for a population-based, age- and gender- stratified sero-survey study for SARS-CoV-2

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1

The number of confirmed COVID-19 cases detected and reported in each country is influenced by many factors including limited access and/or utilization of healthcare and COVID-19 testing, limited surveillance, lack of knowledge amongst the population about when to seek testing, an asymptomatic pres... more

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Severe Acute Malnutrition Update: Current WHO Guidelines and the WHO Essential Medicine List for Children

Williams, Phoebe CM.; Berkley, James A. (2016) C1

This document was prepared in response to a need to review and potentially update the current recommendations for the antibiotic treatment of both inpatient and outpatient management of severe acute malnutrition (SAM). The current recommendations (Table 1) are based on guidelines published in 2013 i... more

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Antimicrobial resistance and causes of non-prudent use of antibiotics in human medicine in the EU

European Commission (2017) C1

Antimicrobial resistance (AMR) is an increasing worldwide public health problem with important implications for the European Union (EU). When antibiotics become ineffective, bacterial infections lead to increased morbidity, use of healthcare, mortality and cost. Globally, estimates suggest that ... more

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Psychological first aid for schools: Field operations guide, 2nd Edition

Brymer M., Taylor M., Escudero P., Jacobs A., Kronenberg M., Macy R., Mock L., Payne L., Pynoos R., & Vogel J. National Child Traumatic Stress Network (NCTSN) & National Center for PTSD (2012) C2

National Child Traumatic Stress Network National Center for PTSD | The field of school safety and emergency management has evolved significantly over the past decade. Tragically, acts of violence, natural disasters, and terrorist attacks have taught us many lessons. We also know that other types of ... more

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World Heart Federation Roadmap on Atrial Fibrillation – A 2020 Update

Freedman, B.; Hindricks, G.; Banerjee, A. Global Heart (2021) CC

The World Heart Federation (WHF) commenced a Roadmap initiative in 2015 to reduce the global burden of cardiovascular disease and resultant burgeoning of healthcare costs. Roadmaps provide a blueprint for implementation of priority solutions for the principal cardiovascular diseases leading to death... more

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Donor Funding for Newborn Survival: An Analysis of Donor-Reported Data, 2002–2010

Pitt1, C.; J. E. Lawn; M. Ranganathan et al. PLoS Med (2012) CC

Background:Neonatal mortality accounts for 43% of global under-five deaths and is decreasing more slowly than maternal or child mortality. Donor funding has increased for maternal, newborn, and child health (MNCH), but no analysis to date has disaggregated aid for newborns. We evaluated if and how a... more

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The Core Elements of Human Antibiotic Stewardship Programs in Resource-Limited Settings

Centers for Disease Control and Prevention CDC (2018) C_CDC

Antibiotic stewardship refers to coordinated efforts and activities that seek to measure and improve use of antibiotics. Implementation of ASPs has demonstrated positive public health and clinical impacts including reducing costs, lengths of hospital stays, and the burden of antibiotic resistance wh... more

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Summary the modified Delphi process for common structure and process indicators for hospital antimicrobial stewardship programs

Pollack L. A., D. Plachouras, H. Gruhler et al. Transatlantic Taskforce on Antimicrobial Resistance (TATFAR) (2015) C_CDC

The Transatlantic Task Force on Antimicrobial Resistance (TATFAR) fosters cooperation between the European Union (EU) andthe United States (US) on the issue of antimicrobial resistance. The first TATFAR recommendation refers to appropriate use of antimicrobials in human medicine through hospital Ant... more

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International Pharmaceutical Federation (FIP) Resource Page

International Pharmaceutical Federation (FIP) (2022) CC

The International Pharmaceutical Federation (FIP) is the global body representing over 4 million pharmacists and pharmaceutical scientists. We work to meet the world's health care needs. FIP is a non-governmental organisation that has been in official relations with the World Health Organization sin... more

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HIV Viral load testing operational guide. 60 Lessons learned from the OPP-ERA Project

OPP-ERA, et al. Solthis, et al. (2019) C1

The Guide to operationalize HIV viral load testing HIV presents 60 lessons learnt from the project in a systemic approach including: viral load strategy, laboratories, procurement and supply management, patient care and economy.

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How to Investigate Antimicrobial Use in Hospitals: Selected Indicators

USAID; Strengthening Pharmaceutical Systems (2008) C1

The purpose of this manual is to define a limited number of indicators that will objectively describe the management and use of antimicrobials in hospitals and to provide tools and step-by-step instructions for designing and carrying out an assessment of antibiotic use and management in hospitals. T... more

Сборник научных статей по материалам Конгресса ≪Психическое здоровье человека XXI века≫ recommended

COTS (Cholera Outbreak Training and Shigellosis) Program Health Promotion Worker Pocket Card recommended

Сборник научных статей по материалам Конгресса ≪Психическое здоровье человека XXI века≫
recommended

COTS (Cholera Outbreak Training and Shigellosis) Program Health Promotion Worker Pocket Card
recommended