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In November 2022, WHO launched a strategy to address antimalarial drug resistance in Africa, emphasizing the need for stronger surveillance. While regional monitoring networks have been active in other regions, most in Africa have not convened since 2017–2018. To renew collaboration, WHO organized
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a meeting bringing together countries from the African and Eastern Mediterranean regions. Participants shared recent data on antimalarial efficacy and resistance. While artemisinin-based combination therapies remain highly effective, some sites in Uganda and the United Republic of Tanzania reported lower-than-expected efficacy of artemether–lumefantrine. Delayed parasite clearance linked to Plasmodium falciparum Kelch-13 mutations was noted in Eritrea, Rwanda, Uganda and the United Republic of Tanzania. Discussions highlighted challenges in therapeutic efficacy studies, molecular marker surveillance and the need for improved genotyping to distinguish relapses from new infections.
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The WHO Mekong Malaria Elimination programme hosted a two-day workshop in Nha Trang City, Viet Nam, from 31 October to 1 November 2024, gathering representatives from the Greater Mekong Subregion (GMS) countries of Cambodia, China, the Lao People’s Democratic Republic, Thailand and Viet Nam, as we
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ll as technical experts. The workshop focused on reviewing malaria surveillance, progress towards elimination and prevention of re-establishment of malaria transmission.
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Malaria remains a significant public health concern, particularly in sub-Saharan Africa, where the majority of cases and fatalities occur, especially among children under five. Although there was a significant decline in global mortality and incidence between 2000 and 2015, progress has stalled sinc
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e the late 2010s due to climate change, conflict, drug and insecticide resistance, and the ongoing effects of the pandemic. Economic modelling shows that achieving the Sustainable Development Goal target of reducing malaria incidence by 90% by 2030 could generate substantial economic benefits, including an increase in GDP of $142.7 billion in endemic countries and $80.7 billion in global trade gains. To save lives, strengthen health systems, and drive sustainable economic growth, renewed investments in malaria control and elimination programmes, vaccine deployment, and coordinated international support are essential.
Accessed on 25/08/2025.
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The ongoing global pandemic of SARS-CoV-2 (Covid-19) poses unique diagnostic and clinical management challenges in regions where seasonal epidemic-prone diseases are endemic. Diseases such as dengue, malaria, seasonal influenza, leptospirosis, chikungunya, scrub typhus and bacterial infections often
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present with febrile syndromes that mimic or co-exist with SARS-CoV-2 infection, complicating diagnosis and treatment. This document provides guidelines for preventing, diagnosing and managing such co-infections. A high level of suspicion is essential during the monsoon and post-monsoon seasons, taking into account region-specific disease prevalence. While the WHO's case definition for SARS-CoV-2 is broad and sensitive, the need for parallel testing for co-infections, in accordance with the protocols of the MoHFW, ICMR, NVBDCP and NCDC, is necessitated by overlapping clinical features. Ensuring the availability of reliable rapid diagnostic kits and applying integrated clinical and laboratory approaches are crucial to improving patient outcomes in the context of concurrent infections.
Accessed on 26/08/2025.
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The emergence of SARS-CoV-2 has significantly altered the epidemiology of other infectious diseases, making investigations into its co-infection with malaria particularly relevant in endemic regions. This review examines the epidemiological, incubation and clinical features of the two diseases, high
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lighting the diagnostic challenges and strategies for accurate detection. Emerging immunological and genetic evidence indicates that prior exposure to malaria may reduce the severity of outcomes of SARS-CoV-2 infection through mechanisms involving ACE2 downregulation, TLR signalling, T-cell activation and upregulation of coinhibitory receptors. Additionally, potential control measures are discussed, including vaccine development, the repurposing of antimalarial drugs, the exploration of natural products, innovations in bioinsecticides, and the strengthening of electronic disease surveillance. These insights provide valuable guidance for clinical management and public health policy, while emphasising the need for continued research into the complex interactions between SARS-CoV-2 and malaria.
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Malaria is a significant risk for travelers to endemic regions. This patient information highlights essential prevention through mosquito protection and, when indicated, chemoprophylaxis with Atovaquone/Proguanil, Doxycycline, or Mefloquine. Emergency self-treatment options may be carried in specifi
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c settings. Travelers are advised to follow medication schedules carefully, use consistent bite protection, and seek immediate medical care if fever occurs during or after travel. Early recognition and treatment are crucial to prevent severe or life-threatening complications.
Accessed on 26/08/2025.
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The Centrum für Reisemedizin (CRM) is a comprehensive source of information, guidelines and resources on travel medicine for healthcare professionals and travellers. Its website offers up-to-date recommendations on disease prevention, vaccinations, malaria prophylaxis and health risks in different
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regions around the world. As part of the Thieme Group, the CRM promotes evidence-based medical counselling, training and educational materials for patients, with the aim of improving travel health outcomes and ensuring safe international mobility.
Accessed on 26/08/2025.
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The website "Bereit zu Reisen" provides comprehensive guidance on malaria prophylaxis for travelers to endemic regions. It emphasizes preventive strategies, including mosquito bite avoidance through protective clothing, insect repellents, and sleeping under treated nets. In addition, the site detail
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s chemoprophylaxis options, explaining recommended medications, dosing schedules, and duration of use before, during, and after travel. Emergency self-treatment procedures are also outlined for situations where immediate medical care is unavailable. Overall, the resource serves as a practical reference for travelers, combining evidence-based recommendations on exposure prevention, medication use, and prompt response to potential malaria symptoms to ensure safe and healthy travel.
Accessed on 26/08/2025.
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This infographic from the Tropeninstitut illustrates the malaria transmission cycle. It begins when an Anopheles mosquito bites a human and injects its sporozoites into the bloodstream. The sporozoites then travel to the liver where they mature and release merozoites back into the bloodstream. The m
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erozoites then infect red blood cells, resulting in the clinical symptoms of malaria. Some merozoites develop into gametocytes, which can be ingested by another mosquito when it bites the infected person again, thus continuing the transmission cycle.
The infographic serves as an educational tool, helping to explain the complex life cycle of the malaria parasite and the role of mosquitoes in spreading the disease.
Accessed on 26/08/2025.
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The poster is a public health communication tool designed to prevent the transmission of diseases such as chikungunya, dengue and Zika. The poster emphasises that Aedes mosquitoes bite aggressively during the day and sometimes at night, and recommends the key prevention strategies.
Accessed on 27
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/08/2025.
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The 'Mosquito Bite Prevention Poster – Kids' is an educational public health resource designed to teach children how to protect themselves from mosquito bites. Using clear, simple instructions and visual cues, the poster engages young audiences by emphasising practical prevention strategies, such
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as correctly applying insect repellent, wearing protective clothing and avoiding standing water where mosquitoes breed. This tool serves as a preventive guide for children and caregivers alike, encouraging health-conscious behaviours within the community.
Accessed on 27/08/2025.
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This website provides comprehensive guidance on vaccinations, malaria prevention and general health measures for travellers to tropical and developing regions. It emphasises two main vaccination criteria: the administrative requirements of the destination country and the actual health risks to the t
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raveller. Malaria prevention measures include chemoprophylaxis (e.g. atovaquone-proguanil, doxycycline or mefloquine) and vector control methods such as insecticide-treated nets, insect repellents and environmental protection measures. Additional travel health risks covered include bites from other arthropods, envenomations, dog and mammal bites, food and water hygiene, traveller's diarrhoea, and considerations for pregnant women, infants, the elderly, and people with chronic conditions. It strongly recommends carrying a travel medical kit and having a pre-travel consultation. Overall, the document aims to minimise illness and ensure safe travel.
Accessed on 27/08/2025.
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This ECDC overview summarises the number of travel-associated malaria cases reported in the EU/EEA in 2023. The cases are based on confirmed reports through the EpiPulse platform and only include infections acquired outside mainland Europe. The data show the number of cases and the infection rate pe
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r 100,000 travellers by country of infection. The aim is to inform public health authorities and travellers about malaria risk. Analyses are limited to locations with repeated cases or sufficient case numbers. Infection rates were calculated using IATA air travel data. The findings reflect reported cases only and do not imply ongoing transmission.
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Model List of Essential Medicines eEML
recommended
The eEML is a comprehensive, freely accessible online database containing information on essential medicine
The Mekong Malaria Elimination (MME) programme is an initiative aimed at supporting Greater Mekong Subregion (GMS) countries – Cambodia, Lao People's Democratic Republic, Myanmar, Thailand, Viet Nam, and Yunnan (China) – in achieving the goal of malaria elimination by 2030. Data for this epidemi
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ological summary were compiled from country reports. Between July and September 2024, 48 115 malaria cases were reported. During that period, GMS countries recorded 44% fewer cases, with P. falciparum + mixed and P. vivax cases declining by 81% and 36%, respectively. Meanwhile, testing declined by 25% when compared to the same period in 2023.
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This document provides technical guidance for manufacturers seeking World Health Organization (WHO) prequalification of in vitro diagnostic devices (IVDs) for malaria, with a focus on rapid diagnostic tests (RDTs) for symptomatic patients. It summarises the minimum performance requirements, includin
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g analytical and clinical performance standards, and emphasises considerations relating to diverse specimen types, testing environments and user populations in low- and middle-income countries. The guidance is aligned with the criteria and prequalification processes of the WHO Global Malaria Programme, while clarifying that demonstration of clinical utility is outside the scope of prequalification.
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Malaria remains a significant public health concern in the SADC region, accounting for 20% of childhood deaths, as well as prompting numerous outpatient visits and hospitalisations. Around three-quarters of the population, including 35 million children under the age of five and 8.5 million pregnant
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women, are at risk. Transmission patterns vary from high and stable in the north to malaria-free in the south, with low, unstable and seasonal zones in between. Although interventions such as indoor residual spraying (IRS), insecticide-treated nets (ITNs/LLINs), intermittent preventive treatment in pregnancy (IPTp), rapid diagnostic tests (RDTs), and artemisinin-based combination therapies (ACTs) have reduced the malaria burden, challenges persist in terms of funding, human resources, surveillance, and cross-border coordination. Achieving malaria elimination in the SADC region requires harmonised regional standards, strengthened surveillance, and improved access to quality treatment and policy prioritisation.
Accessed on 27/08/2025.
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En 2024, le Cap-Vert et l’Égypte ont été certifiés exempts de paludisme, ce qui prouve qu'il est possible d'éliminer la maladie avec une volonté politique et des ressources adaptées. Cependant, en Afrique, où se concentrent 95 % des cas mondiaux et 97 % des décès (en 2023), les progrès
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stagnent et l’objectif d’élimination d’ici 2030 est menacé. Les principaux obstacles sont le déficit de financement, la résistance aux insecticides et aux médicaments, l'expansion du moustique Anopheles stephensi, le changement climatique, les crises humanitaires et la croissance démographique. Pour inverser la tendance, l’Afrique doit accélérer le déploiement de nouveaux outils (moustiquaires de nouvelle génération, vaccins), renforcer la mobilisation des ressources nationales et diversifier les financements. Une feuille de route de l’Union africaine vise à transformer ces engagements en actions concrètes pour éliminer le paludisme et ses conséquences sanitaires et économiques.
Accessed 27/08/2025.
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YouTube Video
Tobacco mythbusters: tools for debunking common myths promoted by the tobacco industry
