|
65679f63212eaade2e0f052a
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
2016008403
|
108403
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0590168
|
0
|
0
|
0
|
0.0590168
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
SLAMF6 AND 2B4: ROLES AND MODE...S OF ACTION IN NORMAL IMMUNITY AND CANCER IMMUNOTHERAPY
more
|
SLAMF6 and 2B4: Roles and mode...s of action in normal immunity and cancer immunotherapy
more
|
A functioning immune system is... critical for successful treatment of cancer. Recent studies have shown an improvement of the immune response against cancer triggered by new drugs that block the function of certain types of receptors at the surface of immune cells. This project seeks to understand the role of two new potential molecular targets for immunotherapy against cancer in humans: the SLAMF6 receptor and the 2B4 receptor. These receptors are at the surface of key immune cells (CD8+T and NK lymphocytes), and they play an important regulatory role during the anti-tumor response mediated by these cells. The research team hypothesizes that pharmacological targeting of SLAMF6 and 2B4 could be helpful in the treatment of cancer. Findings from this research project will further basic knowledge of the role of SLAMF6 and 2B4 in immune cells, and determine whether these two receptors are valid clinical targets for pharmacologic treatment of human cancers. The project is led in Canada by the Institut de recherches cliniques de Montréal (affiliated with the University of Montreal), in collaboration with the Hadassah Hebrew University (Israel), Universidad Autónoma del Estado de Morelos (Mexico), and the Hebrew University (Israel). This project was selected and approved for funding through the second research competition of the Joint Canada-Israel Health Research Program, which is a partnership between Canada's International Development Research Centre, the Canadian Institutes for Health Research, the Israel Science Foundation and the Azrieli Foundation. This 7-year, $35M Canadian-Israeli effort draws on the unique scientific strengths of both countries and facilitates networking opportunities with peers from Africa, Asia, and Latin America. Projects include a plan for integrating researchers from low- and middle-income countries that will establish long-term scientific relationships.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Institut de recherches cliniqu...es de Montréal
more
|
|
|
|
65679f63212eaade2e0f052b
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
2017008587
|
108587
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.126417
|
0
|
0
|
0
|
0.126417
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
SYSTEMATIC AND COMPREHENSIVE A...NALYSIS OF MUTANT P53 PROTEINS IN LUNG CANCER IN VITRO AND IN VIVO
more
|
Systematic and comprehensive a...nalysis of mutant p53 proteins in lung cancer in vitro and in vivo
more
|
The gene p53 is a well-known t...umour suppressor gene that prevents cancer formation. It is the most commonly mutated gene among individuals with a diagnosis of cancer. Through recent advances in DNA sequencing abilities, researchers are now in a position to take a patient's tumour and identify the exact mutation in p53 and other cancers' genes, which potentially allows the development of personalized patient care. This project aims to systematically characterize proteins that bind to mutant p53 in order to identify all the proteins that stabilize and activate mutant p53, as well as the molecular pathways that are co-opted/corrupted by mutant p53. The analysis will occur in living tissues (in vivo) and in a laboratory vessel (in vitro). Once identified, the ultimate goal is to screen for compounds that disrupt these interactions with the hope of finding novel therapeutic strategies to treat patients harbouring these specific p53 mutations. The project findings will possibly extend to other cancers associated with p53 mutations.The project is being implemented by the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital (Toronto), the Weizmann Institute of Science (Israel), the Universidade Federal do Rio Grande do Sul (Brazil), and the Universidad San Martin (Argentina). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
11000
|
Donor Government
|
Sinai Health System
|
|
|
|
65679f63212eaade2e0f052c
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
2017008589
|
108589
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.13162
|
0
|
0
|
0
|
0.13162
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF EPITRANSCRIPTOME A...ND TRANSLATIONAL DYSREGULATION IN CANCER
more
|
The role of epitranscriptome a...nd translational dysregulation in cancer
more
|
Proteins represent the final p...roduct of genes and are implicated in governing most cellular functions. Production of proteins from genes is referred to as gene expression. Genes are first transcribed into messenger ribonucleic acid (mRNA). This is followed by mRNA translation, a process whereby the translation machinery reads the code stored in the mRNAs to produce proteins. In addition, mRNAs are also regulated by degradation. Malignant transformation is a phenomenon during which normal cells acquire malignant properties to become cancer. Malignant transformation and cancer progression are characterized by dramatic changes in gene expression. Recent years have brought evidence of dynamic chemical changes in mRNA molecules that have been shown to influence gene expression. These modifications are induced by factors called writers, removed by factors called erasers, and recognized by factors called readers. Levels and/or function of writers, erasers, and readers are reported to be altered in a variety of cancers, but their precise role in dysregulation of gene expression in cancer remains poorly understood. This project will investigate the contribution of mRNA modifications in cancer by employing a unique combination of recently developed systems of biology technologies and classical cellular and molecular biology techniques. The partners implementing this project are the Lady Davis Institute for Medical Research of McGill University (Montreal), the Sheba Cancer Research Centre (Israel), and the A.C. Camargo Cancer Centre (Brazil). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Sir Mortimer B. Davis Jewi...sh General Hospital / Centre intégré universitaire de santé et de serv
more
|
|
|
|
65679f63212eaade2e0f052d
|
2017
|
United States
|
State Department
|
2017008590
|
65_11302
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.2535159
|
0
|
0
|
0
|
0.76823
|
0
|
0
|
0
|
0
|
Emergency projects (meeting ad...ditional funding needs)
more
|
|
33
|
FUNDING FOR PROGRAM FOR PROTEC...TION AND LRNPROVED HEALTH AND EDUCATION FOR THE MOST VULNERABLE TIBETAN REFUGEES IN SOUTH ASIA
more
|
Funding for Program for Protec...tion and Lrnproved Health and Education for the Most Vulnerable Tibetan Refugees in South Asia
more
|
United States Population Migra...tion and Refugee Assistance, Appropriation 1143. Protection and assistance needs of refugees, migrants and conflict vicitms worldwide. [Tibet Fund]
more
|
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
|
22000
|
National NGOs
|
Tibet Fund
|
|
|
|
65679f63212eaade2e0f052e
|
2017
|
United States
|
State Department
|
2017008593
|
65_11319
|
1
|
Ethiopia
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
B03
|
0.99435
|
0.04348
|
0
|
0
|
0.99435
|
0.04348
|
0
|
0.99435
|
|
|
Emergency projects (meeting ad...ditional funding needs)
more
|
|
100
|
GENDER-BASED VIOLENCE (GENDER-...BASED VIOLENCE) RESPONSE AND PREVENTION PROGRAMMING FOR SOMALI REFUGEE WOMEN AND GIRLS IN BURAMINO AND HILAWEYN REFUGEE
more
|
Gender-Based Violence (Gender-...Based Violence) Response and Prevention Programming for Somali Refugee Women and Girls in Buramino and Hilaweyn Refugee Camps in Dollo Ado, Ethiopia
more
|
United States Population Migra...tion and Refugee Assistance, Appropriation 1143. Protection and assistance needs of refugees, migrants and conflict vicitms worldwide. [International Rescue Committee]
more
|
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
|
21000
|
International NGOs
|
International Rescue Committee
|
|
|
|
65679f63212eaade2e0f052f
|
2017
|
United States
|
State Department
|
2017008594
|
65_11320
|
3
|
Ethiopia
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
B03
|
0
|
0.80298
|
0
|
0
|
0
|
0.80298
|
0
|
0
|
0
|
0
|
Emergency projects (meeting ad...ditional funding needs)
more
|
|
100
|
GENDER-BASED VIOLENCE (GENDER-...BASED VIOLENCE) RESPONSE AND PREVENTION FOR SOMALI REFUGEES IN DOLLO ADO
more
|
Gender-Based Violence (Gender-...Based Violence) Response and Prevention for Somali Refugees in Dollo Ado
more
|
United States Population Migra...tion and Refugee Assistance, Appropriation 1143. Protection and assistance needs of refugees, migrants and conflict vicitms worldwide. [International Rescue Committee]
more
|
|
72010
|
Material relief assistance and... services
more
|
|
VIII.1. Emergency Response
|
21000
|
International NGOs
|
International Rescue Committee
|
|
|
|
65679f64212eaade2e0f0530
|
2018
|
Switzerland
|
Swiss Agency for Development a...nd Co-operation
more
|
2018008817
|
177-Q37-2018-51132
|
3
|
South Africa
|
South of Sahara
|
UMICs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0
|
0.005113
|
0
|
0
|
0
|
0.005113
|
0
|
0
|
0
|
0
|
Classified as not health-speci...fic activity
more
|
|
100
|
CONTRIBUTIONS DE PROGRAMME AUX... ONG SUISSES
more
|
Contributions de programme aux... ONG suisses
more
|
Action de Carême focalise son... programme sur la transformation positive de la société. Il s'adresse aux personnes de toutes confessions défavorisées sur le plan économique et social. Le droit à l'alimentation et une économie durable sont, en plus du thème transversal « genre », les thèmes stratégiques sur lesquels reposent le programme d'Action de Carême.
more
|
Based on information regarding... focus areas of specific implementing organization
more
|
99810
|
Sectors not specified
|
|
IX. Unallocated / Unspecified
|
22000
|
Donor country-based NGO
|
Fastenopfer
|
|
|
|
65679f64212eaade2e0f0531
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20190091503
|
109150
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.128963
|
0.0185706
|
0
|
0
|
0.128963
|
0.0185706
|
0
|
0.128963
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
IMMUNOMETABOLIC ROLES AND THER...APEUTIC POTENTIAL OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)
more
|
Immunometabolic roles and ther...apeutic potential of glucose-dependent insulinotropic polypeptide (GIP)
more
|
Obesity, type 2 diabetes, and ...cardiovascular disease share common features, including inflammation in multiple tissues. Inflammation arising in the context of diabetes or obesity is thought to contribute to some of the complications of these disorders, including increased risk of cancer and, most notably, higher rates of heart attacks and strokes. Inflammation may arise in part from the gut, which harbours bacterial organisms and products. Inflammation in turn induces the secretion of some gut peptides — hormonal messengers that relay signals from the gut to distant tissues, including immune cells. Preliminary data suggest that the increased action of a gut hormone known as glucose-dependent insulinotropic polypeptide (GIP) suppresses inflammation, whereas reduced or complete absence of GIP has the contrary effect, with adverse consequences for metabolism and accelerated development of atherosclerosis. There are currently multiple drug development programs under way to explore whether modulation of GIP activity might be a useful therapeutic approach to treat metabolic disorders such as diabetes and obesity. This project aims to understand how GIP controls inflammation in adipose tissue immune cells and in blood vessels susceptible to the development of atherosclerosis. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
11000
|
Donor Government
|
Sinai Health System
|
|
|
|
65679f64212eaade2e0f0532
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088214
|
108821
|
3
|
Egypt
|
North of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0386489
|
0
|
0
|
0
|
0.0386489
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ECONOMICS OF WATERPIPE TOB...ACCO SMOKING IN THE EASTERN MEDITERRANEAN
more
|
The Economics of Waterpipe Tob...acco Smoking in the Eastern Mediterranean
more
|
Tobacco remains a leading caus...e of death and ill-health globally, including in low and middle-income countries. Extensive empirical research confirms that higher excise taxes reduce tobacco use and discourage non-smokers from initiating smoking. However, this mechanism is still under-used in many countries.This project will specifically address the knowledge gap on the economics of waterpipe tobacco smoking in the eastern Mediterranean region. A four-institution collaboration across Lebanon, the West Bank, Egypt, and Jordan will generate critically needed information on the increasing popularity and rate of waterpipe smoking and model the economic impact of fiscal policies on tobacco control. It is led by the American University of Beirut, which also hosts the Global Knowledge Hub for waterpipe tobacco smoking. The project team will present this economic evidence in a format that can be used by policymakers to strengthen the coherence and coverage of tobacco control policies in the region with the aim of improving population health and contributing to public revenues.This project is funded through the Economics of Tobacco Control Research Initiative, an IDRC and Cancer Research UK co-funding partnership launched in October 2017. The objective is to generate evidence that provides the economic rationale for the prevention of tobacco-related diseases. The research uptake by policy actors will allow for the adoption of tobacco-control policies across low and middle-income countries.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
American University of Beirut
|
|
|
|
65679f64212eaade2e0f0533
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20170086461
|
108646
|
3
|
El Salvador
|
Caribbean & Central America
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0490203
|
0
|
0
|
0
|
0.0490203
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
MODELLING THE IMPACT OF STRATE...GIES TO ADDRESS THE BURDEN OF SUGARY DRINKS CONSUMPTION IN LATIN AMERICA AND THE CARIBBEAN
more
|
Modelling the impact of strate...gies to address the burden of sugary drinks consumption in Latin America and the Caribbean
more
|
Non-communicable diseases are ...responsible for more than half of the global burden of disease. Overweight and obesity are among the main modifiable risk factors worldwide and their prevalence has been steadily increasing in Latin America and the Caribbean. Sugar-sweetened beverages (SSBs) usually constitute a major source of discretionary calories, and have been linked to an increased risk of obesity, type 2 diabetes, several cancers, hypertension, coronary heart disease, and tooth decay. For these reasons, many countries are considering, or have begun implementing, a series of measures aimed at reducing SSB consumption. The implementation of these interventions needs to be supported by adequate scientific evidence and requires the commitment of different stakeholders in order to be successful. However, there is a lack of data on the burden of disease attributable to SSBs, and an absence of tools to assess the potential impact of policies. These factors result in a lack of consensus on the need to implement such policies and on the priority they should be given. The aim of this project, implemented by the Argentina-based Instituto de Efectividad Clinica y Sanitaria Asociación Civil is to fulfill these information needs by generating country-level evidence on the disease burdens attributable to SSB consumption and compiling a knowledge base on available interventions in the region. The research team will develop an economic model to estimate the disease burden and cost-effectiveness of relevant policies in Latin America and the Caribbean. The project will be carried out, and the model tested, in Argentina, Brazil, El Salvador, and Trinidad and Tobago. Results from this study are expected to empower decision-makers to select the best set of interventions to reduce the consumption of SSBs and their related health toll in Latin America and the Caribbean.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
IECS - Instituto de Efectivida...d Clinica Y Sanitaria Asociacion Civil
more
|
|
|
|
65679f64212eaade2e0f0534
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088222
|
108822
|
3
|
Far East Asia, regional
|
Far East Asia
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0309741
|
0.0101552
|
0
|
0
|
0.0309741
|
0.0101552
|
0
|
0.0309741
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
IMPROVING THE IMPLEMENTATION O...F TOBACCO TAXATION IN SOUTHEAST ASIA
more
|
Improving the implementation o...f tobacco taxation in Southeast Asia
more
|
Tobacco is a significant contr...ibutor to the rising global burden of non-communicable diseases. The Framework Convention on Tobacco Control, the implementation of which is a specific target (3.a) of the 2030 Sustainable Development Goals, recognizes that raising taxes is the most cost-effective tobacco control measure. However, tobacco tax evasion and the illicit tobacco trade can undermine the effective implementation of tobacco taxes. In 2013, a landmark package of tobacco tax reforms implemented in the Philippines raised taxes by 825%, leading to declines in smoking levels, particularly among the young and the poor. The revenue raised by this initiative paid for health insurance premiums for 14.7 million poor families. The Philippines is one of the highest consumers of illicit cigarettes, and prevalence rates are still high at 23%. Researchers have shown that this illicit trade undermines price and tax controls on tobacco and must be addressed for further momentum on tobacco tax reform.This project hypothesizes that the implementation of tobacco taxation in the Philippines can be improved by strengthening the local evidence base on tobacco tax evasion. Implemented by the Ateneo School of Government in Quezon City, Philippines, it will address the knowledge gaps on illicit trade dynamics that can undermine policy discussions on effective tobacco control. The project will also foster a network of economics researchers in the region who can apply methodological tools and gender-responsive policy analysis towards generating reliable evidence to inform tobacco control policy development. The research will generate independent data on the level and effect of tobacco tax evasion for the Philippines and, through the research fellow network, provide support for similar reform across Southeast Asia. This project is funded through the Economics of Tobacco Control Research Initiative, a co-funding partnership between IDRC and Cancer Research UK, launched in October 2017.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Ateneo de Manila University (Q...uezon City), Inc.
more
|
|
|
|
65679f64212eaade2e0f0535
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088191
|
108819
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0431501
|
0
|
0
|
0
|
0.0431501
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
STRENGTHENING THE EVIDENCE FOR... ADVANCING TOBACCO CONTROL POLICY IN MEXICO, COLOMBIA, AND INDIA
more
|
Strengthening the evidence for... advancing tobacco control policy in Mexico, Colombia, and India
more
|
The Framework Convention on To...bacco Control, the implementation of which is a specific target (3.a) of the 2030 Sustainable Development Goals, recognises that raising taxes is the most cost effective tobacco control measure. India, Mexico and Colombia are all rapidly growing economies with a large share of the youth population and where effective and pro poor means of making smoking unaffordable and improving health outcomes for the over 115 million number of smokers who live in these countries is a critical priority.The Global Tobacco Economics Consortium, led by the Instituto Nacional de Salud Pública in Mexico, will use the extended cost effective analysis method to estimate the effect at the national and subnational level of tobacco tax increases on health care costs and poverty. It will also deepen the understanding the differential impacts of the household costs of tobacco use on gender over time. The consortium brings together research teams in Colombia, Mexico, and India, who will improve their understanding of how tobacco control policy is developed in their specific country context. This will allow them to better communicate the value of using economic tools and evidence for setting optimal tobacco taxes. The integration of evidence from across these three country contexts will contribute to global literature and momentum for large scale tax increases in low and middle income countries for progress on the Sustainable Development Goals.This project is funded through the Economics of Tobacco Control Research Initiative, a 5-year IDRC and Cancer Research UK partnership launched in October 2017.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Instituto Nacional de Salud P...blica
more
|
|
|
|
65679f65212eaade2e0f0536
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088213
|
108821
|
3
|
Jordan
|
Middle East
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0386489
|
0
|
0
|
0
|
0.0386489
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ECONOMICS OF WATERPIPE TOB...ACCO SMOKING IN THE EASTERN MEDITERRANEAN
more
|
The Economics of Waterpipe Tob...acco Smoking in the Eastern Mediterranean
more
|
Tobacco remains a leading caus...e of death and ill-health globally, including in low and middle-income countries. Extensive empirical research confirms that higher excise taxes reduce tobacco use and discourage non-smokers from initiating smoking. However, this mechanism is still under-used in many countries.This project will specifically address the knowledge gap on the economics of waterpipe tobacco smoking in the eastern Mediterranean region. A four-institution collaboration across Lebanon, the West Bank, Egypt, and Jordan will generate critically needed information on the increasing popularity and rate of waterpipe smoking and model the economic impact of fiscal policies on tobacco control. It is led by the American University of Beirut, which also hosts the Global Knowledge Hub for waterpipe tobacco smoking. The project team will present this economic evidence in a format that can be used by policymakers to strengthen the coherence and coverage of tobacco control policies in the region with the aim of improving population health and contributing to public revenues.This project is funded through the Economics of Tobacco Control Research Initiative, an IDRC and Cancer Research UK co-funding partnership launched in October 2017. The objective is to generate evidence that provides the economic rationale for the prevention of tobacco-related diseases. The research uptake by policy actors will allow for the adoption of tobacco-control policies across low and middle-income countries.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
American University of Beirut
|
|
|
|
65679f65212eaade2e0f0537
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180086412
|
108641
|
3
|
Lebanon
|
Middle East
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.20633
|
0
|
0
|
0
|
0.20633
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TACKLING SCHOOL AND COMMUNITY ...DRIVERS OF CHILDREN'S UNHEALTHY DIETS IN ARAB CITIES
more
|
Tackling school and community ...drivers of children's unhealthy diets in Arab cities
more
|
Low and middle-income countrie...s of the Arab region are undergoing a rapid nutrition transition with increases in the prevalence of overweight and obesity among young and adult populations accompanied by a rise in diet-related non-communicable diseases (NCDs). Although children's food choices and dietary behaviours are early risk factors for the development of NCDs, research on what influences these behaviours remains scant in the region. School and neighbourhood environments have the potential to counter the effect of societal forces on children's diets, but little is known about the drivers of children's food choices within these environments and their potential to be used as levers for intervention. This research project, implemented in collaboration with the American University of Beirut, aims to inform context-specific interventions targeting childhood overweight in the urban settings of Greater Beirut and Greater Tunis, and ultimately to foster the development of food environments that enable healthy eating among children and their families. The research uses a combination of quantitative and qualitative methods to assess individual diets and the contextual factors that influence children's food choices. Innovative locally relevant tools will be developed to describe and map food environments and food choices experienced by children at the level of families, schools, and communities. The aim is to identify moments in the daily lives of children that represent threats to, and opportunities for, healthy eating. These results, together with nutrition survey data, will inform the development of interventions that influence children's eating in Lebanon and Tunisia. Possible interventions may include school and community-level food policies with the potential for replicability in similar urban contexts of the region.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
American University of Beirut
|
|
|
|
65679f65212eaade2e0f0538
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088212
|
108821
|
3
|
Lebanon
|
Middle East
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0386489
|
0
|
0
|
0
|
0.0386489
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ECONOMICS OF WATERPIPE TOB...ACCO SMOKING IN THE EASTERN MEDITERRANEAN
more
|
The Economics of Waterpipe Tob...acco Smoking in the Eastern Mediterranean
more
|
Tobacco remains a leading caus...e of death and ill-health globally, including in low and middle-income countries. Extensive empirical research confirms that higher excise taxes reduce tobacco use and discourage non-smokers from initiating smoking. However, this mechanism is still under-used in many countries.This project will specifically address the knowledge gap on the economics of waterpipe tobacco smoking in the eastern Mediterranean region. A four-institution collaboration across Lebanon, the West Bank, Egypt, and Jordan will generate critically needed information on the increasing popularity and rate of waterpipe smoking and model the economic impact of fiscal policies on tobacco control. It is led by the American University of Beirut, which also hosts the Global Knowledge Hub for waterpipe tobacco smoking. The project team will present this economic evidence in a format that can be used by policymakers to strengthen the coherence and coverage of tobacco control policies in the region with the aim of improving population health and contributing to public revenues.This project is funded through the Economics of Tobacco Control Research Initiative, an IDRC and Cancer Research UK co-funding partnership launched in October 2017. The objective is to generate evidence that provides the economic rationale for the prevention of tobacco-related diseases. The research uptake by policy actors will allow for the adoption of tobacco-control policies across low and middle-income countries.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
American University of Beirut
|
|
|
|
65679f65212eaade2e0f0539
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088193
|
108819
|
3
|
Mexico
|
Caribbean & Central America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0503419
|
0
|
0
|
0
|
0.0503419
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
STRENGTHENING THE EVIDENCE FOR... ADVANCING TOBACCO CONTROL POLICY IN MEXICO, COLOMBIA, AND INDIA
more
|
Strengthening the evidence for... advancing tobacco control policy in Mexico, Colombia, and India
more
|
The Framework Convention on To...bacco Control, the implementation of which is a specific target (3.a) of the 2030 Sustainable Development Goals, recognises that raising taxes is the most cost effective tobacco control measure. India, Mexico and Colombia are all rapidly growing economies with a large share of the youth population and where effective and pro poor means of making smoking unaffordable and improving health outcomes for the over 115 million number of smokers who live in these countries is a critical priority.The Global Tobacco Economics Consortium, led by the Instituto Nacional de Salud Pública in Mexico, will use the extended cost effective analysis method to estimate the effect at the national and subnational level of tobacco tax increases on health care costs and poverty. It will also deepen the understanding the differential impacts of the household costs of tobacco use on gender over time. The consortium brings together research teams in Colombia, Mexico, and India, who will improve their understanding of how tobacco control policy is developed in their specific country context. This will allow them to better communicate the value of using economic tools and evidence for setting optimal tobacco taxes. The integration of evidence from across these three country contexts will contribute to global literature and momentum for large scale tax increases in low and middle income countries for progress on the Sustainable Development Goals.This project is funded through the Economics of Tobacco Control Research Initiative, a 5-year IDRC and Cancer Research UK partnership launched in October 2017.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Instituto Nacional de Salud P...blica
more
|
|
|
|
65679f65212eaade2e0f053a
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20190091502
|
109150
|
1
|
Middle East, regional
|
Middle East
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.12517
|
0.0180244
|
0
|
0
|
0.12517
|
0.0180244
|
0
|
0.12517
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
IMMUNOMETABOLIC ROLES AND THER...APEUTIC POTENTIAL OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)
more
|
Immunometabolic roles and ther...apeutic potential of glucose-dependent insulinotropic polypeptide (GIP)
more
|
Obesity, type 2 diabetes, and ...cardiovascular disease share common features, including inflammation in multiple tissues. Inflammation arising in the context of diabetes or obesity is thought to contribute to some of the complications of these disorders, including increased risk of cancer and, most notably, higher rates of heart attacks and strokes. Inflammation may arise in part from the gut, which harbours bacterial organisms and products. Inflammation in turn induces the secretion of some gut peptides — hormonal messengers that relay signals from the gut to distant tissues, including immune cells. Preliminary data suggest that the increased action of a gut hormone known as glucose-dependent insulinotropic polypeptide (GIP) suppresses inflammation, whereas reduced or complete absence of GIP has the contrary effect, with adverse consequences for metabolism and accelerated development of atherosclerosis. There are currently multiple drug development programs under way to explore whether modulation of GIP activity might be a useful therapeutic approach to treat metabolic disorders such as diabetes and obesity. This project aims to understand how GIP controls inflammation in adipose tissue immune cells and in blood vessels susceptible to the development of atherosclerosis. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
11000
|
Donor Government
|
Sinai Health System
|
|
|
|
65679f65212eaade2e0f053b
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20190091511
|
109151
|
1
|
Middle East, regional
|
Middle East
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.12517
|
0.0206147
|
0
|
0
|
0.12517
|
0.0206147
|
0
|
0.12517
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
G PROTEIN FUNCTIONAL SELECTIVI...TY IN METABOLIC DISORDERS
more
|
G protein functional selectivi...ty in metabolic disorders
more
|
Type 2 diabetes is a metabolic... disease characterized by elevated circulating sugar levels that result from reduced insulin secretion from pancreatic beta cells and reduced sensitivity to insulin. Current treatments are effective in reversing many of the symptoms, but they do not stop the progression of the metabolic dysfunction. As a result, the vast majority of patients with diabetes will die from a heart attack or stroke, and the disease remains the main cause of blindness, kidney failure, and non-traumatic amputations. There is an urgent need to develop new treatments. Both genetic and functional studies have identified G protein-coupled receptors (GPCR) and regulators of G protein signaling expressed in beta cells as potential targets for the development of new treatments. The value of GPCR-targeted therapy for type 2 diabetes has been demonstrated by drugs targeting the glucagon-like peptide-1 (GLP1) receptor, but various side effects accompany their use, including nausea, hypoglycemic episodes, and no long-term restoration of beta cell function. An underlying cause of these undesirable effects relates to the fact that each GPCR can engage several signaling pathways that are responsible for their different actions. Recent progress in GPCR studies revealed that it should be possible to design drugs that selectively regulate the therapeutically relevant pathways while sparing those responsible for the adverse effects. For this purpose, a better understanding of the molecular determinants controlling the different pathways engaged by a given GPCR and its cognate G proteins is needed. Combining structure-based in-silico modelling with biochemical/biophysical assays, this project aims to identify protein partners and function/specificity determinants to probe the role of the individual signaling pathways engaged by the GLP1 receptor that will allow the development of more efficacious and safer drugs against type 2 diabetes. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Université de Montréal
|
|
|
|
65679f65212eaade2e0f053c
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20190091531
|
109153
|
1
|
Middle East, regional
|
Middle East
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.12517
|
0.0201885
|
0
|
0
|
0.12517
|
0.0201885
|
0
|
0.12517
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
METABOLIC AND CHROMATIN REPROG...RAMMING OF HEMATOPOIETIC STEM CELLS (HSC) DURING DAY-NIGHT OSCILLATIONS AND AGING
more
|
Metabolic and chromatin reprog...ramming of hematopoietic stem cells (HSC) during day-night oscillations and aging
more
|
Humans have enormous demands f...or blood production. Alterations in the functioning of the human blood system lie at the heart of many diseases, including cancer, infections, and auto-immune disorders. With age, human blood production changes and immune function is decreased. There is a need to improve our understanding of how our blood system develops from the rare hematopoietic stem cells (HSC) that originate all blood cells, and how aging disrupts this process. This information is critical to develop new therapies against many diseases that originate from abnormal immune cell functioning and to potentially alleviate and/or reverse accelerated decline in HSC function. Previous studies have shown that melatonin is critical to the day/night oscillation pattern that controls the switch HSCs make between the generation of mature blood cells and their replenishment. They also show that sphingolipids govern HSC function and the generation of mature blood cells. Melatonin and sphingolipids are therefore linked, and their levels change with age. This project will use state-of-the-art assays to study normal human blood cells as well as genetically engineered mice to investigate whether these molecules are behind the age-related decline in HSC function. The project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University Health Network/Rés...eau universitaire de santé
more
|
|
|
|
65679f66212eaade2e0f053d
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20190091542
|
109154
|
1
|
Middle East, regional
|
Middle East
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.128707
|
0.0209247
|
0
|
0
|
0.128707
|
0.0209247
|
0
|
0.128707
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF IRON HOMEOSTASIS I...N THE MICROBIOME MEDIATED MODULATION OF METABOLIC SYNDROME
more
|
The role of iron homeostasis i...n the microbiome mediated modulation of metabolic syndrome
more
|
A link has been recognized bet...ween iron overload and metabolic syndrome (MetS), a health disorder that greatly increases the risk of many chronic illnesses such as diabetes and heart disease. MetS is also associated with a modified microbiome, suggesting a causative relationship. Nevertheless, research into the mechanisms leading to metabolic dysfunction after iron overload and dysbiosis (a microbial imbalance) is lacking. This project is designed to examine the general hypothesis that iron-mediated gut dysbiosis has a negative impact on peripheral metabolism. The research team will characterize changes in gut microbiota composition upon iron overload in MetS patients and in mouse models of altered iron status and distribution; verify the functional significance of this alteration via fecal transplantation; and examine cellular mechanisms of iron action in a unique three-dimensional artificial gut model. New knowledge derived from these studies may allow for novel diagnostic and therapeutic approaches related to bacterial signatures and mediators that penetrate the gut and influence peripheral metabolic status in patients with MetS. The project will be led by York University in Canada and the Technion Faculty of Medicine, Israel, in collaboration with Srinakharinwirot University in Thailand. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
York University
|
|
|
|
65679f66212eaade2e0f053e
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20190091551
|
109155
|
1
|
Middle East, regional
|
Middle East
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.125169
|
0.0207589
|
0
|
0
|
0.125169
|
0.0207589
|
0
|
0.125169
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TRANSCRIPTION FACTOR INTERPLAY... AS A DRIVING FORCE IN THE HEPATIC RESPONSE TO FASTING AND ITS DYSREGULATION IN METABOLIC DISEASE
more
|
Transcription factor interplay... as a driving force in the hepatic response to fasting and its dysregulation in metabolic disease
more
|
Metabolic diseases, including ...diabetes, obesity, and non-alcoholic fatty liver disease are reaching epidemic levels worldwide. Improper cellular energy production, storage, and use underlie many of these conditions. The enzymes that control glucose, fat, and ketone body production in the liver are under the control of numerous proteins called transcription factors. In response to fasting, a specific series of transcription factors are required to ensure proper activation of the enzymes that are important for maintaining fuel levels in the absence of an external food source. In this project, researchers will use specific gene knockout mouse models of these transcription factors, in combination with state-of-the-art DNA and RNA sequencing technologies, to uncover the importance of these transcription factors in modifying the basic physiologic response to fasting and how these are modified in disease. The team will also test novel small molecules that target these transcription factors for their ability to restore the proper fasting response in a mouse model of diet-induced obesity. The project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Governing Council of the U...niversity of Toronto
more
|
|
|
|
65679f66212eaade2e0f053f
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088202
|
108820
|
3
|
Nigeria
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0297683
|
0
|
0
|
0
|
0.0297683
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TOBACCO TAX REFORMS FOR HEALTH... AND ECONOMIC DEVELOPMENT IN SUB-SAHARAN AFRICA
more
|
Tobacco tax reforms for health... and economic development in Sub-Saharan Africa
more
|
Tobacco is a significant contr...ibutor to the rising global burden of non-communicable diseases. The Framework Convention on Tobacco Control, the implementation of which is a specific target (3.a) of the 2030 Sustainable Development Goals, recognizes that raising taxes is the most cost-effective tobacco control measure. However, this measure remains under-used worldwide. This project primarily aims to use tobacco-tax simulation models to demonstrate the impact of increases in tobacco excise taxes on government revenue and tobacco consumption in three West African countries: Senegal, Sierra Leone, and Nigeria. These countries, which have rising levels of tobacco use and sub-optimal tobacco taxation laws, are members of the regional trade bloc the Economic Community of West African States (ECOWAS). In December 2017, ECOWAS adopted a directive on raising tobacco taxes. However, the capacity of its member states to implement the new directive is limited specifically by lack of country-specific data on the potential health and socio-economic impact of raising tobacco taxes. This project is therefore timely and strategic as it aims to estimate this impact and to communicate the results to policymakers in order to promote effective implementation of the directive. The results will also help dispel misinformation that tends to exaggerate the impact of taxes on, for example, low-income tobacco users, tobacco-related jobs, and tobacco smuggling. This project involves a strong research consortium led by the University of Cape Town in South Africa and the Consortium pour la Recherche Économique et Sociale (CRES) in Senegal. CRES in particular has spent the past decade influencing tobacco control policy, including the new ECOWAS directive, through research in West Africa that has been significantly funded by IDRC. This project is funded through the Economics of Tobacco Control Research Initiative, a co-funding partnership between IDRC and Cancer Research UK, launched in October 2017.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University of Cape Town
|
|
|
|
65679f66212eaade2e0f0540
|
2018
|
Switzerland
|
Swiss Agency for Development a...nd Co-operation
more
|
2018008825
|
177-Q37-2018-51147
|
3
|
Burkina Faso
|
South of Sahara
|
LDCs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0
|
0.0363023
|
0
|
0
|
0
|
0.0363023
|
0
|
0
|
0
|
0
|
Classified as not health-speci...fic activity
more
|
|
100
|
CONTRIBUTIONS DE PROGRAMME AUX... ONG SUISSES
more
|
Contributions de programme aux... ONG suisses
more
|
Action de Carême focalise son... programme sur la transformation positive de la société. Il s'adresse aux personnes de toutes confessions défavorisées sur le plan économique et social. Le droit à l'alimentation et une économie durable sont, en plus du thème transversal « genre », les thèmes stratégiques sur lesquels reposent le programme d'Action de Carême.
more
|
Based on information regarding... focus areas of specific implementing organization
more
|
99810
|
Sectors not specified
|
|
IX. Unallocated / Unspecified
|
22000
|
Donor country-based NGO
|
Fastenopfer
|
|
|
|
65679f66212eaade2e0f0541
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088221
|
108822
|
3
|
Philippines
|
Far East Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.123896
|
0.0406206
|
0
|
0
|
0.123896
|
0.0406206
|
0
|
0.123896
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
IMPROVING THE IMPLEMENTATION O...F TOBACCO TAXATION IN SOUTHEAST ASIA
more
|
Improving the implementation o...f tobacco taxation in Southeast Asia
more
|
Tobacco is a significant contr...ibutor to the rising global burden of non-communicable diseases. The Framework Convention on Tobacco Control, the implementation of which is a specific target (3.a) of the 2030 Sustainable Development Goals, recognizes that raising taxes is the most cost-effective tobacco control measure. However, tobacco tax evasion and the illicit tobacco trade can undermine the effective implementation of tobacco taxes. In 2013, a landmark package of tobacco tax reforms implemented in the Philippines raised taxes by 825%, leading to declines in smoking levels, particularly among the young and the poor. The revenue raised by this initiative paid for health insurance premiums for 14.7 million poor families. The Philippines is one of the highest consumers of illicit cigarettes, and prevalence rates are still high at 23%. Researchers have shown that this illicit trade undermines price and tax controls on tobacco and must be addressed for further momentum on tobacco tax reform.This project hypothesizes that the implementation of tobacco taxation in the Philippines can be improved by strengthening the local evidence base on tobacco tax evasion. Implemented by the Ateneo School of Government in Quezon City, Philippines, it will address the knowledge gaps on illicit trade dynamics that can undermine policy discussions on effective tobacco control. The project will also foster a network of economics researchers in the region who can apply methodological tools and gender-responsive policy analysis towards generating reliable evidence to inform tobacco control policy development. The research will generate independent data on the level and effect of tobacco tax evasion for the Philippines and, through the research fellow network, provide support for similar reform across Southeast Asia. This project is funded through the Economics of Tobacco Control Research Initiative, a co-funding partnership between IDRC and Cancer Research UK, launched in October 2017.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Ateneo de Manila University (Q...uezon City), Inc.
more
|
|
|
|
65679f66212eaade2e0f0542
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088203
|
108820
|
3
|
Senegal
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0297683
|
0
|
0
|
0
|
0.0297683
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TOBACCO TAX REFORMS FOR HEALTH... AND ECONOMIC DEVELOPMENT IN SUB-SAHARAN AFRICA
more
|
Tobacco tax reforms for health... and economic development in Sub-Saharan Africa
more
|
Tobacco is a significant contr...ibutor to the rising global burden of non-communicable diseases. The Framework Convention on Tobacco Control, the implementation of which is a specific target (3.a) of the 2030 Sustainable Development Goals, recognizes that raising taxes is the most cost-effective tobacco control measure. However, this measure remains under-used worldwide. This project primarily aims to use tobacco-tax simulation models to demonstrate the impact of increases in tobacco excise taxes on government revenue and tobacco consumption in three West African countries: Senegal, Sierra Leone, and Nigeria. These countries, which have rising levels of tobacco use and sub-optimal tobacco taxation laws, are members of the regional trade bloc the Economic Community of West African States (ECOWAS). In December 2017, ECOWAS adopted a directive on raising tobacco taxes. However, the capacity of its member states to implement the new directive is limited specifically by lack of country-specific data on the potential health and socio-economic impact of raising tobacco taxes. This project is therefore timely and strategic as it aims to estimate this impact and to communicate the results to policymakers in order to promote effective implementation of the directive. The results will also help dispel misinformation that tends to exaggerate the impact of taxes on, for example, low-income tobacco users, tobacco-related jobs, and tobacco smuggling. This project involves a strong research consortium led by the University of Cape Town in South Africa and the Consortium pour la Recherche Économique et Sociale (CRES) in Senegal. CRES in particular has spent the past decade influencing tobacco control policy, including the new ECOWAS directive, through research in West Africa that has been significantly funded by IDRC. This project is funded through the Economics of Tobacco Control Research Initiative, a co-funding partnership between IDRC and Cancer Research UK, launched in October 2017.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University of Cape Town
|
|
|
|
65679f67212eaade2e0f0543
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088201
|
108820
|
3
|
Sierra Leone
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0306704
|
0
|
0
|
0
|
0.0306704
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TOBACCO TAX REFORMS FOR HEALTH... AND ECONOMIC DEVELOPMENT IN SUB-SAHARAN AFRICA
more
|
Tobacco tax reforms for health... and economic development in Sub-Saharan Africa
more
|
Tobacco is a significant contr...ibutor to the rising global burden of non-communicable diseases. The Framework Convention on Tobacco Control, the implementation of which is a specific target (3.a) of the 2030 Sustainable Development Goals, recognizes that raising taxes is the most cost-effective tobacco control measure. However, this measure remains under-used worldwide. This project primarily aims to use tobacco-tax simulation models to demonstrate the impact of increases in tobacco excise taxes on government revenue and tobacco consumption in three West African countries: Senegal, Sierra Leone, and Nigeria. These countries, which have rising levels of tobacco use and sub-optimal tobacco taxation laws, are members of the regional trade bloc the Economic Community of West African States (ECOWAS). In December 2017, ECOWAS adopted a directive on raising tobacco taxes. However, the capacity of its member states to implement the new directive is limited specifically by lack of country-specific data on the potential health and socio-economic impact of raising tobacco taxes. This project is therefore timely and strategic as it aims to estimate this impact and to communicate the results to policymakers in order to promote effective implementation of the directive. The results will also help dispel misinformation that tends to exaggerate the impact of taxes on, for example, low-income tobacco users, tobacco-related jobs, and tobacco smuggling. This project involves a strong research consortium led by the University of Cape Town in South Africa and the Consortium pour la Recherche Économique et Sociale (CRES) in Senegal. CRES in particular has spent the past decade influencing tobacco control policy, including the new ECOWAS directive, through research in West Africa that has been significantly funded by IDRC. This project is funded through the Economics of Tobacco Control Research Initiative, a co-funding partnership between IDRC and Cancer Research UK, launched in October 2017.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University of Cape Town
|
|
|
|
65679f67212eaade2e0f0544
|
2018
|
Switzerland
|
Swiss Agency for Development a...nd Co-operation
more
|
2018008824
|
177-Q37-2018-51146
|
3
|
Burkina Faso
|
South of Sahara
|
LDCs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0
|
0.0342571
|
0
|
0
|
0
|
0.0342571
|
0
|
0
|
0
|
0
|
Classified as not health-speci...fic activity
more
|
|
100
|
CONTRIBUTIONS DE PROGRAMME AUX... ONG SUISSES
more
|
Contributions de programme aux... ONG suisses
more
|
Action de Carême focalise son... programme sur la transformation positive de la société. Il s'adresse aux personnes de toutes confessions défavorisées sur le plan économique et social. Le droit à l'alimentation et une économie durable sont, en plus du thème transversal « genre », les thèmes stratégiques sur lesquels reposent le programme d'Action de Carême.
more
|
Based on information regarding... focus areas of specific implementing organization
more
|
99810
|
Sectors not specified
|
|
IX. Unallocated / Unspecified
|
22000
|
Donor country-based NGO
|
Fastenopfer
|
|
|
|
65679f67212eaade2e0f0545
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20190091543
|
109154
|
1
|
Thailand
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.124921
|
0.0203093
|
0
|
0
|
0.124921
|
0.0203093
|
0
|
0.124921
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF IRON HOMEOSTASIS I...N THE MICROBIOME MEDIATED MODULATION OF METABOLIC SYNDROME
more
|
The role of iron homeostasis i...n the microbiome mediated modulation of metabolic syndrome
more
|
A link has been recognized bet...ween iron overload and metabolic syndrome (MetS), a health disorder that greatly increases the risk of many chronic illnesses such as diabetes and heart disease. MetS is also associated with a modified microbiome, suggesting a causative relationship. Nevertheless, research into the mechanisms leading to metabolic dysfunction after iron overload and dysbiosis (a microbial imbalance) is lacking. This project is designed to examine the general hypothesis that iron-mediated gut dysbiosis has a negative impact on peripheral metabolism. The research team will characterize changes in gut microbiota composition upon iron overload in MetS patients and in mouse models of altered iron status and distribution; verify the functional significance of this alteration via fecal transplantation; and examine cellular mechanisms of iron action in a unique three-dimensional artificial gut model. New knowledge derived from these studies may allow for novel diagnostic and therapeutic approaches related to bacterial signatures and mediators that penetrate the gut and influence peripheral metabolic status in patients with MetS. The project will be led by York University in Canada and the Technion Faculty of Medicine, Israel, in collaboration with Srinakharinwirot University in Thailand. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
York University
|
|
|
|
65679f67212eaade2e0f0546
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180086411
|
108641
|
3
|
Tunisia
|
North of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.20633
|
0
|
0
|
0
|
0.20633
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TACKLING SCHOOL AND COMMUNITY ...DRIVERS OF CHILDREN'S UNHEALTHY DIETS IN ARAB CITIES
more
|
Tackling school and community ...drivers of children's unhealthy diets in Arab cities
more
|
Low and middle-income countrie...s of the Arab region are undergoing a rapid nutrition transition with increases in the prevalence of overweight and obesity among young and adult populations accompanied by a rise in diet-related non-communicable diseases (NCDs). Although children's food choices and dietary behaviours are early risk factors for the development of NCDs, research on what influences these behaviours remains scant in the region. School and neighbourhood environments have the potential to counter the effect of societal forces on children's diets, but little is known about the drivers of children's food choices within these environments and their potential to be used as levers for intervention. This research project, implemented in collaboration with the American University of Beirut, aims to inform context-specific interventions targeting childhood overweight in the urban settings of Greater Beirut and Greater Tunis, and ultimately to foster the development of food environments that enable healthy eating among children and their families. The research uses a combination of quantitative and qualitative methods to assess individual diets and the contextual factors that influence children's food choices. Innovative locally relevant tools will be developed to describe and map food environments and food choices experienced by children at the level of families, schools, and communities. The aim is to identify moments in the daily lives of children that represent threats to, and opportunities for, healthy eating. These results, together with nutrition survey data, will inform the development of interventions that influence children's eating in Lebanon and Tunisia. Possible interventions may include school and community-level food policies with the potential for replicability in similar urban contexts of the region.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
American University of Beirut
|
|
|
|
65679f67212eaade2e0f0547
|
2018
|
Switzerland
|
Swiss Agency for Development a...nd Co-operation
more
|
2018008823
|
177-Q37-2018-51145
|
3
|
Burkina Faso
|
South of Sahara
|
LDCs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0
|
0.010226
|
0
|
0
|
0
|
0.010226
|
0
|
0
|
0
|
0
|
Classified as not health-speci...fic activity
more
|
|
100
|
CONTRIBUTIONS DE PROGRAMME AUX... ONG SUISSES
more
|
Contributions de programme aux... ONG suisses
more
|
Action de Carême focalise son... programme sur la transformation positive de la société. Il s'adresse aux personnes de toutes confessions défavorisées sur le plan économique et social. Le droit à l'alimentation et une économie durable sont, en plus du thème transversal « genre », les thèmes stratégiques sur lesquels reposent le programme d'Action de Carême.
more
|
Based on information regarding... focus areas of specific implementing organization
more
|
99810
|
Sectors not specified
|
|
IX. Unallocated / Unspecified
|
22000
|
Donor country-based NGO
|
Fastenopfer
|
|
|
|
65679f67212eaade2e0f0548
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088211
|
108821
|
3
|
West Bank and Gaza Strip
|
Middle East
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0386489
|
0
|
0
|
0
|
0.0386489
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ECONOMICS OF WATERPIPE TOB...ACCO SMOKING IN THE EASTERN MEDITERRANEAN
more
|
The Economics of Waterpipe Tob...acco Smoking in the Eastern Mediterranean
more
|
Tobacco remains a leading caus...e of death and ill-health globally, including in low and middle-income countries. Extensive empirical research confirms that higher excise taxes reduce tobacco use and discourage non-smokers from initiating smoking. However, this mechanism is still under-used in many countries.This project will specifically address the knowledge gap on the economics of waterpipe tobacco smoking in the eastern Mediterranean region. A four-institution collaboration across Lebanon, the West Bank, Egypt, and Jordan will generate critically needed information on the increasing popularity and rate of waterpipe smoking and model the economic impact of fiscal policies on tobacco control. It is led by the American University of Beirut, which also hosts the Global Knowledge Hub for waterpipe tobacco smoking. The project team will present this economic evidence in a format that can be used by policymakers to strengthen the coherence and coverage of tobacco control policies in the region with the aim of improving population health and contributing to public revenues.This project is funded through the Economics of Tobacco Control Research Initiative, an IDRC and Cancer Research UK co-funding partnership launched in October 2017. The objective is to generate evidence that provides the economic rationale for the prevention of tobacco-related diseases. The research uptake by policy actors will allow for the adoption of tobacco-control policies across low and middle-income countries.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
American University of Beirut
|
|
|
|
65679f68212eaade2e0f0549
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091510003
|
109151
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.042194
|
0
|
0
|
0
|
0.042194
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
G PROTEIN FUNCTIONAL SELECTIVI...TY IN METABOLIC DISORDERS
more
|
G protein functional selectivi...ty in metabolic disorders
more
|
Type 2 diabetes is a metabolic... disease characterized by elevated circulating sugar levels that result from reduced insulin secretion from pancreatic beta cells and reduced sensitivity to insulin. Current treatments are effective in reversing many of the symptoms, but they do not stop the progression of the metabolic dysfunction. As a result, the vast majority of patients with diabetes will die from a heart attack or stroke, and the disease remains the main cause of blindness, kidney failure, and non-traumatic amputations. There is an urgent need to develop new treatments. Both genetic and functional studies have identified G protein-coupled receptors (GPCR) and regulators of G protein signaling expressed in beta cells as potential targets for the development of new treatments. The value of GPCR-targeted therapy for type 2 diabetes has been demonstrated by drugs targeting the glucagon-like peptide-1 (GLP1) receptor, but various side effects accompany their use, including nausea, hypoglycemic episodes, and no long-term restoration of beta cell function. An underlying cause of these undesirable effects relates to the fact that each GPCR can engage several signaling pathways that are responsible for their different actions. Recent progress in GPCR studies revealed that it should be possible to design drugs that selectively regulate the therapeutically relevant pathways while sparing those responsible for the adverse effects. For this purpose, a better understanding of the molecular determinants controlling the different pathways engaged by a given GPCR and its cognate G proteins is needed. Combining structure-based in-silico modelling with biochemical/biophysical assays, this project aims to identify protein partners and function/specificity determinants to probe the role of the individual signaling pathways engaged by the GLP1 receptor that will allow the development of more efficacious and safer drugs against type 2 diabetes. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Université de Montréal
|
|
|
|
65679f68212eaade2e0f054a
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091530003
|
109153
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.042365
|
0
|
0
|
0
|
0.042365
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
METABOLIC AND CHROMATIN REPROG...RAMMING OF HEMATOPOIETIC STEM CELLS (HSC) DURING DAY-NIGHT OSCILLATIONS AND AGING
more
|
Metabolic and chromatin reprog...ramming of hematopoietic stem cells (HSC) during day-night oscillations and aging
more
|
Humans have enormous demands f...or blood production. Alterations in the functioning of the human blood system lie at the heart of many diseases, including cancer, infections, and auto-immune disorders. With age, human blood production changes and immune function is decreased. There is a need to improve our understanding of how our blood system develops from the rare hematopoietic stem cells (HSC) that originate all blood cells, and how aging disrupts this process. This information is critical to develop new therapies against many diseases that originate from abnormal immune cell functioning and to potentially alleviate and/or reverse accelerated decline in HSC function. Previous studies have shown that melatonin is critical to the day/night oscillation pattern that controls the switch HSCs make between the generation of mature blood cells and their replenishment. They also show that sphingolipids govern HSC function and the generation of mature blood cells. Melatonin and sphingolipids are therefore linked, and their levels change with age. This project will use state-of-the-art assays to study normal human blood cells as well as genetically engineered mice to investigate whether these molecules are behind the age-related decline in HSC function. The project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University Health Network/Rés...eau universitaire de santé
more
|
|
|
|
65679f68212eaade2e0f054b
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091550003
|
109155
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.043379
|
0
|
0
|
0
|
0.043379
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TRANSCRIPTION FACTOR INTERPLAY... AS A DRIVING FORCE IN THE HEPATIC RESPONSE TO FASTING AND ITS DYSREGULATION IN METABOLIC DISEASE
more
|
Transcription factor interplay... as a driving force in the hepatic response to fasting and its dysregulation in metabolic disease
more
|
Metabolic diseases, including ...diabetes, obesity, and non-alcoholic fatty liver disease are reaching epidemic levels worldwide. Improper cellular energy production, storage, and use underlie many of these conditions. The enzymes that control glucose, fat, and ketone body production in the liver are under the control of numerous proteins called transcription factors. In response to fasting, a specific series of transcription factors are required to ensure proper activation of the enzymes that are important for maintaining fuel levels in the absence of an external food source. In this project, researchers will use specific gene knockout mouse models of these transcription factors, in combination with state-of-the-art DNA and RNA sequencing technologies, to uncover the importance of these transcription factors in modifying the basic physiologic response to fasting and how these are modified in disease. The team will also test novel small molecules that target these transcription factors for their ability to restore the proper fasting response in a mouse model of diet-induced obesity. The project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Governing Council of the U...niversity of Toronto
more
|
|
|
|
65679f69212eaade2e0f054c
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091500001
|
109150
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.038242
|
0
|
0
|
0
|
0.038242
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
IMMUNOMETABOLIC ROLES AND THER...APEUTIC POTENTIAL OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)
more
|
Immunometabolic roles and ther...apeutic potential of glucose-dependent insulinotropic polypeptide (GIP)
more
|
Obesity, type 2 diabetes, and ...cardiovascular disease share common features, including inflammation in multiple tissues. Inflammation arising in the context of diabetes or obesity is thought to contribute to some of the complications of these disorders, including increased risk of cancer and, most notably, higher rates of heart attacks and strokes. Inflammation may arise in part from the gut, which harbours bacterial organisms and products. Inflammation in turn induces the secretion of some gut peptides — hormonal messengers that relay signals from the gut to distant tissues, including immune cells. Preliminary data suggest that the increased action of a gut hormone known as glucose-dependent insulinotropic polypeptide (GIP) suppresses inflammation, whereas reduced or complete absence of GIP has the contrary effect, with adverse consequences for metabolism and accelerated development of atherosclerosis. There are currently multiple drug development programs under way to explore whether modulation of GIP activity might be a useful therapeutic approach to treat metabolic disorders such as diabetes and obesity. This project aims to understand how GIP controls inflammation in adipose tissue immune cells and in blood vessels susceptible to the development of atherosclerosis. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
11000
|
Donor Government
|
Sinai Health System
|
|
|
|
65679f69212eaade2e0f054d
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091500002
|
109150
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.002289
|
0
|
0
|
0
|
0.002289
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
IMMUNOMETABOLIC ROLES AND THER...APEUTIC POTENTIAL OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)
more
|
Immunometabolic roles and ther...apeutic potential of glucose-dependent insulinotropic polypeptide (GIP)
more
|
Obesity, type 2 diabetes, and ...cardiovascular disease share common features, including inflammation in multiple tissues. Inflammation arising in the context of diabetes or obesity is thought to contribute to some of the complications of these disorders, including increased risk of cancer and, most notably, higher rates of heart attacks and strokes. Inflammation may arise in part from the gut, which harbours bacterial organisms and products. Inflammation in turn induces the secretion of some gut peptides — hormonal messengers that relay signals from the gut to distant tissues, including immune cells. Preliminary data suggest that the increased action of a gut hormone known as glucose-dependent insulinotropic polypeptide (GIP) suppresses inflammation, whereas reduced or complete absence of GIP has the contrary effect, with adverse consequences for metabolism and accelerated development of atherosclerosis. There are currently multiple drug development programs under way to explore whether modulation of GIP activity might be a useful therapeutic approach to treat metabolic disorders such as diabetes and obesity. This project aims to understand how GIP controls inflammation in adipose tissue immune cells and in blood vessels susceptible to the development of atherosclerosis. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
11000
|
Donor Government
|
Sinai Health System
|
|
|
|
65679f69212eaade2e0f054e
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091510001
|
109151
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.038637
|
0
|
0
|
0
|
0.038637
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
G PROTEIN FUNCTIONAL SELECTIVI...TY IN METABOLIC DISORDERS
more
|
G protein functional selectivi...ty in metabolic disorders
more
|
Type 2 diabetes is a metabolic... disease characterized by elevated circulating sugar levels that result from reduced insulin secretion from pancreatic beta cells and reduced sensitivity to insulin. Current treatments are effective in reversing many of the symptoms, but they do not stop the progression of the metabolic dysfunction. As a result, the vast majority of patients with diabetes will die from a heart attack or stroke, and the disease remains the main cause of blindness, kidney failure, and non-traumatic amputations. There is an urgent need to develop new treatments. Both genetic and functional studies have identified G protein-coupled receptors (GPCR) and regulators of G protein signaling expressed in beta cells as potential targets for the development of new treatments. The value of GPCR-targeted therapy for type 2 diabetes has been demonstrated by drugs targeting the glucagon-like peptide-1 (GLP1) receptor, but various side effects accompany their use, including nausea, hypoglycemic episodes, and no long-term restoration of beta cell function. An underlying cause of these undesirable effects relates to the fact that each GPCR can engage several signaling pathways that are responsible for their different actions. Recent progress in GPCR studies revealed that it should be possible to design drugs that selectively regulate the therapeutically relevant pathways while sparing those responsible for the adverse effects. For this purpose, a better understanding of the molecular determinants controlling the different pathways engaged by a given GPCR and its cognate G proteins is needed. Combining structure-based in-silico modelling with biochemical/biophysical assays, this project aims to identify protein partners and function/specificity determinants to probe the role of the individual signaling pathways engaged by the GLP1 receptor that will allow the development of more efficacious and safer drugs against type 2 diabetes. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Université de Montréal
|
|
|
|
65679f69212eaade2e0f054f
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091510002
|
109151
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.002311
|
0
|
0
|
0
|
0.002311
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
G PROTEIN FUNCTIONAL SELECTIVI...TY IN METABOLIC DISORDERS
more
|
G protein functional selectivi...ty in metabolic disorders
more
|
Type 2 diabetes is a metabolic... disease characterized by elevated circulating sugar levels that result from reduced insulin secretion from pancreatic beta cells and reduced sensitivity to insulin. Current treatments are effective in reversing many of the symptoms, but they do not stop the progression of the metabolic dysfunction. As a result, the vast majority of patients with diabetes will die from a heart attack or stroke, and the disease remains the main cause of blindness, kidney failure, and non-traumatic amputations. There is an urgent need to develop new treatments. Both genetic and functional studies have identified G protein-coupled receptors (GPCR) and regulators of G protein signaling expressed in beta cells as potential targets for the development of new treatments. The value of GPCR-targeted therapy for type 2 diabetes has been demonstrated by drugs targeting the glucagon-like peptide-1 (GLP1) receptor, but various side effects accompany their use, including nausea, hypoglycemic episodes, and no long-term restoration of beta cell function. An underlying cause of these undesirable effects relates to the fact that each GPCR can engage several signaling pathways that are responsible for their different actions. Recent progress in GPCR studies revealed that it should be possible to design drugs that selectively regulate the therapeutically relevant pathways while sparing those responsible for the adverse effects. For this purpose, a better understanding of the molecular determinants controlling the different pathways engaged by a given GPCR and its cognate G proteins is needed. Combining structure-based in-silico modelling with biochemical/biophysical assays, this project aims to identify protein partners and function/specificity determinants to probe the role of the individual signaling pathways engaged by the GLP1 receptor that will allow the development of more efficacious and safer drugs against type 2 diabetes. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Université de Montréal
|
|
|
|
65679f69212eaade2e0f0550
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091530001
|
109153
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.038801
|
0
|
0
|
0
|
0.038801
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
METABOLIC AND CHROMATIN REPROG...RAMMING OF HEMATOPOIETIC STEM CELLS (HSC) DURING DAY-NIGHT OSCILLATIONS AND AGING
more
|
Metabolic and chromatin reprog...ramming of hematopoietic stem cells (HSC) during day-night oscillations and aging
more
|
Humans have enormous demands f...or blood production. Alterations in the functioning of the human blood system lie at the heart of many diseases, including cancer, infections, and auto-immune disorders. With age, human blood production changes and immune function is decreased. There is a need to improve our understanding of how our blood system develops from the rare hematopoietic stem cells (HSC) that originate all blood cells, and how aging disrupts this process. This information is critical to develop new therapies against many diseases that originate from abnormal immune cell functioning and to potentially alleviate and/or reverse accelerated decline in HSC function. Previous studies have shown that melatonin is critical to the day/night oscillation pattern that controls the switch HSCs make between the generation of mature blood cells and their replenishment. They also show that sphingolipids govern HSC function and the generation of mature blood cells. Melatonin and sphingolipids are therefore linked, and their levels change with age. This project will use state-of-the-art assays to study normal human blood cells as well as genetically engineered mice to investigate whether these molecules are behind the age-related decline in HSC function. The project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University Health Network/Rés...eau universitaire de santé
more
|
|
|
|
65679f69212eaade2e0f0551
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091530002
|
109153
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.002319
|
0
|
0
|
0
|
0.002319
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
METABOLIC AND CHROMATIN REPROG...RAMMING OF HEMATOPOIETIC STEM CELLS (HSC) DURING DAY-NIGHT OSCILLATIONS AND AGING
more
|
Metabolic and chromatin reprog...ramming of hematopoietic stem cells (HSC) during day-night oscillations and aging
more
|
Humans have enormous demands f...or blood production. Alterations in the functioning of the human blood system lie at the heart of many diseases, including cancer, infections, and auto-immune disorders. With age, human blood production changes and immune function is decreased. There is a need to improve our understanding of how our blood system develops from the rare hematopoietic stem cells (HSC) that originate all blood cells, and how aging disrupts this process. This information is critical to develop new therapies against many diseases that originate from abnormal immune cell functioning and to potentially alleviate and/or reverse accelerated decline in HSC function. Previous studies have shown that melatonin is critical to the day/night oscillation pattern that controls the switch HSCs make between the generation of mature blood cells and their replenishment. They also show that sphingolipids govern HSC function and the generation of mature blood cells. Melatonin and sphingolipids are therefore linked, and their levels change with age. This project will use state-of-the-art assays to study normal human blood cells as well as genetically engineered mice to investigate whether these molecules are behind the age-related decline in HSC function. The project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University Health Network/Rés...eau universitaire de santé
more
|
|
|
|
65679f69212eaade2e0f0552
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091540001
|
109154
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.03851
|
0
|
0
|
0
|
0.03851
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF IRON HOMEOSTASIS I...N THE MICROBIOME MEDIATED MODULATION OF METABOLIC SYNDROME
more
|
The role of iron homeostasis i...n the microbiome mediated modulation of metabolic syndrome
more
|
A link has been recognized bet...ween iron overload and metabolic syndrome (MetS), a health disorder that greatly increases the risk of many chronic illnesses such as diabetes and heart disease. MetS is also associated with a modified microbiome, suggesting a causative relationship. Nevertheless, research into the mechanisms leading to metabolic dysfunction after iron overload and dysbiosis (a microbial imbalance) is lacking. This project is designed to examine the general hypothesis that iron-mediated gut dysbiosis has a negative impact on peripheral metabolism. The research team will characterize changes in gut microbiota composition upon iron overload in MetS patients and in mouse models of altered iron status and distribution, verify the functional significance of this alteration via fecal transplantation, and examine cellular mechanisms of iron action in a unique three-dimensional artificial gut model. New knowledge derived from these studies may allow for novel diagnostic and therapeutic approaches related to bacterial signatures and mediators that penetrate the gut and influence peripheral metabolic status in patients with MetS. The project will be led by York University in Canada and the Technion Faculty of Medicine, Israel, in collaboration with Srinakharinwirot University in Thailand. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
York University
|
|
|
|
65679f6a212eaade2e0f0553
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091540002
|
109154
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.002304
|
0
|
0
|
0
|
0.002304
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF IRON HOMEOSTASIS I...N THE MICROBIOME MEDIATED MODULATION OF METABOLIC SYNDROME
more
|
The role of iron homeostasis i...n the microbiome mediated modulation of metabolic syndrome
more
|
A link has been recognized bet...ween iron overload and metabolic syndrome (MetS), a health disorder that greatly increases the risk of many chronic illnesses such as diabetes and heart disease. MetS is also associated with a modified microbiome, suggesting a causative relationship. Nevertheless, research into the mechanisms leading to metabolic dysfunction after iron overload and dysbiosis (a microbial imbalance) is lacking. This project is designed to examine the general hypothesis that iron-mediated gut dysbiosis has a negative impact on peripheral metabolism. The research team will characterize changes in gut microbiota composition upon iron overload in MetS patients and in mouse models of altered iron status and distribution, verify the functional significance of this alteration via fecal transplantation, and examine cellular mechanisms of iron action in a unique three-dimensional artificial gut model. New knowledge derived from these studies may allow for novel diagnostic and therapeutic approaches related to bacterial signatures and mediators that penetrate the gut and influence peripheral metabolic status in patients with MetS. The project will be led by York University in Canada and the Technion Faculty of Medicine, Israel, in collaboration with Srinakharinwirot University in Thailand. This project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
York University
|
|
|
|
65679f6a212eaade2e0f0554
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091550001
|
109155
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.039726
|
0
|
0
|
0
|
0.039726
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TRANSCRIPTION FACTOR INTERPLAY... AS A DRIVING FORCE IN THE HEPATIC RESPONSE TO FASTING AND ITS DYSREGULATION IN METABOLIC DISEASE
more
|
Transcription factor interplay... as a driving force in the hepatic response to fasting and its dysregulation in metabolic disease
more
|
Metabolic diseases, including ...diabetes, obesity, and non-alcoholic fatty liver disease are reaching epidemic levels worldwide. Improper cellular energy production, storage, and use underlie many of these conditions. The enzymes that control glucose, fat, and ketone body production in the liver are under the control of numerous proteins called transcription factors. In response to fasting, a specific series of transcription factors are required to ensure proper activation of the enzymes that are important for maintaining fuel levels in the absence of an external food source. In this project, researchers will use specific gene knockout mouse models of these transcription factors, in combination with state-of-the-art DNA and RNA sequencing technologies, to uncover the importance of these transcription factors in modifying the basic physiologic response to fasting and how these are modified in disease. The team will also test novel small molecules that target these transcription factors for their ability to restore the proper fasting response in a mouse model of diet-induced obesity. The project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Governing Council of the U...niversity of Toronto
more
|
|
|
|
65679f6a212eaade2e0f0555
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20190091550002
|
109155
|
3
|
Caribbean & Central America, r...egional
more
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.002378
|
0
|
0
|
0
|
0.002378
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TRANSCRIPTION FACTOR INTERPLAY... AS A DRIVING FORCE IN THE HEPATIC RESPONSE TO FASTING AND ITS DYSREGULATION IN METABOLIC DISEASE
more
|
Transcription factor interplay... as a driving force in the hepatic response to fasting and its dysregulation in metabolic disease
more
|
Metabolic diseases, including ...diabetes, obesity, and non-alcoholic fatty liver disease are reaching epidemic levels worldwide. Improper cellular energy production, storage, and use underlie many of these conditions. The enzymes that control glucose, fat, and ketone body production in the liver are under the control of numerous proteins called transcription factors. In response to fasting, a specific series of transcription factors are required to ensure proper activation of the enzymes that are important for maintaining fuel levels in the absence of an external food source. In this project, researchers will use specific gene knockout mouse models of these transcription factors, in combination with state-of-the-art DNA and RNA sequencing technologies, to uncover the importance of these transcription factors in modifying the basic physiologic response to fasting and how these are modified in disease. The team will also test novel small molecules that target these transcription factors for their ability to restore the proper fasting response in a mouse model of diet-induced obesity. The project was selected for funding through the fifth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Governing Council of the U...niversity of Toronto
more
|
|
|
|
65679f6b212eaade2e0f0556
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20160084010002
|
108401
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.010133
|
0
|
0
|
0
|
0.010133
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
REGULATION OF STEM-CELL MEDIAT...ED HOST IMMUNITY BY THE SPHINGOLIPID PATHWAY
more
|
Regulation of stem-cell mediat...ed host immunity by the sphingolipid pathway
more
|
Changes in the functioning of ...the human immune system are the main cause for many diseases, including auto-immunity, infections, and cancer. Research suggests that the sphingolipid pathway plays an important role in hematopoietic stem cell functions and, as a consequence, in the generation of mature immune cells and the functioning of the surrounding environment. This project uses advanced molecular biology and genetic methods with human cells and genetically engineered mice to examine how the human immune system develops from hematopoietic stem cells and how host immunity is established. It will also explore day/night cycles that influence the functioning of the immune system in order to decipher the mechanism controlling different host immunity responses and mortality rates from bacterial infections induced in the afternoon (high mortality) and at midnight (low mortality). This research has the potential to contribute to our understanding of the immune system and to advancements in the treatment of patients. Other positive impacts can include optimized methods to generate immune cells for cell transplantation, better drugs to treat diseases that involve abnormal immune cell functioning, and better methods to time the delivery of drugs in order to achieve maximum effect. The project is led in Canada by the University Health Network and the University of Toronto, in collaboration with the Weizmann Institute (Israel) and the Oncology Hospital of the Instituto Mexicano del Seguro Social (Mexico). It is funded through the second research competition of the Joint Canada-Israel Health Research Program, a partnership between Canada's International Development Research Centre, the Canadian Institutes for Health Research, the Israel Science Foundation and the Azrieli Foundation. This 7-year, $35M Canadian-Israeli effort draws on the unique scientific strengths of both countries and facilitates networking opportunities with peers from Africa, Asia, and Latin America. Projects include a plan for integrating researchers from low- and middle-income countries that will establish long-term scientific relationships.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University Health Network/Rés...eau universitaire de santé
more
|
|
|
|
65679f6b212eaade2e0f0557
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085870002
|
108587
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.023665
|
0
|
0
|
0
|
0.023665
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
SYSTEMATIC AND COMPREHENSIVE A...NALYSIS OF MUTANT P53 PROTEINS IN LUNG CANCER IN VITRO AND IN VIVO
more
|
Systematic and comprehensive a...nalysis of mutant p53 proteins in lung cancer in vitro and in vivo
more
|
The gene p53 is a well-known t...umour suppressor gene that prevents cancer formation. It is the most commonly mutated gene among individuals with a diagnosis of cancer. Through recent advances in DNA sequencing abilities, researchers are now in a position to take a patient's tumour and identify the exact mutation in p53 and other cancers' genes, which potentially allows the development of personalized patient care. This project aims to systematically characterize proteins that bind to mutant p53 in order to identify all the proteins that stabilize and activate mutant p53, as well as the molecular pathways that are co-opted/corrupted by mutant p53. The analysis will occur in living tissues (in vivo) and in a laboratory vessel (in vitro). Once identified, the ultimate goal is to screen for compounds that disrupt these interactions with the hope of finding novel therapeutic strategies to treat patients harbouring these specific p53 mutations. The project findings will possibly extend to other cancers associated with p53 mutations.The project is being implemented by the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital (Toronto), the Weizmann Institute of Science (Israel), the Universidade Federal do Rio Grande do Sul (Brazil), and the Universidad San Martin (Argentina). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
11000
|
Donor Government
|
Sinai Health System
|
|
|
|
65679f6b212eaade2e0f0558
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085890002
|
108589
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.026707
|
0
|
0
|
0
|
0.026707
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF EPITRANSCRIPTOME A...ND TRANSLATIONAL DYSREGULATION IN CANCER
more
|
The role of epitranscriptome a...nd translational dysregulation in cancer
more
|
Proteins represent the final p...roduct of genes and are implicated in governing most cellular functions. Production of proteins from genes is referred to as gene expression. Genes are first transcribed into messenger ribonucleic acid (mRNA). This is followed by mRNA translation, a process whereby the translation machinery reads the code stored in the mRNAs to produce proteins. In addition, mRNAs are also regulated by degradation. Malignant transformation is a phenomenon during which normal cells acquire malignant properties to become cancer. Malignant transformation and cancer progression are characterized by dramatic changes in gene expression. Recent years have brought evidence of dynamic chemical changes in mRNA molecules that have been shown to influence gene expression. These modifications are induced by factors called writers, removed by factors called erasers, and recognized by factors called readers. Levels and/or function of writers, erasers, and readers are reported to be altered in a variety of cancers, but their precise role in dysregulation of gene expression in cancer remains poorly understood. This project will investigate the contribution of mRNA modifications in cancer by employing a unique combination of recently developed systems of biology technologies and classical cellular and molecular biology techniques. The partners implementing this project are the Lady Davis Institute for Medical Research of McGill University (Montreal), the Sheba Cancer Research Centre (Israel), and the A.C. Camargo Cancer Centre (Brazil). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Sir Mortimer B. Davis Jewi...sh General Hospital / Centre intégré universitaire de santé et de serv
more
|
|
|
|
65679f6c212eaade2e0f0559
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085900002
|
108590
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.025656
|
0
|
0
|
0
|
0.025656
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NOTCH AS MASTER REGULATOR OF B...REAST CANCER SUBTYPE AND INTRATUMOURAL HETEROGENEITY
more
|
Notch as master regulator of b...reast cancer subtype and intratumoural heterogeneity
more
|
Tumour heterogeneity is a driv...ing force for disease progression and one of the major obstacles to effective treatment. Heterogeneity is driven by mutations and other processes that generate diverse cancer cell phenotypes and functions. Uncovering the pathways controlling this diversity is of critical importance for the development of effective therapies targeting distinct cell types, and, potentially, for inducing changes in tumour differentiation status. Estrogen receptor-negative breast tumours include cells with a mixture of differentiated states. Cellular heterogeneity within these cancers can lead to the generation of subpopulations that resist therapy. In many biological systems, signaling through so-called Notch receptors is used to create the cell diversity associated with functional tissues. This issue represents a challenge with respect to the development of effective treatment for breast cancer. This project aims to define mechanisms by which breast cancer cellular diversity or heterogeneity develops and is maintained. Since Notch signaling is activated in so many types of breast cancers and leads to regulation of cell fate in this context, results from this project may help to identify how these receptors can be targeted for therapeutic benefit.The project is being implemented by the Hospital for Sick Children in Toronto, the Hebrew University of Jerusalem (Israel), and the Indian Institute of Science. It was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Hospital for Sick Children
|
|
|
|
65679f6c212eaade2e0f055a
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085910002
|
108591
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.022137
|
0
|
0
|
0
|
0.022137
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF IL6 IN LIVER CANCE...R LINKED TO METABOLIC LIVER DISEASE
more
|
The role of IL6 in liver cance...r linked to metabolic liver disease
more
|
Liver cancer is highly fatal, ...it has very few treatment options, and it is one of the few cancers whose incidence is rising worldwide. One poorly understood risk factor for liver cancer is obesity/metabolic disease (such as diabetes and fatty liver disease). Since these conditions are reaching epidemic proportions in many countries, the prevalence of liver cancer is expected to continue to rise. In order to find innovative ways to treat liver cancer, this project aims to identify proteins and cell pathways that influence liver tumour development and growth, specifically in obesity. The team will investigate whether a new signaling pathway for interleukin 6 (IL6) controls liver tumour development in mice that have been made obese by diets high in sugar and fat, and in obese patients with liver cancer. IL6 is a hormone that circulates in the blood, and thus has the potential to be both a new biomarker of liver cancer and a new therapeutic target to treat the disease. The project is led in Canada by the Institut de recherches cliniques de Montréal with the collaboration of the Hadassah Medical Centre (Israel), and the Dokuz Eylul University (Turkey). It was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Institut de recherches cliniqu...es de Montréal
more
|
|
|
|
65679f6c212eaade2e0f055b
|
2020
|
Canada
|
International Development Rese...arch Centre
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20170085930002
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108593
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3
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Developing countries, unspecif...ied
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Regional and Unspecified
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Part I unallocated by income
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ODA Grants
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1
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10
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110
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C01
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0
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0.026253
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0
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0
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0
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0.026253
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0
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Other health problems
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Other health problems Research... and Development
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100
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TARGETING SENESCENCE CELLS IN ...PANCREATIC CANCER
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Targeting senescence cells in ...pancreatic cancer
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Cellular senescence is a progr...ammed response to oncogenic (tumour-causing) stress that aims to halt the expansion of cells with malignant potential. It does this by stopping the proliferation of pre-cancerous lesions and recruitment of the immune system for their elimination. If these processes fail, senescent cells create chronic inflammation and suppress the immune response, which promotes resistance to therapy, progression of tumours, and relapse of tumours. Using animal models and genomic engineering technologies, this project aims to eliminate senescent cells in the pancreas with a novel class of drugs known as senolytics, which were developed by the research team. The findings of this research will provide a proof of concept for new modalities of treatment against pancreatic cancer. The project is being implemented by the Université de Montréal, the Weizmann Institute of Science (Israel), and the Federal University of Parana (Brazil). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
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12182
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Medical research
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3
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I.2.a. Health, General
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51000
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University, college or other t...eaching institution, research institute or think-tank
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Université de Montréal
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