|
65679f53212eaade2e0f04c6
|
2016
|
Austria
|
Ministry for Science, Research... and Economy
more
|
2014-81-9029
|
kef-202/2014
|
3
|
South of Sahara, regional
|
South of Sahara
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.010947
|
0
|
0
|
0
|
0.010947
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
ENDOAFRICA - VASCULAR ENDOTHEL...IAL DYSFUNCTION: THE PUTATIVE INTERFACE OF EMERGING CARDIOVASCULAR RISK FACTORS
more
|
EndoAfrica - Vascular endothel...ial dysfunction: The putative interface of emerging cardiovascular risk factors
more
|
EndoAfrica - Vascular endothel...ial dysfunction: The putative interface of emerging cardiovascular risk factors affecting populations living with and without HIV in Sub-Saharan Africa.
more
|
|
12191
|
Medical services
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Medizinische Universität Graz
|
|
|
|
65679f53212eaade2e0f04c7
|
2014
|
Belgium
|
DGCD
|
2014011772
|
3011772
|
8
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0.0930967
|
0.0930967
|
0
|
0
|
0.0930967
|
0.0930967
|
0
|
0.0930967
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
#NAME?
|
#NAME?
|
Background: Among under -five... Tanzanian children, high rates of stunting and underweight occur. Although multiple factors may be responsible for this several studies suggest that one of the important causes might be found in the too high dietary exposure to mycotoxins.Particular pre - and postharvest practices such as selection of varieties, application of fertilizer, sorting and dehulling influenced significantly fumonisin contamination of maize. In addition, we showed that traditionally complementary foods are mainly composed of maize, a crop known to be very prone to mould infestation and therefore mycotoxins contamination. Although several prevention strategies are potentially available to lower dietary mycotoxin exposure via complementary foods, the effectiveness and applicability of a selection or combination of these strategies still need to be evaluated and validated in several African regions. In parallel, the awareness of all the food chain stakeholders of the mycotoxin issue should be strengthened. An integrated mycotoxin risk analysis approach consisting of appropriate risk assessment, management and communication is considered the most effective way to implement measures enabling reduction of dietary mycotoxin exposure via the consumption of complementary foods. Therefore, capacity building at both TFDA and SUA are necessary in view of their complementary expertise and responsibilities. - General objective: Overall developmental objective :To improve general public health in Tanzania via an improvement of food safetyOverall academic objective :To improve research and training capacity at both SUA and TFDA with respect to mould infestation and mycotoxin occurrence in agricultural commodities and at TFDA with respect to risk analysis. - Specific objective: Specific developmental objective :To reduce the risk of exposure to mycotoxins from complementary foods in Tanzania by use of a food based, pre -and postharvest integrated approachSpecific academic objective :To strengthen capacity at SUA in the development of pre - and postharvest strategies for management of mycotoxins in agricultural crops - Results: Results related to RESEARCH : 1. Toxigenic mould population, mycotoxin pattern, potential pre - and postharvest local risks factor to toxigenic mould infection of maize and mycotoxins intake in complementary foods are known2. Good preharvest crop management practices for prevention of mycotoxin contamination of maize, elaborated from the current local practices, are identified3. Good postharvest management practices for prevention of mycotoxins contamination of maize4. Field trial data with respect to mycotoxin exposure via consumption of complementary foods after intervention with respect to a combination of (1) changed CF composition and (2) application of more optimal post -harvest practices5. Field trial data with respect to mycotoxin exposure via consumption of complementary foods after intervention with respect to combinatio
more
|
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12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
VLIR - Vlaamse Interuniversita...ire Raad - Flemish Interuniversity Council
more
|
|
|
|
65679f53212eaade2e0f04c8
|
2015
|
Belgium
|
DGCD
|
2015016974
|
3016974
|
3
|
Suriname
|
South America
|
UMICs
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0.0449063
|
0.0449063
|
0
|
0
|
0.0449063
|
0.0449063
|
0
|
0.0449063
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
VLIR 2015 'ZUID INITIATIEVEN' ... SSSLT: SURINAME SPEECH LANGUAGE THERAPY (SLT) HEALTH CARE PROVISION: THE ROLE FOR THE SLT BA-DEGREE, THE PROFESSION
more
|
VLIR 2015 'Zuid Initiatieven' ... SSSLT: Suriname Speech Language Therapy (SLT) health care provision: the role for the SLT BA-degree, the profession
more
|
VLIR 2015 'Zuid Initiatieven' ... SSSLT: Suriname Speech Language Therapy (SLT) health care provision: the role for the SLT BA-degree, the professional SLT-association and the social SLT-field.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
VLIR-UOS - Vlaamse Interuniver...sitaire Raad - Flemish Interuniversity Council
more
|
|
|
|
65679f53212eaade2e0f04c9
|
2016
|
Belgium
|
Directorate General for Co-ope...ration and Development
more
|
2016016956
|
3016956
|
8
|
Democratic Republic of the Con...go
more
|
South of Sahara
|
LDCs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0.0903063
|
0.0903063
|
0
|
0
|
0.0903063
|
0.0903063
|
0
|
0.0903063
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
DIAGNOSTIC ET TRAITEMENT PAR H...YDROXYURÉE DE LA DRÉPANOCYTOSE EN RÉPUBLIQUE DÉMOCRATIQUE DU CONGO: ÉTUDE SCIENTIFIQUE.
more
|
Diagnostic et traitement par h...ydroxyurée de la drépanocytose en République Démocratique du Congo: étude scientifique.
more
|
VLIR 2015 ''Eigen Initiatieven...'' Diagnostic et traitement par hydroxyurée de la drépanocytose en République Démocratique du Congo: étude scientifique.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
VLIR-UOS - Vlaamse Interuniver...sitaire Raad - Flemish Interuniversity Council
more
|
|
|
|
65679f53212eaade2e0f04ca
|
2016
|
Belgium
|
Directorate General for Co-ope...ration and Development
more
|
2016016974
|
3016974
|
8
|
Suriname
|
South America
|
UMICs
|
ODA Grants
|
7
|
10
|
110
|
B01
|
0.0377485
|
0.0377485
|
0
|
0
|
0.0377485
|
0.0377485
|
0
|
0.0377485
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
SSSLT: SURINAME SPEECH LANGUAG...E THERAPY (SLT) HEALTH CARE PROVISION: THE ROLE FOR THE SLT BA-DEGREE, THE PROFESSIONAL SLT-ASSOCIATION AND THE SOCIAL S
more
|
SSSLT: Suriname Speech Languag...e Therapy (SLT) health care provision: the role for the SLT BA-degree, the professional SLT-association and the social S
more
|
VLIR 2015 ''Zuid Initiatieven'...' SSSLT: Suriname Speech Language Therapy (SLT) health care provision: the role for the SLT BA-degree, the professional SLT-association and the social SLT-field.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
VLIR-UOS - Vlaamse Interuniver...sitaire Raad - Flemish Interuniversity Council
more
|
|
|
|
65679f54212eaade2e0f04cb
|
2017
|
Belgium
|
Directorate General for Co-ope...ration and Development
more
|
2017C11678
|
3011678
|
8
|
Cuba
|
North & Central America
|
UMICs
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PROJECT OF UNIVERSITY DEVELOPM...ENT COOPERATION - OWN INITIATIVE 2011 - MOLECULAR CHARACTERIZATION AND VALORIZATION OF CUBAN NATURAL PRODUCTS :VIMANG® A
more
|
Project of University Developm...ent Cooperation - Own Initiative 2011 - Molecular characterization and valorization of Cuban natural products :Vimang® a
more
|
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
VLIR-UOS - Vlaamse Interuniver...sitaire Raad - Flemish Interuniversity Council
more
|
|
|
|
65679f54212eaade2e0f04cc
|
2017
|
Belgium
|
Directorate General for Co-ope...ration and Development
more
|
2017C00548
|
3000548
|
8
|
Democratic Republic of the Con...go
more
|
South of Sahara
|
LDCs
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PROJECT OF UNIVERSITY DEVELOPM...ENT COOPERATION - OWN INITIATIVE 2004 - DIABÈTE SUCRÉ & INSTALLATION ET MISE EN MARCHE DU TRAITEMENT AU LASER DE LA RÉT
more
|
Project of University Developm...ent Cooperation - Own Initiative 2004 - Diabète sucré & Installation et mise en marche du traitement au laser de la rét
more
|
|
|
11420
|
Higher education
|
|
I.1.d. Post-Secondary Educatio...n
more
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
VLIR-UOS - Vlaamse Interuniver...sitaire Raad - Flemish Interuniversity Council
more
|
|
|
|
65679f54212eaade2e0f04cd
|
2017
|
Belgium
|
Directorate General for Co-ope...ration and Development
more
|
2017C16956
|
3016956
|
8
|
Democratic Republic of the Con...go
more
|
South of Sahara
|
LDCs
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0.108072
|
0.108072
|
0
|
0
|
0.108072
|
0.108072
|
0
|
0.108072
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
VLIR 2015 EIGEN INITIATIEVEN D...IAGNOSTIC ET TRAITEMENT PAR HYDROXYURÉE DE LA DRÉPANOCYTOSE EN RÉPUBLIQUE DÉMOCRATIQUE DU CONGO: ÉTUDE SCIENTIFIQUE.
more
|
VLIR 2015 Eigen Initiatieven D...iagnostic et traitement par hydroxyurée de la drépanocytose en République Démocratique du Congo: étude scientifique.
more
|
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
VLIR-UOS - Vlaamse Interuniver...sitaire Raad - Flemish Interuniversity Council
more
|
|
|
|
65679f54212eaade2e0f04ce
|
2017
|
Belgium
|
Directorate General for Co-ope...ration and Development
more
|
2017C16974
|
3016974
|
8
|
Suriname
|
South America
|
UMICs
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
VLIR 2015 ZUID INITIATIEVEN ... SSSLT: SURINAME SPEECH LANGUAGE THERAPY (SLT) HEALTH CARE PROVISION: THE ROLE FOR THE SLT BA-DEGREE, THE PROFESSIONAL
more
|
VLIR 2015 Zuid Initiatieven ... SSSLT: Suriname Speech Language Therapy (SLT) health care provision: the role for the SLT BA-degree, the professional
more
|
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
VLIR-UOS - Vlaamse Interuniver...sitaire Raad - Flemish Interuniversity Council
more
|
|
|
|
65679f54212eaade2e0f04cf
|
2017
|
Belgium
|
Directorate General for Co-ope...ration and Development
more
|
2017C11772
|
3011772
|
8
|
Tanzania
|
South of Sahara
|
LDCs
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PROJECT OF UNIVERSITY DEVELOPM...ENT COOPERATION - OWN INITIATIVE 2011 - DEVELOPING EFFECTIVE STRATEGIES FOR MINIMIZING EXPOSURE TO MYCOTOXINS IN MAIZE B
more
|
Project of University Developm...ent Cooperation - Own Initiative 2011 - Developing effective strategies for minimizing exposure to mycotoxins in maize b
more
|
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
VLIR-UOS - Vlaamse Interuniver...sitaire Raad - Flemish Interuniversity Council
more
|
|
|
|
65679f54212eaade2e0f04d0
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2016008401XZA1
|
108401
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.129238
|
0
|
0
|
0
|
0.129238
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
REGULATION OF STEM-CELL MEDIAT...ED HOST IMMUNITY BY THE SPHINGOLIPID PATHWAY
more
|
Regulation of stem-cell mediat...ed host immunity by the sphingolipid pathway
more
|
Changes in the functioning of ...the human immune system are the main cause for many diseases, including auto-immunity, infections, and cancer. Research suggests that the sphingolipid pathway plays an important role in hematopoietic stem cell functions and, as a consequence, in the generation of mature immune cells and the functioning of the surrounding environment. This project uses advanced molecular biology and genetic methods with human cells and genetically engineered mice to examine how the human immune system develops from hematopoietic stem cells and how host immunity is established. It will also explore day/night cycles that influence the functioning of the immune system in order to decipher the mechanism controlling different host immunity responses and mortality rates from bacterial infections induced in the afternoon (high mortality) and at midnight (low mortality). This research has the potential to contribute to our understanding of the immune system and to advancements in the treatment of patients. Other positive impacts can include optimized methods to generate immune cells for cell transplantation, better drugs to treat diseases that involve abnormal immune cell functioning, and better methods to time the delivery of drugs in order to achieve maximum effect. The project is led in Canada by the University Health Network and the University of Toronto, in collaboration with the Weizmann Institute (Israel) and the Oncology Hospital of the Instituto Mexicano del Seguro Social (Mexico). It is funded through the second research competition of the Joint Canada-Israel Health Research Program, a partnership between Canada's International Development Research Centre, the Canadian Institutes for Health Research, the Israel Science Foundation and the Azrieli Foundation. This 7-year, $35M Canadian-Israeli effort draws on the unique scientific strengths of both countries and facilitates networking opportunities with peers from Africa, Asia, and Latin America. Projects include a plan for integrating researchers from low- and middle-income countries that will establish long-term scientific relationships.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
32000
|
Networks
|
University Health Network/Rés...eau universitaire de santé
more
|
|
|
|
65679f55212eaade2e0f04d1
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2016008403XZA1
|
108403
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.120662
|
0
|
0
|
0
|
0.120662
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
SLAMF6 AND 2B4: ROLES AND MODE...S OF ACTION IN NORMAL IMMUNITY AND CANCER IMMUNOTHERAPY
more
|
SLAMF6 and 2B4: Roles and mode...s of action in normal immunity and cancer immunotherapy
more
|
A functioning immune system is... critical for successful treatment of cancer. Recent studies have shown an improvement of the immune response against cancer triggered by new drugs that block the function of certain types of receptors at the surface of immune cells. This project seeks to understand the role of two new potential molecular targets for immunotherapy against cancer in humans: the SLAMF6 receptor and the 2B4 receptor. These receptors are at the surface of key immune cells (CD8+T and NK lymphocytes), and they play an important regulatory role during the anti-tumor response mediated by these cells. The research team hypothesizes that pharmacological targeting of SLAMF6 and 2B4 could be helpful in the treatment of cancer. Findings from this research project will further basic knowledge of the role of SLAMF6 and 2B4 in immune cells, and determine whether these two receptors are valid clinical targets for pharmacologic treatment of human cancers. The project is led in Canada by the Institut de recherches cliniques de Montréal (affiliated with the University of Montreal), in collaboration with the Hadassah Hebrew University (Israel), Universidad Autónoma del Estado de Morelos (Mexico), and the Hebrew University (Israel). This project was selected and approved for funding through the second research competition of the Joint Canada-Israel Health Research Program, which is a partnership between Canada's International Development Research Centre, the Canadian Institutes for Health Research, the Israel Science Foundation and the Azrieli Foundation. This 7-year, $35M Canadian-Israeli effort draws on the unique scientific strengths of both countries and facilitates networking opportunities with peers from Africa, Asia, and Latin America. Projects include a plan for integrating researchers from low- and middle-income countries that will establish long-term scientific relationships.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
22000
|
National NGOs
|
Institut de recherches cliniqu...es de Montréal
more
|
|
|
|
65679f55212eaade2e0f04d2
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2017008587XZA1
|
108587
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.387593
|
0.0645651
|
0
|
0
|
0.387593
|
0.0645651
|
0
|
0.387593
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
SYSTEMATIC AND COMPREHENSIVE A...NALYSIS OF MUTANT P53 PROTEINS IN LUNG CANCER IN VITRO AND IN VIVO
more
|
Systematic and comprehensive a...nalysis of mutant p53 proteins in lung cancer in vitro and in vivo
more
|
The gene p53 is a well-known t...umor suppressor gene that prevents cancer formation. It is the most commonly mutated gene among individuals with a diagnosis of cancer. Through recent advances in DNA sequencing abilities, researchers are now in the position to take a patient's tumor and identify the exact mutation in p53 and other cancers genes, which potentially allow the development of personalized patient care. This project aims to systematically characterize proteins that bind to mutant p53 in order to identify all the proteins that stabilize and activate mutant p53 as well as the molecular pathways that are coopted/corrupted by mutant p53. Once identified, the ultimate goal is to screen for compounds that disrupt these interactions with the hope to find novel therapeutic strategies to treat patients harbouring specifically these p53 mutations. The project findings will possibly extend to other cancers associated with p53 mutations.The project is led in Canada by Dr. Daniel Schramek (Lunenfeld-Tanenbaum Research Institute - Mount Sinai Hospital). His main collaborators are Dr. Moshe Oren from the Weizmann Institute of Science (Israel), Dr. Patricia Aston-Prola from the Universidade Federal do Rio Grande do Sul (Brazil), and Dr. Lucia Chemes from the Universidad San Martin (Argentina). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between Canada's International Development Research Centre, the Canadian Institutes of Health Research, the Israel Science Foundation and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
11000
|
Donor government
|
Sinai Health System
|
|
|
|
65679f55212eaade2e0f04d3
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2017008589XZA1
|
108589
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.379273
|
0.055086
|
0
|
0
|
0.379273
|
0.055086
|
0
|
0.379273
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF EPITRANSCRIPTOME A...ND TRANSLATIONAL DYSREGULATION IN CANCER
more
|
The role of epitranscriptome a...nd translational dysregulation in cancer
more
|
Proteins represent the final p...roduct of genes and are implicated in governing most cellular functions. Production of proteins from genes is referred to as gene expression. Genes are first transcribed into messenger RNA (mRNA). This is followed by mRNA translation, which is a process whereby the translation machinery reads the code stored in the mRNAs to produce proteins. In addition, mRNAs are also regulated by degradation. Malignant transformation is a phenomenon during which normal cells acquire malignant properties to become cancer. Malignant transformation and cancer progression are characterized by dramatic changes in gene expression. Recent years have also brought evidence of dynamic chemical changes in mRNA molecules that have been shown to influence gene expression. These modifications are induced by factors called writers, removed by factors called erasers and recognized by factors called readers. Levels and/or function of writers, erasers and readers are reported to be altered in a variety of cancers, but their precise role in dysregulation of gene expression in cancer remains poorly understood. In this project, a team of researchers from Israel, Canada and Brazil has come together to investigate the contribution of mRNA modifications in cancer by employing a unique combination of recently developed systems of biology technologies and classical cellular and molecular biology techniques. The project is led in Canada by Dr. Ivan Topisirovic (Lady Davis Institute for Medical Research of McGill University). His main collaborators are Dr. Dan Dominissini from the Sheba Cancer Research Centre (Israel), and Dr. Glaucia Maroso Hajj from the A.C. Camargo Cancer Centre (Brazil). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between Canada's International Development Research Centre, the Canadian Institutes of Health Research, the Israel Science Foundation and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Sir Mortimer B. Davis Jewi...sh General Hospital / Centre intégré universitaire de santé et de serv
more
|
|
|
|
65679f55212eaade2e0f04d4
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2017008590XZA1
|
108590
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.387823
|
0.0602964
|
0
|
0
|
0.387823
|
0.0602964
|
0
|
0.387823
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NOTCH AS MASTER REGULATOR OF B...REAST CANCER SUBTYPE AND INTRATUMORAL HETEROGENEITY
more
|
NOTCH as master regulator of b...reast cancer subtype and intratumoral heterogeneity
more
|
Tumor heterogeneity is a drivi...ng force for disease progression and one of the major obstacles to effective treatment. Heterogeneity is driven by mutations, as well as by differentiation-like processes that generate diverse cancer cell phenotypes and functions. Uncovering regulatory pathways controlling this diversity is of critical importance for the development of effective therapies targeting distinct cell types, and, potentially, for inducing changes in tumor differentiation status. Estrogen receptor-negative breast tumors include cells with a mixture of differentiated states. Cellular heterogeneity within these cancers can lead to the generation of subpopulations that resist therapy. In many biological systems, signaling through so-called Notch receptors is used to create the cell diversity associated with functional tissues. This issue represents a challenge with respect to development of effective treatment for breast cancer. This proposal describes a collaborative project whereby team members in Canada, Israel and India work together to define mechanisms by which breast cancer cellular diversity or heterogeneity develops and is maintained. Since Notch signaling is activated in so many types of breast cancers and leads to regulation of cell fate in this context, results from this project may help to identify how these receptors can be targeted to therapeutic benefit.The project is led in Canada by Dr. Sean Egan (Hospital for Sick Children). His main collaborators are Dr. Ittai Ben-Porat from the Hebrew University of Jerusalem (Israel), and Dr. Annapoorni Rangarajan from the Indian Institute of Science (India). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between Canada's International Development Research Centre, the Canadian Institutes of Health Research, the Israel Science Foundation and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
11000
|
Donor government
|
Hospital for Sick Children
|
|
|
|
65679f55212eaade2e0f04d5
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2017008591XZA1
|
108591
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.387746
|
0.0715554
|
0
|
0
|
0.387746
|
0.0715554
|
0
|
0.387746
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF IL6 IN LIVER CANCE...R LINKED TO METABOLIC LIVER DISEASE
more
|
The role of IL6 in liver cance...r linked to metabolic liver disease
more
|
Liver cancer, a highly fatal c...ancer with very few treatment options, is one of few cancers whose incidence is rising worldwide. One poorly understood risk factor for liver cancer is obesity and metabolic diseases, such as diabetes and fatty liver disease. Since these conditions are reaching epidemic proportions in many countries, we can expect the prevalence of liver cancer to continue to rise. In order to find innovative ways to treat liver cancer, this projects aims to identify proteins and cell pathways that influence liver tumor development and growth, specifically in obesity. The team will investigate whether a new signaling pathway for interleukin 6 (IL6) controls liver tumor development in mice made obese by diets high in sugar and fat, and in obese patients with liver cancer. IL6 is a hormone that circulates in the blood, and thus, has the potential to be both a new biomarker of liver cancer and a new therapeutic target to treat the disease. The project is led in Canada by Dr. Jennifer Estall (Institut de recherches cliniques de Montreal). Her main collaborators are Dr. Eithan Galun from the Hadassah Medical Centre (Israel), and Dr. Mehmet Ozturk from the Dokuz Eylul University (Turkey). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between Canada's International Development Research Centre, the Canadian Institutes of Health Research, the Israel Science Foundation and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
22000
|
National NGOs
|
Institut de recherches cliniqu...es de Montréal
more
|
|
|
|
65679f56212eaade2e0f04d6
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2017008593XZA1
|
108593
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.387592
|
0.0560151
|
0
|
0
|
0.387592
|
0.0560151
|
0
|
0.387592
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TARGETING SENESCENCE CELLS IN ...PANCREATIC CANCER
more
|
Targeting senescence cells in ...pancreatic cancer
more
|
Cellular senescence is a progr...ammed response to oncogenic stress that aims to halt the expansion of cells with malignant potential by stopping the proliferation of pre-cancerous lesions and recruitment of the immune system for their elimination. If these processes fail, senescent cells create chronic inflammation and suppress the immune response, which promotes resistance to therapy, tumor progression and tumor relapse. Using animal models and genomic engineering technologies, this project aims to eliminate senescent cells in the pancreas with a novel class of drugs developed by the research team (senolytics). The findings of this research will provide a proof of concept for new modalities of treatment against pancreatic cancer.The project is led in Canada by Dr. Gerardo Ferbeyre (Université de Montréal). His main collaborators are Dr. Valery Krizhanovsky from the Weizmann Institute of Science (Israel) and Paloma Kalegari from the Federal University of Parana (Brazil). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between Canada's International Development Research Centre, the Canadian Institutes of Health Research, the Israel Science Foundation and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Université de Montréal
|
|
|
|
65679f56212eaade2e0f04d7
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2017008594XZA1
|
108594
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.387746
|
0.0646245
|
0
|
0
|
0.387746
|
0.0646245
|
0
|
0.387746
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
UNDERSTANDING THE ROLE OF TYPE... 1 INTERFERON IN RESISTANCE TO CANCER IMMUNOTHERAPY
more
|
Understanding the role of type... 1 interferon in resistance to cancer immunotherapy
more
|
Chemotherapy is the main form ...of treatment for cancer but cannot cure most types of cancer. Immunotherapy is another form of treatment that tries to stimulate cells of the body's immune system (T cells) to kill cancer cells. Unfortunately, cancers may become resistant to T cells in the same way they learn to resist chemotherapy. This resistance is partly caused by a blood protein called interferon. This project aims to improve the effectiveness of cancer immunotherapy. Based on previous work, the research team will investigate the use of interferon inhibitors to treat cancer cells from patients with leukemia. The choice of leukemia as a model is convenient due to large availability of cell samples. This approach is expected to increase cure rates with immunotherapy in leukemia and also many other forms of cancer. Moreover, the results of this study can open the path to the development of new innovative cancer drugs based on interferon inhibition.The project is led in Canada by Dr. David Spaner (Sunnybrook Research Institute – University of Toronto). His main collaborators are Dr. Gideon Schreiber from the Weizmann Institute of Science (Israel), and Dr. You-Jun Li from the Jilin University (China). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between Canada's International Development Research Centre, the Canadian Institutes of Health Research, the Israel Science Foundation and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
21000
|
International NGOs
|
Sunnybrook Research Institute
|
|
|
|
65679f56212eaade2e0f04d8
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2017008642XZA1
|
108642
|
1
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.112395
|
0.0533896
|
0
|
0
|
0.112395
|
0.0533896
|
0
|
0.112395
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
ECONOMICS OF NCDS IN LOW- AND ...MIDDLE-INCOME COUNTRIES
more
|
Economics of NCDs in low- and ...middle-income countries
more
|
This research support project ...will inform strategic program development to strengthen innovative, cutting-edge economic analyses and research capacity in low and middle income countries (LMICs) that support the prevention of non-communicable diseases (NCDs). It will engage senior members of the Applied Economics and Development Research Group at the American University of Beirut to carry out a state-of-the-art review and synthesis on the economics of NCDs with the aim of building the case for increased investments in disease prevention. It will also contribute new analyses of research gaps and needs, and guide the Food Environment and Health program in strengthening LMIC networks of researchers in applied economics interested in population health policy interventions and the assessment of associated social, environmental and economic trade-offs. This includes targeting researchers in universities with a focus on Middle East and North Africa (MENA) region, international development agencies (e.g. Word Bank, UN System, WHO) and other independent research institutes (e.g. Economic Research Forum, World Economic Forum).
more
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
American University of Beirut
|
|
|
|
65679f56212eaade2e0f04d9
|
2017
|
Canada
|
International Development Rese...arch Centre
more
|
2016999987
|
108578
|
3
|
Middle East, regional
|
Middle East
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0118565
|
0
|
0
|
0
|
0.0118565
|
0
|
0
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
DEVELOPMENT OF RESEARCH PROPOS...ALS FOR PREVENTING DIET RELATED CHRONIC DISEASES IN THE MIDDLE EAST AND NORTH AFRICA
more
|
Development of research propos...als for preventing diet related chronic diseases in the Middle East and North Africa
more
|
This project will support the ...development of a first set of research proposals (up to six full proposals) and provision of expert technical guidance to selected research teams from the Middle East and North Africa. It will foster the creation of a critical mass of scientists leading a new field of research on health-supporting food systems in the region, with the aim of curbing the rapid deterioration of diets in low- and middle-income countries and the associated sharp rise in chronic diseases. The project will fund a first proposal development workshop with four selected multidisciplinary teams from five countries of the Middle East. The workshop will be hosted at the American University of Beirut (AUB) in Lebanon. Proposal development support will include guidance from experts in food systems, nutrition and health, and gender equity. This support will be provided through the experts' participation at the AUB workshop and follow-up meetings (virtual and in person) over a six-month period. Overall activities of the project include: conceptual and methodological discussions with invited teams on linkages between food systems, diets, and health; incorporation of gender equity dimensions in research design; the dissemination of regional reviews on the current state of knowledge and gaps on food- and diet-related risk factors for chronic diseases; exploration of the regional funding landscape for partnership opportunities; and strategies to expand collaboration between scientific and policy communities. Planned activities will evolve and adapt to emerging opportunities for engaging new research leaders and teams from the region and potential funding partners over the duration of the project.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
11000
|
Donor government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/C
more
|
|
|
|
65679f56212eaade2e0f04da
|
2018
|
Canada
|
Global Affairs Canada
|
20172013750002
|
P005055001
|
3
|
Africa, regional
|
Africa
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
B03
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
-0.00712727
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CANADA'S ASSESSED CONTRIBUTION... TO THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC)/LA CONTRIBUTION DU CANADA AU CENTRE INTERNATIONAL DE RECHERC
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC)/La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC) / La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
47000
|
Other multilateral institution...s
more
|
Centre international deRecherc...he sur le Cancer (CIRC/IARC)
more
|
|
|
|
65679f56212eaade2e0f04db
|
2018
|
Canada
|
Global Affairs Canada
|
20182006770002
|
P005055002
|
1
|
Africa, regional
|
Africa
|
Part I unallocated by income
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0.260629
|
0.258628
|
0
|
0
|
0.260629
|
0.258628
|
0
|
0.260629
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CANADA'S ASSESSED CONTRIBUTION... TO THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC)/LA CONTRIBUTION DU CANADA AU CENTRE INTERNATIONAL DE RECHERC
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC)/La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC) / La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Centre international deRecherc...he sur le Cancer (CIRC/IARC)
more
|
|
|
|
65679f57212eaade2e0f04dc
|
2018
|
Canada
|
Global Affairs Canada
|
20172013750003
|
P005055001
|
3
|
America, regional
|
America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
B03
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
-0.00712727
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CANADA'S ASSESSED CONTRIBUTION... TO THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC)/LA CONTRIBUTION DU CANADA AU CENTRE INTERNATIONAL DE RECHERC
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC)/La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC) / La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
47000
|
Other multilateral institution...s
more
|
Centre international deRecherc...he sur le Cancer (CIRC/IARC)
more
|
|
|
|
65679f57212eaade2e0f04dd
|
2018
|
Canada
|
Global Affairs Canada
|
20182006770003
|
P005055002
|
1
|
America, regional
|
America
|
Part I unallocated by income
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0.260629
|
0.258628
|
0
|
0
|
0.260629
|
0.258628
|
0
|
0.260629
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CANADA'S ASSESSED CONTRIBUTION... TO THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC)/LA CONTRIBUTION DU CANADA AU CENTRE INTERNATIONAL DE RECHERC
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC)/La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC) / La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Centre international deRecherc...he sur le Cancer (CIRC/IARC)
more
|
|
|
|
65679f57212eaade2e0f04de
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170086430002
|
108643
|
3
|
Argentina
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.051074
|
0.049113
|
0
|
0
|
0.051074
|
0.049113
|
0
|
0.051074
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
IMPROVING DIET QUALITY THROUGH... FOOD AFFORDABILITY AND ACCESSIBILITY IN ARGENTINA
more
|
Improving diet quality through... food affordability and accessibility in Argentina
more
|
Cardiovascular disease (CVD) i...s the cause of one-third of deaths in Argentina. An unhealthy diet is a major contributor to CVD and the related rapidly increasing incidence of obesity and diabetes in the country. However, there is not enough information about the extent to which people from different socio-economic groups have access to healthy foods. This project proposes to improve understanding of the factors that affect food purchasing, and specifically how the food environment is affecting accessibility and affordability of healthy food among different social groups.Implemented by the Buenos Aires-based Centro de Estudios de Estado y Sociedad, this project will generate knowledge on the different factors that affect diet quality in Argentina, focusing on price, consumer preference, and food retail structure, including the availability of healthy foods. The team will use a mix of econometric modelling (for tax analysis and consumption demand modelling), statistical analyses (tracking relative price changes), and an environmental study (to describe household behavioural patterns). The project will also describe policy options and a regulatory framework for municipal and national-level actions that would support healthier diets. It will address how gender disparities and socio-economic differences in food purchasing can be reduced. The project will also strengthen local and national capacity to assess food environments and the policies that influence them in order to promote healthy eating and NCD prevention.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
Centro de Estudios de Estado y... Sociedad
more
|
|
|
|
65679f57212eaade2e0f04df
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170086430001
|
108643
|
3
|
Argentina
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.093946
|
0
|
0
|
0
|
0.093946
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
IMPROVING DIET QUALITY THROUGH... FOOD AFFORDABILITY AND ACCESSIBILITY IN ARGENTINA
more
|
Improving diet quality through... food affordability and accessibility in Argentina
more
|
Cardiovascular disease (CVD) i...s the cause of one-third of deaths in Argentina. An unhealthy diet is a major contributor to CVD and the related rapidly increasing incidence of obesity and diabetes in the country. However, there is not enough information about the extent to which people from different socio-economic groups have access to healthy foods. This project proposes to improve understanding of the factors that affect food purchasing, and specifically how the food environment is affecting accessibility and affordability of healthy food among different social groups. Implemented by the Buenos Aires-based Centro de Estudios de Estado y Sociedad, this project will generate knowledge on the different factors that affect diet quality in Argentina, focusing on price, consumer preference, and food retail structure, including the availability of healthy foods. The team will use a mix of econometric modelling (for tax analysis and consumption demand modelling), statistical analyses (tracking relative price changes), and an environmental study (to describe household behavioural patterns). The project will also describe policy options and a regulatory framework for municipal and national-level actions that would support healthier diets. It will address how gender disparities and socio-economic differences in food purchasing can be reduced. The project will also strengthen local and national capacity to assess food environments and the policies that influence them in order to promote healthy eating and NCD prevention.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
Centro de Estudios de Estado y... Sociedad
more
|
|
|
|
65679f57212eaade2e0f04e0
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086460006
|
108646
|
3
|
Argentina
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0642697
|
0
|
0
|
0
|
0.0642697
|
0
|
|
0
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
MODELLING THE IMPACT OF STRATE...GIES TO ADDRESS THE BURDEN OF SUGARY DRINKS CONSUMPTION IN LATIN AMERICA AND THE CARIBBEAN
more
|
Modelling the impact of strate...gies to address the burden of sugary drinks consumption in Latin America and the Caribbean
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
IECS - Instituto de Efectivida...d Clinica Y Sanitaria Asociacion Civil
more
|
|
|
|
65679f57212eaade2e0f04e1
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170086460005
|
108646
|
3
|
Caribbean, regional
|
Caribbean & Central America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.001625
|
0
|
0
|
0
|
0.001625
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
MODELLING THE IMPACT OF STRATE...GIES TO ADDRESS THE BURDEN OF SUGARY DRINKS CONSUMPTION IN LATIN AMERICA AND THE CARIBBEAN
more
|
Modelling the impact of strate...gies to address the burden of sugary drinks consumption in Latin America and the Caribbean
more
|
Non-communicable diseases are ...responsible for more than half of the global burden of disease. Overweight and obesity are among the main modifiable risk factors worldwide and their prevalence has been steadily increasing in Latin America and the Caribbean. Sugar-sweetened beverages (SSBs) usually constitute a major source of discretionary calories, and have been linked to an increased risk of obesity, type 2 diabetes, several cancers, hypertension, coronary heart disease, and tooth decay. For these reasons, many countries are considering, or have begun implementing, a series of measures aimed at reducing SSB consumption. The implementation of these interventions needs to be supported by adequate scientific evidence and requires the commitment of different stakeholders in order to be successful. However, there is a lack of data on the burden of disease attributable to SSBs, and an absence of tools to assess the potential impact of policies. These factors result in a lack of consensus on the need to implement such policies and on the priority they should be given. The aim of this project, implemented by the Argentina-based Instituto de Efectividad Clinica y Sanitaria Asociación Civil is to fulfill these information needs by generating country-level evidence on the disease burdens attributable to SSB consumption and compiling a knowledge base on available interventions in the region. The research team will develop an economic model to estimate the disease burden and cost-effectiveness of relevant policies in Latin America and the Caribbean. The project will be carried out, and the model tested, in Argentina, Brazil, El Salvador, and Trinidad and Tobago. Results from this study are expected to empower decision-makers to select the best set of interventions to reduce the consumption of SSBs and their related health toll in Latin America and the Caribbean.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
IECS - Instituto de Efectivida...d Clinica Y Sanitaria Asociacion Civil
more
|
|
|
|
65679f57212eaade2e0f04e2
|
2018
|
Canada
|
Global Affairs Canada
|
20172013750004
|
P005055001
|
3
|
Asia, regional
|
Asia
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
B03
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
-0.00712727
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CANADA'S ASSESSED CONTRIBUTION... TO THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC)/LA CONTRIBUTION DU CANADA AU CENTRE INTERNATIONAL DE RECHERC
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC)/La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC) / La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
47000
|
Other multilateral institution...s
more
|
Centre international deRecherc...he sur le Cancer (CIRC/IARC)
more
|
|
|
|
65679f58212eaade2e0f04e3
|
2018
|
Canada
|
Global Affairs Canada
|
20182006770004
|
P005055002
|
1
|
Asia, regional
|
Asia
|
Part I unallocated by income
|
ODA Grants
|
3
|
10
|
110
|
B01
|
0.260629
|
0.258628
|
0
|
0
|
0.260629
|
0.258628
|
0
|
0.260629
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
CANADA'S ASSESSED CONTRIBUTION... TO THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC)/LA CONTRIBUTION DU CANADA AU CENTRE INTERNATIONAL DE RECHERC
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC)/La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
Canada's assessed contribution... to the International Agency for Research on Cancer (IARC) / La contribution du Canada au Centre international de Recherche sur le Cancer (CIRC)
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Centre international deRecherc...he sur le Cancer (CIRC/IARC)
more
|
|
|
|
65679f58212eaade2e0f04e4
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086460008
|
108646
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0642697
|
0
|
0
|
0
|
0.0642697
|
0
|
|
0
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
MODELLING THE IMPACT OF STRATE...GIES TO ADDRESS THE BURDEN OF SUGARY DRINKS CONSUMPTION IN LATIN AMERICA AND THE CARIBBEAN
more
|
Modelling the impact of strate...gies to address the burden of sugary drinks consumption in Latin America and the Caribbean
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
IECS - Instituto de Efectivida...d Clinica Y Sanitaria Asociacion Civil
more
|
|
|
|
65679f58212eaade2e0f04e5
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086460007
|
108646
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.151917
|
0
|
0
|
0
|
0.151917
|
0
|
0
|
0.151917
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
MODELLING THE IMPACT OF STRATE...GIES TO ADDRESS THE BURDEN OF SUGARY DRINKS CONSUMPTION IN LATIN AMERICA AND THE CARIBBEAN
more
|
Modelling the impact of strate...gies to address the burden of sugary drinks consumption in Latin America and the Caribbean
more
|
Non-communicable diseases are ...responsible for more than half of the global burden of disease. Overweight and obesity are among the main modifiable risk factors worldwide and their prevalence has been steadily increasing in Latin America and the Caribbean. Sugar-sweetened beverages (SSBs) usually constitute a major source of discretionary calories, and have been linked to an increased risk of obesity, type 2 diabetes, several cancers, hypertension, coronary heart disease, and tooth decay. For these reasons, many countries are considering, or have begun implementing, a series of measures aimed at reducing SSB consumption. The implementation of these interventions needs to be supported by adequate scientific evidence and requires the commitment of different stakeholders in order to be successful. However, there is a lack of data on the burden of disease attributable to SSBs, and an absence of tools to assess the potential impact of policies. These factors result in a lack of consensus on the need to implement such policies and on the priority they should be given. The aim of this project, implemented by the Argentina-based Instituto de Efectividad Clinica y Sanitaria Asociación Civil is to fulfill these information needs by generating country-level evidence on the disease burdens attributable to SSB consumption and compiling a knowledge base on available interventions in the region. The research team will develop an economic model to estimate the disease burden and cost-effectiveness of relevant policies in Latin America and the Caribbean. The project will be carried out, and the model tested, in Argentina, Brazil, El Salvador, and Trinidad and Tobago. Results from this study are expected to empower decision-makers to select the best set of interventions to reduce the consumption of SSBs and their related health toll in Latin America and the Caribbean.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
IECS - Instituto de Efectivida...d Clinica Y Sanitaria Asociacion Civil
more
|
|
|
|
65679f58212eaade2e0f04e6
|
2018
|
Canada
|
Miscellaneous
|
2018899983a
|
161021-1
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.00115732
|
0
|
0
|
0
|
0.00115732
|
0
|
|
0
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
EXPLORING KNOWLEDGE, ATTITUDES... AND PRACTICES REGARDING NON-COMMUNICABLE DISEASES AMONG COMMUNITY HEALTH WORKERS IN SÃO PAULO, BRAZIL
more
|
Exploring Knowledge, Attitudes... and Practices Regarding Non-Communicable Diseases Among Community Health Workers in São Paulo, Brazil
more
|
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
McGill University/Université ...McGill
more
|
|
|
|
65679f58212eaade2e0f04e7
|
2018
|
Canada
|
Miscellaneous
|
2018899983b
|
161021-1
|
3
|
Brazil
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.00115732
|
0
|
0
|
0
|
0.00115732
|
0
|
0
|
0.00115732
|
0
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
EXPLORING KNOWLEDGE, ATTITUDES... AND PRACTICES REGARDING NON-COMMUNICABLE DISEASES AMONG COMMUNITY HEALTH WORKERS IN SÃO PAULO, BRAZIL
more
|
Exploring Knowledge, Attitudes... and Practices Regarding Non-Communicable Diseases Among Community Health Workers in São Paulo, Brazil
more
|
Chronic diseases are the main ...causes of death in Brazil and around the world. They include heart diseases, lung diseases, diabetes and cancers. They are a big health challenge as there are not enough health professionals, especially doctors, to care for people with these diseases in an optimal way. One of the solutions is to share some of the clinical responsibilities with community health workers (CHWs). CHWs are people from the community who are briefly trained to provide basic health education to people in their neighborhood. These CHWs are integrated in family health teams and are very present in Brazil and in the city of Sao Paulo, where our research partner is located. CHWs do home visits, and work with nurses and physicians on a daily basis. However, we do not know much about their knowledge and current practices related to prevention and control of chronic diseases. Therefore, this participatory research project will first send an online survey to all CHWs working for our research partner. This survey will assess what they currently know and do about chronic diseases. In a second phase, focus groups will be conducted with CHWs and the nurses and physicians they work with regularly. The focus groups will address questions of potential knowledge gaps, of how CHWs could contribute more effectively to chronic disease management in collaboration with nurses and physicians, and of additional training needs. The results of this project will help improve community health workers' knowledge and skills. This has the potential of increasing the effectiveness of family health teams in providing preventive care and treatments to people at risk of or living with chronic diseases in their community. In turn, this could translate into better health outcomes on the long term and on a larger scale.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
McGill University/Université ...McGill
more
|
|
|
|
65679f58212eaade2e0f04e8
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088190004
|
108819
|
3
|
Colombia
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.021995
|
0
|
0
|
0
|
0.021995
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
STRENGTHENING THE EVIDENCE FOR... ADVANCING TOBACCO CONTROL POLICY IN MEXICO, COLOMBIA, AND INDIA
more
|
Strengthening the evidence for... advancing tobacco control policy in Mexico, Colombia, and India
more
|
The Framework Convention on To...bacco Control, the implementation of which is a specific target (3.a) of the 2030 Sustainable Development Goals, recognises that raising taxes is the most cost effective tobacco control measure. India, Mexico and Colombia are all rapidly growing economies with a large share of the youth population and where effective and pro poor means of making smoking unaffordable and improving health outcomes for the over 115 million number of smokers who live in these countries is a critical priority.The Global Tobacco Economics Consortium, led by the Instituto Nacional de Salud Pública in Mexico, will use the extended cost effective analysis method to estimate the effect at the national and subnational level of tobacco tax increases on health care costs and poverty. It will also deepen the understanding the differential impacts of the household costs of tobacco use on gender over time. The consortium brings together research teams in Colombia, Mexico, and India, who will improve their understanding of how tobacco control policy is developed in their specific country context. This will allow them to better communicate the value of using economic tools and evidence for setting optimal tobacco taxes. The integration of evidence from across these three country contexts will contribute to global literature and momentum for large scale tax increases in low and middle income countries for progress on the Sustainable Development Goals.This project is funded through the Economics of Tobacco Control Research Initiative, a 5-year IDRC and Cancer Research UK partnership launched in October 2017.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Instituto Nacional de Salud P...blica
more
|
|
|
|
65679f59212eaade2e0f04e9
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088190003
|
108819
|
3
|
Colombia
|
South America
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.023524
|
0
|
0
|
0
|
0.023524
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
STRENGTHENING THE EVIDENCE FOR... ADVANCING TOBACCO CONTROL POLICY IN MEXICO, COLOMBIA, AND INDIA
more
|
Strengthening the evidence for... advancing tobacco control policy in Mexico, Colombia, and India
more
|
The Framework Convention on To...bacco Control, the implementation of which is a specific target (3.a) of the 2030 Sustainable Development Goals, recognises that raising taxes is the most cost effective tobacco control measure. India, Mexico and Colombia are all rapidly growing economies with a large share of the youth population and where effective and pro poor means of making smoking unaffordable and improving health outcomes for the over 115 million number of smokers who live in these countries is a critical priority. The Global Tobacco Economics Consortium, led by the Instituto Nacional de Salud Pública in Mexico, will use the extended cost effective analysis method to estimate the effect at the national and subnational level of tobacco tax increases on health care costs and poverty. It will also deepen the understanding the differential impacts of the household costs of tobacco use on gender over time. The consortium brings together research teams in Colombia, Mexico, and India, who will improve their understanding of how tobacco control policy is developed in their specific country context. This will allow them to better communicate the value of using economic tools and evidence for setting optimal tobacco taxes. The integration of evidence from across these three country contexts will contribute to global literature and momentum for large scale tax increases in low and middle income countries for progress on the Sustainable Development Goals. This project is funded through the Economics of Tobacco Control Research Initiative, a 5-year IDRC and Cancer Research UK partnership launched in October 2017.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Instituto Nacional de Salud P...blica
more
|
|
|
|
65679f59212eaade2e0f04ea
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20160084010001
|
108401
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.008634
|
0
|
0
|
0
|
0.008634
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
REGULATION OF STEM-CELL MEDIAT...ED HOST IMMUNITY BY THE SPHINGOLIPID PATHWAY
more
|
Regulation of stem-cell mediat...ed host immunity by the sphingolipid pathway
more
|
Changes in the functioning of ...the human immune system are the main cause for many diseases, including auto-immunity, infections, and cancer. Research suggests that the sphingolipid pathway plays an important role in hematopoietic stem cell functions and, as a consequence, in the generation of mature immune cells and the functioning of the surrounding environment. This project uses advanced molecular biology and genetic methods with human cells and genetically engineered mice to examine how the human immune system develops from hematopoietic stem cells and how host immunity is established. It will also explore day/night cycles that influence the functioning of the immune system in order to decipher the mechanism controlling different host immunity responses and mortality rates from bacterial infections induced in the afternoon (high mortality) and at midnight (low mortality). This research has the potential to contribute to our understanding of the immune system and to advancements in the treatment of patients. Other positive impacts can include optimized methods to generate immune cells for cell transplantation, better drugs to treat diseases that involve abnormal immune cell functioning, and better methods to time the delivery of drugs in order to achieve maximum effect. The project is led in Canada by the University Health Network and the University of Toronto, in collaboration with the Weizmann Institute (Israel) and the Oncology Hospital of the Instituto Mexicano del Seguro Social (Mexico). It is funded through the second research competition of the Joint Canada-Israel Health Research Program, a partnership between Canada's International Development Research Centre, the Canadian Institutes for Health Research, the Israel Science Foundation and the Azrieli Foundation. This 7-year, $35M Canadian-Israeli effort draws on the unique scientific strengths of both countries and facilitates networking opportunities with peers from Africa, Asia, and Latin America. Projects include a plan for integrating researchers from low- and middle-income countries that will establish long-term scientific relationships.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University Health Network/Rés...eau universitaire de santé
more
|
|
|
|
65679f59212eaade2e0f04eb
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20160084030001
|
108403
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.120848
|
0
|
0
|
0
|
0.120848
|
0
|
|
0
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
SLAMF6 AND 2B4: ROLES AND MODE...S OF ACTION IN NORMAL IMMUNITY AND CANCER IMMUNOTHERAPY
more
|
SLAMF6 and 2B4: Roles and mode...s of action in normal immunity and cancer immunotherapy
more
|
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Institut de recherches cliniqu...es de Montréal
more
|
|
|
|
65679f59212eaade2e0f04ec
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085870001
|
108587
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.020161
|
0
|
0
|
0
|
0.020161
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
SYSTEMATIC AND COMPREHENSIVE A...NALYSIS OF MUTANT P53 PROTEINS IN LUNG CANCER IN VITRO AND IN VIVO
more
|
Systematic and comprehensive a...nalysis of mutant p53 proteins in lung cancer in vitro and in vivo
more
|
The gene p53 is a well-known t...umour suppressor gene that prevents cancer formation. It is the most commonly mutated gene among individuals with a diagnosis of cancer. Through recent advances in DNA sequencing abilities, researchers are now in a position to take a patient's tumour and identify the exact mutation in p53 and other cancers' genes, which potentially allows the development of personalized patient care. This project aims to systematically characterize proteins that bind to mutant p53 in order to identify all the proteins that stabilize and activate mutant p53, as well as the molecular pathways that are co-opted/corrupted by mutant p53. The analysis will occur in living tissues (in vivo) and in a laboratory vessel (in vitro). Once identified, the ultimate goal is to screen for compounds that disrupt these interactions with the hope of finding novel therapeutic strategies to treat patients harbouring these specific p53 mutations. The project findings will possibly extend to other cancers associated with p53 mutations.The project is being implemented by the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital (Toronto), the Weizmann Institute of Science (Israel), the Universidade Federal do Rio Grande do Sul (Brazil), and the Universidad San Martin (Argentina). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
11000
|
Donor Government
|
Sinai Health System
|
|
|
|
65679f59212eaade2e0f04ed
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085890001
|
108589
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.022748
|
0
|
0
|
0
|
0.022748
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF EPITRANSCRIPTOME A...ND TRANSLATIONAL DYSREGULATION IN CANCER
more
|
The role of epitranscriptome a...nd translational dysregulation in cancer
more
|
Proteins represent the final p...roduct of genes and are implicated in governing most cellular functions. Production of proteins from genes is referred to as gene expression. Genes are first transcribed into messenger ribonucleic acid (mRNA). This is followed by mRNA translation, a process whereby the translation machinery reads the code stored in the mRNAs to produce proteins. In addition, mRNAs are also regulated by degradation. Malignant transformation is a phenomenon during which normal cells acquire malignant properties to become cancer. Malignant transformation and cancer progression are characterized by dramatic changes in gene expression. Recent years have brought evidence of dynamic chemical changes in mRNA molecules that have been shown to influence gene expression. These modifications are induced by factors called writers, removed by factors called erasers, and recognized by factors called readers. Levels and/or function of writers, erasers, and readers are reported to be altered in a variety of cancers, but their precise role in dysregulation of gene expression in cancer remains poorly understood. This project will investigate the contribution of mRNA modifications in cancer by employing a unique combination of recently developed systems of biology technologies and classical cellular and molecular biology techniques. The partners implementing this project are the Lady Davis Institute for Medical Research of McGill University (Montreal), the Sheba Cancer Research Centre (Israel), and the A.C. Camargo Cancer Centre (Brazil). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Sir Mortimer B. Davis Jewi...sh General Hospital / Centre intégré universitaire de santé et de serv
more
|
|
|
|
65679f59212eaade2e0f04ee
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085900001
|
108590
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.021854
|
0
|
0
|
0
|
0.021854
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
NOTCH AS MASTER REGULATOR OF B...REAST CANCER SUBTYPE AND INTRATUMOURAL HETEROGENEITY
more
|
Notch as master regulator of b...reast cancer subtype and intratumoural heterogeneity
more
|
Tumour heterogeneity is a driv...ing force for disease progression and one of the major obstacles to effective treatment. Heterogeneity is driven by mutations and other processes that generate diverse cancer cell phenotypes and functions. Uncovering the pathways controlling this diversity is of critical importance for the development of effective therapies targeting distinct cell types, and, potentially, for inducing changes in tumour differentiation status. Estrogen receptor-negative breast tumours include cells with a mixture of differentiated states. Cellular heterogeneity within these cancers can lead to the generation of subpopulations that resist therapy. In many biological systems, signaling through so-called Notch receptors is used to create the cell diversity associated with functional tissues. This issue represents a challenge with respect to the development of effective treatment for breast cancer. This project aims to define mechanisms by which breast cancer cellular diversity or heterogeneity develops and is maintained. Since Notch signaling is activated in so many types of breast cancers and leads to regulation of cell fate in this context, results from this project may help to identify how these receptors can be targeted for therapeutic benefit.The project is being implemented by the Hospital for Sick Children in Toronto, the Hebrew University of Jerusalem (Israel), and the Indian Institute of Science. It was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Hospital for Sick Children
|
|
|
|
65679f59212eaade2e0f04ef
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085910001
|
108591
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.018856
|
0
|
0
|
0
|
0.018856
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
THE ROLE OF IL6 IN LIVER CANCE...R LINKED TO METABOLIC LIVER DISEASE
more
|
The role of IL6 in liver cance...r linked to metabolic liver disease
more
|
Liver cancer is highly fatal, ...it has very few treatment options, and it is one of the few cancers whose incidence is rising worldwide. One poorly understood risk factor for liver cancer is obesity/metabolic disease (such as diabetes and fatty liver disease). Since these conditions are reaching epidemic proportions in many countries, the prevalence of liver cancer is expected to continue to rise. In order to find innovative ways to treat liver cancer, this project aims to identify proteins and cell pathways that influence liver tumour development and growth, specifically in obesity. The team will investigate whether a new signaling pathway for interleukin 6 (IL6) controls liver tumour development in mice that have been made obese by diets high in sugar and fat, and in obese patients with liver cancer. IL6 is a hormone that circulates in the blood, and thus has the potential to be both a new biomarker of liver cancer and a new therapeutic target to treat the disease. The project is led in Canada by the Institut de recherches cliniques de Montréal with the collaboration of the Hadassah Medical Centre (Israel), and the Dokuz Eylul University (Turkey). It was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Institut de recherches cliniqu...es de Montréal
more
|
|
|
|
65679f5a212eaade2e0f04f0
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085930001
|
108593
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.022368
|
0
|
0
|
0
|
0.022368
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
TARGETING SENESCENCE CELLS IN ...PANCREATIC CANCER
more
|
Targeting senescence cells in ...pancreatic cancer
more
|
Cellular senescence is a progr...ammed response to oncogenic (tumour-causing) stress that aims to halt the expansion of cells with malignant potential. It does this by stopping the proliferation of pre-cancerous lesions and recruitment of the immune system for their elimination. If these processes fail, senescent cells create chronic inflammation and suppress the immune response, which promotes resistance to therapy, progression of tumours, and relapse of tumours. Using animal models and genomic engineering technologies, this project aims to eliminate senescent cells in the pancreas with a novel class of drugs known as senolytics, which were developed by the research team. The findings of this research will provide a proof of concept for new modalities of treatment against pancreatic cancer. The project is being implemented by the Université de Montréal, the Weizmann Institute of Science (Israel), and the Federal University of Parana (Brazil). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Université de Montréal
|
|
|
|
65679f5a212eaade2e0f04f1
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170085940001
|
108594
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.020139
|
0
|
0
|
0
|
0.020139
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
UNDERSTANDING THE ROLE OF TYPE... 1 INTERFERON IN RESISTANCE TO CANCER IMMUNOTHERAPY
more
|
Understanding the role of type... 1 interferon in resistance to cancer immunotherapy
more
|
Chemotherapy is the main form ...of treatment for cancer, but it cannot cure most types of cancer. Another form of treatment is immunotherapy, which aims to stimulate cells of the body's immune system (T cells) to kill cancer cells. Unfortunately, cancers may become resistant to T cells in the same way they learned to resist chemotherapy. This resistance is partly caused by a blood protein called interferon. This project aims to improve the effectiveness of cancer immunotherapy. Based on previous work, the research team will investigate the use of interferon inhibitors to treat cancer cells from patients with leukemia. This approach is expected to increase cure rates with immunotherapy in leukemia and many other forms of cancer. Moreover, the results of this study can open the path to the development of new and innovative cancer drugs based on interferon inhibition.The project is led in Canada by the Sunnybrook Research Institute-University of Toronto in collaboration with the Weizmann Institute of Science (Israel), and Jilin University (China). This project was selected for funding through the third research competition of the Joint Canada-Israel Health Research Program, a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
21000
|
International NGO
|
Sunnybrook Research Institute
|
|
|
|
65679f5a212eaade2e0f04f2
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086420001
|
108642
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0534681
|
0
|
0
|
0
|
0.0534681
|
0
|
|
0
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
ECONOMICS OF NCDS IN LOW AND M...IDDLE-INCOME COUNTRIES
more
|
Economics of NCDs in low and m...iddle-income countries
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
American University of Beirut
|
|
|
|
65679f5a212eaade2e0f04f3
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170087780002
|
108778
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0179968
|
0
|
0
|
0
|
0.0179968
|
0
|
|
0
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PROFESSIONAL DEVELOPMENT AWARD... 2018 – FOOD, ENVIRONMENT, AND HEALTH PROGRAM
more
|
Professional Development Award... 2018 – Food, Environment, and Health Program
more
|
|
|
12240
|
Basic nutrition
|
|
I.2.b. Basic Health
|
11000
|
Donor Government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/
more
|
|
|
|
65679f5a212eaade2e0f04f4
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170087780001
|
108778
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0300903
|
0
|
0
|
0
|
0.0300903
|
0
|
0
|
0.0300903
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PROFESSIONAL DEVELOPMENT AWARD... 2018 – FOOD, ENVIRONMENT, AND HEALTH PROGRAM
more
|
Professional Development Award... 2018 – Food, Environment, and Health Program
more
|
IDRC's Food, Environment, and ...Health (FEH) program is currently mid-way through its 2015-2020 strategy, having made significant investments to reduce the burden of diet-related non-communicable diseases (NCDs). This is an opportune time to reflect on the food systems work that has been developed over the first half of the program, and to make strategic decisions about the second phase of the programming period and beyond. Of great common interest among partners and stakeholders in low and middle-income countries is understanding the role that future programming may have in addressing the double burden of malnutrition among youth, and the entry points for having an impact. The general objective of this award is to produce research outputs relevant to the development of the FEH program strategy, partnerships, and network expansion objectives. The project will review the evidence on youth food environments and increased NCD risk, including school and urban food environments, and youth-targeted marketing of food and beverages. During this 12-month award, under the mentorship of a program officer, the recipient will conduct research on issues related to youth diets, the opportunities for intervention to address the double burden of malnutrition (the co-existence of malnutrition along with overweight and obesity or other NCDs), as well as contribute to various program activities. Research activities will include literature reviews, primary data collection, data analysis, and report writing. Expected results include syntheses of the knowledge gaps in this area and the relevant results of early FEH investments. Primary data collection with key stakeholders will help identify emerging opportunities for thought leadership and partnerships for maximum impact in youth nutrition and health outcomes. This award's outputs will provide new information on the state of the evidence and on informed opinions in the field, which the program staff will use to elaborate the most relevant strategic direction for FEH in the future.
more
|
|
12240
|
Basic nutrition
|
|
I.2.b. Basic Health
|
11000
|
Donor Government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/
more
|
|
|
|
65679f5a212eaade2e0f04f5
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170087780004
|
108778
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0115106
|
0
|
0
|
0
|
0.0115106
|
0
|
|
0
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PROFESSIONAL DEVELOPMENT AWARD... 2018 – FOOD, ENVIRONMENT, AND HEALTH PROGRAM??????
more
|
Professional Development Award... 2018 – Food, Environment, and Health Program??????
more
|
|
|
12240
|
Basic nutrition
|
|
I.2.b. Basic Health
|
11000
|
Donor Government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/
more
|
|
|
|
65679f5a212eaade2e0f04f6
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170087780003
|
108778
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0578659
|
0
|
0
|
0
|
0.0578659
|
0
|
0
|
0.0578659
|
0
|
0
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
PROFESSIONAL DEVELOPMENT AWARD... 2018 – FOOD, ENVIRONMENT, AND HEALTH PROGRAM??????
more
|
Professional Development Award... 2018 – Food, Environment, and Health Program??????
more
|
IDRC's Food, Environment, and ...Health (FEH) program is currently mid-way through its 2015-2020 strategy, having made significant investments to reduce the burden of diet-related non-communicable diseases (NCDs). This is an opportune time to reflect on the food systems work that has been developed over the first half of the program, and to make strategic decisions about the second phase of the programming period and beyond. Of great common interest among partners and stakeholders in low and middle-income countries is understanding the role that future programming may have in addressing the double burden of malnutrition among youth, and the entry points for having an impact. The general objective of this award is to produce research outputs relevant to the development of the FEH program strategy, partnerships, and network expansion objectives. The project will review the evidence on youth food environments and increased NCD risk, including school and urban food environments, and youth-targeted marketing of food and beverages. During this 12-month award, under the mentorship of a program officer, the recipient will conduct research on issues related to youth diets, the opportunities for intervention to address the double burden of malnutrition (the co-existence of malnutrition along with overweight and obesity or other NCDs), as well as contribute to various program activities. Research activities will include literature reviews, primary data collection, data analysis, and report writing. Expected results include syntheses of the knowledge gaps in this area and the relevant results of early FEH investments. Primary data collection with key stakeholders will help identify emerging opportunities for thought leadership and partnerships for maximum impact in youth nutrition and health outcomes. This award's outputs will provide new information on the state of the evidence and on informed opinions in the field, which the program staff will use to elaborate the most relevant strategic direction for FEH in the future.??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????†???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
more
|
|
12240
|
Basic nutrition
|
|
I.2.b. Basic Health
|
11000
|
Donor Government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/
more
|
|
|
|
65679f5b212eaade2e0f04f7
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088170002
|
108817
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.009715
|
0
|
0
|
0
|
0.009715
|
0
|
|
|
|
Other health problems
|
Other health problems Research... and Development
more
|
100
|
FINANCING OF NON COMMUNICABLE ...DISEASE PREVENTION IN LOW AND MIDDLE INCOME COUNTRIES
more
|
Financing of Non Communicable ...Disease Prevention in Low and Middle Income Countries
more
|
Non-communicable diseases (NCD...s) are the leading cause of death and disability worldwide. Four out of five premature deaths due to NCDs are in a low and middle income country (LMIC). The evidence shows that prevention of NCDs is cost effective. Despite this, both national governments and international development assistance provides very little financing for NCD prevention. However policy action, even if cost effective, does incur implementation costs, and the lack of knowledge on how to put in place sustainable financing and approaches for NCD prevention have been a critical barrier to progress. This project will address a key knowledge gap by generating information on the different models for financing NCD prevention and integration with existing health systems. The research team will use a case study approach to collect up to 10 examples of how NCD prevention has been, or could be addressed and financed in LMICs.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
Heartfile the National Heart F...oundation of Pakistan
more
|
|
|
