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BCG Vaccine – Current use, safety & skin test

TBFACTS.ORG (2017) C1

Accessed December 2017

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Rapid communication: TB antigen-based skin tests for the diagnosis of TB infection

World Health Organization WHO (2022) C_WHO

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Laboratory testing for the monkeypox virus
recommended

World Health Organization (WHO) (2022) C_WHO

Any individual that meets the suspected case definition of monkeypox should be offered testing in appropriately equipped laboratories by staff trained in the relevant technical and safety procedures. Confirmation of monkeypox virus infection is based on nucleic acid amplification testing (NAAT), usi... more

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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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WHO operational handbook on tuberculosis: module 3: diagnosis: tests for tuberculosis infection

World Health Organization WHO (2022) C_WHO

Three classess of tests are now recommended in the latest consolidated guideles on tests for tuberculosis infection. It includes for the first-time a new class of Mycobacterium tuberculosis antigen-based skin tests (TBSTs), and the two existing classes of tests: the tuberculin skin test (TST) and t... more

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Target product profile for a point-of-care diagnostic test for dermal leishmaniases - Control of Neglected Tropical Diseases

World Health Organization WHO (2022) C_WHO

Localized cutaneous leishmaniasis and its evolving forms (diffuse cutaneous leishmaniasis, mucosal leishmaniasis and cutaneous leishmaniasis recidivans), together with the sequela of visceral leishmaniasis (post-kala-azar dermal leishmaniasis), account for about one million cases of dermal leishmani... more

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First meeting of the network on Buruli ulcer PCR laboratories in the WHO African Region Centre Pasteur du Cameroon, Yaoundé, 21–24 October 2019

World Health Organization WHO (2020) CC

Research to develop point-of-care tests is in progress. Treatment of Buruli ulcer comprises 8 weeks of combined antibiotics (rifampicin and clarithromycin). Complementary therapies such as wound care, skin graft and prevention of disability are needed in some cases to ensure full recovery. The targ... more

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Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial

Biccard, B.M.; V. Msosa, A.L Samateh et al. TheLancet (2021) CC

Surgical site infection (SSI) is the most common postoperative complication worldwide. WHO guidelines to prevent SSI recommend alcoholic chlorhexidine skin preparation and fascial closure using triclosan-coated sutures, but called for assessment of both interventions in low-resource settings. This s... more

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Report of the fifth annual meeting of the network of Buruli ulcer PCR laboratories in the WHO African Region, Accra, Ghana, 23-25 October 2023

World Health Organization WHO (2024) C_WHO

The aim of the meeting was to broaden the network’s initiatives. Preliminary work involved integrating laboratory testing for skin NTDs other than Buruli ulcer, such as cutaneous leishmaniasis, mycetoma, leprosy and yaws, while extending the network’s reach to encompass additional laboratories.

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Yaws: International Journal of STD & AIDS

Marks, M.; Lebari, D.; Higgins,S. et al. International Journal of STD & AIDS (2014) CC

Yaws is a non-venereal endemic treponemal infection caused by Treponema pallidum sub-species pertenue, a bacterium closely related to Treponema pallidum ssp. pallidum, the agent of venereal syphilis. Yaws predominantly affects children living in tropical regions of the world. It causes lesions of th... more

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What is Dengue? Causes, Signs and Symptoms, Diagnosis and treatment.

Medical Centric Medical Centric (2018) CC

Chapters 0:00 Introduction 0.27 Causes of Dengue Fever 1:09 Signs and Symptoms of Dengue Fever 2:30 Dengue Hemorrhagic Fever 3:53 Diagnosis of Dengue Fever 4:10 Treatment of Dengue Fever Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically beg... more

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Scabies: Diagnosis and Treatment

American Academy of Dermatology Association (2022) CC

A dermatologist can often diagnose scabies by visually examining a patient’s skin from head to toe. To make sure that a patient has scabies, a dermatologist may remove some skin. This is painless. Your dermatologist will put the skin on a glass slide and look at the slide under a microscope. If y... more

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Lo que necesita saber sobre la prueba cutánea de la tuberculina

Centers for Disease Control and Prevention CDC (2022) C_CDC

La prueba cutánea de la tuberculina le indicará si alguna vez ha tenido los microbios de la tuberculosis (TB) en el cuerpo.

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Collection of Dried Blood Spots (DBS) from Infants for PCR Testing

Centers for Disease Control and Prevention (CDC) (2018) C1

This clinical job aid provides health care workers with information on how to collect specimens for early infant diagnosis on dried blood spots, as well as drying and packaging for transport.

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How To Do A Skin Smear Examination For Leprosy

The International Federation of Anti-Leprosy Associations (ILEP) (2001) C1

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Diagnostic tests in the management of seizures and altered consciousness in children

World Health Organization WHO (2015) C_WHO

Mental health

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Interferon-γ-Tests in der Tuberkulose-Diagnostik - Aktueller Stand

B. Hauer, R. Loddenkemper, A. Detjen, et al. (2006) C2

Interferon-γ Assays - Description and Assessment of a New Tool in the Diagnosis of Tuberculosis. Haür B et al. Interferon-γ-Tests in der ...Pneumologie 2006; 60: 29-44

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Тестування на туберкульозну інфекцію та скринінг на туберкульоз серед біженців, які прибувають до країн Європи з України

European Centre for Disease Prevention and Control ECDC (2022) C1

7 April 2022. Aimed at national policymakers, public health and healthcare planners, staff working in reception centres, and healthcare staff caring for displaced persons, the information note concludes that universal testing of incoming refugees from Ukraine for tuberculosis (TB) infection is not r... more

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Guidelines on the treatment of skin and oral HIV-associated conditions in children and adults

World Health Organization WHO (2014) C_WHO

Skin and mucosal conditions are extremely common in all children and adults in particular in HIV-infected adults and children and are one of the commonest daily management problems faced by health care workers caring for patients with HIV infection

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Ending the neglect to attain the sustainable development goals: a strategic framework for integrated control and management of skin-related neglected tropical diseases

World Health Organization WHO (2022) C_WHO

Skin-related neglected tropical diseases, or “skin NTDs”, are historically neglected because active case detection, individual case management, significant resources and intensive effort are required to control, eliminate and eradicate them. Integrated control and management of skin NTDs offers ... more

Laboratory testing for the monkeypox virus recommended

Laboratory testing for the monkeypox virus
recommended