Eur J Med Res 28, 80 (2023). https://doi.org/10.1186/s40001-023-01046-1. Africa has a higher burden of malaria-related cases and deaths globally. Children under five accounted for over two-thirds of all malaria deaths in sub-Saharan Africa (SSA). This scoping review aims to map evidence of the preva...lence, contextual factors and health education interventions of malaria amongst children under 5 years (UN5) in SSA.
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Buruli ulcer (BU), a neglected tropical disease (NTD), is an infection of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. The disease has been documented in many South American, Asian, and Western Pacific countries and is widespread throughout much of Africa, especially in West... and Central Africa.
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J Mov Disord > Volume 11(2); 2018 > Article
Review Article
J Mov Disord 2018; 11(2): 53-64.
Published online: May 30, 2018
DOI: https://doi.org/10.14802/jmd.17028
Buruli ulcer caused by Mycobacterium ulcerans is a neglected tropical disease characterized by extensive ulceration involving predominantly the upper and lower limbs of patients. The disease is common in rural tropical communities in West and Central Africa, where access to proper health care is lim...ited. Pathogenesis of the characteristic painless ulcers is linked to the elaboration by M. ulcerans of a lipid toxin called mycolactone that has potent cytopathic, immunosuppressive, and analgesic effects on a host of cells in cutaneous tissues. Mycolactone is known to profoundly inhibit secretion of a plethora of proteins that are essential for wound healing. Even though a combination antibacterial therapy of streptomycin and rifampicin for 8 weeks is effective for treatment, it relies on good and appropriate wound management to prevent secondary bacterial infections and improve healing. Evidence-based interventions for wound care in Buruli ulcer disease are often lacking and have relied on expert advice and recommendations. Surgical interventions are limited to debridement of necrotic tissue and grafting of extensive ulcers, usually after antibiotic therapy. Patients’ rehabilitation is an important component of care to reduce disabilities associated with the disease and proper integration into the community after treatment.
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Clinical Pharmacology: Advances and Applications, 2025:17 29–47
Cognitive deficits in schizophrenia can massively impact functionality and quality of life, furthering the importance of cognitive training. Despite the development of the field in Europe and in the United States, no programmes have been developed and tested in developing countries. Different cultur...al backgrounds, budget restrictions, and other difficulties may render treatment packages created in high income countries difficult for adoption by developing nations. We performed a pilot double-blind, randomized, controlled trial in order to investigate the efficacy and feasibility of an attention and memory training programme specially created in
a developing nation. The intervention used simple, widely available materials, required minimal infrastructure, and was conducted in groups.The sample included seventeen stable Brazilians with schizophrenia. Sessions were conducted weekly during five months. The cognitive training group showed significant improvements in inhibitory control and set-shifting over time. Both groups showed improvements in symptoms, processing speed, selective attention, executive function, and long-term visual memory. Improvements were found in the control group in long-term verbal memory and concentration. Our findings reinforce the idea that cognitive training in schizophrenia can be constructed using simple resources and infrastructure, facilitating its adoption by developing countries, and it may improve cognition.
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Journal of Computational Biophysics and ChemistryVol. 22, No. 01, pp. 31-41 (2023)
Lancet Glob Health 2022; 10: e491–500
BioMed Central; BMC International Health and Human Rights (2016) 16:20; DOI 10.1186/s12914-016-0094-y
Pharmaceuticals 2024, 17(6), 691; https://doi.org/10.3390/ph17060691
In 2015, the United Nations set important targets to reduce premature
cardiovascular disease (CVD) deaths by 33% by 2030. Africa disproportionately
bears the brunt of CVD burden and has one of the highest risks of dying
from non-communicable diseases (NCDs) worldwide. There is currently
an epide...miological transition on the continent, where NCDs is projected
to outpace communicable diseases within the current decade. Unchecked
increases in CVD risk factors have contributed to the growing burden of three
major CVDs—hypertension, cardiomyopathies, and atherosclerotic diseasesleading to devastating rates of stroke and heart failure. The highest age
standardized disability-adjusted life years (DALYs) due to hypertensive heart
disease (HHD) were recorded in Africa. The contributory causes of heart failure
are changing—whilst HHD and cardiomyopathies still dominate, ischemic
heart disease is rapidly becoming a significant contributor, whilst rheumatic
heart disease (RHD) has shown a gradual decline. In a continent where health
systems are traditionally geared toward addressing communicable diseases,
several gaps exist to adequately meet the growing demand imposed by CVDs.
Among these, high-quality research to inform interventions, underfunded
health systems with high out-of-pocket costs, limited accessibility and
affordability of essential medicines, CVD preventive services, and skill
shortages. Overall, the African continent progress toward a third reduction
in premature mortality come 2030 is lagging behind. More can be done in
the arena of effective policy implementation for risk factor reduction and
CVD prevention, increasing health financing and focusing on strengthening
primary health care services for prevention and treatment of CVDs, whilst
ensuring availability and affordability of quality medicines. Further, investing
in systematic country data collection and research outputs will improve the accuracy of the burden of disease data and inform policy adoption on
interventions. This review summarizes the current CVD burden, important
gaps in cardiovascular medicine in Africa, and further highlights priority
areas where efforts could be intensified in the next decade with potential
to improve the current rate of progress toward achieving a 33% reduction
in CVD mortality.
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Le présent guide pratique explique ce qu’est un plan de gestion de la sécurité sanitaire de l’eau (PGSSE) et de quelle manière celui-ci peut vous aider à renforcer la sécurité sanitaire de votre alimentation en eau potable, notamment par une amélioration progressive, étape par étape et... quotidienne de votre système. Il vous fournit une gamme de modèles prêts à l’emploi pour vous aider à concevoir votre propre PGSSE. Les conseils prodigués et les modèles fournis vous aideront à prendre conscience de la facilité avec laquelle un PGSSE peut être mis en œuvre et vous permettront de mettre en place des améliorations rapidement.
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Serie: Documentos Técnico Normativiso 495
Inhaltsangabe: Vorwort; Trauma bei Kindern und JugendlichenTraumatisierte Kinder im pädagogischen; Sekundäre Traumatisierung des Helfer_innensystems – Der Versuch
zu verstehen und ein Pläydoyer für Enttabuisierung und Prävention; Trauma und Traumafolgen im Kindesalter; Zusammenarbeit mit E...ltern traumatisierter Kinder; „Traumasog“ – oder wie halte ich meine Arbeit eigentlich (noch) aus?; Pädagogisches Arbeiten mit traumatisierten Kindern; Pädagogisches Arbeiten mit traumatisierten Kindern; Traumata zwischengeschlechtlich geborener Kinder und co-traumatische Belastungen für deren Familien; Sexüll übergriffige Buben und Burschen: eigene Traumatisierung ein Thema?; Gefühle unter dem Mikroskop und im Hirnscanner
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recommandations à l’intention des agents de santé
Diagnostics 2019, 9(4), 204; https://doi.org/10.3390/diagnostics9040204
Dermatologic Clinics Volume 29, Issue 1p1-8January 2011
Buruli ulcer (BU) is a bacterial skin infection that is caused by Mycobacterium ulcerans and mainly affects people who reside in the rural areas of Africa and in suburban and beach resort communities in Australia.