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UNAIDS 90–90–90 targets to end the AIDS epidemic by 2020 are not realistic: comment on “Can the UNAIDS 90–90– 90 target be achieved? A systematic analysis of national HIV treatment cascades”

L. Engelbert Bain; C. Nkoke; J. J. N. Noubiap BMJ Global Health (2017) C2

Bain LE, et al. BMJ Glob Health 2017;2:e000227. doi:10.1136/bmjgh-2016-000227

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Stunting as a Risk Factor of Soil-Transmitted Helminthiasis in Children: A Literature Review

Fauziah, N.; Ar-Rizqi, M.A.; Hana, S. et al. Interdisciplinary Perspectives on Infectious Diseases (2022) CC

As a high-burden neglected tropical disease, soil-transmitted helminth (STH) infections remain a major problem in the world, especially among children under five years of age. Since young children are at high risk of being infected, STH infection can have a long-term negative impact on their life, i... more

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Clinical and epidemiological characteristics associated with unfavorable tuberculosis treatment outcomes in TB-HIV co-infected patients in Brazil: a hierarchical polytomous analysis

T. N. do Pradoa; J.t V. Rajand; A. E. Miranda; et al. The Brazilian Journal of infectious diseases; Elsevier Editora Ltda. (2016) C2

braz j infect dis 2 0 1 7;2 1(2):162–170 http://dx.doi.org/10.1016/j.bjid.2016.11.006 1413-8670/© 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Multimorbidity, control and treatment of noncommunicable diseases among primary healthcare attenders in the Western Cape, South Africa

Folb, N., Levitt, N.S., Backmann, M.O., et al (2015) CC

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Asbestos-related diseases in mineworkers: a clinicopathological study

Ndlovu, N.; Rees, D.; Murray, J.; et al. ERJ Open Research, part of the European Respiratory Society (ERS) (2017) CC

This study compared clinical and autopsy findings for three asbestos-related diseases (asbestosis, mesothelioma and lung cancer) in former asbestos mineworkers, and explored factors that influenced agreement between clinical and autopsy findings using data from two compensation systems. In South Afr... more

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Epidemiology and Challenges of Managing COPD in sub-Saharan Africa

Magitta, N.F.; Sciences, A. Acta Scientific Medical Sciences (2018) CC2

There is paucity of data on the burden and specific drivers operative in the pathogenesis of chronic obstructive pulmonary disease (COPD) in the African setting and populations. Lack of awareness and inadequate knowledge on the aetio-pathogenesis of the disease together with inadequate capacity for ... more

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Occupational COPD—The most under-recognized occupational lung disease?

Mugia, N.; Gambelunghe, A. John Wiley & Sons Australia, Ltd (Respirology) (2022) CC2

The article discusses chronic obstructive pulmonary disease (COPD) as a common but under-recognized occupational disease. While smoking is the main cause, occupational exposure to vapors, gases, dusts, and fumes (VGDF) significantly contributes to the development and progression of COPD. Epidemiolog... more

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2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes: Developed by the task force on the management of cardiovascular disease in patients with diabetes of the Eur

Marx, N.; Federici, M.; Schütt, K. et al. European Heart Journal (2023) CC

Patients with diabetes are at increased risk of developing cardiovascular disease (CVD) with its manifestations of coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF), and stroke, as well as aortic and peripheral artery diseases. In addition, diabetes is a major risk factor f... more

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Cardiovascular diseases in Africa in the twenty-first century: Gaps and priorities going forward

Minja, N.W.; Nakagaayi, D.; Aliku, T. et al. Frontiers in Cardiovascular Medicine (2022) CC

In 2015, the United Nations set important targets to reduce premature cardiovascular disease (CVD) deaths by 33% by 2030. Africa disproportionately bears the brunt of CVD burden and has one of the highest risks of dying from non-communicable diseases (NCDs) worldwide. There is currently an epide...miological transition on the continent, where NCDs is projected to outpace communicable diseases within the current decade. Unchecked increases in CVD risk factors have contributed to the growing burden of three major CVDs—hypertension, cardiomyopathies, and atherosclerotic diseasesleading to devastating rates of stroke and heart failure. The highest age standardized disability-adjusted life years (DALYs) due to hypertensive heart disease (HHD) were recorded in Africa. The contributory causes of heart failure are changing—whilst HHD and cardiomyopathies still dominate, ischemic heart disease is rapidly becoming a significant contributor, whilst rheumatic heart disease (RHD) has shown a gradual decline. In a continent where health systems are traditionally geared toward addressing communicable diseases, several gaps exist to adequately meet the growing demand imposed by CVDs. Among these, high-quality research to inform interventions, underfunded health systems with high out-of-pocket costs, limited accessibility and affordability of essential medicines, CVD preventive services, and skill shortages. Overall, the African continent progress toward a third reduction in premature mortality come 2030 is lagging behind. More can be done in the arena of effective policy implementation for risk factor reduction and CVD prevention, increasing health financing and focusing on strengthening primary health care services for prevention and treatment of CVDs, whilst ensuring availability and affordability of quality medicines. Further, investing in systematic country data collection and research outputs will improve the accuracy of the burden of disease data and inform policy adoption on interventions. This review summarizes the current CVD burden, important gaps in cardiovascular medicine in Africa, and further highlights priority areas where efforts could be intensified in the next decade with potential to improve the current rate of progress toward achieving a 33% reduction in CVD mortality. more

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The many faces of diabetes. Is there a need for re-classification? A narrative review

Sakran, N.; Graham, Yiitka.; Pintar, T.; et al. BMC Endocrine Disorders Volume 22 Article Number 9 (2022) CC

The alarming rise in the worldwide prevalence of obesity and associated type 2 diabetes mellitus (T2DM) have reached epidemic portions. Diabetes in its many forms and T2DM have different physiological backgrounds and are difficult to classify. Bariatric surgery (BS) is considered the most effective ... more

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Heart failure in low-income and middle-income countries: failing REPORT card grades

Naik, N.; Narula, J. The Lancet Global Health (2020) CC

Heart failure is an important global health problem, and the associated public health and economic effect is increasing across all societies and geographies. Epidemiological studies have estimated that there are more than 25 million patients with heart failure globally, and population-based studie... more

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Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden

Papadopoulos, N.G.; Custovic, A.; Deschildre, A. et al. The Journal of Allergy and Clinical Immunology: In Practice (2020) CC

Coronavirus disease 2019 has a mild disease course in children and adolescents. Chronic respiratory conditions, including asthma, have been suggested as risk factors; however, asthma in children is highly variable in both triggers and severity. During the pandemic, pediatric asthma services limite... more

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2021 World Health Organization guideline on pharmacological treatment of hypertension: Policy implications for the region of the Americas

Campbell, N.R.C.; Burnens, M.P.; Whelton, P.K. et al. The Lancet Regional Health - Americas (2022) CC

Cardiovascular disease (CVD) is the leading cause of death in the Americas and raised blood pressure accounts for over 50% of CVD. In the Americas over a quarter of adult women and four in ten adult men have hypertension and the diagnosis, treatment and control are suboptimal. In 2021, the World Hea... more

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Sprachmittlung für geflüchtete Menschen im Bereich der sexuellen und reproduktiven Gesundheit und Rechte. Praxisempfehlungen für Sprachmittler*innen

Yakmanesh, N. et al. Der Paritätische Gesamtverband e.V. (2023) CC

Es fasst in kompakter und praxistauglicher Art und Weise die Erfahrungen und Impulse aus dem ersten Projektjahr zusammen. Sie gibt wertvolle Handlungsempfehlungen für die Praxis der Sprachmittlung im Bereich der sexuellen und reproduktiven Gesundheit und Rechte. Sie richtet sich als Leitfaden direk... more

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Navegación de pacientes en cáncer de mama Documento programático

Robles, N.; Pesce, V. et al. Ministerio de Salud Argentina (2021) C2

El siguiente documento es elaborado por el Programa Nacional de Control de Cáncer de Mama (PNCM) para la gestión de las diferentes acciones involucradas en la estrategia de Navegación de Pacientes en Cáncer de Mama. Se busca poder generar una herramienta para la gestión cotidiana de los/las ... more

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Diagnostics to support the eradication of yaws—Development of two target product profiles

Fongwen, N.; Handley, B.; Martin, D. et al. PLoS Neglected Tropical diseases (2022) CC

Yaws is targeted for eradication by 2030, using a strategy based on mass drug administration (MDA) with azithromycin. New diagnostics are needed to aid eradication. Serology is currently the mainstay for yaws diagnosis; however, inaccuracies associated with current serological tests makes it difficu... more

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Overview of rabies post-exposure prophylaxis access, procurement and distribution in selected countries in Asia and Africa, 2017–2018

Sreenivasan, N.; Li, A.; Shiferaw, M. et al. Science Direct (2019) CC

Rabies is a neglected zoonotic disease with a global burden of approximately 59,000 human deaths a year. Once clinical symptoms appear, rabies is almost invariably fatal; however, with timely and appropriate post-exposure prophylaxis (PEP) consisting of wound washing, vaccine, and in some cases rabi... more

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Ukraine Conflict: Impact on food security - Issue Brief

Berger, N.; The MEDBOX Team (2023) CC

The war has not only triggered the largest movement of refugees in Europe since the end of the Second World War. Its manifold effects can be seen worldwide: forexample, consumer prices have risen and, in view of blocked grain exports of wheat, barley, and maize, food security in Africa is at risk. ... more

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Translation of human African trypanosomiasis biomarkers towards field application

Tiberti, N.; Hainard, A.; Sanchez, JC Elsevier ScienceDirect (2013) CC

Sleeping sickness is a neglected tropical disease affecting rural communities in sub-Saharan Africa. The reduction in the number of reported cases in recent years indicates that disease transmission is under control. However, many aspects of patient management still need to be improved. Undiagnosed ... more

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A review of dengue diagnostics and implications for surveillance and control

Raafat, N.; S. D. Blacksell and R.J. Maude Transactions of the Royal Society of Tropical Medicine and Hygiene (2019) CC

Transactions of the Royal Society of Tropical Medicine and Hygiene vik,113 no.11. Dengue is the world's most common arboviral infection, with almost 4 billion people estimated to be living at risk of dengue infection. A recently introduced vaccine is currently recommended only for seropositive indi... more