DOI: 10.5772/intechopen.102891Little progress has been made since the 1960s and 19. 70s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and opera...tional challenges in the clinical drug development of a novel antitrypanosomal agent for Chagas disease. The various elements that contribute to a robust assessment of treatment effect including dose selection, choice of patient population, trial methodology, endpoint measures, and regulatory perspectives are discussed. The learnings herein should serve as resource to help researchers and other stakeholders optimize their clinical development plans and speed delivery of new medicines to patients with Chagas disease.
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Long-lasting insecticidal nets (LLINs) treated with a pyrethroid insecticide and the synergist piperonyl butoxide (PBO) have become available. Two of these nets (Olyset®Plus and PermaNet®3.0) have a WHO Pesticide Evaluation Scheme (WHOPES) interim recommendation as LLINs
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Yaws is targeted for eradication by WHO in the 2021-2030 NTD Roadmap. It is therefore crucial to know how to identify cases, design and implement activities to eradicate the disease at the community level.
In the context of integration of skin NTDs it is vital to learn to recogn...ize a disease targeted for eradication. At the individual level yaws lesions may mimic other skin diseases. At the community level, it is key to know how to design and implement the total community treatment strategy and monitor its impact. This course aims at providing health workers with the basic knowledge to understand the epidemiology, diagnosis, treatment, impact, eradication strategy and reporting of yaws.
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Le Cameroun conduit actuellement une évaluation d’impact à grande échelle pour étudier les effets du Financement basé sur la Performance sur les résultats de santé dans le contexte spécifique du Cameroun. Bien que l’évaluation d’impact repose largement sur l’analyse quantitative à ...partir d’enquêtes de base et finale, l’équipe de l’évaluation d’impact a proposé d’introduire une composante qualitative à l’évaluation globale pour creuser en profondeur afin d’obtenir des explications ou explorer des questions spécifiques relatives à l’expérimentation du PBF au Cameroun. Les rôles de la recherche qualitative en lien avec l’évaluation de l’impact du PBF sont nombreux : (i) identifier les problèmes inhérents au contexte camerounais; (ii) élaborer des mesures quantitatives pertinentes; (iii) investiguer les questions importantes plus en profondeur et de manière détaillée; (iv) comprendre le rôle du lieu, du moment, des pratiques et des processus et; (v) améliorer l’interprétation des résultats quantitatifs.
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Este documento traz recomendações para a implementação de planos operacionais em redes de serviços de saúde, tanto na atenção primária (incluindo assistência domiciliar) quanto em hospitais, para reorganizar a entrega dos serviços e ganhar eficiência na gestão e expansão da oferta de l...eitos, considerando a complexidade crescente dos casos. Essas recomendações concentram-se na gestão dos serviços de saúde para reorganizar e expandir a resposta desses serviços de acordo com a evolução da epidemia. Este documento de trabalho será atualizado na medida em que novos conhecimentos e evidências em relação ao SAR-Cov2 forem disponibilizados, e as recomendações fornecidas devem ser adaptadas para a realidade de cada país, considerando-se as características do respectivo sistema de saúde.
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El ámbito de aplicación incluye a todos los trabajadores involucrados en trabajos de asistencia sanitaria (comprendidos los desarrollados en aislamiento, traslados, labores de limpieza, eliminación de residuos,etc.), así como los de transportes aéreo,marítimo y ferrocarril de ...larga distancia o internacional, los colectivos de rescate (bomberos, salvamento marítimo, policía, guardia civil, etc.), atención al público, hostelería, sector servicios, etc. Dado que el contacto con el virus puede afectar a entornos sanitarios y no sanitarios, corresponde a las empresas evaluar el riesgo de exposición y seguir las recomendaciones que sobre el particular emita el servicio de prevención,siguiendo las pautas y recomendaciones formuladas por las autoridades sanitarias.
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BMJ 2020;368:m800 doi: 10.1136/bmj.m800 (Published 5 March 2020)
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Abstract-The paper precisely and briefly explains the socio-economic challenges of persons with disabilities with focus on Ethiopia. The findings of the paper also indicates that, across the countries persons with disabilities have poorer health accesses, lower education achievements,... less social and economic participation and less rate of income than Persons disabilities experience barriers in accessing services that many of us have long taken for granted, including health, education, employment, transport and information as well as rehabilitation. These difficulties are exacerbated with high level of disability disadvantaged individuals. Based on the findings of this study, major socio-economic remedy directions are recommended which will be included in future policy enactment and implementations.
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Community health workers (CHWs) play a vital role in facilitating social connectedness, building trust, decrease stigma, and link communities to essential healthcare and social support services. More studies are needed to understand the factors facilitating these interactions among CHWs, clients, an...d community members.
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The NACS User’s Guide is a series of modules that provide program managers and implementers with a package of essential information and resources. These modules are living documents and will be updated as appropriate when new evidence, guidelines, or field experience emerges. Additional modules ar...e slated to be released on such topics as nutrition support, monitoring and reporting, tools, and service implementation. Readers are invited to submit comments and suggestions for improving or updating the guidance.
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Orientations provisoires, 4 novembre 2020