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Review Challenges in Chagas Disease Drug Development

Francisco, A.; Jayawardhana, S.; Olmo, F. et al. Molecules MDPI (2020) CC

The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public health problem throughout Latin America. Current therapeutic options are characterised by limited efficacy, long treatment regimens and frequent toxic side-effects. Advances in this area have been compromised by gaps... more

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Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig G, Bernhard SC, Blum J, Burri C, Mpanya A, et al. PLOS Neclected Tropical Diseases (2016) CC

This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospita... more

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Prevalence, infection intensity and geographical distribution of schistosomiasis among pre‑school and school aged children in villages surrounding Lake Nyasa

Deogratias Mazigo, H.; Uisso, C.; Kazyoba, P. et al. Nature Research (2021) CC

The sub-Saharan African region, carries 90% of the over 250 million cases of schistosomiasis occurring worldwide. In this region, after Nigeria, Tanzania is second country having the highest cases of schistosomiasis and approximately 51.5%0 of the Tanzanian population is either exposed or live in ar... more

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Urogenital Schistosomiasis among Schoolchildren and the Associated Risk Factors in Selected Rural Communities of Kwara State, Nigeria

Sundar, S.; Abdulkareem, B.; Habeeb, K. et al. (2018) CC

Urogenital schistosomiasis is a common neglected tropical disease in many rural communities in African countries, with patches of infection in the Eastern Mediterranean Region. Globally, an estimated 239 million people are currently infected, with burden estimated at more than 3.5 million disability... more

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Impact of human schistosomiasis in sub-Saharan Africa

Adenowo, A.; Oyinloye, B.; Ogunyinka, B. et al. (2015) CC

Human schistosomiasis otherwise called bilharzia, is a fresh- water snail transmitted intravascular debilitating disease resulting from infection by the parasitic dimorphic Schistosoma trematode worms, which lives in the bloodstream of humans. The World Health Organization (WHO) regards the disease ... more

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Schistosomiasis risk factors based on the infection status among school-going children in the Ndumo area, uMkhanyakude district, South Africa

Kabuyaya, M.; KwaZulu-Natal, Chimbari, M. et al. (2019) CC

Schistosomiasis, commonly known as bilharzia, is an acute and chronic tropical disease caused by trematodes of the genus Schistosoma. The schistosome parasite is transmitted through a snail intermediate host with the human being the definitive host. Worldwide, schistosomiasis continues to cause a pu... more

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Residence Time, Water Contact, and Age-driven Schistosoma mansoni Infection in Hotspot Communities in Uganda

Moses, A.; Adriko, M.; Kibwika, B. et al. The American Jornal of Tropical Medicine and Hygiene (2021) CC

Schistosomiasis, which is the second most important parasitic infection after malaria in terms of its socioeconomic impact, is responsible for the loss of an estimated 4.5 million disability-adjusted life years (DALYs) worldwide. Schistosomiasis, including both intestinal and urinary forms of the di... more

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Prevalence and distribution of schistosomiasis in human, livestock, and snail populations in northern Senegal: a One Health epidemiological study of a multi-host system

Léger, E.; Borlase, A.; Fall, C. et al. The Lancet Planetary Health (2020) CC

Schistosomiasis is a neglected tropical disease of global medical and veterinary importance. As efforts to eliminate schistosomiasis as a public health problem and interrupt transmission gather momentum, the potential zoonotic risk posed by livestock Schistosoma species via viable hybridisation in s... more

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Male Genital Schistosomiasis Along the Shoreline of Lake Malawi: Baseline Prevalence and Associated Knowledge, Attitudes and Practices Among Local Fishermen in Mangochi District

Kayuni, S.; Alharbi, M.; Makaula, P. et al frontiers in Public Health (2021) CC

Schistosomiasis is a prevalent parasitic, neglected tropical disease (NTD) affecting over 220 million people globally, especially in sub-Saharan Africa (SSA). The pathology of this disease in terms of intestinal, liver and urinary presentations is well-known, yet its chronic effect on host genitalia... more

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Cervicovaginal Immune Activation in Zambian Women With Female Genital Schistosomiasis

Sturt, A.; Webb, E.; Patterson, C.; et al. Frontiers Media S.A. (2021) CC

HIV-1 infection disproportionately affects women in sub-Saharan Africa, where areas of high HIV-1 prevalence and Schistosoma haematobium endemicity largely overlap. Female genital schistosomiasis (FGS), caused most frequently by S. haematobium egg deposition in the genital tract, has been associated... more

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The Chagas disease study landscape: A systematic review of clinical and observational antiparasitic treatment studies

Maguire, B.; Dahal, P.; Rashan, S.; et al. (2021) CC

PLoS Neglected Tropical diseases August 16, 2021 https://doi.org/10.1371/journal.pntd.0009697 Chagas disease, also known as American trypanosomiasis, is a neglected tropical disease transmitted by triatomine insects, first identified in 1909. Chagas disease affects approximately 6–7 million peop... more

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“We know about schistosomiasis but we know nothing about FGS”

Mazigo, H.; Sanson, A.; Lambert, V.; et al. (2021) CC

A qualitative assessment of knowledge gaps about female genital schistosomiasis among communities living in Schistosoma haematobium endemic districts of Zanzibar and Northwestern Tanzania. PloS Neglected Tropical Diseases September 30, 2021 https://doi.org/10.1371/journal.pntd.0009789 Schistosoma... more

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Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

Medina-Rincón, G.; Gallo-Bernal, S.; Jiménez, P.; et al. (2021) CC

Pathogens . 2021 Nov 16;10(11):1493.doi: 10.3390/pathogens10111493 .Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mech... more

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Increasing access to comprehensive care for Chagas disease: development of a patient-centered model in Colombia

Marchiol, A; Forsyth, C.; Bernal, O.; et al. Pan American Health Organization PAHO (2017) C_WHO

Rev. Panam Salud Publica. 2017;41:e153. doi: 10.26633/RPSP.2017.153 Worldwide, over 6 million people are infected with Trypanosoma cruzi, the pathogen that causes Chagas disease (CD). In the Americas, CD creates the greatest burden in disability-adjusted life years of any parasitic infection. In Co... more

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Improving access to testing for Chagas disease in Colombia

Caicedo Díaz, RA,; Forsyth, C.; Bernal, OA; et al. Drugs for Neglected Diseases initiative DNDi (2019) CC

This is a summary of the following peer-reviewed, scientific article: Comparative Evaluation of Immunoassays to Improve Access to Diagnosis for Chagas Disease in Colombia.

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Diagnosis and Prevalence of Chagas Disease in an Indigenous Population of Colombia

Kann, S.; Dib, J.; Aristizabal, A.; et al. Multidisciplinary Digital Publishing Institute (2022) CC

Microorganisms . 2022 Jul 14;10(7):1427. Chagas disease (CD) is endemic in about 21 countries of the Americas. The disease has spread to recently Chagas-free regions, mainly due to migration, and can now also be diagnosed in countries such as the USA, Canada, many European and some African, eastern... more

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Diagnosis and Clinical Management of Chagas Disease
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Suárez, C.; Nolder, D.; García-Mingo, A.; et al. (2022) CC

Research and Reports in Tropical Medicine 2022:13 25–40 Chagas disease (CD) or American trypanosomiasis is a neglected parasitic disease associated with significant mortality and morbidity that includes long-term disability, social stigma and a mental health toll. Perceived as a disease of the ve... more

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Chagas Disease: Detection of Trypanosoma cruzi by a New, High-Specific Real Time PCR

Kann, S.; Kunz, M.; Hansen, J.; et al. (2020) CC

J Clin Med . 2020 May 18;9(5):1517. doi: 10.3390/jcm9051517. Chagas disease (CD) is a major burden in Latin America, expanding also to non-endemic countries. A gold standard to detect the CD causing pathogen Trypanosoma cruzi is currently not available. Existing real time polymerase chain reaction... more

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Chagas disease: Current perspectives on a forgotten disease

Àlvarenz-Hernández, D.; Framyuti-Kelly, G.; Díaz-López-Silva, R.; et al. (2016) CC

Revista Médica del Hospital General de México, Vol. 81. Issue 3.Pages 154-164 (July - September 2018) Chagas disease is a parasitic zoonosis caused by Trypanosoma cruzi, a protozoan whose transmission to humans is primarily vector-borne. It is estimated that 6–8 million people worldwide are inf... more

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Health beliefs and health seeking behavior towards lymphatic filariasis morbidity management and disability prevention services in Luangwa District, Zambia: Community and provider perspectives

Maritim, P., A. Silumbwe, J.M. Zulu, et al. (2021) C2

Lymphatic filariasis (LF) infection if untreated results in fluid accumulation in the limbs or breasts (lymphedema) or genitalia (hydrocele) that is painful and causes great discomfort. Morbidity management and disability prevention (MMDP) strategies such as surgery for hydrocele, treatment of acute... more

Diagnosis and Clinical Management of Chagas Disease recommended

Diagnosis and Clinical Management of Chagas Disease
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