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Each year 1–2 million people are diagnosed with a tropical disease called leishmaniasis, which is caused by single-celled parasites. People are infected when they are bitten by sandflies carrying the parasite, and often develop skin lesions around
...
the bite site. Though mild cases may recover on their own or with treatment, sometimes the parasites multiply and spread elsewhere causing further skin lesions and facial disfigurement. Furthermore, the parasites can also infect internal organs such as the spleen and the liver, which without treatment can be fatal.
more
Leishmaniasis is still considered to be a global health problem, which spreads in most countries in the world. Leishmania is an intracellular obligate protistan parasite that causes different clinical symptoms in infected humans and other animals. T
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here are clinically different types of the disease including: visceral, cutaneous or muco-cutaneous leishmaniasis. Approximately, two million new infections occurring annually; 0.7 to 1.2 million cases are recorded with cutaneous leishmaniasis and 200,000–400,000 cases return for visceral leishmaniasis. However, Cutaneous leishmaniasis considers one of uncontrolled wobbling endemic diseases, especially in Iraq, which occurs at the skin to cause a dermal lesion. Usually, the lesion is spontaneously healed to leave a colorless depressed scar and permanent immunity.
more
Rabies remains an under-reported neglected zoonosis with a case-fatality rate of almost 100% in humans and animals. Dog-mediated human rabies causes tens of thousands of human deaths annually despite being 100% preventable. More than 95% of human cases are caused by the bite of a rabies-
...
infected dog. Dog-mediated human rabies disproportionately affects rural communities, particularly children, and economically disadvantaged areas of Africa and Asia, where awareness of the disease and access to appropriate post-exposure prophylaxis (PEP) can be limited or nonexistent.
more
Rabies remains an under-reported neglected zoonosis with a case-fatality rate of almost 100% in humans and animals. Dog-mediated human rabies causes tens of thousands of human deaths annually despite being 100% preventable. More than 95% of human cases are caused by the bite of a rabies-
...
infected dog. Dog-mediated human rabies disproportionately affects rural communities, particularly children, and economically disadvantaged areas of Africa and Asia, where awareness of the disease and access to appropriate post-exposure prophylaxis (PEP) can be limited or nonexistent.
more
Background: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are infected with helminths. Whils
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t the WHO treatment guidelines for helminth infections are mostly aimed at controlling morbidity, there has been a recent shift with some countries moving towards goals of disease elimination through mass drug administration, especially for LF and onchocerciasis. However, as prevalence is driven lower, treating entire populations may no longer be the most efficient or cost-effective strategy. Instead, it may be beneficial to identify individuals or demographic groups who are persistently infected, often termed as being “predisposed” to infection, and target treatment at them.
Methods: The authors searched Embase, MEDLINE, Global Health, and Web of Science for all English language, humanbased papers investigating predisposition to helminth infections published up to October 31st, 2017. The varying definitions used to describe predisposition, and the statistical tests used to determine its presence, are summarised. Evidence for predisposition is presented, stratified by helminth species, and risk factors for predisposition to infection are identified and discussed.
Results: In total, 43 papers were identified, summarising results from 34 different studies in 23 countries. Consistent evidence of predisposition to infection with certain species of human helminth was identified. Children were regularly found to experience greater predisposition to Ascaris lumbricoides, Schistosoma mansoni and S. haematobium than adults. Females were found to be more predisposed to A. lumbricoides infection than were males. Household clustering of infection was identified for A. lumbricoides, T. trichiura and S. japonicum. Ascaris lumbricoides and T. trichiura also showed evidence of familial predisposition. Whilst strong evidence for predisposition to hookworm infection was identified, findings with regards to which groups were affected were considerably more varied than for other helminth species.
Conclusion: This review has found consistent evidence of predisposition to heavy (and light) infection for certain human helminth species. However, further research is needed to identify reasons for the reported differences between demographic groups. Molecular epidemiological methods associated with whole genome sequencing to determine ‘who infects whom’ may shed more light on the factors generating predisposition.
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Stunting as a Risk Factor of Soil-Transmitted Helminthiasis in Children: A Literature Review
Fauziah, N.; Ar-Rizqi, M.A.; Hana, S.
Interdisciplinary Perspectives on Infectious Diseases
(2022)
CC
As a high-burden neglected tropical disease, soil-transmitted helminth (STH) infections remain a major problem in the world, especially among children under five years of age. Since young children are at high risk of being infected, STH infection ca
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n have a long-term negative impact on their life, including impaired growth and development. Stunting, a form of malnutrition in young children, has been long assumed as one of the risk factors in acquiring the STH infections. However, the studies on STH infection in children under five with stunting have been lacking, resulting in poor identification of the risk. Accordingly, we collected and reviewed existing related research articles to provide an overview of STH infection in a susceptible population of stunted children under five years of age in terms of prevalence and risk factors. There were 17 studies included in this review related to infection with Ascaris lumbricoides, Trichuris trichiura, hookworm, and Strongyloides stercoralis from various countries. The prevalence of STH infection in stunted children ranged from 12.5% to 56.5%. Increased inflammatory markers and intestinal microbiota dysbiosis might have increased the intensity of STH infection in stunted children that caused impairment in the immune system. While the age from 2 to 5 years along with poor hygiene and sanitation has shown to be the most common risk factors of STH infections in stunted children; currently there are no studies that show direct results of stunting as a risk factor for STH infection. While stunting itself may affect the pathogenesis of STH infection, further research on stunting as a risk factor for STH infection is encouraged.
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Website last accessed on 22.05.2023
Leishmaniasis refers to a diverse group of diseases caused by single-celled parasites called Leishmania. About 12 million people are infected at any one time, causing up to 40,000 deaths annually.
The VALID
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ATE Network - Vaccine development for complex intracellular neglected pathogens
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Demographic and socioeconomic data Progress towards HIV testing and treatment cascade targets by 2025 (2023) Health sector cascade (2023) Estimated number of people newly infected with HIV
Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory
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droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA.
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Tuberculosis (TB) is among the top ten most common causes of death globally and as a single infectious disease it top among infectious diseases. Furthermore, it is noted as the top causes of death among people infected with the human immunodeficienc
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y virus (HIV). Despite recent decreases in the number of notified cases, Namibia still has a high TB burden and is included among the top 30 high-burden TB countries by the World Health Organisation (WHO). In the 2018 Global TB Report, the estimated incidence rate of TB in Namibia was 423/100,000. The same report estimated that 60 people per 100,000 populations died of TB in Namibia, which is a concern, for a disease that is curable and preventable.
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The consortium is an international public-private partnership that aims to reduce the global disease burden of schistosomiasis by addressing the medical needs of infected children between the ages of 3 months and 6 years. By doing so, we hope to con
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tribute to the ongoing efforts to eliminate schistosomiasis and improve child health.
more
Chikungunya virus (CHIKV) has expanded its geographical reach in recent decades and is an emerging global health threat. CHIKV can cause significant morbidity and lead to chronic, debilitating arthritis/arthralgia in up to 40% of infected individual
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s. Prevention, early identification, and clinical management are key for improving outcomes. The aim of this review is to evaluate the quality, availability, inclusivity, and scope of evidence-based clinical management guidelines (CMG) for CHIKV globally.
more
Every two minutes, a child under the age of 5 dies from malaria. Under-five children accounted for 67 per cent of all malaria deaths worldwide in 2018. Most of them occurred in sub-Saharan Africa where an estimated 24 million children were infected
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with its deadliest form. In addition to being the third-deadliest infectious disease for children, malaria infection and the costs of treatment traps families in a cycle of illness, suffering and poverty.This year’s World Malaria Day is marred by the emergence of the COVID-19 outbreak, which further threatens people’s lives and well-being. Public health officials are taking precautionary and often aggressive measures to limit transmission of this virus, including reductions in social movement, physical distancing, hand-washing and recommending the use of personal protection equipment in high-risk settings. However, while focusing on combating this disease, the world cannot afford to ignore other diseases, such as malaria.
more
HUMANITIES AND SOCIAL SCIENCES COMMUNICATIONS | (2022)9:295 | https://doi.org/10.1057/s41599-022-01312-3 .
Sub-Saharan Africa (SSA), particularly Southern and East Africa, has the highest AIDS deaths
and HIV-infected people in the world. Even tho
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ugh considerable effort has been made over
the years to study HIV transmission risk behaviours of different population groups in SSA,
there is little evidence of studies that have looked at pooled effects of associated HIV risk
factors among men, particularly in Southern Africa.
more
J Infect Dev Ctries 2023; 17(7):1022-1029. doi:10.3855/jidc.15105
Opportunistic co-infections are more prevalent in HIV-infected patients with a CD4 + cell count of < 200 cells/mm3, poor drug adherence, and also associated with the occupation. So, regular examination
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and appropriate medication can reduce the prevalence of opportunistic co-infections.
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The objectives of these WHO guidelines are to provide updated evidence- based recommendations for the treatment of persons with hepatitis C infection using, where possible, all DAA-only combinations. The guidelines also provide recommendations on the preferred regimens based on a patient’s HCV gen
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otype and clinical history, and assess the appropriateness of continued use of certain medicines. This document also includes existing recommendations on screening for HCV infection and care of persons infected with HCV that were first issued in 2014
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Ebola Virus Disease: Personal Protective Equipment, UNICEF Specifications (March 2015)
UNICEF
(2015)
UNICEF provides a detailed update and list of Ebola virus disease personal protective equipment technical specifications for use in high- and low-risk settings. It includes barriers for full body protection, as well as the head, nose, mouth, eyes, hands and feet. In selecting the right PPE specifica
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tions for frontline workers, the degree of contact with infectious material, and the potential for infected fluid penetration should be considered.
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Learn more about the Ebola virus and how to avoid it. Free online course.
Having completed this course the learner will be able to: - Describe what the Ebola virus is; - List the countries where the outbreak has occurred; - Explain what the signs and symptoms of an infection are; - Explain how an i
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nfection is treated; - Explain how to avoid becoming infected
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Planning and preparedness are the keys to dealing effectively with threats that include infectious diseases caused by SARS and the Middle East Respiratory Syndrome or MERS, novel influenza viruses like H1N1, and Ebola. During outbreaks or epidemics of these emerging infectious diseases, healthcare f
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acilities must carefully monitor the global situation as it evolves and conduct robust planning to promptly identify and safely manage a patient who may be infected and prevent further transmission. This module focuses on preparedness considerations for Ebola and how to engage a multi-disciplinary team to prepare your institution. Planning, preparedness, and practice will protect patients, visitors, and staff.
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The World Health Organization's cholera fact sheet provides essential information about cholera, an acute diarrheal infection caused by ingesting food or water contaminated with Vibrio cholerae bacteria. The disease remains a global public health threat, particularly in areas lacking safe water and
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adequate sanitation. While many infected individuals exhibit mild or no symptoms, severe cases can lead to rapid dehydration and death if untreated. Prevention focuses on ensuring access to clean water, proper sanitation, and hygiene practices. Effective treatment primarily involves prompt administration of oral rehydration solutions. The fact sheet also highlights the importance of surveillance, preparedness, and response strategies to control outbreaks.
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