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Publication Years
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2
Long Acting Muscarinic Antagonists (LAMA) such as tiotropium and glycopyrronium are used in the management of COPD1. They have been shown to improve lung function, quality of life and exercise tolerance. They have also been associated with reduced COPD-related exacerbations, associated hospitalisati
...
ons and duration of hospital stay. Both the South African Thoracic Society (SATS) and Global Initiative for Chronic Obstructive Lung Disease (GOLD), guidelines recommend the use of long acting anticholinergic drugs (or long acting beta agonists) in moderate to very severe disease as defined by lung function (FEV1). The most up to date guideline, utilizing the GRADE methodology (European Respiratory Society guidelines of 2017), confirms their superiority over long acting β agonists (LABA) as monotherapy for COPD in that LAMA's have demonstrated greater efficacy in terms of exacerbation reduction, with similar safety profile.2 These recommnedations are supported by published peer-reviewed
evidence including individual papers and Cochrane reviews.
more
The ICMR type 1 diabetes guidelines come at a time when the SARS-CoV-2 pandemic
has disproportionately affected people with diabetes population, exposing them to a
high risk for severe illness and mortality. Globally, diabetes was responsible for over fourmillion deaths in the year 2019. It was th
...
e leading cause of end-stage kidney disease, adult-onset blindness and cardiovascular diseases. Further, there was a considerable heterogeneity in the prevalence of complications and deaths associated with diabetes across the countries.
more
Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and annually updated a global strategy for asthma management and prevention that has formed the basis for many national guidelines. However, uptake of existing guidelines is poor. A major revision of the GINA r
...
eport was published in 2014, and updated in 2015, reflecting an evolving understanding of heterogeneous airways disease, a broader evidence base, increasing interest in targeted treatment, and evidence about effective implementation approaches. During development of the report, the clinical utility of recommendations and strategies for their practical implementation were considered in parallel with the scientific evidence.
more
Asthma is the commonest chronic childhood disease and encompasses a spectrum of airway diseases with similar symptoms. Inaccurate diagnosis remains common, especially in younger children, with failure to characterize the different “asthmas.” Children worldwide repeatedly suffer symptoms which se
...
verely affect their everyday lives. Children die from asthma, especially in low and middle-income countries (LMICs). In many countries, asthma prevalence is rising. Access to effective care and changing environments are hugely variable and may explain the higher morbidity in inner-city children, in LMICs, and in deprived populations in high-income countries. Despite the disease being eminently controllable, morbidity and mortality persist.
more
Asbestos-related cancers: the‘Hidden Killer’remains a global threat
van Zandwijk, N.; Reid, G.; Frank, A.
EXPERT REVIEW OF ANTICANCER THERAPY2020, VOL. 20, NO. 4, 271–278
(2020)
CC2
Asbestos, the most frequent cause of occupational cancer, continues to be consumed ona massive scale, with millions of people exposed on a daily basis. This review explains why we havefailed in curtailing the silent epidemic of asbestos-related disease and why the numbers of asbestosvictims are like
...
ly to remain high. Emerging and developed countries have to be reminded that asbestosexposure has yet to become a problem of the past. The worldwide spread of asbestos, followed by thesurge of asbestos-related cancers, resembles the lung cancer epidemic caused by smoking andstimulated by manufacturers.
more
A review of prospects for existing antibiotics ad new therapeutics
This resulting toolkit is a practical guide intended to assist users to become advocates for palliative care in a practical and effective
way. It is not necessarily a resource to read from cover to cover; rather, it can also be used selectively to each reader’s needs to engage audiences and
...
ensure that there is a real understanding of the need for palliative care. It should also be read in conjunction with the supplementary resources listed at the end of each of the toolkit’s sections.
more
To contribute to the availability of basic knowledge and skills for the provision of palliative care in
the African region, the African Palliative Care Association (APCA) has developed a competencybased core curriculum framework for use in introductory training on palliative care. The curriculum
...
is based on the APCA Standards for Providing Quality Palliative Care Across Africa to ensure that care providers are trained to the appropriate competence for their cadre and level of skill. This curriculum therefore aims to facilitate the development of the best basic skills and attitudes required for the delivery of palliative care services that meet the desired standards of palliative care. The curriculum incorporates theoretical, practical, mentorship and supervision components that are critical to the effective application of knowledge in practice.
more
Diagnostic de mpox.
Core Guidance. Differentiated service delivery is highlighted as a key approach for HIV programmes to enhance implementation quality and efficiency.
Technical Document
Indicators and questions to monitor progress towards the Global AIDS Strategy 2026-2031 targets
This review article provides a comprehensive overview of Ebola Virus Disease (EVD), covering its epidemiology, clinical presentation, diagnosis, treatment, and prevention. It explains that Ebola is a severe zoonotic infection caused by the Ebola virus, most likely originating from fruit bats and tra
...
nsmitted to humans through contact with infected animals or body fluids. The article summarizes the history of Ebola outbreaks in Africa, including the major West African epidemic of 2013–2016 and subsequent outbreaks in the Democratic Republic of Congo. It describes the disease’s clinical course, ranging from nonspecific flu-like symptoms to severe dehydration, multiorgan failure, shock, and death. The authors discuss diagnostic methods, supportive and intensive care management, emerging antiviral therapies and monoclonal antibodies, as well as the development and use of Ebola vaccines. The review also highlights the importance of infection control, contact tracing, community engagement, safe burial practices, and healthcare worker protection in controlling outbreaks. Finally, it addresses long-term complications in survivors and the persistence of Ebola virus in certain body compartments, particularly semen, which may contribute to delayed transmission.
more
Mainstreaming Gender in Water and Sanitation
Report commissioned by the IASC Inter-Agency Humanitarian Evaluations Steering Group as part of the Syria Coordinated Accountability and Lessons Learning Initiative
War Surgery. Vol.1
recommended
Working with limited resources in armed conflict and other situations of violence. Vol.1
A practical manual presenting the specific knowledge, skills and practices that First Aiders should have to act safely and effectively when caring for people caught up in armed conflicts and other situations of violence, such as internal disturbances and tensions.
This Technical Brief reviews current practice and evidence on nutrition-specific preventive approaches to MAM, providing practical guidance for implementers and programme managers, and highlighting gaps in evidence and guidance.
Real Time Evaluation of the Ebola Control Programs in Guinea, Sierra Leone and Liberia. Final Report
The scope includes the assessment of activities to improve the response to affected populations, stakeholders, partners and donors, building on lessons learnt so far in this outbreak.
