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Government policy interventions to reduce human antimicrobial use: A systematic review and evidence map

Van Katwyk, S. R.; Grimshaw, J. M.; et al (2019) C2

BACKGROUND: Growing political attention to antimicrobial resistance (AMR) offers a rare opportunity for achieving meaningful action. Many governments have developed national AMR action plans, but most have not yet implemented policy interventions to reduce antimicrobial overuse. A systematic evidenc...e map can support governments in making evidence-informed decisions about implementing programs to reduce AMR, by identifying, describing, and assessing the full range of evaluated government policy options to reduce antimicrobial use in humans. METHODS AND FINDINGS: Seven databases were searched from inception to January 28, 2019, (MEDLINE, CINAHL, EMBASE, PAIS Index, Cochrane Central Register of Controlled Trials, Web of Science, and PubMed). We identified studies that (1) clearly described a government policy intervention aimed at reducing human antimicrobial use, and (2) applied a quantitative design to measure the impact. We found 69 unique evaluations of government policy interventions carried out across 4 of the 6 WHO regions. These evaluations included randomized controlled trials (n = 4), non-randomized controlled trials (n = 3), controlled before-and-after designs (n = 7), interrupted time series designs (n = 25), uncontrolled before-and-after designs (n = 18), descriptive designs (n = 10), and cohort designs (n = 2). From these we identified 17 unique policy options for governments to reduce the human use of antimicrobials. Many studies evaluated public awareness campaigns (n = 17) and antimicrobial guidelines (n = 13); however, others offered different policy options such as professional regulation, restricted reimbursement, pay for performance, and prescription requirements. Identifying these policies can inform the development of future policies and evaluations in different contexts and health systems. Limitations of our study include the possible omission of unpublished initiatives, and that policies not evaluated with respect to antimicrobial use have not been captured in this review. CONCLUSIONS: To our knowledge this is the first study to provide policy makers with synthesized evidence on specific government policy interventions addressing AMR. In the future, governments should ensure that AMR policy interventions are evaluated using rigorous study designs and that study results are published. more

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Assessing the impact of imperfect immunoassays on HIV prevalence estimates from surveys conducted by the DHS program

Mathieu Maheu-Giroux, Lawrence Joseph, Patrick Belisle and others (2017) C2

This report investigates the impact of potential misclassification of samples on HIV prevalence estimates for 23 surveys conducted from 2010-2014. In addition to visual inspection of laboratory results, we examined how accounting for potential misclassification of HIV status through Bayesian latent ... more

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Measuring Disability in Surveys and Programs: A Summary (Cameroon)

International Centre for Evidence in Disability (ICED) London School of Hygiene and Tropical Medicine (LSHTM) (2015) C2

Funded by CBM: www.cbm.org

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RAPPORT MONDIAL SUR LE HANDICAP - RÉSUMÉ

World Health Organization (WHO) & The World Bank (WB) (2011) C_WHO

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World Report of Disability - Summary

World Health Organization (WHO) & The World Bank (WB) (2011) C_WHO

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Élimination sans risques des déchets

Organisation Mondiale de la Santé OMS (1998)

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Evaluation finale du projet Sécurisation et Élimination des Pesticides Obsolètes au Bénin

Organisation des Nations Unies pour l'alimentation et l'agriculture, Bureau de l'Évaluation (2016) C1

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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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The Union - Treat TB

International Union Against Tuberculosis and Lung Disease; USAID (2017)

Accessed November 2017

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Disability in the South-East Asia Region

World Health Organization (WHO) (2013) C_WHO

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Human Rights based research into COVID-19 related violations with focus on persons with disabilities

Malawi Human Rights Commission (2021) CC

The goal of the study was to assess the feasibility of the COVID-19 measures and their resultant impact on Persons with Disabilities in Malawi. Specifically, the study addressed the following objectives: a) To evaluate Government’s response to COVID-19 following the adoption of the new measures... more

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MAMI Care Pathway Package

MAMI, Irish Aid, Eleanor Crook Foundation (2020) CC

MAMI refers to the management of small and nutritionally at risk infants under six months of age (infants u6m) and their mothers.

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The Mental Health of Internally Displaced People and the General Population in Ukraine

I. Kuznetsova, O.Mikheieva, J. Catling, et al. (2019) C1

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Obstacles to Housing, Land and Property Rights in Northern Mon State

Norwegian Refugee Council European Union (2019) C1

A Field-Based Assessment of Formal and Informal Procedures and Practices

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Collective Voices: Qualitative Case Study Report

Three Millennium Development Goal Fund (3MDG) (2018) C1

Civil Society Organisations’ contribution towards community engagement to access and demand health services and encourage communities to practice appropriate health-seeking behaviour in Mon and Chin States. The study recognizes that civil society can promote people-centered health by creating an e... more

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Root and tuber crops: Untapped potential for food and nutrition security and rural livelihood development in Myanmar. Results of a scoping study

Moe Aung FoodSTART+ (2018) C1

This scoping study done in Myanmar offers the chance for FoodSTART+ to explore prospects for future partnerships in another important country of the region. The study was done from October 2016 to February 2017 and included visits to selected major potato and cassava production areas to meet with re... more