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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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WHO country cooperation strategy 2014-2018, Myanmar

World Health Organization (WHO), Country Office for Myanmar (2014) C_WHO

The strategic priorities of the CCS 2014–2018 are:
(1) Strengthening the health system.
(2) Enhancing the achievement of communicable disease control targets.
(3) Controlling the growth of the noncommunicable disease burden.
(4) Promoting health throughout the life course.
... more

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Mass Casualty Management Systems. Strategies and guidelines for building health sector capacity

Health Action in Crisis Word Health Organization (2007)

Disaster planning - organization and administration. 2.Emergency medical services - methods. 3.Emergency medical services - organization and administration. 4.Emergencies. 5.Health policy. 6.Health facilities.7.Guidelines.

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Botswana: Guidelines on Good Manufacturing Practices

Ministry of Health, Gabarone, Botswana (2009) C2

Drug Advisory Board

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Ethical considerations for use of unregistered interventions for Ebola viral disease

World Health Organization (2014)

West Africa is experiencing the largest, most severe, most complex outbreak of Ebola virus disease in history. On 11 August 2014, WHO convened a consultation where the participants concluded that in the particular context of the current Ebola outbreak in West Africa, it is ethically acceptable to of... more

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HIV/AIDS treatment and care in Belarus

J. D. Lundgren; D. Raben; I. Eramova; V. Ilyenkova World Health Organization (Europe); Centre for Heath & Infectious Disease Research (2014) C_WHO

Evaluation report January 2014

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Sanitation Safety Planning

World Health Organization WHO (2022) C_WHO

Manual for step-by-step risk management for safely managed sanitation systems. 2nd edition. This Sanitation safety planning (SSP) manual provides practical, step-by-step guidance to assist in the implementation of the 2018 World Health Organization (WHO) Guidelines on sanitation and health and the ... more

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Survey of the Quality of Selected Antimalarial Medicines Circulating in Six Countries of Sub-Saharan Africa
recommended

World Health Organization WHO (2011) C_WHO

The survey aimed at evaluating the quality of selected antimalarials in six countries of sub-Saharan Africa (Cameroon, Ethiopia, Ghana, Kenya, Nigeria and the United Republic of Tanzania). These countries have been supported by WHO to strengthen their regulatory controls o... more

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Abortion care guideline

World Health Organization WHO (2022) C_WHO

The objective of this guideline is to present the complete set of all WHO recommendations and best practice statements relating to abortion. While legal, regulatory, policy and service-delivery contexts may vary from country to country, the recommendations and best practices described in this docume... more

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WHO Country Cooperation Strategy Nepal, 2013-2017

World Health Organisation (WHO) Country Office for Nepal (2013) C_WHO

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Outbreak Communication

World Health Organization (2005)

Best practices for communicating with the public during an outbreak

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Transforming the medical PPE ecosystem: Joint action can protect healthcare workers with effective and high-quality personal protective equipment

Global Fund (2021) CC

Access to medical personal protective equipment (PPE) is essential for routine healthcare delivery, and a critical tool for containing outbreaks, as well as preventing and responding to pandemics. It is one of our most effective tools against COVID-19, and an undervalued tool more generally in infec... more

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Consolidated Guidelines on HIV Prevention, Diagnosis, Treatment and Care for key populations

C. Beyrer; A. Kamarulzaman; E. Aaraj; et al. World Health Organization WHO (2016) CC

2016 Update Key population

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UNAIDS Guidance Note on HIV and Sex Work

UNAIDS (2012) C2

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Operational guidance on the use of yellow fever assays in the context of surveillance

World Health Organization WHO (2023) C_WHO

This publication aims to provide updated guidance on the specific use of yellow fever laboratory assays in the context of surveillance to be used across the Global Yellow Fever Laboratory Network for disease surveillance. In the recent years, new commercial assays became available and are now recomm... more

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Planning Guide for national implementation of the Global Strategy for Infant and Young Child Feeding

World Health Organization; UNICEF (2007) C_WHO

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Community-based rehabilitation: CBR guidelines - Supplementary booklet

Kamala Achu, Kathy Al Jubah, Svein Brodtkorb, et al. WHO (2010) C_WHO

Available in: English, French, Chinese, Spanish, Russian, Arabic, Thai, Korean, Tajik, Vietnamese, Uzbek http://www.who.int/disabilities/cbr/guidelines/en/

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Pandemic influenza preparedness and response WHO guidance document

World Health Organization (2009)

This document should be used in conjunction with the WHO checklist for influenza preparedness planning published by the World Health Organization in 2005. Available in English; Chinese; French

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Guidelines for training personnel in developing countries for prosthetics and orthotics services
recommended

World Health Organization WHO (2005) C_WHO

1.Orthopedics - education 2.Prostheses and implants - utilization 3. Orthotic devices - utilization 4.Developing countries 5.Guidelines 6.Teaching materials I.World Health Organization II.International Society for Prosthetics and Orthotics

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Reproductive, Maternal, Neonatal and Child Health Program Overview and Pharmaceuticals Management Training for Pharmacy Professionals. Participant Manual

Ministry of Health, Federal Democratic Republic of Ethiopia (2018) CC

The Federal Ministry of Health (FMOH) has been coordinating sector wide reforms that aim to improve equity and quality of maternal and child health services. As part of these efforts, the ministry is also exerting concerted efforts to improve availability and use of quality... more

Survey of the Quality of Selected Antimalarial Medicines Circulating in Six Countries of Sub-Saharan Africa recommended

Guidelines for training personnel in developing countries for prosthetics and orthotics services recommended

Survey of the Quality of Selected Antimalarial Medicines Circulating in Six Countries of Sub-Saharan Africa
recommended

Guidelines for training personnel in developing countries for prosthetics and orthotics services
recommended