This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospita...ls in the Democratic Republic of the Congo between August 2005 and September 2009 to support the registration of pafuramidine for treatment of first stage HAT in collaboration with the United States Food and Drug Administration. Patients were treated with either 100 mg of pafuramidine orally twice a day for 10 days or 4 mg/kg pentamidine intramuscularly once daily for 7 days to assess the efficacy and safety of pafuramidine versus pentamidine. Pregnant and lactating women as well as adolescents were included.
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A practical tool for field based humanitarian workers. It provides up-to-date, clear and succint guidance on topics accross the humanitarian sector including references to current, relevant resources and practical tools.
Brochure on 'increase in the risk of violence against older people' and what can be done to adress it.
This document provides guidance on the application of non-pharmaceutical countermeasures to minimise the spread of the 2019 novel coronavirus (2019-nCoV) in the population. Some of the measures proposed refer specifically to certain phases of the epidemic (containment or mitigation phases), and can ...be adapted depending on the assessed severity/impact of the infection. Other measures are valid for all phases of an epidemic.
The guidance is based on the current knowledge of the 2019-nCoV and evidence available on other viral respiratory pathogens, mainly the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), the Middle East Respiratory Syndrome-related coronavirus (MERS-CoV) and seasonal or pandemic influenza viruses.
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La communication sur les risques est un aspect à part entière des interventions d’urgence. Il s’agit de l’échange en temps réel d’informations, de conseils et d’avis entre les experts, les responsables communautaires, les décideurs politiques et les populations en situation de risque.... Lors d’une épidémie, d’une pandémie, d’une crise humanitaire ou d’une catastrophe naturelle, une communication sur les risques efficace permet aux populations les plus exposées de comprendre les comportements à adopter pour se protéger. Ainsi, les autorités et les experts peuvent être à l’écoute des inquiétudes et des besoins, chercher à y répondre et faire en sorte que leurs conseils soient pertinents, fiables et recevables
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The guide is organized into the major types of toxicities, the associated symp-toms, possible offending medications, and the suggested nursing assessments and interventions. Some symptoms (e.g. nausea) may be associated with a num-ber of underlying causes and may be mild, or a symptom of... a more serious medical situation requiring urgent attention. The pathophysiology for medica-tion-related fatigue and hypersalivation are unclear and these symptoms are not grouped under a specific type of toxicity. Additional information (comments) are provided for each toxicity to highlight relevant clinical information that may assist in management of side effects. Medications more strongly associated with the side effect appear in bold text. The appendices include tools nurses can use to more thoroughly assess patient complaints of pain, depression and neuropathy.
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Responding to a poliovirus event and outbreak, Part 1: General (SOPs) describes the general principles and steps to facilitate timely and effective responses to poliovirus events and outbreaks, and incorporate lessons learned from recent previous outbreak response efforts. This document summarizes r...oles and responsibilities of national governments and Global Polio Eradication Initiative (GPEI) partners.
Effective 01 November 2017 until 30 April 2018
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PLOS ONE | https://doi.org/10.1371/journal.pone.0186835 October 30, 2017
PeerJ PrePrints , http://dx.doi.org/10.7287/peerj.preprints.579v1 2 Nov 2014
Adresssing climate change impacts on infrastructure: preparing for change. Fact sheet
Psychosocial support is a very important component in Gender Based Violence response that provide appropriate care, protection and social integration. Psychological aspects affect thoughts, emotions, behavior, memory, learning ability, perceptions and understanding. While the social aspects have ef...fects on relationships, often shaped by traditions, culture ,values, family and community, but also include one’s status in the community and economic wellbeing. These have different effects on the women, men, boys and girls as victims /survivors and perpetuators.
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Guidance Document
Unite for Children