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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Key Messages for Safe School Operations In Countries with Outbreaks of Ebola

UNICEF; CDC; WHO (2015)

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Document de référence en RÉANIMATION à l'usage des Commissions de Qualification

Ordre National des Médecins (2017) CC

La réanimation a pour objectifs de prévenir et de pallier les différentes défaillances viscérales aiguës. Elle s’adresse aux malades graves et est actuellement considérée comme un élément normal de l’arsenal thérapeutique. Les médecins et les soignants ont démontré l’utilité ... more

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Update on COVID-19 vaccination in Syria

World Health Organization WHO; Eastern Mediterranean Region (2021) C_WHO

22 April 2021

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Clinic Supervisor Manual

Management Sciences for Health; USAID (2006) C1

This Clinic Supervisor’s Manual is helpful for focusing managers on the key elements of integrated primary health care as they simultaneously integrate new interventions for HIV/AIDS, tuberculosis, and malaria. This tool contains 12 sections. Section 1 explains how to use the manual. Section 2 hel... more

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Birth defects surveillance: a manual for programme managers

World Health Organization (2014)

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Philippines: Typhoon Haiyan Situation Report No. 34 (as of 28 January 2014)

OCHA (2014)

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Rwanda Poverty Profile Report, 2013/14 - Integrated Household Living Conditions Survey

National Institute of Statistics of Rwanda (NISR) (2015) C2

This report provides an update on the level of poverty based on 2013/14 Integrated Household Living Conditions Survey (EICV4) focusing on poverty as measured in consumption terms. The report also highlights other trend dimensions of living conditions captured in other surveys that complement and pro... more

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Healthcare waste

USAID (2019) C1

Sector Environmental Guidelines, Full technical Update

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Situational Analysis of Antimicrobial Use and Resistance in Humans and Animals in Zimbabwe

The Center for Disease Dynamics, Economics & Policy CDDEP (2017) C2

This situation analysis has gathered information about the current state of AMR, contributing factors and antimicrobial use in Zimbabwe from the human, animal, agricultural and environmental sectors. Data has been gathered from different sectors such as the general public, academia, the Ministry of ... more

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Cross-Border Female Genital Mutilation in East Africa

UNFPA ESARO UNFPA; UNICEF (2022) CC

In East Africa, the trend in cross-border FGM puts at risk the progress achieved in eliminating the practice. The only way we can reach zero FGM by 2030 is by concerted and immediate action to address all aspects of FGM. This policy brief highlights the cross-border dimension of FGM (Ethiopia, Keny... more

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Assessment of Learning Disabilities: Cooperation between Teachers, Psychologists and Parents

Tuija Aro and Timo Ahonen Niilo Mäki Institute (2011) C2

African edition

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Community Health Extension Workers Strategy in Uganda (2015/16- 2019/20)

Ministry of Health, Republic of Uganda (2016) C1

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Food Security Program Lifecycle Toolkit

Food for the Hungry (2006) CC

It is our hope and prayer that the guidance and multiple tools provided herein to manage the entire lifecycle of a food security program are useful to our food security staff, our local partners, and our fellow international Cooperating Sponsors throughout the world.

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Enhancing mental health pre-service training with the mhGAP Intervention Guide: experiences and lessons learned

World Health Organization WHO (2020) C_WHO

This document was designed to inform educators, amongst others, about enhancing the pre-service curriculum with mental health Gap Action Programme Intervention Guide (mhGAP-IG) materials, which can provide future professionals with the theoretical and clinical knowledge they need to provide mental h... more

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Ukraine HIV Program Efficiency Study: Can Ukraine improve value for money in HIV service delivery?

International Bank for Reconstruction and Development The World Bank (2019) C2

Accessed: 04.10.2019 The data collection process was organized by UCDC Director, Natalia Nizova, and M&E Department Head, Igor Kuzin, and implemented by M&E specialists from oblast AIDS Centers: Zhanna Antonenko, Oksana Gorbachuk, Volodymyr Zahorovskyi (Kiev City); Anna Lopatenko, Irina Kozina, I... more

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Guidelines for the Development of Pharmaceutical Services in Primary Health Care

Pan American Health Organization (PAHO) (2011) C_WHO

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Philippines: MNCHN Strategy Manual of Operations

Depar tment of Health, National Center for Disease Prevention and Control (2011) C1

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Shaping the Future: How Changing Demographics Can Power Human Development

Palanivel, T. , et al. United Nations Development Programme (2016) C1

Asia-Pacific Human Development Report

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Guidelines for drinking-water quality: small water supplies - Executive summary

World Health Organization WHO (2024) C_WHO

The Guidelines for drinking-water quality: small water supplies have been developed to address the needs and opportunities associated with small supplies to facilitate progressive improvement towards safe and sustainable drinking-water services for all. These Guidelines are based on the principal re... more