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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Kenya Laboratory Biorisk Management Curriculum

Ministry of Health, Kenya (2020) C1

April 2019

External Link

District Laboratory Practice in Tropical Countries Part 1
recommended

Cheesbrough, Monica (2009) C4

2nd edition

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COVID-19 strategic preparedness and response plan: operational planning guideline: 1 February 2021 to 31 January 2022

World Health Organization WHO (2021) C_WHO

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Integrated HIV Program Report January-March 2016

Government of Malawi, Ministry of Health (2016) C1

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Standard Operating Procedures for ART Scale Up to Health Centers and Private Facilities

Addis Ababa City Administration Health Bureau (2006) C1

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Bangladesh/Myanmar: Rakhine Conflict 2017

World Health Organization WHO, Bangladesh (2017) C_WHO

Public Health Situation Analysis and Interventions 10 October 2017

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The Corona Virus Disease 2019 (COVID-19) Strategic Response Plan for the WHO African Region February – December 2020 (Update 4 May 2020)

World Health Organization WHO (2020) C_WHO

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Compendium of data and evidence-related tools for use in TB planning and programming

World Health Organization WHO (2021) C_WHO

The Compendium of data and evidence-related tools for use in TB planning and programming was developed as a companion document to the People-centred framework for tuberculosis programme planning and prioritization – user guide, published by the World Health Organization (WHO)... more

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Task-Shifting and Task-Sharing (TSTS) Policy for Essential Health Care Services in Nigeria

Federal Ministry of Health, Nigeria (2014) C1

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Annexes - List of Content

Stop TB Partnership (2017) C1

Annex 1: Measuring progress towards targets Annex 2: Modelling the impact of the 90-(90)-90 strategy Annex 3: Investment packages by country setting Annex 4: Country strategies Annex 5: Strategic frameworks for research and development for new tools Annex 6 : Estimating the cost of the 90-(90)-... more

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Improving Tuberculosis Case Detection

Stop TB Partnership to reach; Foreign Affairs, Trade and Development Canada (2017) C2

A compendium of TB REACH case studies, lessons learned and a monitoring and evaluation framework. Accessed November 2017.

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Operational Guidelines for ART Centers India

National AIDSControl (NACO), Government of India; Ministry of Health and Family Welfare (2012) C1

The resources provide both the older as well as the updated Operational Guidelines for antiretroviral therapy centres, including administrative issues, functions and establishment of centres, reporting and recording tools, measures to improve retention in HIV care, supply chain management of drugs a... more

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Anuual Report 2022: Lesotho

World Health Organisation (WHO) (2023) C_WHO

This annual report gives an overview of WHO lesotho Country office's undertakings and achievements in the context of an extraordinary health emergency. As we walk another mile this year, may we embrace all lessonst leanred in the previous year, learn from what did not work so well and take on new op... more

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TB and the NSP - Are we on track?

Spotlight NSP (2013) C2

NSP Review Engaging with South Africa’s National Strategic Plan for HIV, STIs and TB Edition 7 July – August 2013 A publication of the Treatment Action Campaign and SECTION27 GeneXpert: An imperfect rollout TB in South African prisons: Where to now? Decentralising DR-TB care: How far alon... more

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Investing in and building longer-term health emergency preparedness during the COVID-19 pandemic
recommended

World Health Organization WHO (2020) C_WHO

Interim Guidance This document is to help Member States build on actions taken during the COVID-19 pandemic to improve national medium- to long-term preparedness for future threats. It maps COVID-19 preparedness and response actions to the building of sustainable International Health Regulations (2... more

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Step up the fight. Investment case

The Global Fund Reliefweb OCHA (2019) CC

Ending the epidemics of HIV, tuberculosis and malaria by 2030 is within reach, but not yet fully in our grasp. With only 11 years left, we have no time to waste. We must step up the fight now.

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Thailand's National Strategic Plan on Antimicrobial Resistance 2017-2021

Ministery of Public Health, Thailand (2017) C1

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WHO implementation tool for pre-exposure prophylaxis of HIV infection - Module 5

World Health Organization (WHO) World Health Organization (WHO) (2018) C_WHO

Module 5 Monitoring and Evaluation October 2018 Module 5: Monitoring and evaluation. This module is for people responsible for monitoring PrEP programmes at the national and site levels. It provides information on how to monitor PrEP for safety and effectiveness, suggesting core and additiona... more

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National Preparedness and Response Plan for the Prevention and Control of Ebola Viral Disease (Ghana)

Ministry of Health, Ghana (2014)

District Laboratory Practice in Tropical Countries Part 1 recommended

Investing in and building longer-term health emergency preparedness during the COVID-19 pandemic recommended

District Laboratory Practice in Tropical Countries Part 1
recommended

Investing in and building longer-term health emergency preparedness during the COVID-19 pandemic
recommended