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Publication Years
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Category
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Toolboxes
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Relapsing malaria caused by Plasmodium vivax parasites poses a significant challenge to global malaria elimination efforts. About one third of the population remains at risk of contracting P. vivax malaria, and 85% of P. vivax infections stem from reactivated latent parasites, leading to chronic ana
...
emia and increased morbidity and mortality. In addition to diagnostic tools that can detect the acute, blood-stage of P. vivax, new tools are needed to detect the dormant infections before they reactivate and contribute to morbidity and onwards transmission
more
This guidance synthesizes current evidence on dengue laboratory testing and diagnostics and provides practical recommendations for laboratories, clinicians, public health officials, and programme managers involved in dengue diagnosis, surveillance, and control, in the context of the global emergency
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. It includes a diagnostic algorithm for suspected cases, outlining appropriate testing methods based on days post symptom onset.
more
The document provides a standardized protocol for evaluating the Early Warning Alert and Response Network (EWARN), a surveillance system used during humanitarian emergencies when regular national health surveillance may be disrupted. The purpose of EWARN is to detect outbreaks of communicable diseas
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es early and enable rapid public health response. The guidance explains how the system should be assessed in terms of its structure, implementation, effectiveness, and usefulness. It outlines the key steps of evaluation: preparation, system description, data collection, and post-evaluation reporting. The protocol highlights common challenges observed in previous EWARN implementations, such as delays in establishing the system, limited data quality, weak outbreak response, and lack of clear transition plans back to routine surveillance systems. It emphasizes the need to evaluate both weekly disease reporting and alert verification processes, and to review attributes such as simplicity, data quality, timeliness, sensitivity, and stability. The document also provides templates for interviews, data review forms, and laboratory assessment, as well as guidance on conducting remote evaluations when access is limited. The overall goal of the protocol is to ensure that EWARN functions effectively to detect and respond to outbreaks and that practical recommendations are developed to improve the system’s performance and sustainability in emergency settings.
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The document “Strengthening the global architecture for health emergency prevention, preparedness, response and resilience” presents a report by the Director-General of the World Health Organization (WHO) to the World Health Assembly on global efforts to improve preparedness and response to heal
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th emergencies. It reviews the implementation of the Health Emergency Prevention, Preparedness, Response and Resilience (HEPR) framework and highlights lessons learned from recent crises such as COVID-19. The report describes international initiatives to strengthen global health governance, surveillance systems, laboratory networks, community protection measures, healthcare capacity and access to medical countermeasures like vaccines and diagnostics. It also discusses coordination of emergency responses, support for countries facing outbreaks or humanitarian crises, and the importance of international cooperation. In addition, the report emphasizes the need for sustainable and coordinated financing to strengthen global health security and ensure that countries can better prevent, detect and respond to future health threats.
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The NIAID Pandemic Preparedness Plan describes the strategy of the National Institute of Allergy and Infectious Diseases (NIAID) to strengthen research and development for future pandemic threats. The plan focuses on identifying and studying viruses with the potential to cause epidemics or pandemics
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and developing medical countermeasures such as vaccines, therapeutics and diagnostics. A key concept is the research on “prototype pathogens,” which represent virus families that may cause future outbreaks, allowing scientists to prepare tools and knowledge in advance. The document also outlines the importance of surveillance, epidemiological research, technological innovation, clinical trials and international collaboration to enable a faster and more effective response to emerging infectious diseases. Overall, the plan aims to improve scientific preparedness so that new health threats can be detected earlier and controlled more rapidly.
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second edition
The current document provides the background, justification and objectives for the revision of WHO policy on LF-LAM. It provides details on the index test (AlereLAM) being assessed. It also describes the process of evidence retrieval, quality assessment and grading; formulation of the recommendation
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s; and GDG decision-making. Finally, the document presents policy recommendations and related remarks.
more
Pour l'achat de tests de diagnostic rapide du paludisme (TDR), plusieurs critères sont recommandés pour garantir la qualité et l'efficacité des tests. Ces critères se basent notamment sur la performance des tests, leur stabilité, leur facilité d'utilisation, leur coût et leur conformité aux
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standards de l'Organisation Mondiale de la Santé (OMS)
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Ces orientations se concentrent sur le SARS-CoV-2, mais s'appliquent également à d'autres agents pathogènes préoccupants pour la santé publique.
This document is a guide defining requirements for quality and safety for malaria rapid diagnostic testing services to safeguard the quality of the results, the safety of the operators and patients and that of the environment for use by national malaria control programmes, regulators, implementers a
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nd rapid diagnostic providers.
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This second edition of the Basic Malaria Microscopy package is a stand-alone product,
providing all that is needed to conduct a complete training course
Multi-country outbreak of cholera External Situation Report # 23, published 20 February 2025
This review article examines 42 years of Ebola virus disease (EVD) outbreaks in Sub-Saharan Africa, from 1976 to 2019. The authors analyze the epidemiology, geographical distribution, mortality rates, and response strategies associated with 34 Ebola outbreaks across 11 African countries. The review
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identifies key challenges in controlling Ebola, including weak health systems, limited surveillance and laboratory capacity, sociocultural practices, environmental changes, and community mistrust. It also discusses advances in diagnostics, treatments, and vaccines, and emphasizes the importance of a One Health approach, community engagement, effective communication, and stronger healthcare systems to improve preparedness, prevention, and response to future Ebola outbreaks.
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The Ethiopia Multi-Sectorial Cholera Elimination Plan (2022-2028) outlines a national strategy to eliminate cholera in Ethiopia by 2028. The plan follows the Global Roadmap to End Cholera by 2030 and is based on six key pillars: Leadership & Coordination, Water, Sanitation & Hygiene (WASH), Surveill
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ance & Reporting, Use of Oral Cholera Vaccines (OCV), Healthcare System Strengthening, and Community Engagement.
Ethiopia has historically faced recurrent cholera outbreaks due to poor sanitation, unsafe water, and weak health infrastructure. The plan prioritizes high-risk areas (hotspot woredas) and aims to reduce cholera-related mortality by 90% by 2028. It includes efforts to improve WASH conditions, strengthen disease surveillance, enhance rapid response capabilities, expand vaccination campaigns, and integrate cholera control into broader health policies.
The government, in collaboration with international partners such as WHO, UNICEF, and the Global Task Force for Cholera Control (GTFCC), will implement and monitor the plan. The estimated budget for the initiative is $390 million over eight years. Ethiopia aims to achieve zero cholera transmission in hotspot regions, ensuring sustainable public health improvements.
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The document outlines the 2017 cholera outbreak in Zambia, mainly in Lusaka, due to poor sanitation and unsafe water. By December, 493 cases were reported, with risks increasing due to the rainy season. The Zambia Red Cross Society (ZRCS), in collaboration with the Ministry of Health, WHO, and UNICE
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F, responded by setting up treatment centers, supplying clean water and chlorine, and conducting hygiene education. 1,500 volunteers were mobilized to support 70,000 people directly. The IFRC allocated CHF 222,351 to control the outbreak, but challenges like limited funding and poor infrastructure remained.
more
The Cholera Outbreak Guidelines: Preparedness, Prevention, and Control provide a practical field guide for responding to cholera outbreaks. Developed by Oxfam GB, the guidelines combine lessons from past cholera interventions and best practices for effective outbreak management. The document outline
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s key strategies, including preparedness planning, rapid response to outbreaks, water and sanitation improvements, hygiene education, and coordination among stakeholders. It covers both non-endemic and endemic cholera outbreaks, offering step-by-step guidance on surveillance, intervention, and monitoring. The aim is to ensure community-based, gender-sensitive, and rapid public health responses to control cholera and minimize mortality.
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On 19 August 2016, the former UN Secretary-General announced a new approach to cholera in Haiti, consisting of two tracks. Track 1 focuses on reducing cholera transmission, improving access to care, and addressing water, sanitation, and health system issues. Track 2 aims to provide material assistan
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ce to those most affected by cholera. The Secretary-General urged Member States to show solidarity with Haiti by increasing contributions. The UN General Assembly, in resolution 71/161, recognized the UN's moral responsibility to cholera victims and called for support to eliminate cholera and address its victims' suffering. The Secretary-General was requested to provide an update on the progress of this approach.
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Filoviral hemorrhagic fever (FHF) is caused by ebolaviruses and marburgviruses, which both belongto the family Filoviridae. Egyptian fruit bats (Rousettus aegyptiacus) are the most likely natural reservoir for marburg viruses and entry into caves and mines that they stay in has often been associated
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with outbreaks of MVD. On the other hand, the natural reservoir for ebola viruses remains elusive;however, handling of wild animal carcasses has been associated with some outbreaks of EVD. In thelast two decades, there has been an increase in the incidence of FHF outbreaks in Africa, some beingcaused by a newly found virus and some occurring in previously unaffected areas such as Guinea, Liberia and Sierra Leone, in which the most recent EVD outbreak occurred in 2014. Indeed, the predicted geographic distribution of filoviruses and their potential reservoirs in Africa includes manycountries in which FHF has not been reported. To minimize the risk of virus dissemination inpreviously unaffected areas, there is a need for increased investment in health infrastructure in African countries, policies to facilitate collaboration between health authorities from different countries, implementation of outbreak control measures by relevant multi-disciplinary teams and education of the populations at risk.
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The document “Hospital Preparedness for Epidemics” published by the World Health Organization (WHO) provides guidance on how hospitals and healthcare facilities can prepare for and respond effectively to infectious disease outbreaks. It outlines key components of epidemic preparedness, including
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planning and management structures, infection prevention and control, communication systems, human resource management, logistics, laboratory capacity, and the continuity of essential health services. The guide emphasizes the importance of coordination within hospitals and with public health authorities, as well as training staff and ensuring adequate supplies and infrastructure. Overall, the document serves as a practical framework to help hospitals strengthen their readiness, maintain critical healthcare services, and respond efficiently during epidemics or other health emergencies.
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