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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Clinic Supervisor Manual

Management Sciences for Health; USAID (2006) C1

This Clinic Supervisor’s Manual is helpful for focusing managers on the key elements of integrated primary health care as they simultaneously integrate new interventions for HIV/AIDS, tuberculosis, and malaria. This tool contains 12 sections. Section 1 explains how to use the manual. Section 2 hel... more

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Healthcare waste

USAID (2019) C1

Sector Environmental Guidelines, Full technical Update

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Philippines: A Training Manual for Health Workers on Healthy Lifestyle - Promoting Mental Health (Module 6/6)

WHO and DOH Philippines (2009) C_WHO

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Policy brief on tuberculosis-associated disability

World Health Organization WHO (2023) C_WHO

People affected by impairments and disabilities associated with TB are even more likely to belong to marginalized segments of society and are more likely to have their human rights unprotected. The challenges faced by people affected by TB include the consequences of impairment and disability associ... more

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African Union AMR Landmark Report: Voicing African Priorities on the Active Pandemic

Africa Center for Disease Control and Prevention (2024) CC

Antimicrobial resistance (AMR) has emerged as a leading cause of death in the African region, surpassing fatalities from malaria, HIV, and TB. In response to this critical threat, the region has adopted the AMR Global Action Plan and the African Union Framework for Antimicrobial Resistance Control 2... more

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Executive Summary - Chapter 4 Human Resources

M. E. Medina-Mora ATLAS on substance use (2010)— Resources for the prevention and treatment of substance use disorder; WHO (2019) C_WHO

ATLAS on substance use (2010)— Resources for the prevention and treatment of substance use disorder Accessed: 14.03.2019

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Analysis of the epidemiological impact of tuberculosis in Georgia

A. Hovhannesyan, P. Moonan, A. Dadu World Health Organization Europe (2015) C_WHO

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Ethical considerations for use of unregistered interventions for Ebola viral disease

World Health Organization (2014)

West Africa is experiencing the largest, most severe, most complex outbreak of Ebola virus disease in history. On 11 August 2014, WHO convened a consultation where the participants concluded that in the particular context of the current Ebola outbreak in West Africa, it is ethically acceptable to of... more

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TB: Why You Should Not Discriminate

World Economic Forum (2017) C2

Adapted from a fact sheet on TB from the International Council of Nurse’s Global TB/MDR-TB Resource Centre at: http://www.icn.ch/tb/stigma.htm. Accessed November 2017

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Improving Cultural Competence - QUICK GUIDE FOR CLINICIANS

SAMSHA (2016) C1

Treatment Improvement Protocol (TIP) Series No. 59 This Quick Guide is based entirely on information contained in TIP 59, published in 2014. No additional research has been conducted to update this topic since publication of TIP 59. | This Quick Guide provides succinct, easily accessible informatio... more

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National Community Health Worker Strategy in Zambia

Ministry of Health, Zambia (2010) C1

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WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update
recommended

World Health Organization WHO (2021) C_WHO

6 July 2021. The “WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update” is the latest document replacing the one issued in 2020. Three new nucleic acid amplification test (NAAT) classes are endorsed by WHO and included in the... more

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Antiretroviral medicines in low- and middle-income countries: forecasts of global and regional demand for 2020-2024

World Health Organization WHO; UNAIDS (2022) C_WHO

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Nigeria 2013 Demographic and Health Survey: Key Findings

National Population Commission (NPCNigeria) and ICF International (2014) C1

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Survey of the Quality of Selected Antimalarial Medicines Circulating in Six Countries of Sub-Saharan Africa
recommended

World Health Organization WHO (2011) C_WHO

The survey aimed at evaluating the quality of selected antimalarials in six countries of sub-Saharan Africa (Cameroon, Ethiopia, Ghana, Kenya, Nigeria and the United Republic of Tanzania). These countries have been supported by WHO to strengthen their regulatory controls o... more

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Introduction to HIV, AIDS and Sexually Transmitted Infection Surveillance - Overview of the HIV/AIDS Epidemic with an Introduction to Public Health Surveillance

United States Department of Health and Human Services; Centers for Disease Control and Prevention (HHS-CDC); Global AIDS Program (GAP); et al. United States Department of Health and Human Services; Centers for Disease Control and Prevention (HHS-CDC); Global AIDS Program (GAP); et al. (2011) C2

Participant Manual February 2011 Edition 3.0

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Quantitative evaluation of essential medicines lists: the South African case study

Velisha Ann Perumal-Pillay & Fatima Suleman BMC Health Services Research (2016) CC

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Save One Million Lives Program for Results

Nigeria, Federal Ministry of Health (2016) C1

Program Implementation Manual (PIM)
The Save One Million Lives Program for Results (SOML PforR) is a Federal Government of Nigeria maternal and child health program, supported by the World Bank, which provides incentives based on achievement of results (health outcomes) and helps to drive insti... more

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National Multisectoral Action Plan (NMAP) for Prevention and Control of Common NCDs (2017-22)

Ministry of Health and Family Welfare Government of India; WHO (2017) C_WHO

India is experiencing rapid demographic and epidemiological transitions with NCDs causing significant disability, morbidity and mortality both in urban and rural populations and across all socioeconomic strata. According to the ICMR State Level Disease Burden Initiative, in 2016, NCDs accounted to a... more

WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update recommended

Survey of the Quality of Selected Antimalarial Medicines Circulating in Six Countries of Sub-Saharan Africa recommended

WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update
recommended

Survey of the Quality of Selected Antimalarial Medicines Circulating in Six Countries of Sub-Saharan Africa
recommended