Chikungunya fever (CHIKF) is an emerging infectious disease caused by an alphavirus transmitted by Aedes spp. mosquitoes. Because mosquito control programs are not highly efficient for outbreak containment, vaccines are essential to reduce the burden of disease. Although no licensed vaccine against ...CHIKF is yet available, many highly promising candidates are undergoing preclinical studies, and a few of them have been tested in human trials of phase 1 or 2. Here, we review recent findings regarding the need for a CHIKF vaccine and provide an update on vaccines nearing or having entered clinical trials. We also address needs to tackle bottlenecks to vaccine development—including scientific and financial barriers—and to accelerate the development of vaccines; several actions should be taken:
(i) design efficacy trials to be conducted during the course of outbreaks;
(ii) evaluate the opportunity for adopting the “animal rule”for demonstration of efficacy for regulatory purposes;
(iii) strengthen the collective commitment of nations, international organizations, potential donors and industry;
(iv) stimulate public and/or private partnerships to invest in vaccine development and licensure; and
(v) identify potential markets for an effective and safe CHIKF vaccine.
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The guide summarizes an assessment of War Child Canada’s three-pronged legal protection model as implemented with South Sudanese refugees in Northern Uganda and uses it to identify the most important lessons for ensuring legal protection mechanisms are in place at the onset of an emergency
The module is currently available in English, French, Nepali, Portuguese, Russian, and Spanish
Senegal is home to nearly 2 million girls and women who have experienced FGM. Overall, 25 per cent of girls and women have undergone the practice, varying from over 90 per cent in Kédougou to just under 1 per cent in Diourbel
Female Genital Mutilation in Mali: Insights from a statistical analysis Mali is home to nearly 8 million girls and women who have experienced FGM. Overall, 89 per cent of girls and women aged 15 to 49 years have undergone the practice, ranging from 96 per cent in Sikasso region to 1 per cent or less... in Gao and Kidal
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Prêt au retour: dossier de formation à la préparation des enseignants vous guidera à travers une réflexion sur l’impact du COVID-19 sur les pratiques pédagogiques quotidiennes et vous fournira des conseils et des suggestions que vous pourrez appliquer en classe. Les informations fournies ici... ne sont qu’une première introduction ; nous espérons que vous les trouverez instructives et utiles, que vous explorerez les sujets plus en profondeur, que vous en discuterez avec vos collègues et que vous utiliserez les ressources disponibles qui vous permettront de changer durablement la vie de vos élèves.
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The aims of this publication is to highlight the lack of diversity in medical literature and education
Rueda S, et al. BMJ Open 2016;6:e011453. doi:10.1136/bmjopen-2016-011453
This article looks at the Baseline Standards developed by the International Society for Paediatric
Oncology (SIOP) for paediatric oncology nursing care in low- and middle-income countries. The
Baseline Standards lay the foundation for effective care and address barriers such as inadequate
staffin...g levels, lack of support, limited access to nurse education and unsafe nursing environments.
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The international community sits at the tipping pointof a post-‐antibiotic era, where common bacterial infections are no longer treatable with the antibiotic armamentarium that exists. In South Africa, t...he identification of the first case of pan-‐resistant Klebsiella pneumoniae(Brink et al, J Clin Microbiol. 2013;51(1):369-‐72) marks a watershed moment and highlights ourtip of the antibiotic resistance ‘iceberg’ in this country. Multi-‐drug resistant (MDR)-‐bacterial infections, predominantly in Gram-‐negative bacteria such as Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosaand Acinetobacter baumanniiare now commonplace in South African hospitals. Whilst a number of expensive new antibiotics for Gram-‐positive bacterial infections have been manufactured recently (some of which are licenced for usein South Africa), no new antibiotics active against Gram-‐negative infections are expected in the next 10-‐15years. Hence what we have now, needs conserving
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EVALUATION REPORT | Esta evaluación es el primer ejercicio mundial de carácter amplio para examinar la respuesta programática del UNICEF en la protección de la infancia en situaciones de emergencia. Su objetivo es fortalecer los programas de protección de la infancia mediante la evaluación del... desempeño en los últimos años y extraer lecciones y recomendaciones que influyan en los programas actuales y futuros. Se espera que los resultados de la evaluación sirvan de base para la puesta en marcha del Plan Estratégico de 2014 a 2017. El diseño de la evaluación incluye estudios de caso de países que analizan los resultados en favor de la infancia con respecto al plan estratégico de mediano plazo (PEMP), los compromisos básicos y preguntas de evaluación seleccionadas. Doce países proporcionaron datos para el análisis, cuatro como estudios de caso con visitas a los países e informes independientes (Colombia, Pakistán, República Democrática del Congo y Sudán del Sur) y otros ocho países con estudios documentales (Afganistán, Estado de Palestina, Filipinas, Haití, Myanmar, Somalia, Sri Lanka y Sudán). Cuatro de los países (Filipinas, Haití, Myanmar y Pakistán) son países afectados por desastres y contextos repentinos, mientras que el resto son sobre todo contextos de conflictos prolongados que incluyen levantamientos violentos repentinos8
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Epilepsia, 55(4):475–482, 2014
doi: 10.1111/epi.12550
Background: Peripheral artery disease is a growing public health problem. We aimed to estimate the global disease burden of peripheral artery disease, its risk factors, and temporospatial trends to inform policy and public measures.
Methods: Data on peripheral artery disease were modelled using the... Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed.
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Дитячий фонд ООН (ЮНІСЕФ) доставив на Полтавщину критично важливу гуманітарну допомогу на 800 000 доларів. 340 тон гуманітарного вантажу мають покрити потреби більш як ...півмільйона мешканців Полтавcької області.
Велика частина вантажу - товари медичного призначення: акушерські та гігієнічні набори, бинти, глюкоза, інфузійні та аспіраційні помпи, портативні реєстратори електрокардіографії, портативні апарати ультразвукової
діагностики, пульсоксиметри.
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On 13 and 14 May 2022, North Korea reported 1,74,400 and 2,60,000 new COVID-19 cases and 21 and 15 deaths, respectively. It is thus hard to believe that the country was officially free from the pandemic until 11 May the same year. On 12 May, Pyongyang admitted to around 5,24,440 total COVID-19 cases... in the period late-April to 13 May 2022. Reportedly, 2,43,630 are now fully cured and 2,80,810 are being treated
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