Les coronavirus sont une vaste famille de virus susceptibles de provoquer des maladies diverses chez l'homme, allant du simple rhume au syndrome respiratoire du Moyen-Orient (MERS) et au syndrome respiratoire aigu sévère (SRAS).
Un nouveau coronavirus (CoV) a été identifié en 2019 à Wuhan, ...en Chine. Il s'agit d'un nouveau coronavirus qui n'avait pas encore été identifié chez l'homme.
Ce cours constitue une introduction générale au nCoV et aux virus respiratoires émergents ; il est destiné aux professionnels de santé publique, aux gestionnaires d'incidents, coordonnateurs d’urgence et aux collaborateurs travaillant pour les Nations Unies, les organisations internationales, ainsi que les ONG.
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The New England Journal of Medicine
Genetic analysis of the virus indicates that it is closely related (97% identical) to variants of Ebola virus (species Zaire ebolavirus) identified earlier in the Democratic Republic of the Congo and Gabon
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Les 25 et 26 février 2015
L’émergence de l’épidémie de la maladie à virus Ebola en Afrique de l’Ouest menace la sécurité sanitaire publique régionale et mondiale. La Guinée, le Mali et le Sénégal partage une longue frontière de plusieurs milliers de kilomètres. La rencontre de La...bé les 25 et 26 février 2015 permettra de renforcer la collaboration transfrontalière afin de prévenir et d’arrêter la propagation de l’épidémie de la maladie à virus Ebola
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Coronavirus es una gran familia de virus conocidos por causar enfermedades que van desde un resfriado común hasta manifestaciones clínicas más severas como las observadas en el Síndrome respiratorio por el coronavirus de Oriente Medio (MERS) y el Síndrome espiratorio agudo grave (SARS).
Un nue...vo coronavirus (2019-n-CoV) se identificó en 2019 en Wuhan, China. Este es un nuevo coronavirus que no se ha identificado previamente en humanos.
Este curso ofrece una introducción general al 2019-nCoV y a los virus respiratorios emergentes .Está dirigido a profesionales de la salud pública, gerentes de incidentes, personal que trabaja para las Naciones Unidas, organizaciones internacionales y ONGs.
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N Engl J Med. 2016 Jan 13. [Epub ahead of print] Free full text
The explosive pandemic of Zika virus infection occurring throughout South America, Central America, and the Caribbean (see map) and potentially threatening the United States is the most recent of four unexpected arrivals of important a...rthropod-borne viral diseases in the Western Hemisphere over the past 20 years. It follows dengue, which entered this hemisphere stealthily over decades and then more aggressively in the 1990s; West Nile virus, which emerged in 1999; and chikungunya, which emerged in 2013. Are the successive migrations of these viruses unrelated, or do they reflect important new patterns of disease emergence?
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A varíola dos macacos é uma doença infeciosa emergente causada por um vírus transmitido aos humanos por animais infetados, na sua maioria roedores. Pode ser propagado a outras pessoas, mas a transmissão de pessoa para pessoa, isoladamente, não pode facilmente sustentar um surto. A apresentaç...o clínica é semelhante à observada no passado com a varíola, mas menos grave. A varíola foi erradicada mundialmente em 1980; no entanto, a varíola dos macacos ainda ocorre esporadicamente em partes da África Central e Ocidental, perto das florestas tropicais húmidas. Normalmente, a mortalidade nos surtos da varíola dos macacos tem sido de 1 a 10%, mas com os cuidados adequados, a maioria dos doentes recupera. Este curso fornece uma introdução geral à varíola dos macacos e destina-se aos profissionais de saúde responsáveis pela prevenção e controlo da varíola dos macacos.
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La viruela del mono es una enfermedad transmisible emergente causada por un virus que se transmite a los seres humanos a partir de animales infectados, generalmente roedores. Puede contagiarse a otras personas, pero la transmisión de persona a persona por sí sola no es capaz de mantener un brote. ...La presentación clínica es similar a la observada en el pasado con la viruela, pero menos grave. La viruela fue erradicada en el mundo en 1980; sin embargo, la viruela del mono sigue produciéndose esporádicamente en partes de África Central y Occidental, cerca de las selvas tropicales. Normalmente, la letalidad en los brotes de viruela del mono ha sido del 1 al 10%, pero con los cuidados adecuados, la mayoría de los pacientes se recupera. Este curso ofrece una introducción general a la viruela del mono y está dirigido al personal sanitario responsable de la prevención y el control de la viruela del mono.
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La variole du singe est une maladie infectieuse émergente causée par un virus transmis par des animaux infectés, le plus souvent des rongeurs. Elle peut ensuite se propager d’une personne à l’autre, mais la transmission de personne à personne ne peut à elle seule entretenir une éclosion. ...La présentation clinique est semblable à celle observée chez les patients atteints autrefois de la variole, mais moins grave. La variole a été éradiquée dans le monde entier en 1980. Cependant, la variole du singe est encore présente sporadiquement dans des régions d'Afrique centrale et occidentale, près des forêts tropicales humides. De manière générale, le taux de létalité dans les épidémies de variole du singe est de 1 à 10 %, mais avec des soins appropriés, la plupart des patients se rétablissent.
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Since the re-emergence of monkeypox in Nigeria in September 2017, the Nigeria Centre
for Disease Control(NCDC) has continued to receive reports and respond to cases of the
disease from States across the country. Between September 2017 when the outbreak started and November 2018, about 300 suspecte...d cases had been reported from 26 out of 36 states and the Federal Capital Territory. The highest number of cases were reported from States in the South-South region of Nigeria. Monkeypox is a zoonotic orthopox virus, which presents in humans with symptoms such as fever, headache, body pain, malaise, lymphadenopathy (enlargement of glands),
sore throat and the typical generalised vesiculopustular rash. Transmission is via direct or
indirect contact with infected animals, human, or contaminated materials.
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Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries.
In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response.
As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa.
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A WHO Guideline for Emergency Risk Communication (ERC) policy and practice.
Recent public health emergencies, such as the Ebola virus disease outbreak in West Africa (2014–2015), the emergence of the Zika virus syndrome in 2015–2016 and multi-country yellow fever outbreaks in Africa in 2016, h...ave highlighted major challenges and gaps in how risk is communicated during epidemics and other health emergencies. The challenges include the rapid transformation in communications technology, including the near-universal penetration of mobile telephones, the widespread use and increasingly powerful influence of digital media which has had an impact on ‘traditional’ media (newspapers, radio and television), and major changes in how people access and trust health information. Important gaps include considerations of context – the social, economic, political and cultural factors influencing people’s perception of risk and their risk-reduction behaviours.
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Ce cours est à destination des cliniciens qui travaillent dans des unités de soins intensifs (ICU) dans les pays à faible et moyen revenu et la prise en charge des patients adultes et pédiatriques atteints de formes d'infection respiratoire aiguë sévère (SARI), notamment la pneumonie sévère..., le syndrome de détresse respiratoire aiguë (SDRA), la septicémie et le choc septique. Ce cours est un guide pratique à l'usage des professionnels de la santé impliqués dans la gestion des soins intensifs lors de flambées d'infection humaine par le virus de la grippe (saisonnière) due à la grippe aviaire (H5N1, H7N9), le MERS-CoV, le nCoV ou d'autres épidémies virales respiratoires émergentes.
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La surveillance épidémiologique est un processus continu de collecte, d’analyse et de diffusion d’informations pour la prise d’actions de riposte. Les activités de surveillance épidémiologique sont mises en œuvre au Sénégal selon la stratégie SIMR (Surveillance Intégrée de la Maladi...e et Riposte) et suivant le RSI (version 2005). Cependant, très souvent les données de surveillance des maladies, surtout au niveau communautaire, ne sont pas toujours bien enregistrées, notifiées et analysées. Aujourd’hui, les maladies transmissibles émergentes et ré-émergentes comme la maladie à virus Ebola (MVE), constituent une menace importante pour la santé et le bien-être de nos communautés.
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La Surveillance épidémiologique est un processus continu de collecte, d'analyse et de diffusion d'informations pour la prise d'actions de riposte. Les activités de surveillance épidémiologique sont mises en oeuvre au Sénégal selon la stratégie SIMR (Surveillance Intégrée de la Maladie et R...iposte) et suivant le RSI (Version 2005). Cependant, très souvent les données de surveillance des maladies, surtout aux niveau communautaire, ne sont pas toujours bien enregistrées, notifiées et analysées.
Aujourd'hui, les maladies transmissibles emergentes et ré-émergentes comme la maldie à Virus Ebola (MVE), constituent une menace importante pour la santé et le bien-êtres de nos communautés. Fort heureusement, les interventions de lutte et de prévention sont bien connues pour certaines.
Il en résulte que des opportunités pour prendre et mettre en place des mesures de riposte appropriées de santé publique pour sauver des vies existens et doivent être clairement indentifiées. Pour cela, il s'avère nécessaire de former de manière adéquate les acteurs communautaires et de mettre en place un système perfomant de surveillance intégrée des maladies aux niveau communautaire soutenu par une communication appropriée avec les populations aussi bien en milieu urbain que rural.
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La Surveillance épidémiologique est un processus continu de collecte, d'analyse et de diffusion d'informations pour la prise d'actions de riposte. Les activités de surveillance épidémiologique sont mises en oeuvre au Sénégal selon la stratégie SIMR (Surveillance Intégrée de la Maladie et R...iposte) et suivant le RSI (Version 2005). Cependant, très souvent les données de surveillance des maladies, surtout aux niveau communautaire, ne sont pas toujours bien enregistrées, notifiées et analysées.
Aujourd'hui, les maladies transmissibles emergentes et ré-émergentes comme la maldie à Virus Ebola (MVE), constituent une menace importante pour la santé et le bien-êtres de nos communautés. Fort heureusement, les interventions de lutte et de prévention sont bien connues pour certaines.
Il en résulte que des opportunités pour prendre et mettre en place des mesures de riposte appropriées de santé publique pour sauver des vies existens et doivent être clairement indentifiées. Pour cela, il s'avère nécessaire de former de manière adéquate les acteurs communautaires et de mettre en place un système perfomant de surveillance intégrée des maladies aux niveau communautaire soutenu par une communication appropriée avec les populations aussi bien en milieu urbain que rural.
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Mpox continues to affect people around the world. A new framework released today by WHO will guide health authorities, communities and other stakeholders in preventing and controlling mpox outbreaks, eliminating human-to-human transmission of the disease, and reducing spillover of the virus from ani...mals to humans.
Mpox is a viral illness caused by the monkeypox virus (MPXV). It can cause a painful rash, enlarged lymph nodes and fever. Most people fully recover, but some get very sick. The virus transmits from person to person through close, including sexual, contact. It also has animal reservoirs in east, central and west Africa, where spillovers from animals to humans can occasionally occur, sparking further outbreaks.
There are two different clades of the virus: clade I and clade II. Clade I outbreaks are deadlier than clade II outbreaks.
A major emergence of mpox linked to clade II began in 2017, and since 2022, has spread to all regions of the world. Between July 2022 and May 2023, the outbreak was declared a Public Health Emergency of International Concern. While that outbreak has largely subsided, cases and deaths continue to be reported today, illustrating that low-level transmission continues around the world.
Currently, there is also a major outbreak of clade I virus in the Democratic Republic of the Congo (DRC), where cases have been on the rise for decades. Since the beginning of the year, over 6500 cases and 345 deaths have been reported in the DRC. Almost half of these are among children under the age of 15 years.
The Strategic framework for enhancing prevention and control of mpox (2024–2027) provides a roadmap for health authorities, communities, and stakeholders worldwide to control mpox outbreaks in every context, advance mpox research and access to countermeasures, and to minimize zoonotic transmission.
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Countries across the world are facing diverse epidemiological situations with varying response
capacities and access to life saving tools. The World Health Organization (WHO) recommends that national authorities continue to apply a risk-based approach when implementing measures related to COVID-19... and international travel while respecting the dignity, human rights and fundamental freedoms of travellers. This approach should consider the risk posed by travel for the importation and exportation of cases in the context of the evolving epidemiology, including the emergence and circulation of virus variants of concern; the expansion of the COVID-19 vaccination roll-out; and lessons learned while responding to the pandemic, including on the early detection and management of cases and the application of public health and social measures.
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Zambia has recognised the Public Health threat of antimicrobial resistance and its impact on morbidity and mortality, as well as the subsequent economic consequences. The country has recorded microorganisms which have developed resistance to antimicrobial drugs. Notable among these are; Multidrug Re...sistant Mycobacterium Tuberculosis (MDR), Human Immunodeficiency virus resistant to antiretroviral drugs, Plasmodium resistance to antimalarial drugs, and fungal species showing indications of resistance to antifungal drugs. Emergence of “Superbugs” such as Methicillin Resistant Staphylococcus aureus (MRSA), Extended Spectrum beta-lactam (ESBL) producing Klebsiella pneumoniae and Vancomycin Resistant Enterococci (VRE) have also been reported.
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The risk of emergence and re-emergence of arboviruses with pandemic potential has increased as a global public health threat and will continue to do so in the years to come. The Global Arbovirus Initiative outlines an integrated approach across these viruses and disciplines that will enable optimal ...use of limited resources to achieve the greatest impact, particularly in areas with the heaviest arboviral burden and in areas that are at risk of emergence of arboviruses. Following a series of global consultations and review by the Technical Advisory Group on Arbovirus (TAG-Arbovirus), the Global Arbovirus Initiative and its 6 constituent pillars, each with strategic objectives and priority activities, are consolidated in this reference document.
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