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Buruli ulcer (Mycobacterium ulcerans infection) Resource Platform

World Health Organization WHO (2025) C_WHO
Buruli ulcer is caused by Mycobacterium and belongs to the family of bacteria that causes tuberculosis and leprosy. Although the causative organism of Buruli ulcer is an environmental bacterium, the mode of transmission to humans remains unknown. The organism produces a unique toxin – mycolactone ... more
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Buruli Ulcer Drug Discovery Database

Department of Biomedical Engineering, University of Ghana (2025) CC
Data available for your search include drug targets, tested compounds, existing drugs, ethnopharmacological plants, and information on the genome of M. ulcerans
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Buruli ulcer. Diagnose it to treat it!

Follereau (2025) CC
Poster. Accessed March 11, 2025
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The Global Health Observatory

World Health Organization WHO (2025) C_WHO
Explore a world of health data
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Formulation and Stability of a 1% Clarithromycin-Based Topical Skin Cream: A New Option to Treat Buruli Ulcers?

Sebti, M.; et al. (2024) CC
Pharmaceuticals 2024, 17(6), 691; https://doi.org/10.3390/ph17060691
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Buruli ulcer, tuberculosis and leprosy: Exploring the One Health dimensions of three most prevalent mycobacterial diseases: A narrative review

Spiliopoulos O.; Solomos Z.; Puchner K. Tropical Medicine & International Health Volume 29 Issue 8; August 2024 (2024) C2
Although Buruli ulcer, tuberculosis, and leprosy are the three most common mycobacterial diseases, One Health dimensions of these infections remain poorly understood. This narrative review aims at exploring the scientific literature with respect to the presence of animal reservoir(s) and other envir... more
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Clinical and microbiological predictors of healing in Buruli ulcer disease

Agbavor B.; Agbanyo A.; Loglo A. et al. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases (2024) C2
Wound measurements are relevant in monitoring the rate of healing (RoH) and may predict time to healing. Predicting the time to healing can help improve the management of Buruli ulcer. We examine three methods for the determination of RoH and their use as predictors of time to healing.
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Fourth annual meeting of the network of Buruli ulcer PCR laboratories in the WHO African Region: Mundi complex, Yaoundé, 24-26 October 2022

World Health Organization WHO (2024) C_WHO
n October 2019, WHO convened the first meeting of the Buruli ulcer laboratory network (BU-LABNET) in Yaoundé, Cameroon, bringing together 11 laboratories from nine countries at the Pasteur Centre of Cameroon (CPC), the network’s Coordinating Centre. The network was formally established at th... more
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Buruli ulcer disease: rethinking diagnostic technique

Jain, S.; and R. Yotsu LSU Health New Orleans (2024) CC
Poster
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A combined effort of 11 laboratories in the WHO African region to improve quality of Buruli ulcer PCR diagnosis: The “BU-LABNET”

Marion E, Hycenth N, Vedithi SC, et al. (2024) CC
PLoS Negl Trop Dis 16(11): e0010908. https://doi.org/10.1371/journal.pntd.0010908
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Report of the fifth annual meeting of the network of Buruli ulcer PCR laboratories in the WHO African Region, Accra, Ghana, 23-25 October 2023

World Health Organization WHO (2024) C_WHO
The aim of the meeting was to broaden the network’s initiatives. Preliminary work involved integrating laboratory testing for skin NTDs other than Buruli ulcer, such as cutaneous leishmaniasis, mycetoma, leprosy and yaws, while extending the network’s reach to encompass additional laboratories.
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How is Buruli Ulcer Transmitted to Humans?

American Society of Microbiology (2023) CC
In the 126 years since it was first described, scientists have learned a great deal about Buruli ulcer, (an ulcerating skin infection caused by the environmental bacterium, Mycobacterium ulcerans), including how to treat it. Yet, there is 1 question about this neglected tropical disease that has rem... more
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Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options - A comprehensive review

Osei-Owusu J.; Fordjour Aidoo O.; Eshu F. et al. Heliyon (2023) C2
Buruli ulcer (BU), a neglected tropical disease (NTD), is an infection of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. The disease has been documented in many South American, Asian, and Western Pacific countries and is widespread throughout much of Africa, especially in West... more
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Buruli ulcer: Status of endemicity of Buruli ulcer 2023

PLOS (2023) C_WHO
Status of endemicity of Buruli ulcer 2023
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Target product profile for a rapid test for diagnosis of Buruli ulcer at the primary health-care level

World Health Organization WHO (2022) C_WHO
In 2009, WHO’s Second International Conference on Buruli Ulcer Control and Research resolved to strengthen the capacity of national laboratories to confirm cases of the disease, but advised that “efforts are still needed to develop simple diagnostic tools usable in the field as well as disabilit... more
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Picturing health: Buruli ulcer in Ghana

Kumar, A.; N. Preston and R. Phillips (2022) CC
The Lancet Volume 399, Issue 10327p786-797February 26, 2022 Free download after free registration
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BuDb: A Curated Drug Discovery Database for Buruli Ulcer

Kwofie, S.K.; et al. (2022) CC
Journal of Computational Biophysics and ChemistryVol. 22, No. 01, pp. 31-41 (2023)
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Countries where buruli ulcer is endemic

Our World in Data (2022) CC
Countries where buruli ulcer is endemic
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Intervention manual for the integrated managment of skin neglected tropcial diseases

Countdown (2021) CC
This manual details a collaboratively developed intervention to detect and refer Buruli ulcer, Hydrocele, Leprosy and Lymphedema cases through the use of integrated approaches at community levels. This intervention has been developed as part of the consortium in partnership with the Nigerian Feder... more
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Linking the Mycobacterium ulcerans environment to Buruli ulcer disease: Progress and challenges

Dhungel L.; Benbow M.; Jordan H. One health Volume 13 December 2021, 100311 (2021) C2
Buruli ulcer (BU), the second most common mycobacterial disease in West Africa, is a necrotizing skin disease that can lead to high morbidity in affected patients. The disease is caused by Mycobacterium ulcerans (MU), whose major virulence factor is mycolactone. Although early infection can be treat... more