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Q 1: Are antidepressants (Tricyclic Antidepressants (TCA) and Selective Serotonin Reuptake Inhibitors (SSRI)) better (more effective than/as safe as) than treatment as usual (placebo) in adults with depressive episode/disorder?
Sci Rep. 2016; 6: 25920. Published online 2016 May 16. doi: 10.1038/srep25920
Q9: Antidepressant medicines in individuals with a depressive episode in bipolar disorder1Q9: In individuals presenting with a depressive episode in bipolar disorder, are antidepressant medicines effective and safe?
Q4: For people with dementia with associated depression, do antidepressants when compared to placebo/comparator produce benefits/harm in the specified outcomes?
Dialogues Clin Neurosci. 2017 Jun; 19(2): 93–107.
Accessed January 22, 2019. This updated version include important research that has added to our knowledge about effective treatments for child and adolescent depression. Its goal is to help parents and families make informed decisions about getting the best care for a child with depression. For ... more
The objective of this book is to provide health workers with easily accessible information on important aspects of the medicines commonly used at primary care level in Zimbabwe. Medicines are a crucial part of the management of most of our patients, yet many medicines are potentially dangerous if no... more
WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses
2nd edition
Q 2: How long should treatment with antidepressants continue in adults with depressive episode/disorder?
Published: February 23, 2010 https://doi.org/10.1371/journal.pmed.1000235 Volume 7 | Issue 2 | e1000235
Q10: Are antidepressants (Tricyclic antidepressants (TCA), Selective serotonin reuptake inhibitors (SSRIs)) effective and safe in children 6-12 years of age with depressive episode/disorder?
Q7. SCOPING QUESTION: In adults with moderate-severe depressive disorder, what is the effectiveness and safety of antidepressant medication (ADM) in comparison with psychological treatment? The WHO mhGAP programme’s existing guidelines recommend that either structured brief psychological treatm... more

Management of drug withdrawal

World Health Organization (2012) C_WHO
Q2: What interventions are safe and effective for drug withdrawal (cannabis, amphetamines, cocaine, benzodiazepines, and inhalants)?
Standard Treatment Guideline
As part of the Mental Health Gap Action Programme, WHO has developed training manuals (Training of trainers and supervisors training manual and Training of health-care providers training manual) to support implementation of the mhGAP Intervention Guide for mental, neurological and substance use (MNS... more
(2015) Scoping question: Are antidepressants (specifically, tricyclic antidepressants and selective serotonin reuptake inhibitors) effective and safe in adolescents with moderate-severe depressive disorder for whom psychosocial interventions have proven ineffective?
March, 2021