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Integrating Clinical Research into Epidemic Response: The Ebola Experience

Gerald Keusch, Keith McAdam, Patricia Cuff, Michelle Mancher, and Emily R. Busta National Academies of Sciences, Engineering, and Medicine (2017) C1
The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Repub ... more
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Ebola research and development landscape of clinical candidates and trials

World Health Organization (WHO) (2015) C_WHO
The report presents current information (updated to September 2015) on candidate vaccines, therapies and medical devices for Ebola and gives an overview of completed and on-going trials.
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Chagas Clinical Research Platform Newsletter

Drugs for Neglected Diseases Initiative DNDi Latin America (2022) CC
To support its R&D activities on Chagas disease, DNDi launched the Chagas Clinical Research Platform (CCRP). The platform brings together partners, experts, and stakeholders to provide support for e ... more
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The Lancet Commission on the future of care and clinical research in autism

The Lancet Commission (2021) CC
Awareness of autism has grown monumentally over the past 20 years. Yet, this increased awareness has not been accompanied by improvements in services to support autistic individuals and their families. Many fundamental questions remain about the care of people with autism—including which intervent ... more
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Nothing About Us Without RIGHTS—Meaningful Engagement of Children and Youth: From Research Prioritization to Clinical Trials, Implementation Science, and Policy

C. Oliveras; L. Cluver; S. Bernays; A. Armstrong JAIDS Journal of Acquired Immune Deficiency Syndromes; PubMed (2018) C2
Supplement Article J Acquir Immune Defic Syndr  Volume 78, Supplement 1, August 15, 2018 www.jaids.com
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The United Nations Convention on the rights of the child and implications for clinical, practice, policy and research

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Diagnosis and Clinical Management of Chagas Disease: An Increasing Challenge in Non-Endemic Areas

Suárez, C., Nolder, D., García-Mingo, A. Research and reports in tropical medicine (2022) CC
Research and Reports in Tropical Medicine 2022:13 25–40. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central, South America, Mexico and the South of the United States. It is an important cause of early mo ... more
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GUIDELINES FOR GOOD CLINICAL LABORATORY PRACTICES (GCLP)

Indian Council of Medical Research (ICMR) (2008) C1
Guidelines for Good Clinical Laboratory Practices (GCLP) outlines the principles and procedures to be followed by medical laboratories involved in clinical ... more
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Global roadmap for research and development of tuberculosis vaccines

European & Developing Countries Clinical Trials Partnership EDCTTP; Amterdam Institute for Global health & Development aighd (2021) C1
The roadmap describes the actions needed to achieve the three development goals for TB vaccines set by the WHO: 1. A safe, effective and affordable TB vaccine for adolescents and adults. 2. An affordable TB vaccine for neonates and infants with improved safety and efficacy. 3. A therapeutic v ... more
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Cognitive Training for Schizophrenia in Developing Countries: A Pilot Trial in Brazil (Clinical Study)

Pontes LM, Martins CB, Napolitano IC, Fonseca JR, Oliveira GM, Iso SM, Menezes AK, Vizzotto AD, di Sarno ES, Elkis H. Schizophrenia Research and Treatment (2013) CC
Cognitive deficits in schizophrenia can massively impact functionality and quality of life, furthering the importance of cognitive training. Despite the development of the field in Europe and in the United States, no programmes have been developed and tested in developing countries. Different cultur ... more
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Towards a Core Set of Clinical Skills for Health-Related Community Based Rehabilitation in Low and Middle Income Countries

Jessica O'Dowd, Malcolm MacLachlan, Chapel Khasnabis, Priscille Geiser Disability, CBR & Inclusive Development Journal (DCIDJ) (2015) CC
This research aims to identify a core set of clinical skills for working in a Community Based Rehabilitation (CBR) setting, and to discuss whether they are appropriate for task shifting to a new or ... more
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Diagnosis and Clinical Management of Chagas Disease
recommended

Suárez, C.; Nolder, D.; García-Mingo, A.; (2022) CC
Research and Reports in Tropical Medicine 2022:13 25–40 Chagas disease (CD) or American trypanosomiasis is a neglected parasitic disease associated with significant mortality and morbidity that includes long-term disability, social stigma and a m ... more
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Tuberculosis in HIV/AIDS Patients - Advanced Techniques in Clinical Microbiology

M. Gjergji; J. Bushati; A. Harxhi; H. Hafizi; P. Pipero iMedPub Journals (2017) C2
Research Article Received: August 21, 2017; Accepted: August 29, 2017; Published: Spetember 05, 2017 This article is available in: http://www.imedpub.com/advanced-techniques-in-clinical-micr ... more
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Toolkit for research and development of paediatric antiretroviral drugs and formulations

World Health Organization (WHO); Unitaid; Unicef; et al. World Health Organization (WHO); Unitaid; Unicef; et al. (2018) C_WHO
WHO and UNITAID in collaboration with IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials) network, PENTA (Paediatric European Network for Treatment of AIDS) foundation and experts from the Paediatric Antiretroviral Working Gr ... more
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National Guidelines For Stem Cell Research

Indian Council of Medical Research & Department of Biotechnology (2017) C1
The guidelines reiterate that the general principles of ethics for biomedical research involving human participants shall also be applicable. In addition, the guidelines specify unique provisions for stem cells, because of their inherent property fo ... more
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Clinical management of COVID-19: living guideline, 13 January 2023

World Health Organisation (WHO) (2023) C_WHO
As of 12 December 2022, over 645 million people worldwide have been diagnosed with COVID-19, with over 6.6 million deaths (4). The Omicron variant, which emerged in late November 2021, and its subvariants, are now the dominant circulating viruses, contributing to the ongoing surge in several countr ... more
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Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

Medina-Rincón, G.; Gallo-Bernal, S.; Jiménez, P.; (2021) CC
Pathogens . 2021 Nov 16;10(11):1493.doi: 10.3390/pathogens10111493 .Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful resear ... more
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First, Do No Harm: A Qualitative Research Documentary

Tim Holland, Alyson Holland (2011) C2
This is a qualitative research documentary that was created by Alyson and Timothy Holland. The documentary explores the ethics of global health clinical electives and volunteer projects in developin ... more
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COVID-19: Chloroquine and hydroxychloroquine research

World Health Organization WHO (2020) C_WHO
This document updates the earlier version published in April 2020. In recent weeks, information on the potential use of chloroquine or hydroxychloroquine for the treatment of people with COVID-19 has been disseminated in academic journals and public media. Although there are now ongoing ... more