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The Lancet Volume 390, Issue 10110p2397-2409November 25, 2017. Human African trypanosomiasis (HAT), also called sleeping sickness, is a parasitic infection that almost invariably progresses to death, unless treatment is provided. HAT caused devastating epidemics during the 20th century. Thanks to ... more

Human African trypanosomiasis (HAT), or sleeping sickness, is an endemic disease in 36 sub-Saharan African countries, typically occurring in underdeveloped areas, where health systems face significant difficulties of diverse natures.

Gambiense human African trypanosomiasis is a deadly infectious disease affecting West and Central Africa, South Sudan and Uganda, and transmitted between humans by tsetse flies. The disease has caused several major epidemics, the latest one in the 1990s. Thanks to recent innovations such as rapid di... more

This analysis focused on the chronic form of HAT caused by T. b. gambiense, as it contributes to the majority of disease burden. Information from the literature review, product development landscape, and stakeholder interviews was compiled to: - Identify use cases and understand current diagnosti... more

Elimination of human African trypanosomiasis: The long last mile

New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine
recommended

Human African trypanosomiasis. Seminar

Human African Trypanosomiasis (sleeping sickness): Current knowledge and future challenges

Fexinidazole and Human African Trypanosomiasis: good news for this important neglected tropical disease

Gambiense human African trypanosomiasis: the bumpy road to elimination

Human African Trypanosomiasis (Sleeping Sickness). The Road to Elimination Revisited—Achievements and Remaining Challenges

Diagnostic Gaps and Recommendations for Human African Trypanosomiasis: Assessment of User Needs, Use Cases, and the Diagnostic Landscape