In 2005, the World Health Organization (WHO) recognized Chagas disease (CD; Trypanosoma cruzi infection) as a neglected tropical disease (NTD) [1] and included it into the global plan to combat NTDs [2]. The Target 3.3 of the United Nations Sustainable Development Goals (UN/SDG) aims at ending the e...pidemics of NTDs by 2030 [3]. Mother-to-child (congenital/connatal) transmission is currently the main mode of transmission of T. cruzi over blood transfusions and organ transplantations in vector-free areas within and outside Latin America (LA). Based on recent demonstrations that congenital transmission can be prevented [4–7], WHO has shifted its objective, in 2018, from control to elimination of congenital CD (cCD).
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Population movements have turned Chagas disease (CD) into a global public health problem. Despite the successful implementation of subregional initiatives to control vectorial and transfusional Trypanosoma cruzi transmission in Latin American settings where the disease is endemic, congenital CD (cCD...) remains a significant challenge. In countries where the disease is not endemic, vertical transmission plays a key role in CD expansion and is the main focus of its control. Although several health organizations provide general protocols for cCD control, its management in each geopolitical region depends on local authorities, which has resulted in a multitude of approaches. The aims of this review are to (i) describe the current global situation in CD management, with emphasis on congenital infection, and (ii) summarize the spectrum of available strategies, both official and unofficial, for cCD prevention and control in countries of endemicity and nonendemicity. From an economic point of view, the early detection and treatment of cCD are cost-effective. However, in countries where the disease is not endemic, national health policies for cCD control are nonexistent, and official regional protocols are scarce and restricted to Europe. Countries of endemicity have more protocols in place, but the implementation of diagnostic methods is hampered by economic constraints. Moreover, most protocols in both countries where the disease is endemic and those where it is not endemic have yet to incorporate recently developed technologies. The wide methodological diversity in cCD diagnostic algorithms reflects the lack of a consensus. This review may represent a first step toward the development of a common strategy, which will require the collaboration of health organizations, governments, and experts in the field.
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The highly complex and largely neglected Chagas disease (CD) has become a global health problem due to population movements between Latin America and non-endemic countries, as well as non-vectorial transmission routes. Data on CD testing and treatment from routine patient care in Germany of almost t...wo decades was collected and analysed.
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Published: April 26, 2017 https://doi.org/10.1371/journal.pone.0176004
Rev. Panam Salud Publica. 2017;41:e153. doi: 10.26633/RPSP.2017.153
Worldwide, over 6 million people are infected with Trypanosoma cruzi, the pathogen that causes Chagas disease (CD). In the Americas, CD creates the greatest burden in disability-adjusted life years of any parasitic infection. In Co...lombia, 437 000 people are infected with T. cruzi, of whom 131 000 suffer from cardiomyopathy. Colombia’s annual costs for treating patients with advanced CD reach US$ 175 016 000. Although timely etiological treatment can significantly delay or prevent development of cardiomyopathy—and costs just US$ 30 per patient—fewer than 1% of people with CD in Colombia and elsewhere receive it.
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Pathogens . 2021 Nov 16;10(11):1493.doi: 10.3390/pathogens10111493
.Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mech...anisms underlying Trypanosoma cruzi’s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particu-larly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.
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Over 6 million people worldwide are infected with Trypanosoma cruzi, the protozoan that causes Chagas disease
(CD). T. cruzi is transmitted by triatomine insects, congenitally, through uncontrolled blood donations and organ transplants,
and via consumption of food or drink contaminated by triatomi...nes.
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Schistosomiasis is a helminthic infection and one of the neglected tropical diseases (NTDs). It is caused by blood flukes of the genus Schistosoma. It is an important public health problem, particularly in poverty-stricken areas, especially those within the tropics and subtropics. It is estimated th...at at least 236 million people worldwide are infected, 90% of them in sub-Saharan Africa, and that this disease causes approximately 300,000 deaths annually. The clinical manifestations are varied and affect practically all organs. There are substantial differences in the clinical presentation, depending on the phase and clinical form of schistosomiasis in which it occurs. Schistosomiasis can remain undiagnosed for a long period of time, with secondary clinical lesion. Here, we review the clinical profile of schistosomiasis. This information may aid in the development of more efficacious treatments and improved disease prognosis.
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Chagas is a complex, multidimensional phenomenon in which political, economic, environmental, biomedical, epidemiological, psychological, and sociocultural factors intersect. Nonetheless, the hegemonic conceptualisation has long envisioned Chagas as primarily a biomedical question, while ignoring or... downplaying the other dimensions, and this limited view has reinforced the disease’s long neglect. Integrating the multiple dimensions of the problem into a coherent approach adapted to field realities and needs represents an immense challenge, but the payoff is more effective and sustainable experiences, with higher social awareness, increased case detection and follow-up, improved adherence to care, and integrated participation of various actors from multiple action levels. Information, Education, and Communication (IEC) initiatives have great potential for impact in the implementation of multidimensional programs of prevention and control successfully customised to the diverse and complex contexts where Chagas disease persists.
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Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central, South America, Mexico and the
South of the United States. It is an important cause of early mortality and morbidity, and it is associated with poverty and stigma. A third of
the cases evolve into chronic... cardiomyopathy and gastrointestinal disease. The infection is transmitted vertically and by blood/organ
donation and can reactivate with immunosuppression. Case identification requires awareness and screening programmes targeting the
population at risk (women in reproductive age, donors, immunocompromised patients). Treatment with benznidazole or nifurtimox is most
effective in the acute phase and prevents progression to chronic phase when given to children. Treating women antenatally reduces but does
not eliminate vertical transmission. Treatment is poorly tolerated, contraindicated during pregnancy, and has little effect modifying the
disease in the chronic phase. Screening is easily performed with serology. Migration has brought the disease outside of the endemic
countries, where the transmission continues vertically and via blood and tissue/organ donations. There are more than 32 million migrants
from Latin America living in non-endemic countries. However, the infection is massively underdiagnosed in this setting due to the lack of
awareness by patients, health authorities and professionals. Blood and tissue donation screening policies have significantly reduced
transmission in endemic countries but are not universally established in the non-endemic setting. Antenatal screening is not commonly
done. Other challenges include difficulties accessing and retaining patients in the healthcare system and lack of specific funding for the
interventions. Any strategy must be accompanied by education and awareness campaigns directed to patients, professionals and policy
makers. The involvement of patients and their communities is central and key for success and must be sought early and actively. This review
proposes strategies to address challenges faced by non-endemic countries
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Glob Heart . 2020 Oct 13;15(1):69. doi: 10.5334/gh.891.
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz volume 63, pages1460–1469(2020)
Die Klimakrise stellt die größte Bedrohung der menschlichen Gesundheit im21. Jahrhundert dar. Die mit ihr
einhergehenden Umweltveränderungen, die unter anderem zu Hitzewellen, Überflutungen und Unterernährung durch
Ernährungsunsicherheit führen, wirken sich bereits heute negativ auf die Ge...sundheit einer großen Anzahl von Menschen aus.
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Am Beispiel des Kontexts der Syrien- und Irakkrise
Das Positionspapier zeigt auf, was gute psychosoziale Arbeit mit Geflüchteten ausmacht und welche Risiken es zu berücksichtigen gilt. Es richtet sich an Akteur*innen aus dem MHPSS-Sektor, die im Kontext der Syrien- und Irakkrisen mit Flüchtlinge...n im Nahen Osten arbeiten sowie an Ministerien und wissenschaftliche Institutionen.
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Eine Stellungnahme des DZK in Zusammenarbeit mit FZB, DGI, DGPI, GPP, DGGG, DRG und DGMP
Pneumologie 2016; 70: 777–780
Rehabilitation wird zunehmend als notwendiger Aspekt der medizinischen Hilfe und patientenorientierten Versorgung anerkannt, wie ihre Aufnahme in die Klassifikation und Mindeststandards für ausländischen medizinischen Teams bei plötzlich auftreten...den Katastrophen zeigt (1). Dieses Dokument, das Erste seiner Art, legt die Standards für die Rehabilitation eindeutig fest und enthält Leitlinien für den Aufbau bzw. die Stärkung der Leistungsfähigkeit von Medizinischen Notfall Teams in diesem Bereich.
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Geflüchtete Menschen sind vielfältigen psychosozialen Belastungen ausgesetzt. Um Versorgungs- und Präventionsbedarfe dieser Bevölkerungsgruppe niedrigschwellig und diversitätssensibel zu decken, werden vermehrt Peer-Ansätze verfolgt. Der vorliegende Beitrag informiert den Diskurs über die (We...iter-)Entwicklung und Implementierung von entsprechenden Angeboten für geflüchtete Menschen in Deutschland, indem zentrale Erkenntnisse aus der Prozessevaluation des präventiven Peer- Ansatzes „Mind-Spring“ (MS) nach Pilotierung in einem kommunalen Setting vorgestellt und diskutiert werden.
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Ziel dieser qualitativen Studie ist eine Situationsanalyse der Regelungen und Maßnahmen auf lokaler Ebene, die zur Prävention und Eindämmung der SARSCoV-2-Ausbreitung in SU für Geflüchtete ergriffen wurden.
Das Management von Krisen hat in den letzten Jahren erheblich an Bedeutung gewonnen, insbesondere auch im Öffentlichen Gesundheitsdienst (ÖGD). Grundsätzlich liegt die Entscheidungshoheit im Rahmen des Krisenmanagements infektiologischer Gefahrenlagen bei den kommunalen Gesundheitsämtern. Aufgru...nd der aktuellen Lage (Stand 18. März 2020) in Zusammenhang mit der Verbreitung des neuen Coronavirus stellen wir hiermit in einer Vorabversion Auszüge unseres Lehrbuchs zur Verfügung.
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