Nota científica
24 de abril de 2020
El desarrollo de inmunidad a un patógeno por infección natural es un proceso de varias etapas que suele producirse a lo largo de una o dos semanas. El organismo responde a una infección vírica de forma inmediata a través de una respuesta innata no específ...ica, en la que los macrófagos, los neutrófilos y las células dendríticas frenan el avance del virus y pueden incluso evitar que este provoque síntomas. A esta respuesta no específica le sigue una respuesta adaptativa en la que el organismo genera anticuerpos que se unen específicamente al virus. Estos anticuerpos son las proteínas denominadas inmunoglobulinas. El organismo también genera linfocitos T que reconocen y eliminan las células infectadas por el virus: es lo que se conoce como inmunidad celular. Esta respuesta adaptativa combinada puede eliminar el virus del organismo y, si la respuesta es suficientemente intensa, puede evitar el agravamiento de la enfermedad o la reinfección por el mismo virus. Este proceso se mide a menudo a través de la presencia de anticuerpos en la sangre.
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Document d’information scientifique
24 avril 2020
Le développement d’une immunité face à un agent pathogène à la suite d’une infection naturelle comporte plusieurs étapes et prend généralement une à deux semaines. Une infection virale entraîne immédiatement une réponse immunit...aire innée, non spécifique, au cours de laquelle les macrophages, les neutrophiles et les cellules dendritiques ralentissent la progression du virus et peuvent même éviter l’apparition de symptômes. Cette réponse non spécifique est suivie d’une réponse adaptative, au cours de laquelle l’organisme produit des anticorps qui se lient spécifiquement au virus. Ces anticorps sont des protéines appelées immunoglobulines. L’organisme produit également des lymphocytes T qui reconnaissent et éliminent les cellules infectées par le virus. Cette réponse adaptative permet parfois d’éliminer le virus de l’organisme et, si elle est suffisamment forte, d’éviter l’aggravation de la maladie ou la réinfection par le même virus. Ce processus est souvent mesuré par la présence d’anticorps dans le sang.
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PLOS One November 20, 2020 https://doi.org/10.1371/journal.pone.0241799 . The first autochthonous case of chikungunya virus (CHIKV) infection in Brazil was in September 2014 in the State of Amapá, and from there it rapidly spread across the country. The present study was conducted in 2016 in the st...ate of Rio Grande do Norte, and the aims were to describe the epidemiological and the clinical aspects of the CHIKV outbreak.
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La Profilaxis Post-Exposición para el VIH (PEP) constituye una herramienta de prevención que consiste en el uso de medicamentos antiretrovirales para reducir el riesgo de infección luego de situaciones de potencial exposición del virus. Su incorporación está recomendada por la Organización Mu...ndial de la Salud en el marco de una estrategia de Prevención Combinada1,2. Cuando se inicia dentro de las 72 horas del episodio de potencial exposición al VIH, la PEP reduce en forma significativa el riesgo de transmisión, por lo que su uso se indica en exposiciones ocupacionales y no ocupacionales esporádicas. En la actualidad, una combinación de 3 drogas antirretrovirales durante 28 días es el esquema estándar empleado como PEP2.
A través de la Dirección de Sida, ETS, Hepatitis y TBC, se distribuye la medicación
necesaria para que la PEP esté disponible en efectores del sistema público de salud cuando está clínicamente indicada.
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In the Indian state of Bihar, visceral leishmaniasis (VL) is a major public health issue that has been aggravated by the rising incidence of new Human immunodeficiency virus (HIV) infections. In endemic areas, the risk of VL infections in patients living with HIV (PLHIV) is higher. It is important t...o investigate the disease-related knowledge, attitude, and practices (KAP) of PLHIV in Bihar in order to monitor HIV/VL co-infection. Adequate knowledge, a positive attitude, and good practices for VL control are essential to stamp out the disease. This study investigated the KAP towards VL in HIV patients attending antiretroviral therapy (ART) clinic at ICMR-RMRIMS, Patna.
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Chapters
0:00 Introduction
0.27 Causes of Dengue Fever
1:09 Signs and Symptoms of Dengue Fever
2:30 Dengue Hemorrhagic Fever
3:53 Diagnosis of Dengue Fever
4:10 Treatment of Dengue Fever
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically beg...in three to fourteen days after infection. This may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash.Recovery generally takes two to seven days. In a small proportion of cases, the disease develops into the life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs.
Dengue is spread by several species of mosquito of the Aedes type, principally A. aegypti.The virus has five different types;infection with one type usually gives lifelong immunity to that type, but only short-term immunity to the others. Subsequent infection with a different type increases the risk of severe complications. A number of tests are available to confirm the diagnosis including detecting antibodies to the virus or its RNA.
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Aperçu: Cette formation complète de niveau intermédiaire est destinée aux agents de santé de première ligne qui s’occupent de cas suspects ou confirmés de maladie à virus Ebola (MVE). Elle porte sur les domaines suivants : transmission de la MVE (en s’intéressant en particulier aux mesu...res de lutte contre l’infection) ; diagnostic de la maladie ; et prise en charge des cas, avec une présentation générale des centres de traitement d’Ebola (CTE) et des informations sur les traitements expérimentaux. Ces modules présentent des stratégies complètes sur la sécurité des patients et des agents de soins et la préparation à la riposte. La formation pourra être utile aux cliniciens de tout secteur du système de santé, notamment ceux qui travaillent dans des postes de santé, prodiguent des soins de santé primaires ou sont employés par des hôpitaux nationaux ou de district. Une attention particulière est accordée aux soins dispensés dans les CTE.
Objectifs d’apprentissage : À la fin de ce cours, vous serez capable de :
identifier les patients présentant des signes et des symptômes de MVE ;
comprendre la transmission de la MVE ;
comprendre les grands volets de la prise en charge clinique de la MVE ;
connaître les stratégies de lutte contre l’infection;
préparer les établissements, la population et les agents de santé à la riposte à la maladie à virus Ebola ; et
gérer les déchets de façon sécurisée et de procéder à des inhumations sans risque et dans la dignité.
Durée du cours : Environ 8 heures.
Enroll: https://openwho.org/courses/ebola-prise-en-charge-clinique
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COVID-19 is a serious disease and all people living with HIV should take all recommended preventive measures to minimize exposure to, and prevent infection by, the virus that causes COVID-19. As in the general population, older people living with HIV or people living with HIV with heart or lung prob...lems may be at a higher risk of becoming infected with the virus and of suffering more serious symptoms.
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La RAM se produce cuando los microorganismos (bacterias, hongos, virus y parásitos) sufren cambios al verse expuestos a los antimicrobianos (antibióticos, antifúngicos, antivíricos, antipalúdicos o antihelmínticos, por ejemplo). Los microorganismos resistentes a la mayoría de los antimicrobia...nos se conocen como ultrarresistentes.
Como resultado, los medicamentos se vuelven ineficaces y las infecciones persisten en el organismo, lo que incrementa el riesgo de propagación a otras personas.
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Contact tracing for COVID-19 is the process of identifying, assessing, and managing people who have been exposed to someone who has been infected with the SARS-CoV-2 virus, while quarantine is the separation of contacts from other people after exposure to a probable or confirmed case of SARS-CoV-2 i...nfection. In the context of growing global population immunity from COVID-19 vaccination and past SARS-CoV-2 infection, WHO recommends that identification, contact, quarantine and follow-up should be prioritized for individuals at high risk who have been in contact with a confirmed or probable case of SARS-CoV-2 infection, rather than targeting all contacts. This updated guidance also introduces shorter recommended quarantine periods, including the ability to further shorten quarantine through the use of testing. National and local health authorities should use risk-based approaches to contact tracing and quarantine that include reviewing and adjusting to their local circumstances and disease epidemiology, population immunity, their health system’s capacities, and risk tolerance.
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Technical Update
Areas of Africa endemic for Buruli ulcer (BU), caused by Mycobacterium ulcerans, also have a high prevalence of human immunodeficiency virus (HIV), with adult prevalence rates between 1% and 5% (Maps). However, there is limited information on the prevalence of BU–HIV coinfection.... Preliminary
evidence suggests that HIV infection may increase the risk of BU disease (1–3). In the Médecins Sans Frontières project in Akonolinga, Cameroon, HIV prevalence was approximately 3–6 times higher among BU patients than the regional estimated HIV prevalence (2). Similarly in Benin and Ghana, BU
patients were 8 times and 3 times respectively more likely to have HIV infection than those without BU (1, 3). Further study is needed to clarify this association and enhance knowledge about the prevalence ofBU–HIV coinfection in endemic areas.
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Representative, quality, timely and continuous genetic surveillance of SARS-CoV-2 is critical to the COVID-19 outbreak response. This document provides practical guidance to Global Influenza Surveillance and Response System (GISRS) laboratories and other relevant national laboratories to move beyond... virus detection to genomic sequencing of SARS-CoV-2 PCR positive materials obtained from sentinel surveillance of influenza-like illness (ILI), acute respiratory infection (ARI) and severe acute respiratory infection (SARI). It contains considerations on sample selection for sequencing, numbers of viruses to be sequenced, metadata and timeliness for sharing genetic sequence data (GSD) and opportunities for technical support.
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Ce cours est à destination des cliniciens qui travaillent dans des unités de soins intensifs (ICU) dans les pays à faible et moyen revenu et la prise en charge des patients adultes et pédiatriques atteints de formes d'infection respiratoire aiguë sévère (SARI), notamment la pneumonie sévère..., le syndrome de détresse respiratoire aiguë (SDRA), la septicémie et le choc septique. Ce cours est un guide pratique à l'usage des professionnels de la santé impliqués dans la gestion des soins intensifs lors de flambées d'infection humaine par le virus de la grippe (saisonnière) due à la grippe aviaire (H5N1, H7N9), le MERS-CoV, le nCoV ou d'autres épidémies virales respiratoires émergentes.
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Antibiotics only fight infections caused by bacteria. Like all drugs, they can be harmful and should only be used when necessary. Taking antibiotics when you have a virus can do more harm than good: you will still feel sick and the antibiotic could give you a skin rash, diarrhea, a yeast infection, ...or worse.
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PAHO has systematically identified and collected basic information on all investigations related to Zika, both those already published and those on track to be published.
Each study has been categorized in the areas of virus, vectors and reservoirs; epidemiology; disease pathogenesis and consequen...ces of Zika infection; clinical management; public health interventions; health systems and services response; research and product development; and causality. You can also search by publication type: published articles, protocol and publication of preliminary results.
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La COVID-19 se ha propagado a los 54 países y territorios de las Américas. Para el 26 de mayo del 2020, los casos y las muertes en América Latina habían sobrepasado los de Europa y Estados Unidos en lo que se refiere al número diario de infecciones por coronavirus notificadas. Para junio, dos d...e los tres países con el mayor número de casos notificados se encontraban en las Américas, región que se ha convertido en el epicentro de la pandemia.
En este informe se expone una visión general de la respuesta de la OPS a la pandemia de COVID-19. Comienza en enero de 2020, cuando la OPS movilizó rápidamente sus expertos y despachó material de laboratorio para la detección molecular del virus hasta el 31 de mayo de
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The Zambia Population Based HIV impact assessment of 2016, reported the prevalence of viral hepatitis in Zambia as ranging between 5.6% among adults aged 15 to 59% in the general population, and 7.1% among HIV infected individuals. It is estimated that the majority of persons with chronic hepatitis ...B and/ or hepatitis C are unware of their infection and do not benefit from promotive, preventive and curative services designed to reduce onward transmission. Zambia introduced hepatitis B virus vaccine to the routine Under 5 vaccination schedule in 2005. Preliminary results from the ZAMPHIA indicate that hundreds of infections have been abated in children since then. However, its also clear that we continue to miss key opportunities to prevent transmission, diagnose and treat infections, prevent serious disease, and in many cases cure people. In addition, high risk groups inter alia health care workers still have limited access to the vaccine.
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n response to the outbreak, the Africa Centres for Disease Control and Prevention (Africa CDC) has been supporting African Union Member States in responding to the COVID-19 pandemic through a variety of interventions such as non-pharmaceutical interventions, quarantine, testing, isolation, contact t...racing, and clinical management. The Test to Treat guideline aims to increase continental testing efforts and reduce COVID-19 transmission in Africa and put-up response measures to control the impact of the virus, both to limit spread and to reduce substantially the risks of severe health outcomes related to COVID-19 infection. These countermeasures include highly effective vaccines and boosters, rapid testing options for monitoring exposure, and effective therapeutic options for both pre-exposure prevention and treatment of mild-to-moderate disease, oxygen therapy for moderate-severe disease, all of which can potentially be updated efficiently as new variants emerge that may affect the effectiveness of the available tools.
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Available in Chinese, English, French, Russian and Spanish; WHO and UNICEF policy brief, 19 April 2021
Persons with disabilities are disproportionately impacted by COVID-19, both directly because of infection, and indirectly because of restrictions to reduce the spread of the virus. Persons with di...sabilities are a diverse group, and the risks, barriers and impacts faced by them will vary in different contexts according to, among other factors, their age, gender identity, type of disability, ethnicity, sexual orientation, and migration status.
This document presents considerations and actions for the following stakeholders to ensure equity in access to vaccination against COVID‑19 for persons with disabilities
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Данный курс предоставляет информацию о том, что следует предпринять для подготовки к реагированию на случай появления респираторных вирусов, таких как новый коро...авирус, как определить, если произошло заражение, как правильно реализовать меры профилактики и контроля инфекций (ПКИ) для предотвращения дальнейшей передачи инфекции медработникам, другим пациентам или другим лицам в учреждении здравоохранения.
Обучающий курс разработан для медработников и специалистов общественного здравоохранения, так как он ориентирован на вопросы ПКИ.
Infection Prevention and Control (IPC) for COVID-19 Virus
also available in: English - 日本語 - français - Bahasa Indonesia - Español - Português - Italiano - српски језик - 中文 - македонски јазик - Türkçe - język polski - Tiếng Việt - العربية - Nederlands - Tetun - বাংলা -فارسي - Soomaaliga - සිංහල
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