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Isoniazid Prophylactic Therapy for the Prevention of Tuberculosis in HIV Infected Adults: A Systematic Review and Meta- Analysis of Randomized Trials

H. T. Ayele, M. S. M. van Mourik, T. P. A. Debray, et al. PLOS One (2015) CC

PLOS ONE | DOI:10.1371/journal.pone.0142290 November 9, 2015; 1 / 16

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Systematic review of Rapid Diagnostic Tests for the diagnosis of meningitis in outbreak response in sub-Saharan Africa

Dr. T. Waite Field Epidemiology Services (Public Health England); WHO= (2014) C_WHO

Report for WHO Meningitis guideline revision Dr Thomas Waite, April 2014 Field Epidemiology Services, Public Health England; UK

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Treatment of cancer in sub-Saharan Africa

Kingham, T.P.; O.I Alatise, V. Vanderpuye, et al. The Lancet (2013) C1

Lancet Oncol 2013; 14: e158–67 Series: Cancer Control in Africa 3

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Roman Catholic ethics and the preferential option for the poor

Nairn, T.P. (2007) CC

Virtual MentorAmerican Medical Association Journal of Ethics May 2007, Volume 9, Number 5:384-387

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Social Ethics, The Philosophy of Medicine, and Professional Responsibility

Ozar, D.T. (1985) CC

TheoreticalMedicine 6 (1985), 281-294. 0167-9902/85.10

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New heroin-assisted treatment - Recent evidence and current practices of supervised injectable heroin treatment in Europe and beyond

J. Strang; T. Groshkova; N. Metrebian European Monitoring Centre for Drugs and Drug Addiction; Publications Office (2019) C2

EMCDDA Insights - 11 Accessed: 14.03.2019

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High Adherence Is Necessary to Realize Health Gains from Water Quality Interventions

Brown, J.; and T. Clasen (2012) CC

PlosOne May 7, 2012 https://doi.org/10.1371/journal.pone.0036735 ; Safe drinking water is critical for health. Household water treatment (HWT) has been recommended for improving access to potable water where existing sources are unsafe. Reports of low adherence to HWT may limit the usefulness of thi... more

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Basic Epidemiology

Bonita, R.; R.Beaglehole, and T. Kjellström World Health Organization WHO (2006) C_WHO

2nd edition

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Cardiovascular diseases in Africa in the twenty-first century: Gaps and priorities going forward

Minja, N.W.; Nakagaayi, D.; Aliku, T. et al. Frontiers in Cardiovascular Medicine (2022) CC

In 2015, the United Nations set important targets to reduce premature cardiovascular disease (CVD) deaths by 33% by 2030. Africa disproportionately bears the brunt of CVD burden and has one of the highest risks of dying from non-communicable diseases (NCDs) worldwide. There is currently an epide...miological transition on the continent, where NCDs is projected to outpace communicable diseases within the current decade. Unchecked increases in CVD risk factors have contributed to the growing burden of three major CVDs—hypertension, cardiomyopathies, and atherosclerotic diseasesleading to devastating rates of stroke and heart failure. The highest age standardized disability-adjusted life years (DALYs) due to hypertensive heart disease (HHD) were recorded in Africa. The contributory causes of heart failure are changing—whilst HHD and cardiomyopathies still dominate, ischemic heart disease is rapidly becoming a significant contributor, whilst rheumatic heart disease (RHD) has shown a gradual decline. In a continent where health systems are traditionally geared toward addressing communicable diseases, several gaps exist to adequately meet the growing demand imposed by CVDs. Among these, high-quality research to inform interventions, underfunded health systems with high out-of-pocket costs, limited accessibility and affordability of essential medicines, CVD preventive services, and skill shortages. Overall, the African continent progress toward a third reduction in premature mortality come 2030 is lagging behind. More can be done in the arena of effective policy implementation for risk factor reduction and CVD prevention, increasing health financing and focusing on strengthening primary health care services for prevention and treatment of CVDs, whilst ensuring availability and affordability of quality medicines. Further, investing in systematic country data collection and research outputs will improve the accuracy of the burden of disease data and inform policy adoption on interventions. This review summarizes the current CVD burden, important gaps in cardiovascular medicine in Africa, and further highlights priority areas where efforts could be intensified in the next decade with potential to improve the current rate of progress toward achieving a 33% reduction in CVD mortality. more

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Potential for additional government spending on HIV/AIDS in 137 low-income and middle-income countries: an economic modelling study

Haakenstad, A.; Moses, M.W.; Tao, T.; et al. (2019) CC

Between 2012 and 2016, development assistance for HIV/AIDS decreased by 20·0%; domestic financing is therefore critical to sustaining the response to HIV/AIDS. To understand whether domestic resources could fill the financing gaps created by declines in development assistance, we aimed to track spe... more

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Snakebite epidemiology, outcomes and multicluster risk modelling in Eswatini

Padidar S.; Monadjem A.; Litschka-Koen T. PLOS (2023) CC

Halving snakebite morbidity and mortality by 2030 requires countries to develop both prevention and treatment strategies. The paucity of data on the global incidence and severity of snakebite envenoming causes challenges in prioritizing and mobilising resources for snakebite prevention and treatment... more

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Understanding the transmission of Mycobacterium ulcerans: A step towards controlling Buruli ulcer

Muleta, A.J., R. Lappan, T. P. Stinear, et al. PLoS Neglected Tropical Diseases (2021) CC

August 26, 2021 https://doi.org/10.1371/journal.pntd.0009678

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Strengthening prehospital clinical practice guideline development in South Africa: Reflections from guideline experts

McCaula, M.; T. Younga and M. Clarke (2021) CC

African Journal of Emergency Medicine Volume 11, Issue 1, March 2021, Pages 132-139

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What business do youth have making HIV and AIDS laws in Nigeria? - 6

F. Akinfaderin-Agarau; T. Fashola participatory learning and action; iied (International Institute for Environmental and Development) (2019) C2

Accessed: 17.11.2019

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Differentiated service delivery for Adolescents and young people living with HIV: A situational analysis in South Africa

L. Ndlovu; A. Ronan; T. Ngoato; et al. PATA; IAS; ITPC; et al. (2019) C2

Accessed: 27.10.2019

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Expanding the Single-Visit Approach for Cervical Cancer Prevention: Successes and Lessons From Burkina Faso

Ouedraogo Y., Furlane G., Fruhauf T. et al. Global Health: Science and Practice (2018) CC

Background: Cervical cancer accounts for 23% of cancer incidence and 22% of cancer mortality among women in Burkina Faso. These proportions are more than 2 and 5 times higher than those of developed countries, respectively. Before 2010, cervical cancer prevention (CECAP) services in Burkina Faso wer...e limited to temporary screening campaigns. Program Description: Between September 2010 and August 2014, program implementers collaborated with the Ministry of Health and professional associations to implement a CECAP program focused on coupling visual inspection with acetic acid (VIA) for screening with same-day cryotherapy treatment for eligible women in 14 facilities. Women with larger lesions or lesions suspect for cancer were referred for loop electrosurgical excision procedure (LEEP). The program trained providers, raised awareness through demand generation activities, and strengthened monitoring capacity. Methods: Data on program activities, service provision, and programmatic lessons were analyzed. Three data collection tools, an individual client form, a client registry, and a monthly summary sheet, were used to track 3 key CECAP service indicators: number of women screened using VIA, proportion of women who screened VIA positive, and proportion of women screening VIA positive who received same-day cryotherapy. Results: Over 4 years, the program screened 13,999 women for cervical cancer using VIA; 8.9% screened positive; and 65.9% received cryotherapy in a single visit. The proportion receiving cryotherapy on the same day started at a high of 82% to 93% when services were provided free of charge, but dropped to 51% when a user fee of $10 was applied to cover the cost of supplies. After reducing the fee to $4 in November 2012, the proportion increased again to 78%. Implementation challenges included difficulties tracking referred patients, stock-outs of key supplies, difficulties with machine maintenance, and prohibitive user fees. Providers were trained to independently monitor services, identify gaps, and take corrective actions. Conclusions: Following dissemination of the results that demonstrated the acceptability and feasibility of the CECAP program, the Burkina Faso Ministry of Health included CECAP services in its minimum service delivery package in 2016. Essential components for such programs include provider training on VIA, cryotherapy, and LEEP; provider and patient demand generation; local equipment maintenance; consistent supply stocks; referral system for LEEP; non-prohibitive fees; and a monitoring data collection system. more