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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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India: Guidelines for the Public Private Partnership Model of ART centres

National AIDS Control Organisation (NACO), Government of India (2017) C1

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Interim Guidance for Protecting Workers from Occupational Exposure to Zika Virus

Centers for Disease Prevention and Control CDC OSHA; NIOSH (2016) C_CDC

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Global Fund Overview

The Global Fund to Fight AIDS, Tuberculosis and Malaria The Global Fund to Fight AIDS, Tuberculosis and Malaria (2020) C2

Accessed: 10.03.2020

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The Global Status Report on Preventing Violence Against Children 2020

UNICEF WHO (2020) C_WHO

As this report shows, reports of child abuse and of children witnessing violence between their parents and caregivers have increased. Ending violence against children is increasingly within our reach. D

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A Field Guide to Antibiotic Stewardship in Outpatient Settings

Telligen, Quality Innovation Network National Coordinating Center, Centers for Medicare & Medicaid Services (CMS) (2018) C2

Antibiotic Stewardship (AS) is a coordinated program that promotes the appropriate use of antimicrobials to improve patient outcomes, reduce microbial resistance, and decrease the spread of multi-drug resistant organisms. In clinical settings, stewardship activities focus on measuring and improving ... more

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More than money — The Joint United Nations Programme on HIV/AIDS and the Global Fund to Fight AIDS, Tuberculosis and Malaria

The Global Fund, UNAIDS UNAIDS (2021) C_WHO

Joint actions by the Global Fund and UNAIDS are guided by a strong alignment of strategies, goals and targets. UNAIDS has worked with all stakeholders to set a common agenda and targets within the Global AIDS Strategy 2021–2026, and the United Nations General Assembly confirmed this strategy and i... more

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Inequality Kills (Arabic Version)

Oxfam (2022) CC

The unparalleled action needed to combat unprecedented inequality in the wake of COVID-19. New billionaire minted every 26 hours, as inequality contributes to the death of one person every four seconds

External Link

Strengthening the collection, analysis and use of health workforce data and information: a handbook

World Health Organisation (WHO) (2023) C_WHO

Access to health workers who are fit for purpose, motivated and protected is a fundamental force of health service delivery and the achievement of universal health coverage and the health and health-related Sustainable Development Goals. Data and knowledge of the distribution, skill mix and future d... more

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COVID-19 Social Media Support Kit
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2020) CC

These campaign support materials have been developed and shared to bolster national initiatives and outreach campaigns in AU Member States. The message will continue to evolve as the COVID-19 pandemic progresses and as understanding of optimal responses develop further. You can download the toolkit... more

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WHO strategic action and resource requirements to end the acute phase of the COVID-19 pandemic 2021

World Health Organization WHO (2021) C_WHO

WHO has a unique combination of technical public health and scientific expertise, and a global operational footprint, with field offices in more than 150 countries. In 2020, this global, technical, and operational reach meant WHO was able to support countries around the world in every aspect of COVI... more

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Myannmar Living Conditions Survey 2017: Key Indicators Report

Central Statistical Organization (CSO), UNDP and WB (2018) C1

External Link

Integrated Disease Surveillance and Response District Level Training Course. Participant Modules

(2011)

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India: National Programme for the Control of Blindness Guidelines

National Rural Health Mission (2009) C1

Guidelines for State Health Society and District Health Society

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Knowledge, Attitude And Practice Surveys In Child Protection

The Child Protection Initiative, Save the Children (2013) C2

A step-by-step guide for child protection programmes to the design and implementation of KAP survey methods. In particular, this guide will help to strengthen the quality of our research, monitoring and evaluation work, and enable Save the Children to contribute to a step-change in the child protect... more

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Management of Tuberculosis: A Guide to the Essentials of Good Clinical Practice
recommended

International Union Against Tuberculosis and Lung Disease (2019) C1

The 7th edition of the Orange Guide provides practical guidance to health workers on the front line of TB control. It includes sections on HIV, MDR-TB and a review of the recommended treatment regimens

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Self-Directed M&E Learning Workbook 2: Doing the “M” of M & E

Ministry of Health & Ministry of Local Government, Gabarone, Botswana (2011) C2

District Level M & E Training and Reference Material for Primary Health Care Programmes

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Status of Sexual and Reproductive Health and Rights in Zambia [Part 2]

Population Council, UNFPA, Government of Zambia Human Rights Commission, WLSA, and United Nations in Zambia (2017) C1

Comprehensive Sexuality Education and Adolescents Sexual and Reproductive Health

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COVID-19:Guidance and advice for older people

HelpAge International (2020) C1

Information on what is Coronavirus or COVID-19 and how it is spread, along with advice on what older people can do to reduce their risk of catching the virus, and what they should do if they need medical help or support

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Rural Madagascar Comprehensive Food and Nutrition Security and Vulnerability Analysis

UNICEF, World Food Programme (WFP) (2011)

COVID-19 Social Media Support Kit recommended

Management of Tuberculosis: A Guide to the Essentials of Good Clinical Practice recommended

COVID-19 Social Media Support Kit
recommended

Management of Tuberculosis: A Guide to the Essentials of Good Clinical Practice
recommended