The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success against HAT and the competing priorities associat...ed with other medical crises ravaging the continent. A series of dedicated interventions and the introduction of innovative routes to develop drugs, involving Product Development Partnerships, has led to a dramatic turnaround in the fight against HAT caused by Trypanosoma brucei gambiense. The World Health Organization have been able to optimize the use of existing tools to monitor and intervene in the disease. A promising new oral medication for stage 1 HAT, pafuramidine maleate, ultimately failed due to unforeseen toxicity issues. However, the clinical trials for this compound demonstrated the possibility of conducting such trials in the resource-poor settings of rural Africa.
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Arsenical monotherapies were previously very successful for treating human African trypanosomiasis (HAT).
Melarsoprol resistance emerged as early as the 1970s and was widespread by the late 1990s.
Melarsoprol resistance represents the only example of widespread drug resistance in HAT patients wher...e the genetic mechanism has been established.
The current goal of elimination of HAT as a public health problem by 2020 may be undermined by the emergence and spread of resistance to current or new drugs.
Insights into potential resistance mechanisms for current and new drugs will facilitate predictions of the likelihood of resistance and will also facilitate rational approaches to minimizing, monitoring, and tackling the future emergence of resistance.
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Info Chagas
What do we need to know abaout Chagas Disease? What is Chagas Disease?
Over 6 million people worldwide are infected with Trypanosoma cruzi, the protozoan that causes Chagas disease. Endemic in 21 Latin American countries, the disease can be transmitted by vector insects called triatomines — also known as “kissing bugs” —, foods or beverages contaminated with th...e parasite, blood transfusions, organ transplants, or congenitally during pregnancy or delivery.
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Information for pregnant women
Neurodiversity is associated with people who experience dyslexia, autism, dyspraxia, ADHD, and other similar neurological conditions. They’re known as “spectrum” conditions that cover a wide range of characteristics but share similarities in how people with these conditions learn and process... different kinds of information.
Many organizations fail to support neurodiverse employees. This is party because working with neurodiverse employees can be perceived as challenging.
In this guide, we’ll explore the benefits of a neurodiverse workplace. We’ll look at some of the competitive advantages of neurodiversity and the legislation surrounding it. Finally, we’ll end with advice on making neurodiversity a workplace strength by supporting neurodiverse employees.
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How do they work in an ICC to prevent or mitigate nosocomial infections?
Are you clear that we can all do something to avoid them?
A simple hand wash can make a difference.
Inés Lavega has a degree in nursing and worked for more than 8 years at the CTI of Hospital Maciel, the first public hospit...al in Uruguay.
She tells us about the intense work of nursing, to control infections.
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This bi-weekly brief details the latest developments in scientific knowledge and public health policy from around the world as well as updates to the COVID-19-related guidance from Africa CDC, WHO and other public health agencies.
The project was developed by the International Federation of Medical Students’ Associations (IFMSA), in line with the Federation’s statement “a world in which students are equipped with knowledge, skills and value to take on health leadership roles locally and globally so to... shape a sustainable future”. This was supported by an ongoing and vital engagement from the World Health Organization (WHO) and their work the United Nations Alliance on Climate Change Education, Training and Public Awareness. The overall objective was to create a “all in one” type of resource to bring together climate change, health and youth advocacy.
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The Story of Cholera was produced in collaboration with award-winning animator Yoni Goodman.
This animation covers cholera transmission, prevention, signs, and care in a simple and accessible way. The film follows evidence-based guidelines, has been field-tested, and reviewed for accuracy and conte...nt. Download flashcards and mobil phone versions from the website
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Poster pregnant and lactating women
In this document you will find:
Coordination and Common Services Key Contacts
Coordination Hubs Key Contacts
Clusters Key Contacts
India is the world’s second most polluted country. Air pollution shortens average Indian life expectancy by 5 years,
relative to what it would be if the World Health Organization (WHO) guideline fine particulate pollution (PM2.5) of 5 μg/m3 was met. Some areas of India fare much worse than avera...ge, with air pollution shortening lives by almost 10
years in the National Capital Territory of Delhi, the most polluted city in the world.
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Bangladesh is the world’s most polluted country. Air pollution shortens the average Bangladeshi’s life expectancy by 6.9 years, relative to what it would be if the World Health Organization (WHO) guideline of 5 μg/m³ was met. Some areas of Bangladesh fare much worse than average, with air poll...ution shortening lives by nearly 9 years in Dhaka, the country’s most polluted city.
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Pakistan is the world’s fourth most polluted country. Air pollution shortens the average Pakistani’s life expectancy by 3.8 years, relative to what it would be if the World Health Organization (WHO) guideline of 5 μg/m3 was met.1 Some areas of Pakistan fare much worse than average, with air pol...lution shortening lives by almost 7 years in the country’s most polluted regions, like Lahore and Peshawar.
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Nepal is the world’s third most polluted country. Air pollution shortens average Nepalese life expectancy by 4.1 years, relative to what it would be if the World Health Organization (WHO) guideline of 5 μg/m3 was met.1 The highest concentrations of air pollution are observed in Nepal’s southwes...tern districts, which share their borders with the highly-polluted Indo-Gangetic Plain of India. Here, residents stand to lose nearly 7 years of life expectancy.
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As the world recovers from the shock of the COVID-19 pandemic and reflects on lessons learnt from failure of global public health systems to contain the global outbreak of SARS-CoV-2, new infectious disease threats, caused by movement of people globally, remain omnipresent, and repeated calls for mo...re proactive action go unheeded. This is aptly shown by the unprecedented and unexpected outbreaks of human monkeypox cases and clusters since May 7, 2022, across Europe, the Americas, and Australia,
which yet again, have taken global public authorities by surprise.
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How authorities and aid workers can help keep children displaced by the war in Ukraine safe from trafficking and other forms of exploitation and abuse.
Die Pandemie bestimmt weiterhin unser alltägliches Leben und macht das Thema Gesundheit zu einem der wichtigsten unserer Zeit. Doch wie sieht die Lebenswelt beim Thema Gesundheit für Asylsuchende aus? Sowohl der Zugang als auch der Umfang von Gesundheitsleistungen hängt in einem starken Maße von... einem Faktor ab – dem Zufall der Unterbringung. Denn wie der Zugang der Asylsuchenden zur medizinischen Versorgung gestaltet ist und wie die Kosten der Versorgung von Asylsuchenden an Kommunen erstattet werden, unterscheidet sich dabei von Bundesland zu Bundesland.
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In dieser Fokuserhebung wurde die deutschsprachige Erhebung durch Interviews in weiteren fünf Sprachen ergänzt. Damit wurden in dieser Erhebung auch Personengruppen erreicht, die in vorherigen Erhebungen aufgrund einer Sprachbarriere nicht erreicht werden konnten. Insgesamt liefert diese Befragung... daher Ergebnisse, die die Bevölkerung in Deutschland besser abbilden können.
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