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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Clinic Supervisor Manual

Management Sciences for Health; USAID (2006) C1

This Clinic Supervisor’s Manual is helpful for focusing managers on the key elements of integrated primary health care as they simultaneously integrate new interventions for HIV/AIDS, tuberculosis, and malaria. This tool contains 12 sections. Section 1 explains how to use the manual. Section 2 hel... more

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Developing, Implementing, and Monitoring the Use of Standard Treatment Guidelines: A SIAPS How-To Manual

Systems for Improved Access to Pharmaceuticals and Services (SIAPS) MSH, USAID (2015) CC

STGs are designed to assist health care professionals in making decisions about appropriate, effective patient care. However, health managers often have trouble setting and meeting the high standards required of modern, developed health care systems. With stakeholders expressing concern over issues ... more

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Supporting the continuity of health and nutrition services in the context of COVID-19 in refugee settings
recommended

UN High Commissioner for Refugees UNHCR (2020) C2

The 2014–2015 Ebola outbreak was catastrophic in West Africa but the indirect impact of increasing the mortality rates of other conditions was also substantial. The increased number of deaths caused by malaria, HIV/AIDS, and tuberculosis attributable to health system failures exceeded deaths from ... more

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Implementation of the Learning for Performance Approach in Rwanda: Final Report

Combary, P., Sinzahera, J., Mukakarara, V., et al. (2009) C2

The Capacity Project used the Learning for Performance (LFP) approach to develop the family planning (FP), HIV/AIDS and gender components included in the competency-based A1 nursing and midwifery pre-service curricula. LFP was also used to adapt the Rwanda national FP curriculum to an on-the-job tra... more

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Guidelines for Pharmacovigilance and Medicine Information System in Rwanda

Ministry of Health, Rwanda (2011) C2

The purpose of these guidelines is to help health workers to participate in the process of continuous surveillance of safety and efficacy of the pharmaceutical products which are used in clinical practice, thus help to achieve the ultimate goal to make safer and more effective treatment available to... more

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Primary Health Care As An Enabler For “Ending The Epidemics” Of High-Impact Communicable Diseases

World Health Organization WHO (2018) C_WHO

The Millennium Development Goals (MDGs) showed that global commitment and collective action could significantly reduce the disease burdens of three deadly communicable diseases: HIV/AIDS, tuberculosis (TB) and malaria. The MDGs helped focus efforts on these three deadly diseases and leveraged ... more

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Data for impact_ How UNADIS data is guiding the world to end AIDS

UNAIDS (2022) C_WHO

As part of the UN’s data strategy—which seeks to nurture data as a strategic asset for insight, impact and integrity—UNAIDS plays an indispensable role in generating data for effective action against the AIDS pandemic. It leads the world’s most extensive data collection on HIV epidemiology,... more

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Target product profile for readers of rapid diagnostic tests

World Health Organisation (WHO) (2023) C_WHO

Lateral-flow rapid diagnostic tests (RDTs) continue to play a vital role in global health in the management and diagnosis of infectious diseases, including malaria, HIV and COVID-19. Visually interpreted RDTs, more than any other class of diagnostics, fulfil WHO’s ASSURED criteria,1 enabling their... more

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Where There Are No Pharmacists

Sarah Andersson; Beverley Snell Third World Network; Health Action International Asia Pacific (2019) C2

2nd edition. A Guide to Managing Medicines for All Health Workers. Available for purchase via following link https://www.twn.my/title2/books/HAI.htm Where there are no trained pharmacists serving communities, other categories of health workers are called upon to order, buy, store, dispense and ad... more

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Infection prevention and control (IPC) guidance summary
recommended

World Health Organization (2014)

The summary of the infection prevention and control (IPC) measures is for anyone providing direct and non-direct care to patients with suspected or confirmed Ebola virus disease (EVD) in health-care facilities (HCFs). Essential IPC measures are also included in the Table which can be used as a stand... more

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Manual de Algoritmos para el diagnostico de Tuberculosis

World Health Organisation (WHO) (2018) C_WHO

Este documento presenta modelos de algoritmos que permiten investigar por métodos bacteriológicos a los pacientes para el diagnóstico de tuberculosis (TB), TB asociada al Virus de Inmunodeficiencia Humana (TB-HIV) y TB drogorresistente (TBDR).

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Management of Type 2 Diabetes Mellitus

Richardson, C.R.; Borgeson, J. R.; Harrison, V.; et al. National Library of Medicine (2021) CC2

The document "Management of Type 2 Diabetes Mellitus" provides comprehensive guidelines for the diagnosis, prevention, and treatment of type 2 diabetes in adults. It emphasizes the importance of individualized glycemic targets, lifestyle interventions like diet and exercise, and the use of medicatio... more

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Administration of Nirmatrelvir-ritonavir for COVID-19
recommended

World Health Organization WHO (2022) C_WHO

This series of supportive tools are based on the WHO Therapeutics and COVID-19: living guideline. They are intended to provide supportive information for healthcare workers who are prescribing, administering and monitoring patients receiving nirmatrelvir-ritonavir for non-severe COVID-19.

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DNDi Strategischer Plan 2021–2028 DNDi - Kurzversion

DNDi - Drugs for neglected diseases initiative (2023) C2

Die Initiative Medikamente gegen vernachlässigte Krankheiten (Drugs for Neglected Diseases initiative, DNDi) ist eine internationale gemeinnützige Organisation, die sichere, wirksame und bezahlbare Behandlungen für die am meisten vernachlässigten Patient:innen erforscht, entwickelt und bereitste... more

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COVID-19: Training slides based on guidelines for case-finding, diagnosis, management and public health response in South Africa

Centre for Respiratory Diseases and Meningitis and Outbreak Response National Department of Health, South Africa (2020) C2

Outline • Welcome and objectives • Microbiology, epidemiology and clinical presentation • Surveillance for imported cases including case definitions • Laboratory diagnosis • Infection prevention and hospital readiness • Patient flow and actions required at each step • Co-ord... more

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Abdominal tuberculosis in Ecuador, a problem that is still not solved

Rojas, C. L., Polanco E. C., Vivar M. C. et al. (2020) CC

Journal of Clinical TB and other Mycobacterial Diseases uberculosis (TB) in the gastrointestinal tract or peritoneum is an uncommon condition in clinical practice. Its rarity, combined with its nonspecific presentations, makes this kind of extrapulmonary tuberculosis difficult to diagnose as it can... more

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Vietnam: National Action Plan on Combating Drug Resistance in the period from 2013 - 2020

Ministry of Health Vietnam (2013) C2

In Vietnam, most of the examination and treatment facilities are facing with of spread of bacteria resistant to many antibiotics. The level and speed of drug resistance are increasing, at alarming level. The burden of drug resistance is increasing due to the increasing cost of treatment, prolonged t... more

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Medicine Information for Primary Care in Zimbabwe

Ministry of Health and Social Welfare, Zimbabwe (2012) C1

The objective of this book is to provide health workers with easily accessible information on important aspects of the medicines commonly used at primary care level in Zimbabwe. Medicines are a crucial part of the management of most of our patients, yet many medicines are potentially dangerous if no... more

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Establishment of PCR laboratory in developing countries, 2nd ed.
recommended

World Health Organization ( WHO), Regional Office for South-East-Asia (2016) C_WHO

Polymerase Chain Reaction (‎PCR)‎ has significantly helped in early diagnosis and commencement of specific interventions for diseases control. It also plays a critical role in understanding the disease epidemiology and unraveling the transmission dynamics of the disease. This manual intends to p... more

Supporting the continuity of health and nutrition services in the context of COVID-19 in refugee settings recommended

Infection prevention and control (IPC) guidance summary recommended

Administration of Nirmatrelvir-ritonavir for COVID-19 recommended

Establishment of PCR laboratory in developing countries, 2nd ed. recommended

Supporting the continuity of health and nutrition services in the context of COVID-19 in refugee settings
recommended

Infection prevention and control (IPC) guidance summary
recommended

Administration of Nirmatrelvir-ritonavir for COVID-19
recommended

Establishment of PCR laboratory in developing countries, 2nd ed.
recommended