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Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig G, Bernhard SC, Blum J, Burri C, Mpanya A, et al. PLOS Neclected Tropical Diseases (2016) CC
This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospita... more
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The Chagas disease study landscape

Maguire, B.; Dahal, P.; Rashan, S. et al. PLoS Neglected Tropical Diseases (2021) CC
A systematic review of clinical and observational antiparasitic treatment studies to assess the potential for establishing an individual participant-level data platform. Chagas disease (CD), caused by the parasite Trypanosoma cruzi, affects ~6–7 million people worldwide. Significant limitations s... more
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Progress towards lymphatic filariasis elimination in Ghana from 2000-2016

N.K. Biritwum; Frempong, K.K.; Verver, S.; et al. PLOS Neglected Tropical Diseases (2019) C1
Analysis of microfilaria prevalence data from 430 communities
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Leishmaniasis East Africa Platform (LEAP)

Drugs for neglected diseases initiative DNDi (2023) C2
The Leishmaniasis East Africa Platform (LEAP) was established to support the generation of scientific evidence for the development and distribution of new treatments for leishmaniasis in Eastern Africa.
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Diabetes Poster - Does your child show any of these symptoms?

Drugs for Neglected Diseases initiative DNDi (2024) CC2
Diabetes Poster - Does your child show any of these symptoms?
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Chagas disease factsheet

Drugs for Neglected Diseases initiative DNDi - Latin America (2019) CC
Chagas is a parasitic disease that affects over 6 million people in the world. As the disease typically remains asymptomatic for years, new cases often go unnoticed and unreported, and most people with the disease are unaware of their condition. Less than 10% of people affected are diagnosed and... more
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DNDi Strategic Plan 2021-2028 | DNDi - English version

DNDi - Drugs for neglected diseases initiative (2023) C2
Accessed on 04.04.2023 The Drugs for Neglected Diseases initiative (DNDi) is an international non-profit organization that discovers, develops, and delivers safe, effective, and affordable treatments for the most neglected patients
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Chagas Clinical Research Platform

Drugs for Neglected Diseases Initiative DNDi Latin America (2022) CC
To support its R&D activities on Chagas disease, DNDi launched the Chagas Clinical Research Platform (CCRP). The platform brings together partners, experts, and stakeholders to provide support for evaluation and development of new treatments for Chagas disease. The patient-centred platform aims to f... more
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Enfermedad de Chagas ESP

Drugs for Neglected Diseases initiative DNDi - Latin America (2019) CC
La enfermedad de Chagas es parasitaria y afecta a más de 6 millones de personas en el mundo. Como normalmente es asintomática durante años, los nuevos casos suelen no detectarse ni reportarse y la mayoría de las personas con la enfermedad no tiene conciencia de su condición. Se diagnostica ... more
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Full prescribing information Fexinidazole tablets, for oral use

Drugs for Neglected Diseases initiative DNDi (2021) C1
Full Perscribing information on Fexinidazole Tablet for oral use INDICATIONS AND USAGE Fexinidazole Tablets are indicated for the treatment of both the first-stage (hemolymphatic) and second-stage (meningoencephalitic) human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense in pati... more
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Visceral leishmaniasis

Drugs for Neglected Diseases initiative DNDi (2023) CC
Visceral leishmaniasis, the most severe form of leishmaniasis also known as kala-azar, is a life-threatening disease caused by Leishmania parasites which are transmitted by female sandflies. Visceral leishmaniasis causes fever, weight loss, spleen and liver enlargement, and, if not treated, death. P... more
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Towards new generation treatments for leishmaniasis

Drugs for Neglected Diseases initiative DNDi (2019) CC
1 billion people are at risk of infection with leishmaniasis, a neglected disease strongly linked to poverty. There’s no single, simple cure: current treatments are complex and need to be adapted to the form of the disease and geographical region.
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Webinar: Knowledge gaps and challenges in managing patients suffering from cutaneous leishmaniasis

Drugs for Neglected Diseases initiative DNDi (2021) CC
Cutaneous leishmaniasis is a painful disease that exerts a serious toll on societies around the world that are afflicted by it. Although not life-threatening, the skin ulcers and scars it causes can lead to isolation and psychosocial pathologies due to social stigma, and its occurrence is often asso... more
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Una Nueva Esperanza Para Pacientes Con Leishmaniasis

Drugs for Neglected Diseases initiative DNDi (2022) CC
La leishmaniasis es una enfermedad tropical desatendida sensible al clima, trasmitida por la picadura de insectos flebótomos y se calcula que amenaza a mil millones de personas en todo el mundo. Esta enfermedad altamente compleja se presenta de varias formas clínicas, causadas por 20 especies ... more
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New hope for leishmaniasis

Drugs for Neglected Diseases initiative DNDi (2022) CC
Leishmaniasis is a climate-sensitive disease. Changes in temperature, rainfall, and humidity can have strong impacts on the sandfly vector, altering their distribution and influencing their survival and population sizes. Increased temperatures shorten vector development time, reduce Leishmania p... more
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Fexinidazole for T.b. gambiense (Sleeping Sickness)

Drugs for Neglected Diseases initiative DNDi (2022) C2
DNDi is now striving to make fexinidazole available to the majority of people who have T.b. gambiense sleeping sickness. We are supporting a three-year access and pharmacovigilance study that began in 2020 and have so far carried out in-country training of relevant staff in 250 hospitals and... more
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Human African Trypanosomiasis (HAT) - Sleeping Sickness

Drugs for Neglected Diseases initiative DNDi (2008) C2
At the forefront of DNDi’s efforts to develop new treatments is the need to understand the realities and treatment needs of patients and health care staff in the field. The ultimate goal for human African trypanosomiasis (HAT) is a truly simplified treatment which can be orally administered, impl... more
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Fexinidazole for T.b. rhodesiense

Drugs for Neglected Diseases initiative DNDi (2021) C1
DNDi’s long-term goal for sleeping sickness, also known as human African trypanosomiasis (HAT), is to develop and register two new drugs that are effective against both Stage 1 and Stage 2 of the disease and both subspecies of the parasite, T.b. gambiense and T.b. rhodesiense. T.b. rhodesiense is ... more
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Improving access to testing for Chagas disease in Colombia

Caicedo Díaz, RA,; Forsyth, C.; Bernal, OA; et al. Drugs for Neglected Diseases initiative DNDi (2019) CC
This is a summary of the following peer-reviewed, scientific article: Comparative Evaluation of Immunoassays to Improve Access to Diagnosis for Chagas Disease in Colombia.
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Für eine gesunde Zukunft: Gemeinsam gegen übertragbare tropische Armutskrankheiten, Mangel- und Unterernährung

Global Network for Neglected Tropical Diseases (2015) C2
Dieses Kurzdossier konzentriert sich besonders auf den Zusammenhang zwischen zwei übertragbaren tropischen Armutserkrankungen – dem Wurmbefall des Darms durch Geohelminthen wie Spul-, Peitschen- und Hakenwürmer sowie der Schistosomiasis (Bilharziose). Es zeigt Möglichkeiten zu deren Bekämpf... more