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WHO Essential Regulatory Laboratories (ERLs), inside the Global Influenza Surveillance and Response System (GISRS), are a crucial element of influenza prevention and control, especially vaccine
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response.
more
Representative, quality, timely and continuous genetic surveillance of SARS-CoV-2 is critical to the COVID-19 outbreak response. This document provides practical guidance to Global Influenza
...
Surveillance and Response System (GISRS) laboratories and other relevant national laboratories to move beyond virus detection to genomic sequencing of SARS-CoV-2 PCR positive materials obtained from sentinel surveillance of influenza-like illness (ILI), acute respiratory infection (ARI) and severe acute respiratory infection (SARI). It contains considerations on sample selection for sequencing, numbers of viruses to be sequenced, metadata and timeliness for sharing genetic sequence data (GSD) and opportunities for technical support.
more
The webpage ”H5 Reference Laboratories” on the WHO Global Influenza Surveillance and Response System (GISRS) site describes a network of specialized laboratories designated by the World Health O
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rganization to support global influenza monitoring — particularly for H5 subtype avian influenza viruses.
It explains that these reference laboratories perform high-level testing, characterization, and sharing of influenza virus samples, including genetic sequencing and antigenic analysis. Their role is to help detect and assess influenza virus strains of public health concern (especially H5 strains with pandemic potential), support vaccine strain selection, and provide technical guidance and capacity building to national influenza centers and other laboratories. The page highlights the importance of this global laboratory network in strengthening early warning, risk assessment, and preparedness for influenza outbreaks and pandemics.
more
Response to the Periodic EpidemicThe document "Zanzibar's Victory Against Cholera Epidemic" details the successful efforts taken by Zanzibar to control and eliminate cholera outbreaks. It highlights the strategies implemented, including improved wat
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er and sanitation infrastructure, public health campaigns, vaccination programs, and rapid response measures. The report emphasizes community engagement, government commitment, and international partnerships as key factors in combating the disease. Zanzibar's experience serves as a model for other regions facing similar public health challenges, demonstrating that sustained efforts in hygiene, disease surveillance, and emergency preparedness can effectively control cholera epidemics.
more
Logistics is a key component of the function of the Global Influenza Surveillance and Response System (GISRS). Logistics supports the smooth functioning of GISRS through providing advice, guidance a
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nd assistance with regards to shipping virus samples, provision of reagents and other laboratory supplies, and interaction with the International Civil Aviation Organization (ICAO), biosafety and courier service. It also includes the management of urgent shipments during outbreaks and other emergencies.
more
The GTFCC Laboratory Support for Public Health Surveillance document provides guidelines on using DNA-based molecular techniques for identifying and monitoring Vibrio cholerae strains in cholera outbreaks. It highlights the importance of genetic seq
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uencing for tracking transmission, detecting new variants, and improving outbreak response. The report explains methods like PCR testing, whole genome sequencing (WGS), and multiple loci VNTR analysis (MLVA), detailing their advantages and applications. It also outlines best practices for sample collection, storage, and transportation, emphasizing collaboration between national and international laboratories to enhance cholera surveillance and control efforts.
more
Emergency WASH in Health Facilities in Conflict Affected Locations 756 health workers trained on disease surveillance and outbreak response.
Around 142 health workers trained on integrated health (
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WASH and Nutrition) response. 405 health facilities are equipped with functional incinerators.
Quality Essential Clinical Health Services 194 health workers are trained on clinical management of rape (CMR) in 2018. 259 sexual and gender based violence (SGBV) survivors referred to the health facilities.
Improving Resilience- Mental Health Response 514 health workers trained on mental health and psychosocial support (MPHSS) in conflict affected areas.
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The document presents Cameroon's National Response Plan for the 2018 cholera outbreak, covering August to October 2018. It highlights the epidemiological situation, with outbreaks reported in the North and Central regions and a total of 109 suspecte
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d cases and 9 deaths by July 2018. The plan outlines strategies for controlling the epidemic, including epidemiological surveillance, improved access to clean water, sanitation, mass vaccination, community awareness campaigns, and hospital and community-based treatment.
The response is coordinated by the Ministry of Public Health, WHO, and various partners, focusing on early detection, rapid response, and multi-sectoral collaboration. Challenges include poor sanitation, limited healthcare infrastructure, and cross-border disease transmission risks. The plan emphasizes resource mobilization, monitoring, and evaluation to contain the outbreak and prevent future cases.
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WHO has a unique combination of technical public health and scientific expertise, and a global operational footprint, with field offices in more than 150 countries. In 2020, this global, technical, and operational reach meant WHO was able to support countries around the world in every aspect of COVI
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D-19 public health response, from surveillance and laboratory testing to maintaining essential health services in the most vulnerable and fragile contexts.
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Technical Note on Antimicrobial Resistance
This document reflects UNICEF’s response to the growing global threat of AMR to child survival, growth and development. It identifies UNICEF’s AMR-specific and AMR-sensitive actions in reducing infecti
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ons, promoting access to and optimal use of antimicrobials, and increasing AMR awareness and understanding. Of particular relevance to this group, UNICEF country offices are directed to provide technical support for development and implementation of national AMR action plans, linking them as appropriate to maternal, newborn and child health programmes and ensuring these are prioritized in both surveillance and policy changes. The guidance note on AMR is intended to inform UNICEF’s AMR-related internal initiatives, programming and activities, as well as external engagements with governments and other stakeholders.
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Launch of the WHO Report on antimalarial drug efficacy, resistance and response: 10 years of surveillance (2010–2019). Key findings
The NIAID Pandemic Preparedness Plan describes the strategy of the National Institute of Allergy and Infectious Diseases (NIAID) to strengthen research and development for future pandemic threats. The plan focuses on identifying and studying viruses with the potential to cause epidemics or pandemics
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and developing medical countermeasures such as vaccines, therapeutics and diagnostics. A key concept is the research on “prototype pathogens,” which represent virus families that may cause future outbreaks, allowing scientists to prepare tools and knowledge in advance. The document also outlines the importance of surveillance, epidemiological research, technological innovation, clinical trials and international collaboration to enable a faster and more effective response to emerging infectious diseases. Overall, the plan aims to improve scientific preparedness so that new health threats can be detected earlier and controlled more rapidly.
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Data for Global Pandemic and Epidemic Intelligence
Fitzner, J.; – WHO Hub for Pandemic and Epidemic Intelligence
World Health Organization (WHO)
(2025)
C_WHO
The presentation “Data for Global Pandemic and Epidemic Intelligence” outlines how improved data collection, surveillance, analytics, and digital tools can strengthen global preparedness and response
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to health emergencies. It explains the concept of epidemic intelligence, highlighting the integration of multiple data sources—such as traditional surveillance, genomics, open-source information, and modelling—to support timely and evidence-based decision-making. The presentation also showcases initiatives of the WHO Hub for Pandemic and Epidemic Intelligence, including collaborative data platforms, pathogen genomics networks, analytic communities of practice, and a decision-support pandemic simulator designed to enhance rapid, coordinated responses to future outbreaks.
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The Partnership Contribution (PC) is one element of the Pandemic Influenza Preparedness (PIP) Framework Benefit Sharing System. It is an annual cash contribution of US$ 28 million given to WHO by influenza vaccine, diagnostic and pharmaceutical manufacturers that use the WHO Global Influenza
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Surveillance and Response System (GISRS). Funds are allocated for pandemic influenza preparedness capacity building, response activities at the time of a pandemic, and the PIP Secretariat for implementation of the Framework. The Guiding Principles for the use of the PIP PC funds for Pandemic Influenza Response can be found below
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This Framework offers a coherent approach for eliminating tuberculosis (TB) in low-incidence countries. It is designed to guide national policy-makers and those responsible for technical aspects of the national TB response in accelerating efforts to
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wards elimination. The document will also be informative for public health surveillance officers, practitioners and nongovernmental and civil society partners working on natioal TB care and prevention and serving the populations most vulnerable to TB.
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The World Health Organization (WHO) has identified mental health as an integral component of the COVID-19 response. Its rapid assessment of service delivery for mental, neurological and substance use (MNS) disorders during the COVID-19 pandemic, on
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which this report is based, is the first attempt to measure the impact of the pandemic on such services at a global level. The data were collected through a web-based survey completed by mental health focal points at ministries of health between June and August 2020. The questionnaire covered the existence and funding of mental health and psychosocial support (MHPSS) plans, the presence and composition of MHPSS coordination platforms, the degree of continuation and causes of disruption of different MNS services, the approaches used to overcome these disruptions, and surveillance mechanisms and research on MNS data.
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Developed through broad and inclusive consultation, and aligned with the WHO Global Health Sector Strategies and the Sustainable Development Goals, the framework promotes a people-centred approach and antimicrobial stewardship across 5 key domains: prevention and
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response, surveillance, research and innovation, laboratory capacity, and governance.
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This Mobile user guidance is aimed at supporting implementation of EWARS in a box, WHO’s electronic early warning, alert and response system in emergencies. This guidance fulfills a long felt need to have an easy to use resource with step-by-step
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instructions in establishing EWARS in a box, facilitating field epidemiologists, surveillance officers and emergency responders.
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The 2026 outlook remains concerning. Without sustained support, health needs will remain acute. Disease outbreak risks persist amid degraded surveillance. Interagency planning indicates 10.8 million people may be in need, with 4.1 million requiring
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health assistance. The burden of noncommunicable diseases and mental health conditions is expected to worsen. At the same time, international financing for Ukraine’s health response has declined, while humanitarian and health needs remain acute, making sustained support in 2026 critical to prevent further deterioration of essential services.
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The Zimbabwe Multi-Sectoral Cholera Elimination Plan (2018–2028) aims to eradicate cholera by improving water, sanitation, and healthcare infrastructure, strengthening disease surveillance, and expanding oral cholera vaccination (OCV). The strateg
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y focuses on five pillars, including public health response, WASH, infrastructure, community empowerment, and financing. A multi-sectoral approach involving government, international organizations, and local communities targets cholera hotspots to prevent outbreaks and ensure long-term disease control.
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