Thirty-three years after its discovery, the Human Immunodeficiency Virus (HIV), responsible for the AIDS pandemic, remains a major public health problem despite advanced researches providing better diagnostic and therapeutic tools. The virus targets especially CD4+ T cells, leading to deficiency of ...the immune system and altering therefore defense against infections and cancer cells. Antiretroviral
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Protocoles des Services de Santé Familiale - Volet Femme
Le texte traite du paludisme grave, une forme sévère du paludisme principalement causée par Plasmodium falciparum. Il explique les circonstances dans lesquelles le diagnostic doit être évoqué, notamment en cas de fièvre au retour d'une zone tropicale. Le document décrit les examens nécessai...res, les signes cliniques et biologiques de gravité, et insiste sur l’urgence du traitement. Le traitement de référence est l’artésunate par voie intraveineuse, suivi d’une thérapie orale. Le texte aborde aussi les complications possibles, les critères d’hospitalisation et l’importance d’une prise en charge rapide et adaptée dans un service spécialisé.
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Malaria in pregnancy is a significant health problem in malaria-endemic areas. It not only causes substantial childhood morbidity and mortality but also increases the risks of adverse events for pregnant women and their developing fetuses. Most of the burden in these areas is due to infection with P...lasmodium falciparum. Artemisinin-based combination therapy (ACT) has been recommended as first-line treatment for uncomplicated P. falciparum malaria in all populations, including pregnant women in their second and third trimesters, since 2006. However, for women in their first trimester of pregnancy, WHO recommended as first-line treatment a combination of quinine and clindamycin.
Based on a review of the evidence conducted in 2022, WHO now recommends artemether–lumefantrine, the ACT with the most human safety data available, as the preferred treatment for uncomplicated P. falciparum malaria in the first trimester of pregnancy. This document presents all relevant evidence on the effects and safety in early pregnancy of artemisinins and partner medicines used in ACTs from both studies in experimental animals and observational studies in humans.
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