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A practical handbook on the pharmacovigilance of antiretroviral medicines

World Health Organization WHO (2013) C_WHO
This is a detailed manual giving a step by step approach to undertaking the pharmacovigilance of antiretrovirals. It is intended to be a source of practical advice for Pharmacovigilance Centres and health professionals involved in HIV/AIDS prevention and treatment programmes. A number of WHO publica... more
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Tuberculosis Infection Control in the Era of Expanding HIV Care and Treatment: Addendum to WHO Guidelines for the Prevention of Tuberculosis in Health Care Facilities in Resource-limited Settings

Center for Disease Control and Prevention, World Health Organisation (2007)
The goal of this addendum is to help management and staff 
minimize the risk of TB transmission at facilities in resource limited settings in which a.) HIV-infected persons receive diagnosis, care, treatment, 
and/or support, and b.) there is a high prevalence of HIV infection, both known 
and... more
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HEARTS. Technical package for cardiovascular disease management in primary health care. Evidence-based treatment protocols

World Health Organization WHO, et al. (2018) C_WHO
In many low- and middle-income countries, there is a wide gap between evidencebased recommendations and current practice. Treatment of major CVD risk factors remains suboptimal, and only a minority of patients who are treated reach their target levels for blood pressure, blood sugar and blood choles... more
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Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection
recommended

World Health Organization (2015) C_WHO
The recommendations in these guidelines promote the use of simple, non-invasive diagnostic tests to assess the stage of liver disease and eligibility for treatment; prioritize treatment for those with most advanced liver disease and at greatest risk of mortality; and recommend the preferred use of n... more
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Best practice portal: standards and guidelines
recommended

European Monitoring Centre for Drugs and Drug Addiction (2019) CC
The Best practice portal is a resource for professionals, policymakers and researchers in the drugs field. We provide information on the available evidence on drug-related prevention, treatment and harm reduction, focusing on the European context. The evidence is compiled following an explicit metho... more
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Best Practice Portal
recommended

European Monitoring Centre for Drugs and Drug Addiction (2022) CC
The Best practice portal is designed to help you find practical and reliable information on what works (and what doesn’t) in the areas of prevention, treatment, harm reduction and social reintegration. It will help you identify tried and tested interventions quickly, allocate resources to what's e... more
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A8 e-Therapy using computer and mobile technologies in treatment

Karolina Stasiak & Sally Merry IACAPAP (2015) C2
This publication seeks to describe the best treatments and practices based on the scientific evidence available at the time of writing as evaluated by the authors and may change as a result of new research. Readers need to apply this knowledge to patients in accordance with the guidelines and laws o... more
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National Guidelines and Operational Manual for Programmatic Management of Drug Resistant TB (PMDT), 2nd ed.

Government of the People’s Republic of Bangladesh, Directorate General of Health Services (2013) C1
Specific measures are being taken within the National Tuberculosis Control Programme (NTP) to address the MDR TB problem through appropriate management of patients and strategies to prevent the propagation and dissemination of MDR TB.
The term "Programmatic Management of Drug Resistant TB" (PMD... more
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Meeting report of the WHO expert consultation on the definition of extensively drug-resistant tuberculosis

World Health Organization WHO (2021) CC
Meeting Report 27-29 October 2020 The overall goal of the meeting was to discuss recent changes in treatment regimens and diagnostics for drug-resistant TB and to determine how these impact on the definition of XDR-TB, with a view to revising this definition. The pre-existing definition of XDR-TB w... more
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Statement on the Use of Ivermectin for COVID-19

African Union; Africa CDC Centres for Disease Control and Prevention (2021) C1
Ivermectin is an antiparasitic drug approved for the treatment of parasitic infections, including strongyloidiasis and onchocerciasis in humans. There is a reported increase in the use of ivermectin for the prevention and treatment of COVID-19 by the public in African Union Member States. Currently... more
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Практический справочник ВОЗ по туберкулезу. Модуль 4. Лечение. Лечение лекарственно-устойчивого туберкулеза

World Health Organization WHO (2021) C_WHO
The consolidated guidelines are complemented by an operational handbook which is designed to assist with implementation of the WHO recommendations by Member States, technical partners and others who are involved in the management of patients with DR-TB. The WHO Operational Handbook on Tuberculosis, ... more
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Update on the use of nucleic acid amplification tests to detect TB and drug-resistant TB: rapid communication

WHO (2021) CC
In 2019, an estimated 10 million individuals fell ill with tuberculosis (TB) and 3 million of them were not reported to have beendiagnosed and notified. The gap is proportionately even wider for drug-resistant TB. Of the estimated 465 000 patients with rifampicin-resistant and multi-drug resistant T... more
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Advisory for Rational use of Remdesivir for COVID-19 Treatment

Ministry of Health& Family Welfare, Goverment of India (2021) CC
The purpose of this document is to stop to irrational use/ over prescription of this reserve/ experimental/ emergency use authorisation drug Remdesivir. For this reason, Joint Monitoring Group under Chairmanship of DGHS took into consideration findings of the followi... more
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Protocolo para el funcionamiento de los centros especiaIados para el tratamiento a personas con consumo problematico de alcohol y otras drogas (CETAD) en el marco de la pandemia por la COVID-19

Paex I, Cederno J.R., Paredes Arce P. et al. (2020) CC
Protocol for the management of specialized centres for the treatment of people with alcohol and other drug abuse problems (CETAD) in the framework of the COVID-19 pandemic. Version 1.
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Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer

Scherr, N.; R. Bieri, S.S. Thomas, et al. (2018) CC
Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... more
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Review Challenges in Chagas Disease Drug Development

Francisco, A.; Jayawardhana, S.; Olmo, F. et al. Molecules MDPI (2020) CC
The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public health problem throughout Latin America. Current therapeutic options are characterised by limited efficacy, long treatment regimens and frequent toxic side-effects. Advances in this area have been compromised by gaps... more
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Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig G, Bernhard SC, Blum J, Burri C, Mpanya A, et al. PLOS Neclected Tropical Diseases (2016) CC
This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospita... more
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New Therapeutics for Chagas Disease: Charting a Course to Drug Approval

Man, A. & Segal, F. IntechOpen (2022) CC
Little progress has been made since the 1960s and 1970s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and operational challenges in the clinica... more
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Recommended package of interventions for HIV, viral hepatis and STI prevention, diagnosis, treatment and care for people who inject drugs: policy brief

World Health Organisation (WHO) (2023) C_WHO
HIV, viral hepatitis and STI epidemics, particularly among people who inject drugs and other key populations, continue to be fuelled by laws and policies criminalizing sex work; drug use or possession; diverse forms of gender expression and sexuality; stigma and discrimination; gender discrimination... more
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Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance, 2nd ed

World Health Organisation (WHO) (2023) C_WHO
Of the more than 10 million people estimated to have fallen ill with tuberculosis (TB) in 2022, just over 400 000 people developed TB resistant to rifampicin (RIF), and 1.3 million people developed TB resistant isoniazid (INH). Drug resistance must be detected rapidly and accurately to initiate appr... more