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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Zimbabwe: Floods Situation Report No. 2, As of 10 April 2019

UN Office for the Coordination of Humanitarian Affairs (OCHA) (2019) C1

299 deaths have been recorded and 329 people are still missing, according to the Government. • Latest assessments indicate that the homes of some tens of thousands of people have been destroyed or damaged beyond habitability. Most of these people are staying with hosts in the extended community. ... more

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A better classification of wet markets is key to safeguarding human health and biodiversity

Bing Lin A. B., M.L Dietrich, R.A.Senior, et al. The Lancet, Planetary Health (2021) CC

Wet markets have been implicated in multiple zoonotic outbreaks, including COVID-19. They are also a conduit for legal and illegal trade in wildlife, which threatens thousands of species. Yet wet markets supply food to millions of people around the world, and differ drastically in their physical com... more

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Laboratory biosafety manual
recommended

World Health Organization WHO WHO (2020) C_WHO

4th edition The WHO Laboratory Biosafety Manual (LBM) has been in broad use at all levels of clinical and public health laboratories, and other biomedical sectors globally, serving as a de facto global standard that presents best practices and sets trends in biosafety. LBM encouraged countries t... more

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Ethiopian Hospital service transformation Guidelines: Chapter 10 Pharmacy Service: Ethiopian Hospital Management Initiative

Federal Democratic Republic of Ethiopia -Ministry of Health (2017) C1

The Ethiopian Hospital Services Transformation Guidelines (EHSTG) build on and expand the Ethiopian Hospital Reform Implementation Guidelines (EHRIG) and are consistent with the Health Sector Transformation Plan (HSTP). The EHSTG, which is consistent with the national focu... more

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Maintaining essential health services: operational guidance for the COVID-19 context interim guidance

WHO (2021) CC

Countries around the world are facing the challenge of increased demand for care of people with COVID-19, compounded by fear, misinformation and limitations on movement that disrupt the delivery of health care for all conditions. Maintaining essential health services: operational guidance for the CO... more

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Emergency Use Designation of COVID-19 candidate vaccines: Ethical considerations for current and future COVID-19 placebo-controlled vaccine trials and trial unblinding

World Health Organization WHO (2020) C_WHO

The conduct of COVID-19 vaccine trials in the context of a candidate vaccine being issued with Emergency Use Designation raises challenging ethical questions, including in relation to the use of placebo controls and unblinding of trial participants in current and future COVID-19 vaccine trials. This... more

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New platforms for engagement. Private accommodation of forced migrants from Ukraine.

DeZIM Institut (2022) C2

As of September 2022, just over one million forced migrants from Ukraine have entered Germany, making Germany the third largest recipient of migrants (Ukraine Refugee Situation, 2022). As early as March 2022, several news outlets reported that accommodation centers were at or near capacity in ma... more

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Ghana’s National Health insurance scheme and maternal and child health: a mixed methods study

Kavita Singh, Isaac Osei-Akoto, Frank Otchere et al. BMC Health Services Research (2015) C1

Ghana is attracting global attention for efforts to provide health insurance to all citizens through the National Health Insurance Scheme (NHIS). With the program’s strong emphasis on maternal and child health, an expectation of the program is that members will have increased use of relevant servi... more

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The mhGAP community toolkit: field test version

World Health Organization WHO (2019) CC

The mhGAP community toolkit: field test version is an integral part of WHO's Mental Health Gap Action Programme (mhGAP), and aims at scaling up services for people with mental health conditions to achieve universal health coverage. The toolkit provides guidance for programme managers on how to i... more

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Women´s Mental Health: An evidence based review

WHO WHO (2000) C_WHO

This document adopts a health determinants framework for examining the evidence related to women’s poor mental health. From this perspective, public policy including economic policy, socio-cultural and environmental factors, community and social support, stressors and life events, personal behavio... more

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Every child alive: The urgent need to end newborn deaths

UNICEF (2018)

Globally, in low-income countries, the average newborn mortality rate is 27 deaths per 1,000 births, the report says. In high-income countries, that rate is 3 deaths per 1,000. Newborns from the riskiest places to give birth are up to 50 times more likely to die than those from the safest places.... more

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UNFPA Myanmar Annual Report 2016

United Nations Population Fund (UNFPA) (2017) C1

Census data shows that Myanmar can harness a double dividend – both youth and gender. This year’s annual report provides many facets of the journey to gender equality. It tells a story of widening horizons for women and girls who are capable in their own right. It is also a story of women fulfil... more

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Sierra Leone: National Strategy Plan for Combating Antimicrobial Resistance

Ministry of Health and Sanitation Sierra Leone (2018) C_WHO

Antimicrobials have been a critical public health tool since the discovery of penicillin in 1928, saving the lives of millions of people around the world. Today, however, the emergence of drug resistance is reversing the miracles of the past eighty years, with drug choices for the treatment of many ... more

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Key considerations for monitoring shock-responsive social assistance: A guiding framework

SPACE - Social Protection Approaches to COVID-19: Expert Advice (2021) CC

June 2021. Shock-responsive social protection (SRSP) operates in contexts where rapid on-set disasters mean needs for assistance are acute and urgent. Monitoring and identifying problems in programme design and delivery are therefore critical. However, there is limited existing guidance on how to mo... more

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Clinical management and infection prevention and control for monkeypox
recommended

World Health Organization WHO (2022) C_WHO

Interim rapid response guidance, 10 June 2022. It includes considerations for certain populations such as patients with mild disease with considerations for community care, patients with moderate to severe disease, sexually active persons, pregnant or breastfeeding women, children and young persons... more

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Connecting Global Priorities: Biodiversity and Human Health

World Health Organization WHO (2015) C_WHO

Healthy communities rely on well-functioning ecosystems. They provide clean air, fresh water, medicines and food security. They also limit disease and stabilize the climate. But biodiversity loss is happening at unprecedented rates, impacting human health worldwide, according to a new state of knowl... more

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Pakistan AIDS Strategy III 2015-2020

Ministry of Health, Pakistan (2015) C1

The purpose of the PAS III is to guide Pakistan’s overall national response for HIV and AIDS through 2020, through focused interventions with set targets, costs, roles and responsibilities. The successful implementation of PAS III involves multiple stakeholders to achieve priority outcomes outline... more

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Baby-Friendly Hospital Initiative: revised, updated and expanded for Integrated Care - Section 2; Session 1: The national infant feeding situation

WHO, UNICEF (2009)

The revised package of BFHI materials includes five sections: 1. Background and Implementation, 2. Strengthening and Sustaining the BFHI: A course for decision-makers, 3. Breastfeeding Promotion and Support in a Baby-friendly Hospital: a 20-hour course for maternity staff, 4. Hospital Self-Appraisal... more

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Global commitments, local action

UNAIDS (2021) C_WHO

3 June 2021. After 40 years of AIDS, charting a course to end the pandemic. The report shows that countries with progressive laws and policies and strong and inclusive health systems have had the best outcomes against HIV. In those countries, people living with and affected by HIV are more likely t... more

Laboratory biosafety manual recommended

Clinical management and infection prevention and control for monkeypox recommended

Laboratory biosafety manual
recommended

Clinical management and infection prevention and control for monkeypox
recommended