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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Infection Control for Viral Haemorraghic Fever in the African Health Care Setting. Part 3

Centers for Disease Control and Prevention , World Health Organization (1998) C_WHO

Part 3: Use Safe Burial Practices

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Hypertension Control Change Package

Centers for Disease Control and Prevention (CDC) (2020) C_CDC

second edition Included more self-measured blood pressure (SMBP)-focused content with tools and resources. Showcased more tools to find patients with potentially undiagnosed HTN. Added new strategies that focus on chronic kidney disease testing and identification.

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Prevention and control of blood- borne viruses in prison settings

European Centre for Disease Prevention and Control; European Monitoring Centre for Drugs and Drug Addiction (2018) C2

Guidance Brief Selected findings from ECDC and EMCDDA scientific guidance, 2018

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Falling short

International Union Against Tuberculosis and Lung Disease; Treatment Action Group; msh; ec al. (2017)

Ensuring Access to Simple, Safe and Effective First-Line Medicines for Tuberculosis. Accessed in November 2017.

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Finding the Missing Tuberculosis Patients

D. P. Chin, C. L. Hanson The Journal of Infectious Disease; IDSA; Oxford, et al. (2017) C2

Supplement article The Journal of Infectious Diseases® 2017;216(S7):S675–8 DOI: 10.1093/infdis/jix368 Finding the Missing Tuberculosis Patients • JID 2017:216 (Suppl 7) • S675 Downloaded from https://academic.oup.com/jid/article-abstract/216/suppl_7/S675/4595547 by guest on 13 Nove... more

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Detailed Emergency Medical Services (EMS) Checklist for Ebola Preparedness

Centers for Disease Control and Prevention CDC (2014)

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Introduction to the Core Curriculum on Tuberculosis: What the Clinician Should Know

Center for Disease Control and Prevention (2013)

Sixth Edition

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Infection Control for Viral Haemorraghic Fever in the African Health Care Setting

Centers for Disease Control and Prevention , World Health Organization WHO (1998)

Important Guideline for Ebola prevention and control It is designed for the following uses: - for prevention through preparedness--to help African health facilities make advance preparations for responding with appropriate precautions when a VHF (including Ebola) case is suspected. - for pl... more

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Core Elements of Hospital Antibiotic Stewardship Programs. Antibiotic Stewardship Program Assessement Tool
recommended

Centers for Disease Control and Prevention CDC Centers for Disease Control and Prevention (CDC) (2019) C_CDC

A growing body of evidence demonstrates that hospital based programs dedicated to improving antibiotic use, commonly referred to as “Antibiotic Stewardship Programs (ASPs),” can both optimize the treatment of infections and reduce adverse events associated with antibiotic use. This document summ... more

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Evidence of HIV Treatment and Viral Suppression in Preventing the Sexual Transmission of HIV

Centers for Disease Control and Prevention CDC (2018)

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Care of the HIV-Exposed Infant

Centers for Disease Control and Prevention (CDC) (2018) C1

This clinical job aid addresses the importance of maternal health and antiretroviral therapy adherence, as well as care and testing for the HIV-exposed infant until the infant’s final HIV diagnosis after the end of breastfeeding.

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Cholera Prevention and Control: Introduction and Community Engagement

Centers for Disease Control and Prevention (CDC) (2015) C_CDC

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Rapid Assessment of Ebola Infection Prevention and Control Needs — Six Districts, Sierra Leone, October 2014

Centers for Disease Control and Prevention CDC (2014)

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Toolkit for engaging in social media activities promoting prudent antibiotic use

European Centers for Disease Control and Prevention ECDC (2012) C_CDC

This guidance document is based on research of social media activity related to antibiotic use at EU level, as well as on a survey of the social media activities of EAAD partner organisations, mostly EU umbrella organisations of patients and health professionals. The research showed that there is al... more

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'Idea to Reality': Strategy and Implementation Plan 2017-2021

Federal Ministry of Health - Nigeria Centre for Disease Control (2017) C2

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Africa CDC Reproductive Health | Strategic Priorities 2022-2026

Centers for Disease Control and Prevention (CDC) (2023) CC

In 2006, the Special Session of African Union Health Ministers adopted the Maputo Plan of Action for implementing the Continental Policy Framework on sexual and reproductive health and rights (SRHR), which expired at the end of 2015. The goal was for all stakeholders and partners to join forces and ... more

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Medical treatment of cystic echinococcosis: systematic review and meta-analysis

Velasco-Tirado, V.; Alonso-Sardón, M.; Lopez-Bernus, A. et al BMC Infectious Diseases (2018) C2

Cystic echinococcosis (CE) is a well-known neglected parasitic disease. However, evidence supporting the four current treatment modalities is inadequate, and treatment options remain controversial. The aim of this work is to analyse the available data to answer clinical questions regarding medical t... more

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Mapping Antimicrobial Resistance and Antimicrobial Use Partnership (MAAP) Country Report Burkina Faso

Africa Center for Disease Control and Prevention (2023) CC

The Mapping Antimicrobial Resistance and Antimicrobial Use Partnership (MAAP) project has conducted a multi-year, multi-country study that provides stark insights on the under-reported depth of the antimicrobial resistance (AMR) crisis across Africa and lays out urgent policy recommendations to addr... more

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Mapping Antimicrobial Resistance and Antimicrobial Use Partnership (MAAP) Country Report Cameroon

Africa Center for Disease Control and Prevention (2023) CC

Core Elements of Hospital Antibiotic Stewardship Programs. Antibiotic Stewardship Program Assessement Tool recommended

Core Elements of Hospital Antibiotic Stewardship Programs. Antibiotic Stewardship Program Assessement Tool
recommended