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Data available for your search include drug targets, tested compounds, existing drugs, ethnopharmacological plants, and information on the genome of M. ulcerans
This malaria case management training manual was developed by the Federal Ministry of Health (FMOH) of Ethiopia, in collaboration with several national and international partners. Primarily based on WHO guidelines and training materials, as well as the 2022 national malaria guidelines and various te
...
chnical documents, it aims to provide a standardised, simplified resource for clinical health workers in both the public and private sectors in Ethiopia. The manual aims to provide clinical health workers in both the public and private sectors in Ethiopia with a standardised, simplified resource.
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This comprehensive reference document is intended for those responsible for training in SMC (Seasonal Malaria Chemoprevention). It assumes that SMC will be implemented using the Community Health Worker strategy.
In 2023, Breakthrough ACTION and Guyana’s Ministry of Health refined the 'Lil Mosquito, Big Problem' malaria campaign using human-centred design. Phase II introduced peer-led videos (Miners' Buzz), community champions, incentives for volunteer testers and a transport network to improve supply deli
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very. These efforts enhanced engagement, coordination and timely reporting, reaching over 7,800 people. The campaign's innovative, community-driven approach has improved malaria prevention in remote mining regions.
Accessed on 20/06/2025.
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The TACT training manuals and patient leaflet were developed as part of the ACT Consortium's initiative to improve malaria case management by promoting the correct use of rapid diagnostic tests (RDTs). The TACT ("Targeting ACTs") initiative aims to ensure that artemisinin-based combination therapies
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(ACTs) are used appropriately, treating only confirmed malaria cases and guiding alternative care for other febrile illnesses.
Please download the manuals and leaflets from the website
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Os manuais de formação TACT e o folheto para o paciente foram desenvolvidos no âmbito da iniciativa do ACT Consortium para melhorar a gestão dos casos de malária e promover a utilização correta dos testes de diagnóstico rápido (RDT). A iniciativa TACT ("Targeting ACTs") visa garantir a util
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ização adequada das terapias combinadas à base de artemisinina (ACT), tratando apenas os casos de malária confirmados e orientando os cuidados alternativos para outras doenças febris. Os manuais oferecem formação interativa, baseada no local de trabalho, para auxiliar os profissionais de saúde na transição do tratamento presuntivo para um diagnóstico baseado em testes, em conformidade com a política da OMS. O folheto para o paciente, disponível em inglês e suáili, utiliza histórias ilustradas para explicar a importância e o objetivo dos TDR, abordar preocupações comuns e incentivar a confiança nos resultados dos testes. Após terem sido pré-testados quanto à sua clareza e compreensão, estes materiais apoiam mudanças sustentáveis na prática clínica e na comunicação com os doentes no âmbito dos cuidados de saúde primários na Tanzânia.
Accessed on 03/07/2025.
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Accessed July 2025. Malaria social and behavior change (SBC) professionals are often asked to justify investments in malaria SBC. Making the case for malaria SBC requires global-level and national-level advocacy, especially given the limited resources available for malaria control and elimination an
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d competing priorities.
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Ce manuel est destiné aux prestataires de soins chargés de la prise en charge des cas de paludisme simple et grave au niveau des structures de santé. C’est un document de référence facile d’utilisation, fournissant des connaissances et des compétences utiles aux agents de santé prenant e
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n charge les cas de paludisme.
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A pesar de los avances, persisten importantes barreras para el diagnóstico y tratamiento oportunos de la malaria en las Américas, especialmente en zonas rurales y de difícil acceso. Para reducir la transmisión, es esencial ampliar el uso de pruebas de diagnóstico rápido y garantizar la disponi
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bilidad gratuita de antimaláricos como bienes públicos. La OPS propone un marco estratégico para eliminar obstáculos, acelerar el inicio del tratamiento y contribuir a la eliminación de la enfermedad en la región.
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2023 was another year of significant progress in the fight against HIV, tuberculosis (TB) and malaria. In countries where the Global
Fund invests, there has been a full recovery from the disruptive impact of the COVID-19 pandemic. The results we have achieved in the last year build on our extraord
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inary track record of progress. Over the last two decades, our partnership has cut the combined death rate from AIDS, TB and malaria by 61%. As of the end of 2023, the Global Fund partnership has saved 65 million lives.
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Poverty and associated health, nutrition, and social factors prevent at least 200 million children in developing countries from attaining their developmental potential. We review the evidence linking compromised development with modifiable biological and psychosocial risks encountered by children fr
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om birth to 5 years of age. We identify four key risk factors where the need for intervention is urgent: stunting, inadequate cognitive stimulation, iodine deficiency, and iron deficiency anaemia. The evidence is also sufficient to warrant interventions for malaria, intrauterine growth restriction, maternal depression, exposure to violence, and exposure to heavy metals. We discuss the research needed to clarify the effect of other potential risk factors on child development. The prevalence of the risk factors and their effect on development and human potential are substantial. Furthermore, risks often occur together or cumulatively, with concomitant increased adverse effects on the development of the world's poorest children.
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Découverte par Alphonse Laveran en 1880, cette maladie parasitaire demeure en 2022 l’endémie la plus répandue dans les régions tropicales et subtropicales. Selon le rapport mondial sur le paludisme de 2021 de l'OMS, on estime à 232 millions le nombre de cas en 2019 dans 87 pays endémiques, d
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ont 94 % sont concentrés en Afrique subsaharienne et sont principalement dus à Plasmodium falciparum. Le nombre de décès est passé de 897 000 en 2000 à 568 000 en 2019, dont près de 95 % sont survenus dans 31 pays. Des baisses marquées sont également observées en Asie du Sud-Est. Avec des financements suffisants et un renforcement des campagnes d'information, le contrôle, voire l'éradication du paludisme, restent envisageables.
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Malaria and HIV, two of the world’s most deadly diseases, are widespread, but their distribution overlaps greatly in sub-Saharan Africa. Consequently, malaria and HIV coinfection (MHC) is common in the region. In this paper, pertinent publications on the prevalence, impact, and treatment strategie
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s of MHC obtained by searching major electronic databases (PubMed, PubMed Central, Google Scholar, ScienceDirect, and Scopus) were reviewed, and it was found that the prevalence of MHC in SSA was 0.7%–47.5% overall. Prevalence was 0.7%–47.5% in nonpregnant adults, 1.2%–27.8% in children, and 0.94%–37% in pregnant women. MHC was associated with an increased frequency of clinical parasitemia and severe malaria, increased parasite and viral load, and impaired immunity to malaria in nonpregnant adults, children, and pregnant women, increased in placental malaria and related outcomes in pregnant women, and impaired antimalarial drug efficacy in nonpregnant adults and pregnant women. Although a few cases of adverse events have been reported in coinfected patients receiving antimalarial and antiretroviral drugs concurrently, available data are very limited and have not prompted major revision in treatment guidelines for both diseases. Artemisinin-based combination therapy and cotrimoxazole are currently the recommended drugs for treatment and prevention of malaria in HIV-infected children and adults. However, concurrent administration of cotrimoxazole and sulfadoxine–pyrimethamine in HIV-infected pregnant women is not recommended, because of high risk of sulfonamide toxicity. Further research is needed to enhance our understanding of the impact of malaria on HIV, drug–drug interactions in patients receiving antimalarials and antiretroviral drugs concomitantly, and the development of newer, safer, and more cost-effective drugs and vaccines to prevent malaria in HIV-infected pregnant women.
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The emergence of SARS-CoV-2 has significantly altered the epidemiology of other infectious diseases, making investigations into its co-infection with malaria particularly relevant in endemic regions. This review examines the epidemiological, incubation and clinical features of the two diseases, high
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lighting the diagnostic challenges and strategies for accurate detection. Emerging immunological and genetic evidence indicates that prior exposure to malaria may reduce the severity of outcomes of SARS-CoV-2 infection through mechanisms involving ACE2 downregulation, TLR signalling, T-cell activation and upregulation of coinhibitory receptors. Additionally, potential control measures are discussed, including vaccine development, the repurposing of antimalarial drugs, the exploration of natural products, innovations in bioinsecticides, and the strengthening of electronic disease surveillance. These insights provide valuable guidance for clinical management and public health policy, while emphasising the need for continued research into the complex interactions between SARS-CoV-2 and malaria.
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Malaria is a significant risk for travelers to endemic regions. This patient information highlights essential prevention through mosquito protection and, when indicated, chemoprophylaxis with Atovaquone/Proguanil, Doxycycline, or Mefloquine. Emergency self-treatment options may be carried in specifi
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c settings. Travelers are advised to follow medication schedules carefully, use consistent bite protection, and seek immediate medical care if fever occurs during or after travel. Early recognition and treatment are crucial to prevent severe or life-threatening complications.
Accessed on 26/08/2025.
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The Centrum für Reisemedizin (CRM) is a comprehensive source of information, guidelines and resources on travel medicine for healthcare professionals and travellers. Its website offers up-to-date recommendations on disease prevention, vaccinations, malaria prophylaxis and health risks in different
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regions around the world. As part of the Thieme Group, the CRM promotes evidence-based medical counselling, training and educational materials for patients, with the aim of improving travel health outcomes and ensuring safe international mobility.
Accessed on 26/08/2025.
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The website "Bereit zu Reisen" provides comprehensive guidance on malaria prophylaxis for travelers to endemic regions. It emphasizes preventive strategies, including mosquito bite avoidance through protective clothing, insect repellents, and sleeping under treated nets. In addition, the site detail
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s chemoprophylaxis options, explaining recommended medications, dosing schedules, and duration of use before, during, and after travel. Emergency self-treatment procedures are also outlined for situations where immediate medical care is unavailable. Overall, the resource serves as a practical reference for travelers, combining evidence-based recommendations on exposure prevention, medication use, and prompt response to potential malaria symptoms to ensure safe and healthy travel.
Accessed on 26/08/2025.
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In 2019, 1.5 billion international tourist trips were counted worldwide. Germany, with 70.8 million vacations lasting ≥ 5 days, was one of the populations most willing to travel. These days, even elderly and multimorbid persons regularly travel long-distance, which can be associated with significa
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nt health risks. By advising travelers and implementing preventive measures, the risk of illness can be reduced significantly.
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This document, issued by the United Nations Medical Directors in July 2021, outlines vaccination and malaria prophylaxis recommendations for UN personnel travelling on official business and UN healthcare workers. The guidance aims to minimise the risk of vaccine-preventable diseases and malaria by f
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ocusing on three key areas:(1) routine vaccines, such as those for influenza, measles, polio, hepatitis B, varicella and SARS-CoV-2 (the virus that causes the disease known as 'Covid-19'), which are recommended for all staff regardless of their destination;
(2) destination-based measures, including mandatory vaccines (e.g. yellow fever, meningitis and polio), recommended vaccines depending on regional risks (e.g. cholera, typhoid, hepatitis A and rabies) and WHO-advised malaria prevention through mosquito protection and chemoprophylaxis. The third area covers vaccines for healthcare workers with direct patient or laboratory exposure, including hepatitis B, influenza, diphtheria, pertussis and others. The recommendations emphasise the importance of pre-travel medical consultations, adherence to host country requirements, and individualised risk assessments.
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The CDC Yellow Book is the Centers for Disease Control and Prevention's comprehensive reference guide to health issues related to international travel. It provides evidence-based recommendations and practical guidance for healthcare professionals advising travellers, as well as for travellers themse
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lves. Topics covered include country-specific vaccination requirements, the prevention and treatment of infectious diseases, malaria prophylaxis, food and water safety, the management of travel-related conditions, and guidance for special populations, such as children, pregnant travellers and individuals with chronic illnesses. Updated every two years, the Yellow Book synthesises global surveillance data, World Health Organization guidelines and CDC expertise to help prevent illness and injury during international travel. Serving as both an authoritative clinical tool and a public health resource, it ensures safe and healthy travel worldwide.
Accessed on 27/08/2025.
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