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Integrating Clinical Research into Epidemic Response: The Ebola Experience

Gerald Keusch, Keith McAdam, Patricia Cuff, Michelle Mancher, and Emily R. Busta National Academies of Sciences, Engineering, and Medicine (2017) C1

The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Repub... more

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Republic of Kenya: National Policy on Prevention and Containment of Antimicrobial Resistance

Government of Kenya (2017) C2

Antimicrobial resistance (AMR) is a global threat that requires urgent collaborative action within and among countries. AMR makes standard treatments ineffective and facilitates the spread of antimicrobial resistant infections rendering communities vulnerable. The Ministry of Health (MOH) and Minist... more

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Practical guide to inclusive and rights-based responses to Covid-19 in the Americas

OAS (2020) CC

WHY THIS GUIDE? Because, in the face of crises and emergencies, it is vital to include a human rights perspective in responses. Vulnerable groups face major obstacles to accessing and benefiting from prevention, mitigation, and health care policies due to structural barriers of inequality. To offer... more

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Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming

Williams, D.; Faiz, M.; Abela-Ridder, B. et al. PLoS Neglected Tropical diseases (2019) CC

In one of his final essays, statesman and former United Nations secretary general Kofi Annan said, ‘Snakebite is the most important tropical disease you’ve never heard of’. Mr. Annan firmly believed that victims of snakebite envenoming should be recognised and afforded greater efforts at impro... more

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The Sphere standards and the Coronavirus response

The Sphere (2021) C_Sphere

Updated 8 June 2021. The document has two sections: A. The first section covers fundamental principles which are crucial to a successful, holistic intervention. B. The second covers relevant standards and guidance in the handbook’s Water Supply, Sanitation and Hygiene Promotion (WASH) and Health... more

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Pandemic and Poverty: COVID-19 Impact on the World’s Poor

World Relief (2022) CC

World Relief published a new report revealing the immense impact of COVID-19 on the world's poor. This report is one of the most comprehensive of its kind, corresponding to the two-year anniversary of when the World Health Organization declared COVID-19 to be a global pandemic.

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Note on the protection of migrants in the face of the COVID-19 pandemic

International Committee of the Red Cross ICRC (2020) C1

Many migrants find themselves with limited access, if any, to information about risks, prevention measures, health care and other essential services. Migrants in transit, those in need of international protection or without legal status are likely to be particularly vulnerable, as well as those who ... more

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Optimal timing of HIV home‐based counselling and testing rounds in Western Kenya

Olney, Jack J.; Eaton, Jeffrey W.; Braitstein, Paula et al. (2018) CC

Journal of the International AIDS Society, vol. 21 Issue no. 6 e 25142
Weaknesses in care programmes providing anti‐retroviral therapy (ART) persist and are often instigated by late HIV diagnosis and poor linkage to care. We investigated the potential for a home‐based counselling and testin... more

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A double dose of inequality; Pharma companies and the Covid-19 vaccines crisis

Amnesty International (2022) C2

22 Sept. 2021 The rapid development of effective Covid-19 vaccines in 2020 gave hope to the world in the darkest days of the deadly pandemic. However, the vaccine roll-out has been massively skewed towards wealthy nations. While rich states have hoarded vaccines, companies have also played a decisi... more

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Nurses as substitutes for doctors in primary care - Review

Laurant M, van der Biezen M, Wijers N et al. Cochrane Library (2018) CC

Current and expected problems such as ageing, increased prevalence of chronic conditions and multi-morbidity, increased emphasison healthy lifestyle and prevention, and substitution for care from hospitals by care provided in the community encourage countries worldwide to develop new models of prima... more

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The Core Elements of Human Antibiotic Stewardship Programs in Resource-Limited Settings: National and Hospital Levels
recommended

Centers for Disease Control and Prevention CDC (2018) C_CDC

Formularies are lists of antibiotics that are suggested for certain healthcare settings. In developing a recommended formulary, countries should consider the needs of patients and facilities where they receive care. For example, clinicians in rural or primary health centers may need wide access to f... more

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Ökonomische Bewertung in der globalen Gesundheit

Kohler, S.; N.Paul, T. Bärnighausen, P. Geldsetzer (2021) CC

In: Bonk M., Ulrichs T. (eds). Global Health: Das Konzept der Globalen Gesundheit. Berlin: De Gruyter, 2021, pp. 557–580

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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Protection, Participation and Potential: Women and Girls in Yemen’s War

International Rescue Committee (2019) C1

Women and girls are paying the price of the war in Yemen – Humanitarian actors must increase the priority given to women and girls’ needs, with specific attention to GBV prevention and response, and reproductive health services

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COVID-19 in Latin America and the caribbean region: Symptoms and morbidities in the epidemiology of infection

Anaya-Covarrubias, J.Y.; et al. (2022) C1

Curr Opin Pharmacol . 2022 Apr;63:102203.doi: 10.1016/j.coph.2022.102203. Epub 2022 Feb 11. The COVID-19 pandemic has widespread economic and social effects on Latin America (LA) and the Caribbean (CA). This region, which has a high prevalence of chronic diseases, has been one of the most affected... more

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The impact of the COVID-19 pandemic on Syrians: An Analysis by Syrian civil society

Half of Syria (2020) C2

A comprehensive briefing by Half of Syria April 2020 A comprehensive briefing on the critical challenges of the COVID-19 pandemic to Syrians, as reported by Syrian civil society organisations. These challenges have been collated following extensive interviews with the teams of member and partner... more

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Global Early Warning – Early Action Report on Food Security and Agriculture: April-June 2020

Food and Agriculture Organization of the United Nations (2017) C1

The Global Early Warning – Early Action (EWEA) report on food security and agriculture is developed by the Food and Agriculture Organization of the United Nations (FAO). The report is part of FAO’s EWEA system, which aims to translate forecasts and early warnings into anticipatory action.

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Averting ethnocide: : Indigenous peoples and territorial rights in crisis in the face of COVID-19 in Latin America

Oxfam (2020) CC

There are indigenous communities at high risk in every country of the region. At stake are the lives of 45 million people who belong to more than 800 indigenous peoples. Of these, some 100 are spread across several countries, around 200 maintain voluntary isolation or are in initial contact, and nea... more

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Patient- and provider-related factors in the success of multidrug-resistant tuberculosis treatment in Colombia

Puerto Castro GM, Montes Zuluaga FN, Alcalde-Rabanal JE, Pérez F, et al. PAHO (2021) C_WHO

Rev Panam Salud Publica. 2021;45:e74. Some characteristics of patients and healthcare providers influence treatment success in MDR-TB cases. Physicians’ and nurses’ knowledge about MDR-TB must be improved, and follow-up of MDR-TB patients who are living with HIV and of those affiliated with the... more

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Ebola- local beliefs and behaviour change

Grant, C. HEART (2014)

What are the local beliefs and practices around illnesses and death, the transmission of disease and spirituality, which affect decision-making (around health-seeking behaviour, caring for relatives and nature of burials) and can inform effective behaviour change interventions for preventing Ebola i... more

The Core Elements of Human Antibiotic Stewardship Programs in Resource-Limited Settings: National and Hospital Levels recommended

The Core Elements of Human Antibiotic Stewardship Programs in Resource-Limited Settings: National and Hospital Levels
recommended