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These updates include shorter novel 6-month all-oral regimens for the treatment of multidrug- and rifampicin-resistant TB (MDR/RR-TB), with or without additional resistance to fluoroquinolones (pre-XDR-TB) as well as an alternative 9-month all-
...
oral regimen for the treatment of MDR/RR-TB.
This Rapid Communication is released in advance of updated WHO consolidated guidelines expected later in 2022, to inform national TB programmes and other stakeholders of key changes in the treatment of DR-TB and to allow for rapid transition and planning at the country level.
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Braz. Oral Res. 2025;39:e0
Available in Englisch, French, Spanish and Chinese
The document provides guidelines for the management of acute diarrhoea, highlighting improved oral rehydration solutions (ORS) with reduced osmolarity and zinc supplementation. It emphasizes their
...
effectiveness in reducing the duration and severity of diarrhoeal episodes and preventing future cases. Aimed at families, communities, and healthcare professionals, it seeks to integrate these practices into routine care at home and in health centers.
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The WHO Cholera Vaccine Position Paper (August 2017) highlights the importance of oral cholera vaccines (OCVs) as a key tool in outbreak response and prevention, alongside water, sanitation, and hygiene (WASH) measures. It recommends OCVs for high-r
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isk populations, endemic areas, and humanitarian crises, emphasizing their effectiveness in reducing cases and mortality. The paper discusses two types of OCVs (Dukoral®, Shanchol™, Euvichol®) and supports the WHO-managed vaccine stockpile for rapid deployment in cholera-prone regions.
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Clinical Presentation and Management for Haiti Cholera Outbreak, 2010
The document provides detailed guidelines for diagnosing and managing cholera cases, with a focus on rehydration therapy and preventing dehydration-related fatalities. It outlines the use of
...
oral rehydration salts (ORS), intravenous fluids for severe dehydration, and appropriate antibiotics for severe cases. The guide also emphasizes the importance of hygiene, safe water usage, and monitoring patient recovery to effectively control cholera outbreaks. It is designed as a practical resource for healthcare workers and public health officials.
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The document provides essential guidelines for managing cholera outbreaks. It includes instructions for preparing oral rehydration solutions (ORS) using simple ingredients like sugar and salt to treat dehydration caused by cholera. The text also emp
...
hasizes the importance of access to clean water, sanitation, and hygiene to prevent the spread of the disease. It is part of the World Health Organization's effort to provide clear, actionable steps for controlling cholera in affected areas.
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Highlights:
- IOM teams reach populations in need in Baggari, south of Wau
- Rapid response teams conduct oral cholera vaccination campaigns across the country
- IOM expands fuel-efficient stove initiative in the Bentiu PoC site
These guidelines provide a recommendation on iodine thyroid blocking (ITB), via oral administration of stable iodine, as an urgent protective action in responding to a nuclear accident. This recommendation aims to support emergency planners, policy
...
makers, public health specialists, clinicians and other relevant stakeholders, in order to strengthen public health preparedness for radiation emergencies in WHO Member States as required by the International Health Regulations (IHR) and in line with the international safety standards (GSR Part 7). The scope of the guidelines is confined to public health aspects of planning and implementation of ITB before and during a radiation emergency, such as dosage and timing of ITB administration, adverse effects of stable iodine, its packaging, storage, and distribution.
These guidelines supersede the 1999 WHO Guidelines for Iodine Prophylaxis following Nuclear Accidents.
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The study on single-dose cholera vaccine in Zambia evaluates the effectiveness of using a single dose of the oral cholera vaccine (OCV) during a 2016 outbreak in Lusaka. Due to limited vaccine supply, authorities opted for a one-dose emergency campa
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ign instead of the usual two-dose regimen. A matched case-control study was conducted to assess vaccine effectiveness, showing 88.9% short-term protection against cholera. The findings suggest that a single-dose approach can be an effective strategy in outbreak settings, especially when vaccine supplies are constrained. However, further research is needed to determine long-term immunity and effectiveness in young children.
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After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery,
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pre-clinical development, and operational challenges of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC50 of around 1 µM against Trypanosoma brucei and is more than 100-fold less toxic to mammalian cells. In the mouse model, fexinidazole cures both the first, haemolymphatic, and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in the Democratic Republic of the Congo demonstrated that oral fexinidazole is safe and effective for use against first- and early second-stage sleeping sickness. Based on the positive opinion issued by the European Medicines Agency in 2018, the WHO has released new interim guidelines for the treatment of HAT including fexinidazole as the new therapy for first-stage and non-severe second-stage sleeping sickness caused by Trypanosoma brucei gambiense (gHAT). This greatly facilitates the diagnosis and treatment algorithm for gHAT, increasing the attainable coverage and paving the way towards the envisaged goal of zero transmission by 2030.
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Website last accessed on 04.06.2023
Treatment options for Visceral Leishmaniasis in HIV-coinfected people include oral miltefosine; find additional information on diagnosis and ART treatment.
The document lists the components of various cholera kits designed for managing cholera outbreaks. It includes items for rehydration therapy (e.g., oral rehydration salts and IV fluids), medications, sanitation supplies, diagnostic tools, and logist
...
ical materials such as cholera beds and water purification systems. These kits aim to support healthcare providers in treating patients, preventing the spread of the disease, and maintaining hygiene in affected areas.
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The document titled "Cómo combatir el cólera" (How to Combat Cholera) provides comprehensive guidelines on the clinical presentation and management of cholera, particularly in the context of the 2010 Haiti outbreak.
It emphasizes the importance of rapid rehydration as a lifesaving measure, deta
...
iling protocols for both oral rehydration solutions (ORS) and intravenous (IV) fluids. The document outlines appropriate antibiotic treatments based on patient categories, underscores the necessity of proper sanitation, and offers strategies for effective outbreak control. Additionally, it provides guidance on recognizing severe dehydration and the need for immediate medical intervention to reduce mortality associated with cholera.
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The document provides comprehensive guidelines on cholera outbreak management, including prevention, diagnosis, and treatment. It emphasizes rapid response measures, the importance of rehydration therapy (oral and intravenous), and public health int
...
erventions such as water sanitation, hygiene promotion, and disease surveillance to control the spread of cholera in affected communities. It is designed as a resource for healthcare providers and public health officials.
more
The document provides comprehensive guidelines on cholera outbreak management, including prevention, diagnosis, and treatment. It emphasizes rapid response measures, the importance of rehydration therapy (oral and intravenous), and public health int
...
erventions such as water sanitation, hygiene promotion, and disease surveillance to control the spread of cholera in affected communities. It is designed as a resource for healthcare providers and public health officials.
more
Revised WHO classification and treatment of childhood pneumonia at health facilities
World Health Organization
(2014)
The revised guidelines present two major changes to existing guidelines: (A) there are now just 2 categories of pneumonia instead of 3 (“pneumonia” which is treated at home with oral amoxicillin and “severe pneumonia” which requires injectab
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le antibiotics) and (B) oral amoxicillin replaces oral cotrimoxazole as first line treatment, preferably in 250mg dispersible tablet form, twice daily for five days which can be reduced to three days in low HIV settings.
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Description illustrée des étapes et précautions nécessaires pour prélever la salive d'un patient décédé et suspecté d'être infecté par le virus Ebola: avant d'entrer dans la chambre du patient, les équipements de protection individuelle, la réalisation d'un écouvillonnage
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oral, la préparation du tube de collecte pour le transport, enlever les équipements de protection individuelle.
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The document provides WHO guidelines on fluid management for children with severe acute malnutrition (SAM) and cholera. It outlines protocols for rehydration therapy, including oral rehydration solutions (ORS) and intravenous fluids for cases of sev
...
ere dehydration or shock. The guidelines emphasize careful monitoring to avoid overhydration and highlight the use of zinc supplementation to reduce diarrhea severity and future episodes. It also discusses the integration of therapeutic feeding to support recovery. The document is a resource for healthcare workers managing vulnerable children in cholera outbreaks.
more
The document provides WHO guidelines on fluid management for children with severe acute malnutrition (SAM) and cholera. It outlines protocols for rehydration therapy, including oral rehydration solutions (ORS) and intravenous fluids for cases of sev
...
ere dehydration or shock. The guidelines emphasize careful monitoring to avoid overhydration and highlight the use of zinc supplementation to reduce diarrhea severity and future episodes. It also discusses the integration of therapeutic feeding to support recovery. The document is a resource for healthcare workers managing vulnerable children in cholera outbreaks.
more
Hygiene Awareness Manual (Arabic) - GIZ
recommended
The "Hygiene Awareness Manual" focuses on promoting improved hygiene practices within communities, emphasizing personal and household hygiene, water safety, and environmental health. It highlights the importance of handwashing, oral hygiene, and mai
...
ntaining cleanliness of the skin and clothing as key aspects of personal and family hygiene. Specific practices such as regular bathing and wearing clean clothes are also emphasized.
For household hygiene, the manual provides guidance on safe food preparation and storage, as well as keeping living spaces, kitchens, and latrines clean to prevent contamination. It also addresses water safety, emphasizing the need to store water in clean containers, treat it for safe consumption, and dispose of wastewater properly to avoid environmental contamination.
The manual underscores the significance of balanced nutrition and food safety, offering guidelines for cooking and preserving food to reduce health risks. It also delves into disease prevention, explaining the causes and transmission of waterborne and hygiene-related diseases, such as cholera and dysentery, and outlining effective methods to prevent them through proper sanitation and hygiene.
This comprehensive guide serves as a practical resource for community health workers and households, aiming to foster better hygiene practices, prevent diseases, and enhance overall health and well-being.
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